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stringlengths 15
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split_0_train_3400 | split_0_train_3400 | [
{
"id": "split_0_train_3400_passage",
"type": "progene_text",
"text": [
"In addition , translation of the enterovirus and rhinovirus ( HRV ) subgroups requires cellular trans - acting factors that are absent from , or limiting in rabbit reticulocytes , but are more abundant in HeLa cell extracts ."
],
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[
0,
225
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]
}
]
| []
| []
| []
| []
|
split_0_train_3401 | split_0_train_3401 | [
{
"id": "split_0_train_3401_passage",
"type": "progene_text",
"text": [
"It has been shown previously that HeLa cells contain two separable activities , each of which independently stimulates HRV IRES - dependent translation when used to supplement reticulocyte lysate ; one of these activities was identified as polypyrimidine tract - binding protein ( PTB ) ."
],
"offsets": [
[
0,
288
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]
}
]
| [
{
"id": "split_0_train_5510_entity",
"type": "progene_text",
"text": [
"polypyrimidine tract - binding protein"
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[
240,
278
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{
"id": "split_0_train_5511_entity",
"type": "progene_text",
"text": [
"PTB"
],
"offsets": [
[
281,
284
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3402 | split_0_train_3402 | [
{
"id": "split_0_train_3402_passage",
"type": "progene_text",
"text": [
"Here , the purification of the second activity is achieved by use of an RNA - affinity column based on the HRV 5' UTR ."
],
"offsets": [
[
0,
119
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]
}
]
| []
| []
| []
| []
|
split_0_train_3403 | split_0_train_3403 | [
{
"id": "split_0_train_3403_passage",
"type": "progene_text",
"text": [
"It comprises two components : a 38 - kD protein ( p38 ) , which is a novel member of the GH-WD repeat protein family and has no intrinsic RNA - binding activity ; and a 96 - to 97 - kD protein doublet , which was identified as unr , an RNA - binding protein with five cold - shock domains ."
],
"offsets": [
[
0,
290
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]
}
]
| [
{
"id": "split_0_train_5512_entity",
"type": "progene_text",
"text": [
"p38"
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"offsets": [
[
50,
53
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"normalized": []
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{
"id": "split_0_train_5513_entity",
"type": "progene_text",
"text": [
"GH-WD repeat protein family"
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89,
116
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{
"id": "split_0_train_5514_entity",
"type": "progene_text",
"text": [
"unr"
],
"offsets": [
[
227,
230
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3404 | split_0_train_3404 | [
{
"id": "split_0_train_3404_passage",
"type": "progene_text",
"text": [
"Coimmunoprecipitation with antibodies against either protein shows that the two proteins interact with each other , and thus p38 is named unrip ( unr - interacting protein ) ."
],
"offsets": [
[
0,
175
]
]
}
]
| [
{
"id": "split_0_train_5515_entity",
"type": "progene_text",
"text": [
"p38"
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[
125,
128
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{
"id": "split_0_train_5516_entity",
"type": "progene_text",
"text": [
"unrip"
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138,
143
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"normalized": []
},
{
"id": "split_0_train_5517_entity",
"type": "progene_text",
"text": [
"unr - interacting protein"
],
"offsets": [
[
146,
171
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3405 | split_0_train_3405 | [
{
"id": "split_0_train_3405_passage",
"type": "progene_text",
"text": [
"Recombinant unr acts synergistically with recombinant PTB to stimulate translation dependent on the rhinovirus IRES ."
],
"offsets": [
[
0,
117
]
]
}
]
| [
{
"id": "split_0_train_5518_entity",
"type": "progene_text",
"text": [
"unr"
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"offsets": [
[
12,
15
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],
"normalized": []
},
{
"id": "split_0_train_5519_entity",
"type": "progene_text",
"text": [
"PTB"
],
"offsets": [
[
54,
57
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3406 | split_0_train_3406 | [
{
"id": "split_0_train_3406_passage",
"type": "progene_text",
"text": [
"In contrast , unr did not significantly augment the PTB - dependent stimulation of poliovirus IRES activity ."
],
"offsets": [
[
0,
109
]
]
}
]
| [
{
"id": "split_0_train_5520_entity",
"type": "progene_text",
"text": [
"unr"
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"offsets": [
[
14,
17
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"normalized": []
},
{
"id": "split_0_train_5521_entity",
"type": "progene_text",
"text": [
"PTB"
],
"offsets": [
[
52,
55
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3407 | split_0_train_3407 | [
{
"id": "split_0_train_3407_passage",
"type": "progene_text",
"text": [
"Control of the tissue inhibitor of metalloproteinases-1 promoter in culture - activated rat hepatic stellate cells : regulation by activator protein-1 DNA binding proteins ."
],
"offsets": [
[
0,
173
]
]
}
]
| [
{
"id": "split_0_train_5522_entity",
"type": "progene_text",
"text": [
"tissue inhibitor of metalloproteinases-1"
],
"offsets": [
[
15,
55
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],
"normalized": []
},
{
"id": "split_0_train_5523_entity",
"type": "progene_text",
"text": [
"activator protein-1"
],
"offsets": [
[
131,
150
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3408 | split_0_train_3408 | [
{
"id": "split_0_train_3408_passage",
"type": "progene_text",
"text": [
"In the injured liver hepatic stellate cells ( HSCs ) undergo a dramatic phenotypic transformation known as \" activation \" in which they become myofibroblast - like and express high levels of the tissue inhibitor of metalloproteinase 1 ( TIMP-1 ) ."
],
"offsets": [
[
0,
247
]
]
}
]
| [
{
"id": "split_0_train_5524_entity",
"type": "progene_text",
"text": [
"tissue inhibitor of metalloproteinase 1"
],
"offsets": [
[
195,
234
]
],
"normalized": []
},
{
"id": "split_0_train_5525_entity",
"type": "progene_text",
"text": [
"TIMP-1"
],
"offsets": [
[
237,
243
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3409 | split_0_train_3409 | [
{
"id": "split_0_train_3409_passage",
"type": "progene_text",
"text": [
"HSC activation is accompanied by transactivation of the TIMP-1 promoter ."
],
"offsets": [
[
0,
73
]
]
}
]
| [
{
"id": "split_0_train_5526_entity",
"type": "progene_text",
"text": [
"TIMP-1"
],
"offsets": [
[
56,
62
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3410 | split_0_train_3410 | [
{
"id": "split_0_train_3410_passage",
"type": "progene_text",
"text": [
"Truncation mutagenesis studies delineated a minimal active promoter consisting of nucleotides - 102 to + 60 relative to the major start site for transcription ."
],
"offsets": [
[
0,
160
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3411 | split_0_train_3411 | [
{
"id": "split_0_train_3411_passage",
"type": "progene_text",
"text": [
"Removal of an AP-1 site located at nucleotides - 93 to - 87 caused almost a complete loss of promoter activity ."
],
"offsets": [
[
0,
112
]
]
}
]
| [
{
"id": "split_0_train_5527_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
14,
18
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3412 | split_0_train_3412 | [
{
"id": "split_0_train_3412_passage",
"type": "progene_text",
"text": [
"Analysis of AP-1 DNA binding activities during culture activation of HSCs initially indicated transient expression of proteins capable of forming a low mobility AP-1 DNA binding complex ( LMAP-1 ) ."
],
"offsets": [
[
0,
198
]
]
}
]
| [
{
"id": "split_0_train_5528_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
12,
16
]
],
"normalized": []
},
{
"id": "split_0_train_5529_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
161,
165
]
],
"normalized": []
},
{
"id": "split_0_train_5530_entity",
"type": "progene_text",
"text": [
"LMAP-1"
],
"offsets": [
[
188,
194
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3413 | split_0_train_3413 | [
{
"id": "split_0_train_3413_passage",
"type": "progene_text",
"text": [
"LMAP-1 was maximally induced at 24 hours of culture and then fell to undetectable levels at 120 hours ."
],
"offsets": [
[
0,
103
]
]
}
]
| [
{
"id": "split_0_train_5531_entity",
"type": "progene_text",
"text": [
"LMAP-1"
],
"offsets": [
[
0,
6
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3414 | split_0_train_3414 | [
{
"id": "split_0_train_3414_passage",
"type": "progene_text",
"text": [
"Western blot studies showed that both c-Fos and c-Jun underwent similar transient inductions ."
],
"offsets": [
[
0,
94
]
]
}
]
| [
{
"id": "split_0_train_5532_entity",
"type": "progene_text",
"text": [
"c-Fos"
],
"offsets": [
[
38,
43
]
],
"normalized": []
},
{
"id": "split_0_train_5533_entity",
"type": "progene_text",
"text": [
"c-Jun"
],
"offsets": [
[
48,
53
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3415 | split_0_train_3415 | [
{
"id": "split_0_train_3415_passage",
"type": "progene_text",
"text": [
"These temporal changes in c-Fos and c-Jun activities were unexpected because TIMP-1 mRNA expression is not detected in HSCs until culture day 3 to 5 and is thereafter sustained at a high level ."
],
"offsets": [
[
0,
194
]
]
}
]
| [
{
"id": "split_0_train_5534_entity",
"type": "progene_text",
"text": [
"c-Fos"
],
"offsets": [
[
26,
31
]
],
"normalized": []
},
{
"id": "split_0_train_5535_entity",
"type": "progene_text",
"text": [
"c-Jun"
],
"offsets": [
[
36,
41
]
],
"normalized": []
},
{
"id": "split_0_train_5536_entity",
"type": "progene_text",
"text": [
"TIMP-1"
],
"offsets": [
[
77,
83
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3416 | split_0_train_3416 | [
{
"id": "split_0_train_3416_passage",
"type": "progene_text",
"text": [
"Previous work in other cell lineages has established a key role for Pea3 binding proteins ( Ets-1 ) in AP-1 mediated transactivation of the TIMP-1 promoter ."
],
"offsets": [
[
0,
157
]
]
}
]
| [
{
"id": "split_0_train_5537_entity",
"type": "progene_text",
"text": [
"Pea3"
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"offsets": [
[
68,
72
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],
"normalized": []
},
{
"id": "split_0_train_5538_entity",
"type": "progene_text",
"text": [
"Ets-1"
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"offsets": [
[
92,
97
]
],
"normalized": []
},
{
"id": "split_0_train_5539_entity",
"type": "progene_text",
"text": [
"AP-1"
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"offsets": [
[
103,
107
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"normalized": []
},
{
"id": "split_0_train_5540_entity",
"type": "progene_text",
"text": [
"TIMP-1"
],
"offsets": [
[
140,
146
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3417 | split_0_train_3417 | [
{
"id": "split_0_train_3417_passage",
"type": "progene_text",
"text": [
"We show that HSCs express relatively low levels Ets-1 and Ets-2 and show that mutagenesis of the Pea3 DNA binding site in the TIMP-1 promoter has less than a twofold effect on its activity in activated HSCs ."
],
"offsets": [
[
0,
208
]
]
}
]
| [
{
"id": "split_0_train_5541_entity",
"type": "progene_text",
"text": [
"Ets-1"
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"offsets": [
[
48,
53
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],
"normalized": []
},
{
"id": "split_0_train_5542_entity",
"type": "progene_text",
"text": [
"Ets-2"
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"offsets": [
[
58,
63
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],
"normalized": []
},
{
"id": "split_0_train_5543_entity",
"type": "progene_text",
"text": [
"Pea3"
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"offsets": [
[
97,
101
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],
"normalized": []
},
{
"id": "split_0_train_5544_entity",
"type": "progene_text",
"text": [
"TIMP-1"
],
"offsets": [
[
126,
132
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3418 | split_0_train_3418 | [
{
"id": "split_0_train_3418_passage",
"type": "progene_text",
"text": [
"Further analysis of AP-1 DNA binding activities in 7 - to 14 - day culture activated HSCs led to the discovery of high mobility AP-1 complexes ( HMAP-1 ) ."
],
"offsets": [
[
0,
155
]
]
}
]
| [
{
"id": "split_0_train_5545_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
20,
24
]
],
"normalized": []
},
{
"id": "split_0_train_5546_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
128,
132
]
],
"normalized": []
},
{
"id": "split_0_train_5547_entity",
"type": "progene_text",
"text": [
"HMAP-1"
],
"offsets": [
[
145,
151
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3419 | split_0_train_3419 | [
{
"id": "split_0_train_3419_passage",
"type": "progene_text",
"text": [
"HMAP-1 DNA binding activities were sequence specific with respect to AP-1 and absent from freshly isolated HSCs ."
],
"offsets": [
[
0,
113
]
]
}
]
| [
{
"id": "split_0_train_5548_entity",
"type": "progene_text",
"text": [
"HMAP-1"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "split_0_train_5549_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
69,
73
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3420 | split_0_train_3420 | [
{
"id": "split_0_train_3420_passage",
"type": "progene_text",
"text": [
"Supershift EMSA and Western blot studies identified JunD , Fra2 , and FosB as potential components of the HMAP-1 ."
],
"offsets": [
[
0,
114
]
]
}
]
| [
{
"id": "split_0_train_5550_entity",
"type": "progene_text",
"text": [
"JunD"
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"offsets": [
[
52,
56
]
],
"normalized": []
},
{
"id": "split_0_train_5551_entity",
"type": "progene_text",
"text": [
"Fra2"
],
"offsets": [
[
59,
63
]
],
"normalized": []
},
{
"id": "split_0_train_5552_entity",
"type": "progene_text",
"text": [
"FosB"
],
"offsets": [
[
70,
74
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],
"normalized": []
},
{
"id": "split_0_train_5553_entity",
"type": "progene_text",
"text": [
"HMAP-1"
],
"offsets": [
[
106,
112
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3421 | split_0_train_3421 | [
{
"id": "split_0_train_3421_passage",
"type": "progene_text",
"text": [
"Mutations of the AP-1 site of the TIMP-1 promoter that prevented formation of HMAP-1 caused a 70 % loss of activity in transfected activated HSCs ."
],
"offsets": [
[
0,
147
]
]
}
]
| [
{
"id": "split_0_train_5554_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
17,
21
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],
"normalized": []
},
{
"id": "split_0_train_5555_entity",
"type": "progene_text",
"text": [
"TIMP-1"
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34,
40
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],
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},
{
"id": "split_0_train_5556_entity",
"type": "progene_text",
"text": [
"HMAP-1"
],
"offsets": [
[
78,
84
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3422 | split_0_train_3422 | [
{
"id": "split_0_train_3422_passage",
"type": "progene_text",
"text": [
"Taken together the data indicate that sustained upregulation of TIMP-1 gene expression may be at least partially controlled by a novel AP-1 dependent regulation of TIMP-1 promoter activity ."
],
"offsets": [
[
0,
190
]
]
}
]
| [
{
"id": "split_0_train_5557_entity",
"type": "progene_text",
"text": [
"TIMP-1"
],
"offsets": [
[
64,
70
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],
"normalized": []
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{
"id": "split_0_train_5558_entity",
"type": "progene_text",
"text": [
"AP-1"
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"offsets": [
[
135,
139
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],
"normalized": []
},
{
"id": "split_0_train_5559_entity",
"type": "progene_text",
"text": [
"TIMP-1"
],
"offsets": [
[
164,
170
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3423 | split_0_train_3423 | [
{
"id": "split_0_train_3423_passage",
"type": "progene_text",
"text": [
"The mouse genome contains two expressed intronless retroposed pseudogenes for the sentrin / sumo-1 / PIC1 conjugating enzyme Ubc9 ."
],
"offsets": [
[
0,
131
]
]
}
]
| [
{
"id": "split_0_train_5560_entity",
"type": "progene_text",
"text": [
"sentrin"
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"offsets": [
[
82,
89
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],
"normalized": []
},
{
"id": "split_0_train_5561_entity",
"type": "progene_text",
"text": [
"sumo-1"
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"offsets": [
[
92,
98
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],
"normalized": []
},
{
"id": "split_0_train_5562_entity",
"type": "progene_text",
"text": [
"PIC1"
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[
101,
105
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],
"normalized": []
},
{
"id": "split_0_train_5563_entity",
"type": "progene_text",
"text": [
"Ubc9"
],
"offsets": [
[
125,
129
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3424 | split_0_train_3424 | [
{
"id": "split_0_train_3424_passage",
"type": "progene_text",
"text": [
"The ubiquitin conjugating ( ubc ) E2 enzyme ubc-9 conjugates the ubiquitin - like peptide sentrin / SUMO-1 / PIC1 to target proteins which include the Fas antigen ."
],
"offsets": [
[
0,
164
]
]
}
]
| [
{
"id": "split_0_train_5564_entity",
"type": "progene_text",
"text": [
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4,
43
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},
{
"id": "split_0_train_5565_entity",
"type": "progene_text",
"text": [
"ubc-9"
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[
44,
49
]
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},
{
"id": "split_0_train_5566_entity",
"type": "progene_text",
"text": [
"ubiquitin"
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[
65,
74
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},
{
"id": "split_0_train_5567_entity",
"type": "progene_text",
"text": [
"sentrin"
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90,
97
]
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},
{
"id": "split_0_train_5568_entity",
"type": "progene_text",
"text": [
"SUMO-1"
],
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[
100,
106
]
],
"normalized": []
},
{
"id": "split_0_train_5569_entity",
"type": "progene_text",
"text": [
"PIC1"
],
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[
109,
113
]
],
"normalized": []
},
{
"id": "split_0_train_5570_entity",
"type": "progene_text",
"text": [
"Fas"
],
"offsets": [
[
151,
154
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3425 | split_0_train_3425 | [
{
"id": "split_0_train_3425_passage",
"type": "progene_text",
"text": [
"We show that the mouse genome contains four copies of the ubc-9 gene ."
],
"offsets": [
[
0,
70
]
]
}
]
| [
{
"id": "split_0_train_5571_entity",
"type": "progene_text",
"text": [
"ubc-9"
],
"offsets": [
[
58,
63
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3426 | split_0_train_3426 | [
{
"id": "split_0_train_3426_passage",
"type": "progene_text",
"text": [
"These include a structural ubc-9 gene consisting of seven exons which encode a protein identical to human ubc-9 , and three intronless processed pseudogenes ."
],
"offsets": [
[
0,
158
]
]
}
]
| [
{
"id": "split_0_train_5572_entity",
"type": "progene_text",
"text": [
"ubc-9"
],
"offsets": [
[
27,
32
]
],
"normalized": []
},
{
"id": "split_0_train_5573_entity",
"type": "progene_text",
"text": [
"ubc-9"
],
"offsets": [
[
106,
111
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3427 | split_0_train_3427 | [
{
"id": "split_0_train_3427_passage",
"type": "progene_text",
"text": [
"The open reading frames ( ORF ) of two of the pseudogenes , ubc9 - psi1 and ubc9 - psi2 , correspond to the cDNA of ubc-9 and encode for proteins which differ from ubc9 by three and one amino acid substitutions respectively ."
],
"offsets": [
[
0,
225
]
]
}
]
| [
{
"id": "split_0_train_5574_entity",
"type": "progene_text",
"text": [
"ubc9"
],
"offsets": [
[
60,
64
]
],
"normalized": []
},
{
"id": "split_0_train_5575_entity",
"type": "progene_text",
"text": [
"ubc9"
],
"offsets": [
[
76,
80
]
],
"normalized": []
},
{
"id": "split_0_train_5576_entity",
"type": "progene_text",
"text": [
"ubc-9"
],
"offsets": [
[
116,
121
]
],
"normalized": []
},
{
"id": "split_0_train_5577_entity",
"type": "progene_text",
"text": [
"ubc9"
],
"offsets": [
[
164,
168
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3428 | split_0_train_3428 | [
{
"id": "split_0_train_3428_passage",
"type": "progene_text",
"text": [
"The third pseudogene , ubc9 - psi3 , contains many mutations and stop codons ."
],
"offsets": [
[
0,
78
]
]
}
]
| [
{
"id": "split_0_train_5578_entity",
"type": "progene_text",
"text": [
"ubc9"
],
"offsets": [
[
23,
27
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3429 | split_0_train_3429 | [
{
"id": "split_0_train_3429_passage",
"type": "progene_text",
"text": [
"ubc9 - psi1 and ubc9 - psi2 are flanked by 5' - and 3' - untranslated ( UT ) regions homologous to those of the structural ubc-9 gene ."
],
"offsets": [
[
0,
135
]
]
}
]
| [
{
"id": "split_0_train_5579_entity",
"type": "progene_text",
"text": [
"ubc9"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_5580_entity",
"type": "progene_text",
"text": [
"ubc9"
],
"offsets": [
[
16,
20
]
],
"normalized": []
},
{
"id": "split_0_train_5581_entity",
"type": "progene_text",
"text": [
"ubc-9"
],
"offsets": [
[
123,
128
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3430 | split_0_train_3430 | [
{
"id": "split_0_train_3430_passage",
"type": "progene_text",
"text": [
"Both genes contain a polyA tail and direct repeats at both ends suggesting that they arose by mRNA retroposition ."
],
"offsets": [
[
0,
114
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3431 | split_0_train_3431 | [
{
"id": "split_0_train_3431_passage",
"type": "progene_text",
"text": [
"Both ubc9 - psi1 and ubc9 - psi2 are transcribed into mRNA in murine cells ."
],
"offsets": [
[
0,
76
]
]
}
]
| [
{
"id": "split_0_train_5582_entity",
"type": "progene_text",
"text": [
"ubc9"
],
"offsets": [
[
5,
9
]
],
"normalized": []
},
{
"id": "split_0_train_5583_entity",
"type": "progene_text",
"text": [
"ubc9"
],
"offsets": [
[
21,
25
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3432 | split_0_train_3432 | [
{
"id": "split_0_train_3432_passage",
"type": "progene_text",
"text": [
"In contrast to ubc9 , the protein products of ubc9 - psil and ubc9 - psi2 fail to bind Fas and to complement an yeast conditional ubc9 mutant ."
],
"offsets": [
[
0,
143
]
]
}
]
| [
{
"id": "split_0_train_5584_entity",
"type": "progene_text",
"text": [
"ubc9"
],
"offsets": [
[
15,
19
]
],
"normalized": []
},
{
"id": "split_0_train_5585_entity",
"type": "progene_text",
"text": [
"ubc9"
],
"offsets": [
[
46,
50
]
],
"normalized": []
},
{
"id": "split_0_train_5586_entity",
"type": "progene_text",
"text": [
"ubc9"
],
"offsets": [
[
62,
66
]
],
"normalized": []
},
{
"id": "split_0_train_5587_entity",
"type": "progene_text",
"text": [
"Fas"
],
"offsets": [
[
87,
90
]
],
"normalized": []
},
{
"id": "split_0_train_5588_entity",
"type": "progene_text",
"text": [
"ubc9"
],
"offsets": [
[
130,
134
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3433 | split_0_train_3433 | [
{
"id": "split_0_train_3433_passage",
"type": "progene_text",
"text": [
"These results suggest that ubc9 - psi1 and ubc9 - psi2 encode for proteins that may interact with targets that differ from those recognized by ubc-9 ."
],
"offsets": [
[
0,
150
]
]
}
]
| [
{
"id": "split_0_train_5589_entity",
"type": "progene_text",
"text": [
"ubc9"
],
"offsets": [
[
27,
31
]
],
"normalized": []
},
{
"id": "split_0_train_5590_entity",
"type": "progene_text",
"text": [
"ubc9"
],
"offsets": [
[
43,
47
]
],
"normalized": []
},
{
"id": "split_0_train_5591_entity",
"type": "progene_text",
"text": [
"ubc-9"
],
"offsets": [
[
143,
148
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3434 | split_0_train_3434 | [
{
"id": "split_0_train_3434_passage",
"type": "progene_text",
"text": [
"Genomic organization and mutational analysis of the human UCP2 gene , a prime candidate gene for human obesity ."
],
"offsets": [
[
0,
112
]
]
}
]
| [
{
"id": "split_0_train_5592_entity",
"type": "progene_text",
"text": [
"UCP2"
],
"offsets": [
[
58,
62
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3435 | split_0_train_3435 | [
{
"id": "split_0_train_3435_passage",
"type": "progene_text",
"text": [
"Uncoupling proteins ( UCPs ) are mitochondrial membrane transporters which are involved in dissipating the proton electrochemical gradient thereby releasing stored energy as heat ."
],
"offsets": [
[
0,
180
]
]
}
]
| [
{
"id": "split_0_train_5593_entity",
"type": "progene_text",
"text": [
"Uncoupling proteins"
],
"offsets": [
[
0,
19
]
],
"normalized": []
},
{
"id": "split_0_train_5594_entity",
"type": "progene_text",
"text": [
"UCPs"
],
"offsets": [
[
22,
26
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3436 | split_0_train_3436 | [
{
"id": "split_0_train_3436_passage",
"type": "progene_text",
"text": [
"This implies a major role of UCPs in energy metabolism and thermogenesis which when deregulated are key risk factors for the development of obesity and other eating disorders ."
],
"offsets": [
[
0,
176
]
]
}
]
| [
{
"id": "split_0_train_5595_entity",
"type": "progene_text",
"text": [
"UCPs"
],
"offsets": [
[
29,
33
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3437 | split_0_train_3437 | [
{
"id": "split_0_train_3437_passage",
"type": "progene_text",
"text": [
"Recent studies have shown that the sympathetic nervous system , via norepinephrine ( beta-adrenoceptors ) and cAMP , as well as thyroid hormones and PPAR gamma ligands seem to be major regulators of UCP expression ."
],
"offsets": [
[
0,
215
]
]
}
]
| [
{
"id": "split_0_train_5596_entity",
"type": "progene_text",
"text": [
"PPAR gamma"
],
"offsets": [
[
149,
159
]
],
"normalized": []
},
{
"id": "split_0_train_5597_entity",
"type": "progene_text",
"text": [
"UCP"
],
"offsets": [
[
199,
202
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3438 | split_0_train_3438 | [
{
"id": "split_0_train_3438_passage",
"type": "progene_text",
"text": [
"From the three different UCPs identified so far by gene cloning UCP1 is expressed exclusively in brown adipocytes while UCP2 is widely expressed ."
],
"offsets": [
[
0,
146
]
]
}
]
| [
{
"id": "split_0_train_5598_entity",
"type": "progene_text",
"text": [
"UCPs"
],
"offsets": [
[
25,
29
]
],
"normalized": []
},
{
"id": "split_0_train_5599_entity",
"type": "progene_text",
"text": [
"UCP1"
],
"offsets": [
[
64,
68
]
],
"normalized": []
},
{
"id": "split_0_train_5600_entity",
"type": "progene_text",
"text": [
"UCP2"
],
"offsets": [
[
120,
124
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3439 | split_0_train_3439 | [
{
"id": "split_0_train_3439_passage",
"type": "progene_text",
"text": [
"The third analogue , UCP3 , is expressed predominantly in human skeletal muscle and was found to exist in a long and a short form ."
],
"offsets": [
[
0,
131
]
]
}
]
| [
{
"id": "split_0_train_5601_entity",
"type": "progene_text",
"text": [
"UCP3"
],
"offsets": [
[
21,
25
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3440 | split_0_train_3440 | [
{
"id": "split_0_train_3440_passage",
"type": "progene_text",
"text": [
"At the amino acid level UCP2 has about 59 % homology to UCP1 while UCP3 is 73 % identical to UCP2 ."
],
"offsets": [
[
0,
99
]
]
}
]
| [
{
"id": "split_0_train_5602_entity",
"type": "progene_text",
"text": [
"UCP2"
],
"offsets": [
[
24,
28
]
],
"normalized": []
},
{
"id": "split_0_train_5603_entity",
"type": "progene_text",
"text": [
"UCP1"
],
"offsets": [
[
56,
60
]
],
"normalized": []
},
{
"id": "split_0_train_5604_entity",
"type": "progene_text",
"text": [
"UCP3"
],
"offsets": [
[
67,
71
]
],
"normalized": []
},
{
"id": "split_0_train_5605_entity",
"type": "progene_text",
"text": [
"UCP2"
],
"offsets": [
[
93,
97
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3441 | split_0_train_3441 | [
{
"id": "split_0_train_3441_passage",
"type": "progene_text",
"text": [
"Both UCP2 and UCP3 were mapped in close proximity ( 75 - 150 kb ) to regions of human chromosome 11 ( 11q13 ) that have been linked to obesity and hyper - insulinaemia ."
],
"offsets": [
[
0,
169
]
]
}
]
| [
{
"id": "split_0_train_5606_entity",
"type": "progene_text",
"text": [
"UCP2"
],
"offsets": [
[
5,
9
]
],
"normalized": []
},
{
"id": "split_0_train_5607_entity",
"type": "progene_text",
"text": [
"UCP3"
],
"offsets": [
[
14,
18
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3442 | split_0_train_3442 | [
{
"id": "split_0_train_3442_passage",
"type": "progene_text",
"text": [
"Furthermore , there is strong evidence that UCP2 , by virtue of its ubiquitous expression , may be important for determining basal metabolic rate ."
],
"offsets": [
[
0,
147
]
]
}
]
| [
{
"id": "split_0_train_5608_entity",
"type": "progene_text",
"text": [
"UCP2"
],
"offsets": [
[
44,
48
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3443 | split_0_train_3443 | [
{
"id": "split_0_train_3443_passage",
"type": "progene_text",
"text": [
"Based on the published full - length cDNA sequence we have deduced the genomic structure of the human UCP2 ( hUCP2 ) gene by PCR and direct sequence analysis ."
],
"offsets": [
[
0,
159
]
]
}
]
| [
{
"id": "split_0_train_5609_entity",
"type": "progene_text",
"text": [
"UCP2"
],
"offsets": [
[
102,
106
]
],
"normalized": []
},
{
"id": "split_0_train_5610_entity",
"type": "progene_text",
"text": [
"hUCP2"
],
"offsets": [
[
109,
114
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3444 | split_0_train_3444 | [
{
"id": "split_0_train_3444_passage",
"type": "progene_text",
"text": [
"The hUCP2 gene spans over 8.4 kb distributed on 8 exons ."
],
"offsets": [
[
0,
57
]
]
}
]
| [
{
"id": "split_0_train_5611_entity",
"type": "progene_text",
"text": [
"hUCP2"
],
"offsets": [
[
4,
9
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3445 | split_0_train_3445 | [
{
"id": "split_0_train_3445_passage",
"type": "progene_text",
"text": [
"The localization of the exon / intron boundaries within the coding region matches precisely the one found in the human UCP1 gene and is almost conserved in the recently discovered UCP3 gene as well ."
],
"offsets": [
[
0,
199
]
]
}
]
| [
{
"id": "split_0_train_5612_entity",
"type": "progene_text",
"text": [
"UCP1"
],
"offsets": [
[
119,
123
]
],
"normalized": []
},
{
"id": "split_0_train_5613_entity",
"type": "progene_text",
"text": [
"UCP3"
],
"offsets": [
[
180,
184
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3446 | split_0_train_3446 | [
{
"id": "split_0_train_3446_passage",
"type": "progene_text",
"text": [
"However , the size of each of the introns in the hUCP2 gene differs from its UCP1 and UCP3 counterparts ."
],
"offsets": [
[
0,
105
]
]
}
]
| [
{
"id": "split_0_train_5614_entity",
"type": "progene_text",
"text": [
"hUCP2"
],
"offsets": [
[
49,
54
]
],
"normalized": []
},
{
"id": "split_0_train_5615_entity",
"type": "progene_text",
"text": [
"UCP1"
],
"offsets": [
[
77,
81
]
],
"normalized": []
},
{
"id": "split_0_train_5616_entity",
"type": "progene_text",
"text": [
"UCP3"
],
"offsets": [
[
86,
90
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3447 | split_0_train_3447 | [
{
"id": "split_0_train_3447_passage",
"type": "progene_text",
"text": [
"It varies from 81 bp ( intron 5 ) to about 3 kb ( intron 2 ) ."
],
"offsets": [
[
0,
62
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3448 | split_0_train_3448 | [
{
"id": "split_0_train_3448_passage",
"type": "progene_text",
"text": [
"The high degree of homology at the nucleotide level and the conservation of the exon / intron boundaries among the three UCP genes suggests that they may have evolved from a common ancestor or are the result from gene duplication events ."
],
"offsets": [
[
0,
238
]
]
}
]
| [
{
"id": "split_0_train_5617_entity",
"type": "progene_text",
"text": [
"UCP"
],
"offsets": [
[
121,
124
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3449 | split_0_train_3449 | [
{
"id": "split_0_train_3449_passage",
"type": "progene_text",
"text": [
"Mutational analysis of the hUCP2 gene in a cohort of 25 children of caucasian origin ( aged 7 - 13 ) characterized by low BMR values revealed a point mutation in exon 4 ( C to T transition at position 164 of the corresponding cDNA resulting in the substitution of an alanine residue by a valine at codon 55 ) and an insertion polymorphism in exon 8 ."
],
"offsets": [
[
0,
350
]
]
}
]
| [
{
"id": "split_0_train_5618_entity",
"type": "progene_text",
"text": [
"hUCP2"
],
"offsets": [
[
27,
32
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3450 | split_0_train_3450 | [
{
"id": "split_0_train_3450_passage",
"type": "progene_text",
"text": [
"The insertion polymorphism consists of a 45 bp repeat located 150 bp downstream of the stop codon in the 3'-UTR ."
],
"offsets": [
[
0,
113
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3451 | split_0_train_3451 | [
{
"id": "split_0_train_3451_passage",
"type": "progene_text",
"text": [
"The allele frequencies were 0.61 and 0.39 for the alanine and valine encoded alleles , respectively , and 0.71 versus 0.29 for the insertion polymorphism ."
],
"offsets": [
[
0,
155
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3452 | split_0_train_3452 | [
{
"id": "split_0_train_3452_passage",
"type": "progene_text",
"text": [
"Expression studies of the wildtype and mutant forms of UCP2 should clarify the functional consequences these mutations may have on energy metabolism and body weight regulation ."
],
"offsets": [
[
0,
177
]
]
}
]
| [
{
"id": "split_0_train_5619_entity",
"type": "progene_text",
"text": [
"UCP2"
],
"offsets": [
[
55,
59
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3453 | split_0_train_3453 | [
{
"id": "split_0_train_3453_passage",
"type": "progene_text",
"text": [
"In addition , mapping of the promoter region and the identification of putative promoter regulatory sequences should give insight into the transcriptional regulation of UCP2 expression - - in particular by anyone of the above mentioned factors - - in vitro and in vivo ."
],
"offsets": [
[
0,
270
]
]
}
]
| [
{
"id": "split_0_train_5620_entity",
"type": "progene_text",
"text": [
"UCP2"
],
"offsets": [
[
169,
173
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3454 | split_0_train_3454 | [
{
"id": "split_0_train_3454_passage",
"type": "progene_text",
"text": [
"A new pathway for mitogen - dependent cdk2 regulation uncovered in p27 ( Kip1 ) - deficient cells ."
],
"offsets": [
[
0,
99
]
]
}
]
| [
{
"id": "split_0_train_5621_entity",
"type": "progene_text",
"text": [
"cdk2"
],
"offsets": [
[
38,
42
]
],
"normalized": []
},
{
"id": "split_0_train_5622_entity",
"type": "progene_text",
"text": [
"p27 ( Kip1 )"
],
"offsets": [
[
67,
79
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3455 | split_0_train_3455 | [
{
"id": "split_0_train_3455_passage",
"type": "progene_text",
"text": [
"BACKGROUND :"
],
"offsets": [
[
0,
12
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3456 | split_0_train_3456 | [
{
"id": "split_0_train_3456_passage",
"type": "progene_text",
"text": [
"The ability of cyclin - dependent kinases ( CDKs ) to promote cell proliferation is opposed by cyclin - dependent kinase inhibitors ( CKIs ) , proteins that bind tightly to cyclin - CDK complexes and block the phosphorylation of exogenous substrates ."
],
"offsets": [
[
0,
251
]
]
}
]
| [
{
"id": "split_0_train_5623_entity",
"type": "progene_text",
"text": [
"cyclin - dependent kinases"
],
"offsets": [
[
15,
41
]
],
"normalized": []
},
{
"id": "split_0_train_5624_entity",
"type": "progene_text",
"text": [
"CDKs"
],
"offsets": [
[
44,
48
]
],
"normalized": []
},
{
"id": "split_0_train_5625_entity",
"type": "progene_text",
"text": [
"cyclin - dependent kinase inhibitors"
],
"offsets": [
[
95,
131
]
],
"normalized": []
},
{
"id": "split_0_train_5626_entity",
"type": "progene_text",
"text": [
"CKIs"
],
"offsets": [
[
134,
138
]
],
"normalized": []
},
{
"id": "split_0_train_5627_entity",
"type": "progene_text",
"text": [
"cyclin"
],
"offsets": [
[
173,
179
]
],
"normalized": []
},
{
"id": "split_0_train_5628_entity",
"type": "progene_text",
"text": [
"CDK"
],
"offsets": [
[
182,
185
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3457 | split_0_train_3457 | [
{
"id": "split_0_train_3457_passage",
"type": "progene_text",
"text": [
"Mice with targeted CKI gene deletions have only subtle proliferative abnormalities , however , and cells prepared from these mice seem remarkably normal when grown in vitro ."
],
"offsets": [
[
0,
174
]
]
}
]
| [
{
"id": "split_0_train_5629_entity",
"type": "progene_text",
"text": [
"CKI"
],
"offsets": [
[
19,
22
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3458 | split_0_train_3458 | [
{
"id": "split_0_train_3458_passage",
"type": "progene_text",
"text": [
"One explanation may be the operation of compensatory pathways that control CDK activity and cell proliferation when normal pathways are inactivated ."
],
"offsets": [
[
0,
149
]
]
}
]
| [
{
"id": "split_0_train_5630_entity",
"type": "progene_text",
"text": [
"CDK"
],
"offsets": [
[
75,
78
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3459 | split_0_train_3459 | [
{
"id": "split_0_train_3459_passage",
"type": "progene_text",
"text": [
"We have used mice lacking the CKIs p21 ( Cip1 ) and p27 ( Kip1 ) to investigate this issue , specifically with respect to CDK regulation by mitogens ."
],
"offsets": [
[
0,
150
]
]
}
]
| [
{
"id": "split_0_train_5631_entity",
"type": "progene_text",
"text": [
"CKIs"
],
"offsets": [
[
30,
34
]
],
"normalized": []
},
{
"id": "split_0_train_5632_entity",
"type": "progene_text",
"text": [
"p21 ( Cip1 )"
],
"offsets": [
[
35,
47
]
],
"normalized": []
},
{
"id": "split_0_train_5633_entity",
"type": "progene_text",
"text": [
"p27 ( Kip1 )"
],
"offsets": [
[
52,
64
]
],
"normalized": []
},
{
"id": "split_0_train_5634_entity",
"type": "progene_text",
"text": [
"CDK"
],
"offsets": [
[
122,
125
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3460 | split_0_train_3460 | [
{
"id": "split_0_train_3460_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3461 | split_0_train_3461 | [
{
"id": "split_0_train_3461_passage",
"type": "progene_text",
"text": [
"We show that p27 is the major inhibitor of Cdk2 activity in mitogen - starved wild - type murine embryonic fibroblasts ( MEFs ) ."
],
"offsets": [
[
0,
129
]
]
}
]
| [
{
"id": "split_0_train_5635_entity",
"type": "progene_text",
"text": [
"p27"
],
"offsets": [
[
13,
16
]
],
"normalized": []
},
{
"id": "split_0_train_5636_entity",
"type": "progene_text",
"text": [
"Cdk2"
],
"offsets": [
[
43,
47
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3462 | split_0_train_3462 | [
{
"id": "split_0_train_3462_passage",
"type": "progene_text",
"text": [
"Nevertheless , inactivation of the cyclin E - Cdk2 complex in response to mitogen starvation occurs normally in MEFs that have a homozygous deletion of the p27 gene ."
],
"offsets": [
[
0,
166
]
]
}
]
| [
{
"id": "split_0_train_5637_entity",
"type": "progene_text",
"text": [
"cyclin E"
],
"offsets": [
[
35,
43
]
],
"normalized": []
},
{
"id": "split_0_train_5638_entity",
"type": "progene_text",
"text": [
"Cdk2"
],
"offsets": [
[
46,
50
]
],
"normalized": []
},
{
"id": "split_0_train_5639_entity",
"type": "progene_text",
"text": [
"p27"
],
"offsets": [
[
156,
159
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3463 | split_0_train_3463 | [
{
"id": "split_0_train_3463_passage",
"type": "progene_text",
"text": [
"Moreover , CDK regulation by mitogens is also not affected by the absence of both p27 and p21 ."
],
"offsets": [
[
0,
95
]
]
}
]
| [
{
"id": "split_0_train_5640_entity",
"type": "progene_text",
"text": [
"CDK"
],
"offsets": [
[
11,
14
]
],
"normalized": []
},
{
"id": "split_0_train_5641_entity",
"type": "progene_text",
"text": [
"p27"
],
"offsets": [
[
82,
85
]
],
"normalized": []
},
{
"id": "split_0_train_5642_entity",
"type": "progene_text",
"text": [
"p21"
],
"offsets": [
[
90,
93
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3464 | split_0_train_3464 | [
{
"id": "split_0_train_3464_passage",
"type": "progene_text",
"text": [
"A titratable Cdk2 inhibitor compensates for the absence of both CKIs , and we identify this inhibitor as p130 , a protein related to the retinoblastoma gene product Rb ."
],
"offsets": [
[
0,
169
]
]
}
]
| [
{
"id": "split_0_train_5643_entity",
"type": "progene_text",
"text": [
"Cdk2"
],
"offsets": [
[
13,
17
]
],
"normalized": []
},
{
"id": "split_0_train_5644_entity",
"type": "progene_text",
"text": [
"CKIs"
],
"offsets": [
[
64,
68
]
],
"normalized": []
},
{
"id": "split_0_train_5645_entity",
"type": "progene_text",
"text": [
"p130"
],
"offsets": [
[
105,
109
]
],
"normalized": []
},
{
"id": "split_0_train_5646_entity",
"type": "progene_text",
"text": [
"retinoblastoma"
],
"offsets": [
[
137,
151
]
],
"normalized": []
},
{
"id": "split_0_train_5647_entity",
"type": "progene_text",
"text": [
"Rb"
],
"offsets": [
[
165,
167
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3465 | split_0_train_3465 | [
{
"id": "split_0_train_3465_passage",
"type": "progene_text",
"text": [
"Thus , cyclin E - Cdk2 kinase activity cannot be inhibited by mitogen starvation of MEFs that lack both p27 and p130 ."
],
"offsets": [
[
0,
118
]
]
}
]
| [
{
"id": "split_0_train_5648_entity",
"type": "progene_text",
"text": [
"cyclin E"
],
"offsets": [
[
7,
15
]
],
"normalized": []
},
{
"id": "split_0_train_5649_entity",
"type": "progene_text",
"text": [
"Cdk2"
],
"offsets": [
[
18,
22
]
],
"normalized": []
},
{
"id": "split_0_train_5650_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
23,
29
]
],
"normalized": []
},
{
"id": "split_0_train_5651_entity",
"type": "progene_text",
"text": [
"p27"
],
"offsets": [
[
104,
107
]
],
"normalized": []
},
{
"id": "split_0_train_5652_entity",
"type": "progene_text",
"text": [
"p130"
],
"offsets": [
[
112,
116
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3466 | split_0_train_3466 | [
{
"id": "split_0_train_3466_passage",
"type": "progene_text",
"text": [
"In addition , cell types that naturally express low amounts of p130 , such as T lymphocytes , are completely dependent on p27 for regulation of the cyclin E - Cdk2 complex by mitogens ."
],
"offsets": [
[
0,
185
]
]
}
]
| [
{
"id": "split_0_train_5653_entity",
"type": "progene_text",
"text": [
"p130"
],
"offsets": [
[
63,
67
]
],
"normalized": []
},
{
"id": "split_0_train_5654_entity",
"type": "progene_text",
"text": [
"p27"
],
"offsets": [
[
122,
125
]
],
"normalized": []
},
{
"id": "split_0_train_5655_entity",
"type": "progene_text",
"text": [
"cyclin E"
],
"offsets": [
[
148,
156
]
],
"normalized": []
},
{
"id": "split_0_train_5656_entity",
"type": "progene_text",
"text": [
"Cdk2"
],
"offsets": [
[
159,
163
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3467 | split_0_train_3467 | [
{
"id": "split_0_train_3467_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3468 | split_0_train_3468 | [
{
"id": "split_0_train_3468_passage",
"type": "progene_text",
"text": [
"Inhibition of Cdk2 activity in mitogen - starved fibroblasts is usually performed by the CKI p27 , and to a minor extent by p21 ."
],
"offsets": [
[
0,
129
]
]
}
]
| [
{
"id": "split_0_train_5657_entity",
"type": "progene_text",
"text": [
"Cdk2"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "split_0_train_5658_entity",
"type": "progene_text",
"text": [
"CKI p27"
],
"offsets": [
[
89,
96
]
],
"normalized": []
},
{
"id": "split_0_train_5659_entity",
"type": "progene_text",
"text": [
"p21"
],
"offsets": [
[
124,
127
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3469 | split_0_train_3469 | [
{
"id": "split_0_train_3469_passage",
"type": "progene_text",
"text": [
"Remarkably p130 , a protein in the Rb family that is not related to either p21 or p27 , will directly substitute for the CKIs and restore normal CDK regulation by mitogens in cells lacking both p27 and p21 ."
],
"offsets": [
[
0,
207
]
]
}
]
| [
{
"id": "split_0_train_5660_entity",
"type": "progene_text",
"text": [
"p130"
],
"offsets": [
[
11,
15
]
],
"normalized": []
},
{
"id": "split_0_train_5661_entity",
"type": "progene_text",
"text": [
"Rb family"
],
"offsets": [
[
35,
44
]
],
"normalized": []
},
{
"id": "split_0_train_5662_entity",
"type": "progene_text",
"text": [
"p21"
],
"offsets": [
[
75,
78
]
],
"normalized": []
},
{
"id": "split_0_train_5663_entity",
"type": "progene_text",
"text": [
"p27"
],
"offsets": [
[
82,
85
]
],
"normalized": []
},
{
"id": "split_0_train_5664_entity",
"type": "progene_text",
"text": [
"CKIs"
],
"offsets": [
[
121,
125
]
],
"normalized": []
},
{
"id": "split_0_train_5665_entity",
"type": "progene_text",
"text": [
"CDK"
],
"offsets": [
[
145,
148
]
],
"normalized": []
},
{
"id": "split_0_train_5666_entity",
"type": "progene_text",
"text": [
"p27"
],
"offsets": [
[
194,
197
]
],
"normalized": []
},
{
"id": "split_0_train_5667_entity",
"type": "progene_text",
"text": [
"p21"
],
"offsets": [
[
202,
205
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3470 | split_0_train_3470 | [
{
"id": "split_0_train_3470_passage",
"type": "progene_text",
"text": [
"This compensatory pathway may be important in settings in which CKIs are not expressed at standard levels , as is the case in many human tumors ."
],
"offsets": [
[
0,
145
]
]
}
]
| [
{
"id": "split_0_train_5668_entity",
"type": "progene_text",
"text": [
"CKIs"
],
"offsets": [
[
64,
68
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3471 | split_0_train_3471 | [
{
"id": "split_0_train_3471_passage",
"type": "progene_text",
"text": [
"Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription ."
],
"offsets": [
[
0,
140
]
]
}
]
| [
{
"id": "split_0_train_5669_entity",
"type": "progene_text",
"text": [
"beta-globin"
],
"offsets": [
[
67,
78
]
],
"normalized": []
},
{
"id": "split_0_train_5670_entity",
"type": "progene_text",
"text": [
"globin"
],
"offsets": [
[
113,
119
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3472 | split_0_train_3472 | [
{
"id": "split_0_train_3472_passage",
"type": "progene_text",
"text": [
"The human beta-globin locus control region ( LCR ) harbors both strong chromatin opening and enhancer activity when assayed in transgenic mice ."
],
"offsets": [
[
0,
144
]
]
}
]
| [
{
"id": "split_0_train_5671_entity",
"type": "progene_text",
"text": [
"beta-globin"
],
"offsets": [
[
10,
21
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3473 | split_0_train_3473 | [
{
"id": "split_0_train_3473_passage",
"type": "progene_text",
"text": [
"To understand the contribution of individual DNase I hypersensitive sites ( HS ) to the function of the human beta-globin LCR , we have mutated the core elements within the context of a yeast artificial chromosome ( YAC ) carrying the entire locus and then analyzed the effect of these mutations on the formation of LCR HS elements and expression of the genes in transgenic mice ."
],
"offsets": [
[
0,
380
]
]
}
]
| [
{
"id": "split_0_train_5672_entity",
"type": "progene_text",
"text": [
"DNase I"
],
"offsets": [
[
45,
52
]
],
"normalized": []
},
{
"id": "split_0_train_5673_entity",
"type": "progene_text",
"text": [
"beta-globin"
],
"offsets": [
[
110,
121
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3474 | split_0_train_3474 | [
{
"id": "split_0_train_3474_passage",
"type": "progene_text",
"text": [
"In the present study , we examined the consequences of two different HS2 mutations ."
],
"offsets": [
[
0,
84
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3475 | split_0_train_3475 | [
{
"id": "split_0_train_3475_passage",
"type": "progene_text",
"text": [
"We first generated seven YAC transgenic lines bearing a deletion of the 375 - bp core enhancer of HS2 ."
],
"offsets": [
[
0,
103
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3476 | split_0_train_3476 | [
{
"id": "split_0_train_3476_passage",
"type": "progene_text",
"text": [
"Single - copy HS2 deletion mutants exhibited severely depressed HS site formation and expression of all of the human beta-globin genes at every developmental stage , confirming that HS2 is a vital , integral component of the LCR ."
],
"offsets": [
[
0,
230
]
]
}
]
| [
{
"id": "split_0_train_5674_entity",
"type": "progene_text",
"text": [
"beta-globin"
],
"offsets": [
[
117,
128
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3477 | split_0_train_3477 | [
{
"id": "split_0_train_3477_passage",
"type": "progene_text",
"text": [
"We also analyzed four transgenic lines in which the core element of HS2 was replaced by that of HS3 and found that while HS3 is able to restore the chromatin - opening activity of the LCR , it is not able to functionally replace HS2 in mediating high - level globin gene transcription ."
],
"offsets": [
[
0,
286
]
]
}
]
| [
{
"id": "split_0_train_5675_entity",
"type": "progene_text",
"text": [
"globin"
],
"offsets": [
[
259,
265
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3478 | split_0_train_3478 | [
{
"id": "split_0_train_3478_passage",
"type": "progene_text",
"text": [
"These results continue to support the hypothesis that HS2 , HS3 , and HS4 act as a single , integral unit to regulate human globin gene transcription as a holocomplex , but they can also be interpreted to say that formation of a DNase I hypersensitive holocomplex alone is not sufficient for mediating high - level globin gene transcription ."
],
"offsets": [
[
0,
342
]
]
}
]
| [
{
"id": "split_0_train_5676_entity",
"type": "progene_text",
"text": [
"globin"
],
"offsets": [
[
124,
130
]
],
"normalized": []
},
{
"id": "split_0_train_5677_entity",
"type": "progene_text",
"text": [
"DNase I"
],
"offsets": [
[
229,
236
]
],
"normalized": []
},
{
"id": "split_0_train_5678_entity",
"type": "progene_text",
"text": [
"globin"
],
"offsets": [
[
315,
321
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3479 | split_0_train_3479 | [
{
"id": "split_0_train_3479_passage",
"type": "progene_text",
"text": [
"We therefore propose that the core elements must productively interact with one another to generate a unique subdomain within the nucleoprotein holocomplex that interacts in a stage - specific manner with individual globin gene promoters ."
],
"offsets": [
[
0,
239
]
]
}
]
| [
{
"id": "split_0_train_5679_entity",
"type": "progene_text",
"text": [
"globin"
],
"offsets": [
[
216,
222
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3480 | split_0_train_3480 | [
{
"id": "split_0_train_3480_passage",
"type": "progene_text",
"text": [
"MDS1 / EVI1 enhances TGF-beta1 signaling and strengthens its growth - inhibitory effect but the leukemia - associated fusion protein AML1 / MDS1 / EVI1 , product of the t ( 3 ; 21 ) , abrogates growth - inhibition in response to TGF-beta1 ."
],
"offsets": [
[
0,
240
]
]
}
]
| [
{
"id": "split_0_train_5680_entity",
"type": "progene_text",
"text": [
"MDS1"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_5681_entity",
"type": "progene_text",
"text": [
"EVI1"
],
"offsets": [
[
7,
11
]
],
"normalized": []
},
{
"id": "split_0_train_5682_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
21,
30
]
],
"normalized": []
},
{
"id": "split_0_train_5683_entity",
"type": "progene_text",
"text": [
"AML1"
],
"offsets": [
[
133,
137
]
],
"normalized": []
},
{
"id": "split_0_train_5684_entity",
"type": "progene_text",
"text": [
"MDS1"
],
"offsets": [
[
140,
144
]
],
"normalized": []
},
{
"id": "split_0_train_5685_entity",
"type": "progene_text",
"text": [
"EVI1"
],
"offsets": [
[
147,
151
]
],
"normalized": []
},
{
"id": "split_0_train_5686_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
229,
238
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3481 | split_0_train_3481 | [
{
"id": "split_0_train_3481_passage",
"type": "progene_text",
"text": [
"MDS1 / EVI1 , located on chromosome 3 band q26 , encodes a zinc - finger DNA - binding transcription activator not detected in normal hematopoietic cells but expressed in several normal tissues ."
],
"offsets": [
[
0,
195
]
]
}
]
| [
{
"id": "split_0_train_5687_entity",
"type": "progene_text",
"text": [
"MDS1"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_5688_entity",
"type": "progene_text",
"text": [
"EVI1"
],
"offsets": [
[
7,
11
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3482 | split_0_train_3482 | [
{
"id": "split_0_train_3482_passage",
"type": "progene_text",
"text": [
"MDS1 / EVI1 is inappropriately activated in myeloid leukemias following chromosomal rearrangements involving band 3q26 ."
],
"offsets": [
[
0,
120
]
]
}
]
| [
{
"id": "split_0_train_5689_entity",
"type": "progene_text",
"text": [
"MDS1"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_5690_entity",
"type": "progene_text",
"text": [
"EVI1"
],
"offsets": [
[
7,
11
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3483 | split_0_train_3483 | [
{
"id": "split_0_train_3483_passage",
"type": "progene_text",
"text": [
"The rearrangements lead either to gene truncation , and to expression of the transcription repressor EVI1 , as seen in the t ( 3 ; 3 ) ( q21 ; q26 ) and inv ( 3 ) ( q21q26 ) , or to gene fusion , as seen in the t ( 3 ; 21 ) ( q26 ; q22 ) which results in the fusion protein AML1 / MDS1 / EVI1 ."
],
"offsets": [
[
0,
294
]
]
}
]
| [
{
"id": "split_0_train_5691_entity",
"type": "progene_text",
"text": [
"EVI1"
],
"offsets": [
[
101,
105
]
],
"normalized": []
},
{
"id": "split_0_train_5692_entity",
"type": "progene_text",
"text": [
"inv"
],
"offsets": [
[
153,
156
]
],
"normalized": []
},
{
"id": "split_0_train_5693_entity",
"type": "progene_text",
"text": [
"AML1"
],
"offsets": [
[
274,
278
]
],
"normalized": []
},
{
"id": "split_0_train_5694_entity",
"type": "progene_text",
"text": [
"MDS1"
],
"offsets": [
[
281,
285
]
],
"normalized": []
},
{
"id": "split_0_train_5695_entity",
"type": "progene_text",
"text": [
"EVI1"
],
"offsets": [
[
288,
292
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3484 | split_0_train_3484 | [
{
"id": "split_0_train_3484_passage",
"type": "progene_text",
"text": [
"This fusion protein contains the DNA - binding domain of the transcription factor AML1 fused in-frame to the entire MDS1 / EVI1 with the exclusion of its first 12 amino acids ."
],
"offsets": [
[
0,
176
]
]
}
]
| [
{
"id": "split_0_train_5696_entity",
"type": "progene_text",
"text": [
"transcription factor"
],
"offsets": [
[
61,
81
]
],
"normalized": []
},
{
"id": "split_0_train_5697_entity",
"type": "progene_text",
"text": [
"AML1"
],
"offsets": [
[
82,
86
]
],
"normalized": []
},
{
"id": "split_0_train_5698_entity",
"type": "progene_text",
"text": [
"MDS1"
],
"offsets": [
[
116,
120
]
],
"normalized": []
},
{
"id": "split_0_train_5699_entity",
"type": "progene_text",
"text": [
"EVI1"
],
"offsets": [
[
123,
127
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3485 | split_0_train_3485 | [
{
"id": "split_0_train_3485_passage",
"type": "progene_text",
"text": [
"In this report , we have analyzed the response of the hematopoietic precursor cell line 32Dcl3 , expressing either the normal protein MDS1 / EVI1 or the fusion protein AML1 / MDS1 / EVI1 , to factors that control cell differentiation or cell replication ."
],
"offsets": [
[
0,
255
]
]
}
]
| [
{
"id": "split_0_train_5700_entity",
"type": "progene_text",
"text": [
"MDS1"
],
"offsets": [
[
134,
138
]
],
"normalized": []
},
{
"id": "split_0_train_5701_entity",
"type": "progene_text",
"text": [
"EVI1"
],
"offsets": [
[
141,
145
]
],
"normalized": []
},
{
"id": "split_0_train_5702_entity",
"type": "progene_text",
"text": [
"AML1"
],
"offsets": [
[
168,
172
]
],
"normalized": []
},
{
"id": "split_0_train_5703_entity",
"type": "progene_text",
"text": [
"MDS1"
],
"offsets": [
[
175,
179
]
],
"normalized": []
},
{
"id": "split_0_train_5704_entity",
"type": "progene_text",
"text": [
"EVI1"
],
"offsets": [
[
182,
186
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3486 | split_0_train_3486 | [
{
"id": "split_0_train_3486_passage",
"type": "progene_text",
"text": [
"The 32Dcl3 cells are IL-3 - dependent for growth and they differentiate into granulocytes when exposed to G-CSF ."
],
"offsets": [
[
0,
113
]
]
}
]
| [
{
"id": "split_0_train_5705_entity",
"type": "progene_text",
"text": [
"IL-3"
],
"offsets": [
[
21,
25
]
],
"normalized": []
},
{
"id": "split_0_train_5706_entity",
"type": "progene_text",
"text": [
"G-CSF"
],
"offsets": [
[
106,
111
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3487 | split_0_train_3487 | [
{
"id": "split_0_train_3487_passage",
"type": "progene_text",
"text": [
"They are growth - inhibited by TGF-beta1 ."
],
"offsets": [
[
0,
42
]
]
}
]
| [
{
"id": "split_0_train_5707_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
31,
40
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3488 | split_0_train_3488 | [
{
"id": "split_0_train_3488_passage",
"type": "progene_text",
"text": [
"We show that whereas the expression of MDS1 / EVI1 has no effect on granulocytic differentiation induced by G-CSF , expression of AML1 / MDS1 / EVI1 blocks differentiation resulting in cell death ."
],
"offsets": [
[
0,
197
]
]
}
]
| [
{
"id": "split_0_train_5708_entity",
"type": "progene_text",
"text": [
"MDS1"
],
"offsets": [
[
39,
43
]
],
"normalized": []
},
{
"id": "split_0_train_5709_entity",
"type": "progene_text",
"text": [
"EVI1"
],
"offsets": [
[
46,
50
]
],
"normalized": []
},
{
"id": "split_0_train_5710_entity",
"type": "progene_text",
"text": [
"G-CSF"
],
"offsets": [
[
108,
113
]
],
"normalized": []
},
{
"id": "split_0_train_5711_entity",
"type": "progene_text",
"text": [
"AML1"
],
"offsets": [
[
130,
134
]
],
"normalized": []
},
{
"id": "split_0_train_5712_entity",
"type": "progene_text",
"text": [
"MDS1"
],
"offsets": [
[
137,
141
]
],
"normalized": []
},
{
"id": "split_0_train_5713_entity",
"type": "progene_text",
"text": [
"EVI1"
],
"offsets": [
[
144,
148
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3489 | split_0_train_3489 | [
{
"id": "split_0_train_3489_passage",
"type": "progene_text",
"text": [
"This effect is similar to that previously described by others for 32Dcl3 cells that express transgenic Evil ."
],
"offsets": [
[
0,
109
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3490 | split_0_train_3490 | [
{
"id": "split_0_train_3490_passage",
"type": "progene_text",
"text": [
"Furthermore , we show that whereas the expression of the fusion protein AML1 / MDS1 / EVI1 completely abrogates the growth - inhibitory effect of TGF-beta1 and allows 32Dcl3 cells to proliferate , expression of the normal protein MDS1 / EVI1 has the opposite effect , and it strengthens the response of cells to the growth - inhibitory effect of TGF-beta1 ."
],
"offsets": [
[
0,
357
]
]
}
]
| [
{
"id": "split_0_train_5714_entity",
"type": "progene_text",
"text": [
"AML1"
],
"offsets": [
[
72,
76
]
],
"normalized": []
},
{
"id": "split_0_train_5715_entity",
"type": "progene_text",
"text": [
"MDS1"
],
"offsets": [
[
79,
83
]
],
"normalized": []
},
{
"id": "split_0_train_5716_entity",
"type": "progene_text",
"text": [
"EVI1"
],
"offsets": [
[
86,
90
]
],
"normalized": []
},
{
"id": "split_0_train_5717_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
146,
155
]
],
"normalized": []
},
{
"id": "split_0_train_5718_entity",
"type": "progene_text",
"text": [
"MDS1"
],
"offsets": [
[
230,
234
]
],
"normalized": []
},
{
"id": "split_0_train_5719_entity",
"type": "progene_text",
"text": [
"EVI1"
],
"offsets": [
[
237,
241
]
],
"normalized": []
},
{
"id": "split_0_train_5720_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
346,
355
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3491 | split_0_train_3491 | [
{
"id": "split_0_train_3491_passage",
"type": "progene_text",
"text": [
"By using the yeast two - hybrid system , we also show that EVI1 ( contained in its entirety in MDS1 / EVI1 and AML1 / MDS1 / EVI1 ) physically interacts with SMAD3 , which is an intracellular mediator of TGF-beta1 signaling ."
],
"offsets": [
[
0,
225
]
]
}
]
| [
{
"id": "split_0_train_5721_entity",
"type": "progene_text",
"text": [
"EVI1"
],
"offsets": [
[
59,
63
]
],
"normalized": []
},
{
"id": "split_0_train_5722_entity",
"type": "progene_text",
"text": [
"MDS1"
],
"offsets": [
[
95,
99
]
],
"normalized": []
},
{
"id": "split_0_train_5723_entity",
"type": "progene_text",
"text": [
"EVI1"
],
"offsets": [
[
102,
106
]
],
"normalized": []
},
{
"id": "split_0_train_5724_entity",
"type": "progene_text",
"text": [
"AML1"
],
"offsets": [
[
111,
115
]
],
"normalized": []
},
{
"id": "split_0_train_5725_entity",
"type": "progene_text",
"text": [
"MDS1"
],
"offsets": [
[
118,
122
]
],
"normalized": []
},
{
"id": "split_0_train_5726_entity",
"type": "progene_text",
"text": [
"EVI1"
],
"offsets": [
[
125,
129
]
],
"normalized": []
},
{
"id": "split_0_train_5727_entity",
"type": "progene_text",
"text": [
"SMAD3"
],
"offsets": [
[
158,
163
]
],
"normalized": []
},
{
"id": "split_0_train_5728_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
204,
213
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3492 | split_0_train_3492 | [
{
"id": "split_0_train_3492_passage",
"type": "progene_text",
"text": [
"Finally , we have correlated the response of the cells to G-CSF or TGF-beta1 with the ability of the normal and fusion proteins to activate or repress promoters which they can directly regulate by binding to the promoter site ."
],
"offsets": [
[
0,
227
]
]
}
]
| [
{
"id": "split_0_train_5729_entity",
"type": "progene_text",
"text": [
"G-CSF"
],
"offsets": [
[
58,
63
]
],
"normalized": []
},
{
"id": "split_0_train_5730_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
67,
76
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3493 | split_0_train_3493 | [
{
"id": "split_0_train_3493_passage",
"type": "progene_text",
"text": [
"We propose that mutations of MDS1 / EVI1 either by gene truncation resulting in the transcription repressor EVI1 or by gene fusion to AML1 lead to an altered cellular response to growth and differentiation factors that could result in leukemic transformation ."
],
"offsets": [
[
0,
260
]
]
}
]
| [
{
"id": "split_0_train_5731_entity",
"type": "progene_text",
"text": [
"MDS1"
],
"offsets": [
[
29,
33
]
],
"normalized": []
},
{
"id": "split_0_train_5732_entity",
"type": "progene_text",
"text": [
"EVI1"
],
"offsets": [
[
36,
40
]
],
"normalized": []
},
{
"id": "split_0_train_5733_entity",
"type": "progene_text",
"text": [
"EVI1"
],
"offsets": [
[
108,
112
]
],
"normalized": []
},
{
"id": "split_0_train_5734_entity",
"type": "progene_text",
"text": [
"AML1"
],
"offsets": [
[
134,
138
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3494 | split_0_train_3494 | [
{
"id": "split_0_train_3494_passage",
"type": "progene_text",
"text": [
"The different response of myeloid cells ectopically expressing the normal or the fusion protein to G-CSF and TGF-beta1 could depend on the different transactivation properties of these proteins resulting in divergent expression of downstream genes regulated by the two proteins ."
],
"offsets": [
[
0,
279
]
]
}
]
| [
{
"id": "split_0_train_5735_entity",
"type": "progene_text",
"text": [
"G-CSF"
],
"offsets": [
[
99,
104
]
],
"normalized": []
},
{
"id": "split_0_train_5736_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
109,
118
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3495 | split_0_train_3495 | [
{
"id": "split_0_train_3495_passage",
"type": "progene_text",
"text": [
"Conformational aspects of HIV-1 integrase inhibition by a peptide derived from the enzyme central domain and by antibodies raised against this peptide ."
],
"offsets": [
[
0,
152
]
]
}
]
| [
{
"id": "split_0_train_5737_entity",
"type": "progene_text",
"text": [
"integrase"
],
"offsets": [
[
32,
41
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3496 | split_0_train_3496 | [
{
"id": "split_0_train_3496_passage",
"type": "progene_text",
"text": [
"Monospecific antibodies were raised against a synthetic peptide K159 ( SQGVVESMNKELKKIIGQVRDQAEHLKTA ) reproducing the segment 147 - 175 of HIV-1 integrase ( IN ) ."
],
"offsets": [
[
0,
164
]
]
}
]
| [
{
"id": "split_0_train_5738_entity",
"type": "progene_text",
"text": [
"integrase"
],
"offsets": [
[
146,
155
]
],
"normalized": []
},
{
"id": "split_0_train_5739_entity",
"type": "progene_text",
"text": [
"IN"
],
"offsets": [
[
158,
160
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3497 | split_0_train_3497 | [
{
"id": "split_0_train_3497_passage",
"type": "progene_text",
"text": [
"Synthesis of substituted and truncated analogs of K159 led us to identify the functional epitope reacting with antibodies within the C - terminal portion 163 - 175 of K159 ."
],
"offsets": [
[
0,
173
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3498 | split_0_train_3498 | [
{
"id": "split_0_train_3498_passage",
"type": "progene_text",
"text": [
"Conformational studies combining secondary structure predictions , CD and NMR spectroscopy together with ELISA assays , showed that the greater is the propensity of the epitope for helix formation the higher is the recognition by anti - K159 ."
],
"offsets": [
[
0,
243
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3499 | split_0_train_3499 | [
{
"id": "split_0_train_3499_passage",
"type": "progene_text",
"text": [
"Both the antibodies and the antigenic peptide K159 exhibited inhibitory activities against IN ."
],
"offsets": [
[
0,
95
]
]
}
]
| [
{
"id": "split_0_train_5740_entity",
"type": "progene_text",
"text": [
"IN"
],
"offsets": [
[
91,
93
]
],
"normalized": []
}
]
| []
| []
| []
|
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