id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_3300 | split_0_train_3300 | [
{
"id": "split_0_train_3300_passage",
"type": "progene_text",
"text": [
"Selective inhibition of human and mouse natural killer tumor recognition using retroviral antisense in primary natural killer cells : involvement with MHC class I killer cell inhibitory receptors ."
],
"offsets": [
[
0,
197
]
]
}
]
| [
{
"id": "split_0_train_5336_entity",
"type": "progene_text",
"text": [
"MHC class I"
],
"offsets": [
[
151,
162
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3301 | split_0_train_3301 | [
{
"id": "split_0_train_3301_passage",
"type": "progene_text",
"text": [
"The natural killer tumor recognition ( NK-TR ) protein has been shown to be a necessary component for the killing of NK - sensitive and virus - infected targets by the rat RNK-16 cell line ."
],
"offsets": [
[
0,
190
]
]
}
]
| [
{
"id": "split_0_train_5337_entity",
"type": "progene_text",
"text": [
"natural killer tumor recognition ( NK-TR ) protein"
],
"offsets": [
[
4,
54
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3302 | split_0_train_3302 | [
{
"id": "split_0_train_3302_passage",
"type": "progene_text",
"text": [
"Class I-recognizing killer cell inhibitory receptors ( KIR ) have been found in the human ( p58 ; NKAT family ) and mouse ( Ly-49 family ) ."
],
"offsets": [
[
0,
140
]
]
}
]
| [
{
"id": "split_0_train_5338_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
55,
58
]
],
"normalized": []
},
{
"id": "split_0_train_5339_entity",
"type": "progene_text",
"text": [
"p58"
],
"offsets": [
[
92,
95
]
],
"normalized": []
},
{
"id": "split_0_train_5340_entity",
"type": "progene_text",
"text": [
"NKAT family"
],
"offsets": [
[
98,
109
]
],
"normalized": []
},
{
"id": "split_0_train_5341_entity",
"type": "progene_text",
"text": [
"Ly-49 family"
],
"offsets": [
[
124,
136
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3303 | split_0_train_3303 | [
{
"id": "split_0_train_3303_passage",
"type": "progene_text",
"text": [
"The principal functional characteristic of these receptors is their ability to block NK cell lysis by recognition of selected class I molecules on target cells ."
],
"offsets": [
[
0,
161
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3304 | split_0_train_3304 | [
{
"id": "split_0_train_3304_passage",
"type": "progene_text",
"text": [
"In the present study , we examined whether abrogation of NK-TR expression by retroviral infection of primary human or mouse NK cells with virus - producing antisense NK-TR also would demonstrate loss of non - MHC - restricted killing and whether the NK-TR was associated with KIR function in humans or with Ly-49 in the mouse ."
],
"offsets": [
[
0,
327
]
]
}
]
| [
{
"id": "split_0_train_5342_entity",
"type": "progene_text",
"text": [
"NK-TR"
],
"offsets": [
[
57,
62
]
],
"normalized": []
},
{
"id": "split_0_train_5343_entity",
"type": "progene_text",
"text": [
"NK-TR"
],
"offsets": [
[
166,
171
]
],
"normalized": []
},
{
"id": "split_0_train_5344_entity",
"type": "progene_text",
"text": [
"MHC"
],
"offsets": [
[
209,
212
]
],
"normalized": []
},
{
"id": "split_0_train_5345_entity",
"type": "progene_text",
"text": [
"NK-TR"
],
"offsets": [
[
250,
255
]
],
"normalized": []
},
{
"id": "split_0_train_5346_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
276,
279
]
],
"normalized": []
},
{
"id": "split_0_train_5347_entity",
"type": "progene_text",
"text": [
"Ly-49"
],
"offsets": [
[
307,
312
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3305 | split_0_train_3305 | [
{
"id": "split_0_train_3305_passage",
"type": "progene_text",
"text": [
"Using short term culture of fresh human or mouse NK cells , antisense NK - TR - treated NK cells demonstrated strong selective reduction of NK cytotoxicity ."
],
"offsets": [
[
0,
157
]
]
}
]
| [
{
"id": "split_0_train_5348_entity",
"type": "progene_text",
"text": [
"NK - TR"
],
"offsets": [
[
70,
77
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3306 | split_0_train_3306 | [
{
"id": "split_0_train_3306_passage",
"type": "progene_text",
"text": [
"NK-TR was necessary for lytic activity even when KIR function was blocked by Ab in experiments involving NK3.3 lysis of HLA.cw3 - expressing targets or killing of Dd targets by Ly-49A + or Ly-49G2 + mouse NK cells ."
],
"offsets": [
[
0,
215
]
]
}
]
| [
{
"id": "split_0_train_5349_entity",
"type": "progene_text",
"text": [
"NK-TR"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_5350_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
49,
52
]
],
"normalized": []
},
{
"id": "split_0_train_5351_entity",
"type": "progene_text",
"text": [
"HLA.cw3"
],
"offsets": [
[
120,
127
]
],
"normalized": []
},
{
"id": "split_0_train_5352_entity",
"type": "progene_text",
"text": [
"Ly-49A"
],
"offsets": [
[
177,
183
]
],
"normalized": []
},
{
"id": "split_0_train_5353_entity",
"type": "progene_text",
"text": [
"Ly-49G2"
],
"offsets": [
[
189,
196
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3307 | split_0_train_3307 | [
{
"id": "split_0_train_3307_passage",
"type": "progene_text",
"text": [
"These studies extend our previous studies in rat NK cell lines to demonstrate that primary mouse and human NK cells require NK-TR for non - MHC - restricted lysis of tumor and virus - infected targets ."
],
"offsets": [
[
0,
202
]
]
}
]
| [
{
"id": "split_0_train_5354_entity",
"type": "progene_text",
"text": [
"NK-TR"
],
"offsets": [
[
124,
129
]
],
"normalized": []
},
{
"id": "split_0_train_5355_entity",
"type": "progene_text",
"text": [
"MHC"
],
"offsets": [
[
140,
143
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3308 | split_0_train_3308 | [
{
"id": "split_0_train_3308_passage",
"type": "progene_text",
"text": [
"In addition , the reversal of KIR or Ly-49 inhibition of NK cell lysis requires NK-TR expression for cellular killing in both human and mouse ."
],
"offsets": [
[
0,
143
]
]
}
]
| [
{
"id": "split_0_train_5356_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
30,
33
]
],
"normalized": []
},
{
"id": "split_0_train_5357_entity",
"type": "progene_text",
"text": [
"Ly-49"
],
"offsets": [
[
37,
42
]
],
"normalized": []
},
{
"id": "split_0_train_5358_entity",
"type": "progene_text",
"text": [
"NK-TR"
],
"offsets": [
[
80,
85
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3309 | split_0_train_3309 | [
{
"id": "split_0_train_3309_passage",
"type": "progene_text",
"text": [
"Identification and characterization of sporulation - dependent promoters upstream of the enterotoxin gene ( cpe ) of Clostridium perfringens ."
],
"offsets": [
[
0,
142
]
]
}
]
| [
{
"id": "split_0_train_5359_entity",
"type": "progene_text",
"text": [
"enterotoxin"
],
"offsets": [
[
89,
100
]
],
"normalized": []
},
{
"id": "split_0_train_5360_entity",
"type": "progene_text",
"text": [
"cpe"
],
"offsets": [
[
108,
111
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3310 | split_0_train_3310 | [
{
"id": "split_0_train_3310_passage",
"type": "progene_text",
"text": [
"Three promoter sites ( P1 , P2 , and P3 ) responsible for the sporulation - associated synthesis of Clostridium perfringens enterotoxin , a common cause of food poisoning in humans and animals , were identified ."
],
"offsets": [
[
0,
212
]
]
}
]
| [
{
"id": "split_0_train_5361_entity",
"type": "progene_text",
"text": [
"enterotoxin"
],
"offsets": [
[
124,
135
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3311 | split_0_train_3311 | [
{
"id": "split_0_train_3311_passage",
"type": "progene_text",
"text": [
"Nested and internal deletions of the cpe promoter region were made to narrow down the location of promoter elements ."
],
"offsets": [
[
0,
117
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3312 | split_0_train_3312 | [
{
"id": "split_0_train_3312_passage",
"type": "progene_text",
"text": [
"To measure the effects of the deletions on the expression of cpe , translational fusions containing the promoter deletions were made with the gusA gene of Escherichia coli , which codes for beta-glucuronidase ; E. coli-C. perfringens shuttle vectors carrying the fusions were introduced into C. perfringens by electroporation ."
],
"offsets": [
[
0,
327
]
]
}
]
| [
{
"id": "split_0_train_5362_entity",
"type": "progene_text",
"text": [
"cpe"
],
"offsets": [
[
61,
64
]
],
"normalized": []
},
{
"id": "split_0_train_5363_entity",
"type": "progene_text",
"text": [
"gusA"
],
"offsets": [
[
142,
146
]
],
"normalized": []
},
{
"id": "split_0_train_5364_entity",
"type": "progene_text",
"text": [
"beta-glucuronidase"
],
"offsets": [
[
190,
208
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3313 | split_0_train_3313 | [
{
"id": "split_0_train_3313_passage",
"type": "progene_text",
"text": [
"In addition , in vitro transcription assays were performed with the cpe promoter region as the DNA template for extracts made from sporulating cells ."
],
"offsets": [
[
0,
150
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3314 | split_0_train_3314 | [
{
"id": "split_0_train_3314_passage",
"type": "progene_text",
"text": [
"DNA sequences upstream of P1 were similar to consensus SigK - dependent promoters , while P2 and P3 were similar to consensus SigE - dependent promoters ."
],
"offsets": [
[
0,
154
]
]
}
]
| [
{
"id": "split_0_train_5365_entity",
"type": "progene_text",
"text": [
"SigK"
],
"offsets": [
[
55,
59
]
],
"normalized": []
},
{
"id": "split_0_train_5366_entity",
"type": "progene_text",
"text": [
"SigE"
],
"offsets": [
[
126,
130
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3315 | split_0_train_3315 | [
{
"id": "split_0_train_3315_passage",
"type": "progene_text",
"text": [
"SigE and SigK are sporulation - associated sigma factors known to be active in the mother cell compartment of sporulating cells of Bacillus subtilis , the same compartment in which enterotoxin is synthesized in C. perfringens ."
],
"offsets": [
[
0,
227
]
]
}
]
| [
{
"id": "split_0_train_5367_entity",
"type": "progene_text",
"text": [
"SigE"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_5368_entity",
"type": "progene_text",
"text": [
"SigK"
],
"offsets": [
[
9,
13
]
],
"normalized": []
},
{
"id": "split_0_train_5369_entity",
"type": "progene_text",
"text": [
"sigma factors"
],
"offsets": [
[
43,
56
]
],
"normalized": []
},
{
"id": "split_0_train_5370_entity",
"type": "progene_text",
"text": [
"enterotoxin"
],
"offsets": [
[
181,
192
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3316 | split_0_train_3316 | [
{
"id": "split_0_train_3316_passage",
"type": "progene_text",
"text": [
"Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition ."
],
"offsets": [
[
0,
124
]
]
}
]
| [
{
"id": "split_0_train_5371_entity",
"type": "progene_text",
"text": [
"HLA-C"
],
"offsets": [
[
96,
101
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3317 | split_0_train_3317 | [
{
"id": "split_0_train_3317_passage",
"type": "progene_text",
"text": [
"Cytotoxicity of human NK cells is under negative control of killer cell Ig - like receptors ( KIR ) specific for HLA class I ."
],
"offsets": [
[
0,
126
]
]
}
]
| [
{
"id": "split_0_train_5372_entity",
"type": "progene_text",
"text": [
"killer cell Ig - like receptors"
],
"offsets": [
[
60,
91
]
],
"normalized": []
},
{
"id": "split_0_train_5373_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
94,
97
]
],
"normalized": []
},
{
"id": "split_0_train_5374_entity",
"type": "progene_text",
"text": [
"HLA class I"
],
"offsets": [
[
113,
124
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3318 | split_0_train_3318 | [
{
"id": "split_0_train_3318_passage",
"type": "progene_text",
"text": [
"To determine the specificity of five KIR containing two Ig domains ( KIR2D ) , direct binding of soluble recombinant KIR2D to a panel of HLA class I transfectants was assayed ."
],
"offsets": [
[
0,
176
]
]
}
]
| [
{
"id": "split_0_train_5375_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
37,
40
]
],
"normalized": []
},
{
"id": "split_0_train_5376_entity",
"type": "progene_text",
"text": [
"Ig"
],
"offsets": [
[
56,
58
]
],
"normalized": []
},
{
"id": "split_0_train_5377_entity",
"type": "progene_text",
"text": [
"KIR2D"
],
"offsets": [
[
69,
74
]
],
"normalized": []
},
{
"id": "split_0_train_5378_entity",
"type": "progene_text",
"text": [
"KIR2D"
],
"offsets": [
[
117,
122
]
],
"normalized": []
},
{
"id": "split_0_train_5379_entity",
"type": "progene_text",
"text": [
"HLA class I"
],
"offsets": [
[
137,
148
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3319 | split_0_train_3319 | [
{
"id": "split_0_train_3319_passage",
"type": "progene_text",
"text": [
"One soluble KIR2D , derived from an inhibitory receptor with a long cytoplasmic tail ( KIR2DL1 ) , bound to HLA-C allotypes containing asparagine 77 and lysine 80 in the heavy chain , as expected , since these allotypes inhibit lysis by NK cells expressing KIR2DL1 ."
],
"offsets": [
[
0,
266
]
]
}
]
| [
{
"id": "split_0_train_5380_entity",
"type": "progene_text",
"text": [
"KIR2D"
],
"offsets": [
[
12,
17
]
],
"normalized": []
},
{
"id": "split_0_train_5381_entity",
"type": "progene_text",
"text": [
"KIR2DL1"
],
"offsets": [
[
87,
94
]
],
"normalized": []
},
{
"id": "split_0_train_5382_entity",
"type": "progene_text",
"text": [
"HLA-C"
],
"offsets": [
[
108,
113
]
],
"normalized": []
},
{
"id": "split_0_train_5383_entity",
"type": "progene_text",
"text": [
"KIR2DL1"
],
"offsets": [
[
257,
264
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3320 | split_0_train_3320 | [
{
"id": "split_0_train_3320_passage",
"type": "progene_text",
"text": [
"Surprisingly , another KIR2D ( KIR2DL2 ) , which inhibits NK lysis of cells expressing HLA-C molecules with serine 77 and asparagine 80 , bound to HLA-C allotypes carrying either amino acid motif ."
],
"offsets": [
[
0,
197
]
]
}
]
| [
{
"id": "split_0_train_5384_entity",
"type": "progene_text",
"text": [
"KIR2D"
],
"offsets": [
[
23,
28
]
],
"normalized": []
},
{
"id": "split_0_train_5385_entity",
"type": "progene_text",
"text": [
"KIR2DL2"
],
"offsets": [
[
31,
38
]
],
"normalized": []
},
{
"id": "split_0_train_5386_entity",
"type": "progene_text",
"text": [
"HLA-C"
],
"offsets": [
[
87,
92
]
],
"normalized": []
},
{
"id": "split_0_train_5387_entity",
"type": "progene_text",
"text": [
"HLA-C"
],
"offsets": [
[
147,
152
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3321 | split_0_train_3321 | [
{
"id": "split_0_train_3321_passage",
"type": "progene_text",
"text": [
"Expression of the KIR2DL receptors in NK cells using recombinant vaccinia viruses confirmed these patterns of recognition , and identified KIR2DL3 as another KIR reacting with both groups of HLA-C allotypes ."
],
"offsets": [
[
0,
208
]
]
}
]
| [
{
"id": "split_0_train_5388_entity",
"type": "progene_text",
"text": [
"KIR2DL"
],
"offsets": [
[
18,
24
]
],
"normalized": []
},
{
"id": "split_0_train_5389_entity",
"type": "progene_text",
"text": [
"KIR2DL3"
],
"offsets": [
[
139,
146
]
],
"normalized": []
},
{
"id": "split_0_train_5390_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
158,
161
]
],
"normalized": []
},
{
"id": "split_0_train_5391_entity",
"type": "progene_text",
"text": [
"HLA-C"
],
"offsets": [
[
191,
196
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3322 | split_0_train_3322 | [
{
"id": "split_0_train_3322_passage",
"type": "progene_text",
"text": [
"Mutagenesis of amino acid 44 in KIR2DL1 and KIR2DL2 suggested this residue controls the affinity of KIR for the 77 / 80 motif of HLA-C molecules ."
],
"offsets": [
[
0,
146
]
]
}
]
| [
{
"id": "split_0_train_5392_entity",
"type": "progene_text",
"text": [
"KIR2DL1"
],
"offsets": [
[
32,
39
]
],
"normalized": []
},
{
"id": "split_0_train_5393_entity",
"type": "progene_text",
"text": [
"KIR2DL2"
],
"offsets": [
[
44,
51
]
],
"normalized": []
},
{
"id": "split_0_train_5394_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
100,
103
]
],
"normalized": []
},
{
"id": "split_0_train_5395_entity",
"type": "progene_text",
"text": [
"HLA-C"
],
"offsets": [
[
129,
134
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3323 | split_0_train_3323 | [
{
"id": "split_0_train_3323_passage",
"type": "progene_text",
"text": [
"Two other soluble KIR2D , derived from noninhibitory receptors with short cytoplasmic tails ( KIR2DS ) , did not bind to any of the HLA class I allotypes tested ."
],
"offsets": [
[
0,
162
]
]
}
]
| [
{
"id": "split_0_train_5396_entity",
"type": "progene_text",
"text": [
"KIR2D"
],
"offsets": [
[
18,
23
]
],
"normalized": []
},
{
"id": "split_0_train_5397_entity",
"type": "progene_text",
"text": [
"KIR2DS"
],
"offsets": [
[
94,
100
]
],
"normalized": []
},
{
"id": "split_0_train_5398_entity",
"type": "progene_text",
"text": [
"HLA class I"
],
"offsets": [
[
132,
143
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3324 | split_0_train_3324 | [
{
"id": "split_0_train_3324_passage",
"type": "progene_text",
"text": [
"One of these receptors ( KIR2DS2 ) is closely related in sequence to KIR2DL2 ."
],
"offsets": [
[
0,
78
]
]
}
]
| [
{
"id": "split_0_train_5399_entity",
"type": "progene_text",
"text": [
"KIR2DS2"
],
"offsets": [
[
25,
32
]
],
"normalized": []
},
{
"id": "split_0_train_5400_entity",
"type": "progene_text",
"text": [
"KIR2DL2"
],
"offsets": [
[
69,
76
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3325 | split_0_train_3325 | [
{
"id": "split_0_train_3325_passage",
"type": "progene_text",
"text": [
"Substitution of tyrosine 45 with the phenylalanine conserved in other KIR was sufficient to permit specific binding of KIR2DS2 to HLA-C ."
],
"offsets": [
[
0,
137
]
]
}
]
| [
{
"id": "split_0_train_5401_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
70,
73
]
],
"normalized": []
},
{
"id": "split_0_train_5402_entity",
"type": "progene_text",
"text": [
"KIR2DS2"
],
"offsets": [
[
119,
126
]
],
"normalized": []
},
{
"id": "split_0_train_5403_entity",
"type": "progene_text",
"text": [
"HLA-C"
],
"offsets": [
[
130,
135
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3326 | split_0_train_3326 | [
{
"id": "split_0_train_3326_passage",
"type": "progene_text",
"text": [
"These results show that KIR2DL receptors are specific for HLA-C , but that recognition of HLA-C allotypes appears more permissive than indicated by previous functional experiments ."
],
"offsets": [
[
0,
181
]
]
}
]
| [
{
"id": "split_0_train_5404_entity",
"type": "progene_text",
"text": [
"KIR2DL"
],
"offsets": [
[
24,
30
]
],
"normalized": []
},
{
"id": "split_0_train_5405_entity",
"type": "progene_text",
"text": [
"HLA-C"
],
"offsets": [
[
58,
63
]
],
"normalized": []
},
{
"id": "split_0_train_5406_entity",
"type": "progene_text",
"text": [
"HLA-C"
],
"offsets": [
[
90,
95
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3327 | split_0_train_3327 | [
{
"id": "split_0_train_3327_passage",
"type": "progene_text",
"text": [
"Molecular cloning of the oncofetal isoform of the human pancreatic bile salt - dependent lipase ."
],
"offsets": [
[
0,
97
]
]
}
]
| [
{
"id": "split_0_train_5407_entity",
"type": "progene_text",
"text": [
"bile salt - dependent lipase"
],
"offsets": [
[
67,
95
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3328 | split_0_train_3328 | [
{
"id": "split_0_train_3328_passage",
"type": "progene_text",
"text": [
"Specific transcripts for bile salt - dependent lipase ( BSDL ) , a 100 - kDa glycoprotein secreted by the human pancreas , were immunodetected in BxPC-3 and SOJ-6 pancreatic tumoral cell lines ."
],
"offsets": [
[
0,
194
]
]
}
]
| [
{
"id": "split_0_train_5408_entity",
"type": "progene_text",
"text": [
"bile salt - dependent lipase"
],
"offsets": [
[
25,
53
]
],
"normalized": []
},
{
"id": "split_0_train_5409_entity",
"type": "progene_text",
"text": [
"BSDL"
],
"offsets": [
[
56,
60
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3329 | split_0_train_3329 | [
{
"id": "split_0_train_3329_passage",
"type": "progene_text",
"text": [
"Sequencing of fragments , obtained by mRNA reverse transcription and amplification , confirmed the presence of BSDL transcripts in these cancer cells ."
],
"offsets": [
[
0,
151
]
]
}
]
| [
{
"id": "split_0_train_5410_entity",
"type": "progene_text",
"text": [
"BSDL"
],
"offsets": [
[
111,
115
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3330 | split_0_train_3330 | [
{
"id": "split_0_train_3330_passage",
"type": "progene_text",
"text": [
"The protein was detected in lysates of pancreatic tumoral cells , where it was mainly associated with membranes ."
],
"offsets": [
[
0,
113
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3331 | split_0_train_3331 | [
{
"id": "split_0_train_3331_passage",
"type": "progene_text",
"text": [
"Only a minute amount of the enzyme was detected in the culture media ."
],
"offsets": [
[
0,
70
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3332 | split_0_train_3332 | [
{
"id": "split_0_train_3332_passage",
"type": "progene_text",
"text": [
"Immunofluorescence studies demonstrated that in SOJ-6 cells , BSDL colocates with the p58 Golgi protein and suggested that the protein may be sequestrated within the Golgi compartment ."
],
"offsets": [
[
0,
185
]
]
}
]
| [
{
"id": "split_0_train_5411_entity",
"type": "progene_text",
"text": [
"BSDL"
],
"offsets": [
[
62,
66
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3333 | split_0_train_3333 | [
{
"id": "split_0_train_3333_passage",
"type": "progene_text",
"text": [
"These results demonstrated that BSDL is expressed in human pancreatic tumoral cells and cannot be secreted ( or for the least very poorly ) ."
],
"offsets": [
[
0,
141
]
]
}
]
| [
{
"id": "split_0_train_5412_entity",
"type": "progene_text",
"text": [
"BSDL"
],
"offsets": [
[
32,
36
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3334 | split_0_train_3334 | [
{
"id": "split_0_train_3334_passage",
"type": "progene_text",
"text": [
"Subsequently , a cDNA covering the entire sequence of BSDL was obtained by reverse transcription - polymerase chain reaction ."
],
"offsets": [
[
0,
126
]
]
}
]
| [
{
"id": "split_0_train_5413_entity",
"type": "progene_text",
"text": [
"BSDL"
],
"offsets": [
[
54,
58
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3335 | split_0_train_3335 | [
{
"id": "split_0_train_3335_passage",
"type": "progene_text",
"text": [
"The sequence of this cDNA indicated that the N - terminal domain encoded by exons 1 - 10 was identical to that of BSDL expressed by the human normal pancreas ."
],
"offsets": [
[
0,
159
]
]
}
]
| [
{
"id": "split_0_train_5414_entity",
"type": "progene_text",
"text": [
"BSDL"
],
"offsets": [
[
114,
118
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3336 | split_0_train_3336 | [
{
"id": "split_0_train_3336_passage",
"type": "progene_text",
"text": [
"However , the sequence corresponding to exon 11 , which should code for the 16 tandem - repeated identical mucin - like sequences of BSDL , was deleted by 330 base pairs ( bp ) and encoded only 6 of these repeated sequences ."
],
"offsets": [
[
0,
225
]
]
}
]
| [
{
"id": "split_0_train_5415_entity",
"type": "progene_text",
"text": [
"mucin"
],
"offsets": [
[
107,
112
]
],
"normalized": []
},
{
"id": "split_0_train_5416_entity",
"type": "progene_text",
"text": [
"BSDL"
],
"offsets": [
[
133,
137
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3337 | split_0_train_3337 | [
{
"id": "split_0_train_3337_passage",
"type": "progene_text",
"text": [
"We conclude that this truncated variant of BSDL would be its oncofetal form , referred to as feto - acinar pancreatic protein ."
],
"offsets": [
[
0,
127
]
]
}
]
| [
{
"id": "split_0_train_5417_entity",
"type": "progene_text",
"text": [
"BSDL"
],
"offsets": [
[
43,
47
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3338 | split_0_train_3338 | [
{
"id": "split_0_train_3338_passage",
"type": "progene_text",
"text": [
"We then investigated whether the deletion of 330 bp affected the secretion of the protein ."
],
"offsets": [
[
0,
91
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3339 | split_0_train_3339 | [
{
"id": "split_0_train_3339_passage",
"type": "progene_text",
"text": [
"For this purpose , the cDNA corresponding to the mature form of the BSDL variant expressed in SOJ-6 cells was cloned into an expression / secretion vector and transfected into CHO-K1 cells ."
],
"offsets": [
[
0,
190
]
]
}
]
| [
{
"id": "split_0_train_5418_entity",
"type": "progene_text",
"text": [
"BSDL"
],
"offsets": [
[
68,
72
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3340 | split_0_train_3340 | [
{
"id": "split_0_train_3340_passage",
"type": "progene_text",
"text": [
"Results indicated that the variant of BSDL isolated from SOJ-6 cells was expressed and secreted by transfected cells ."
],
"offsets": [
[
0,
118
]
]
}
]
| [
{
"id": "split_0_train_5419_entity",
"type": "progene_text",
"text": [
"BSDL"
],
"offsets": [
[
38,
42
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3341 | split_0_train_3341 | [
{
"id": "split_0_train_3341_passage",
"type": "progene_text",
"text": [
"However , the level of BSDL secreted by these transfected CHO-K1 cells was significantly higher than that observed for SOJ-6 cells ."
],
"offsets": [
[
0,
132
]
]
}
]
| [
{
"id": "split_0_train_5420_entity",
"type": "progene_text",
"text": [
"BSDL"
],
"offsets": [
[
23,
27
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3342 | split_0_train_3342 | [
{
"id": "split_0_train_3342_passage",
"type": "progene_text",
"text": [
"Consequently , the retention of the oncofetal variant of BSDL observed in human pancreatic tumoral cells might not result from inherent properties of the protein ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_5421_entity",
"type": "progene_text",
"text": [
"BSDL"
],
"offsets": [
[
57,
61
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3343 | split_0_train_3343 | [
{
"id": "split_0_train_3343_passage",
"type": "progene_text",
"text": [
"Cloning and characterization of RLPK , a novel RSK - related protein kinase ."
],
"offsets": [
[
0,
77
]
]
}
]
| [
{
"id": "split_0_train_5422_entity",
"type": "progene_text",
"text": [
"RLPK"
],
"offsets": [
[
32,
36
]
],
"normalized": []
},
{
"id": "split_0_train_5423_entity",
"type": "progene_text",
"text": [
"RSK"
],
"offsets": [
[
47,
50
]
],
"normalized": []
},
{
"id": "split_0_train_5424_entity",
"type": "progene_text",
"text": [
"protein kinase"
],
"offsets": [
[
61,
75
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3344 | split_0_train_3344 | [
{
"id": "split_0_train_3344_passage",
"type": "progene_text",
"text": [
"A novel protein kinase whose activity can be stimulated by mitogen in vivo was cloned and characterized ."
],
"offsets": [
[
0,
105
]
]
}
]
| [
{
"id": "split_0_train_5425_entity",
"type": "progene_text",
"text": [
"protein kinase"
],
"offsets": [
[
8,
22
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3345 | split_0_train_3345 | [
{
"id": "split_0_train_3345_passage",
"type": "progene_text",
"text": [
"The cDNA of this gene encodes an 802-amino acid protein ( termed RLPK ) with the highest homology ( 37 % identity ) to the two protein kinase families , p90 ( RSK ) and p70 ( RSK ) ."
],
"offsets": [
[
0,
182
]
]
}
]
| [
{
"id": "split_0_train_5426_entity",
"type": "progene_text",
"text": [
"RLPK"
],
"offsets": [
[
65,
69
]
],
"normalized": []
},
{
"id": "split_0_train_5427_entity",
"type": "progene_text",
"text": [
"protein kinase"
],
"offsets": [
[
127,
141
]
],
"normalized": []
},
{
"id": "split_0_train_5428_entity",
"type": "progene_text",
"text": [
"p90 ( RSK )"
],
"offsets": [
[
153,
164
]
],
"normalized": []
},
{
"id": "split_0_train_5429_entity",
"type": "progene_text",
"text": [
"p70 ( RSK )"
],
"offsets": [
[
169,
180
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3346 | split_0_train_3346 | [
{
"id": "split_0_train_3346_passage",
"type": "progene_text",
"text": [
"Like p90 ( RSR ) , but not p70 ( RSK ) , RLPK also contains two complete nonidentical protein kinase domains ."
],
"offsets": [
[
0,
110
]
]
}
]
| [
{
"id": "split_0_train_5430_entity",
"type": "progene_text",
"text": [
"p90 ( RSR )"
],
"offsets": [
[
5,
16
]
],
"normalized": []
},
{
"id": "split_0_train_5431_entity",
"type": "progene_text",
"text": [
"p70 ( RSK )"
],
"offsets": [
[
27,
38
]
],
"normalized": []
},
{
"id": "split_0_train_5432_entity",
"type": "progene_text",
"text": [
"RLPK"
],
"offsets": [
[
41,
45
]
],
"normalized": []
},
{
"id": "split_0_train_5433_entity",
"type": "progene_text",
"text": [
"protein kinase"
],
"offsets": [
[
86,
100
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3347 | split_0_train_3347 | [
{
"id": "split_0_train_3347_passage",
"type": "progene_text",
"text": [
"RLPK mRNA is widely expressed in all human tissues examined and is enriched in the brain , heart , and placenta ."
],
"offsets": [
[
0,
113
]
]
}
]
| [
{
"id": "split_0_train_5434_entity",
"type": "progene_text",
"text": [
"RLPK"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3348 | split_0_train_3348 | [
{
"id": "split_0_train_3348_passage",
"type": "progene_text",
"text": [
"In HeLa cells , transiently expressed epitope - tagged RLPK can be strongly induced by epidermal growth factor , serum , and phorbol 12-myristate 13-acetate , but only moderately up - regulated by tumor necrosis factor - alpha and other stress - related stimuli ."
],
"offsets": [
[
0,
263
]
]
}
]
| [
{
"id": "split_0_train_5435_entity",
"type": "progene_text",
"text": [
"RLPK"
],
"offsets": [
[
55,
59
]
],
"normalized": []
},
{
"id": "split_0_train_5436_entity",
"type": "progene_text",
"text": [
"epidermal growth factor"
],
"offsets": [
[
87,
110
]
],
"normalized": []
},
{
"id": "split_0_train_5437_entity",
"type": "progene_text",
"text": [
"tumor necrosis factor - alpha"
],
"offsets": [
[
197,
226
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3349 | split_0_train_3349 | [
{
"id": "split_0_train_3349_passage",
"type": "progene_text",
"text": [
"The activity of RLPK stimulated by epidermal growth factor was not inhibited by several known protein kinase C inhibitors nor by rapamycin , a known specific inhibitor for p70 ( RSK ) , but could be inhibited by herbimycin A , a tyrosine kinase inhibitor , and partially inhibited by PD98059 or SB203580 , inhibitors for the mitogen - activated protein kinase pathways ."
],
"offsets": [
[
0,
370
]
]
}
]
| [
{
"id": "split_0_train_5438_entity",
"type": "progene_text",
"text": [
"RLPK"
],
"offsets": [
[
16,
20
]
],
"normalized": []
},
{
"id": "split_0_train_5439_entity",
"type": "progene_text",
"text": [
"epidermal growth factor"
],
"offsets": [
[
35,
58
]
],
"normalized": []
},
{
"id": "split_0_train_5440_entity",
"type": "progene_text",
"text": [
"protein kinase C"
],
"offsets": [
[
94,
110
]
],
"normalized": []
},
{
"id": "split_0_train_5441_entity",
"type": "progene_text",
"text": [
"p70 ( RSK )"
],
"offsets": [
[
172,
183
]
],
"normalized": []
},
{
"id": "split_0_train_5442_entity",
"type": "progene_text",
"text": [
"tyrosine kinase"
],
"offsets": [
[
229,
244
]
],
"normalized": []
},
{
"id": "split_0_train_5443_entity",
"type": "progene_text",
"text": [
"mitogen - activated protein kinase"
],
"offsets": [
[
325,
359
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3350 | split_0_train_3350 | [
{
"id": "split_0_train_3350_passage",
"type": "progene_text",
"text": [
"Recombinant RLPK possesses high phosphorylation activity toward histone 2B and the S6 peptide , RRRLSSLRA ."
],
"offsets": [
[
0,
107
]
]
}
]
| [
{
"id": "split_0_train_5444_entity",
"type": "progene_text",
"text": [
"RLPK"
],
"offsets": [
[
12,
16
]
],
"normalized": []
},
{
"id": "split_0_train_5445_entity",
"type": "progene_text",
"text": [
"histone 2B"
],
"offsets": [
[
64,
74
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3351 | split_0_train_3351 | [
{
"id": "split_0_train_3351_passage",
"type": "progene_text",
"text": [
"Although purified recombinant RLPK can be phosphorylated by ERK2 and p38alpha in vitro , its activity is not affected by this phosphorylation ."
],
"offsets": [
[
0,
143
]
]
}
]
| [
{
"id": "split_0_train_5446_entity",
"type": "progene_text",
"text": [
"RLPK"
],
"offsets": [
[
30,
34
]
],
"normalized": []
},
{
"id": "split_0_train_5447_entity",
"type": "progene_text",
"text": [
"ERK2"
],
"offsets": [
[
60,
64
]
],
"normalized": []
},
{
"id": "split_0_train_5448_entity",
"type": "progene_text",
"text": [
"p38alpha"
],
"offsets": [
[
69,
77
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3352 | split_0_train_3352 | [
{
"id": "split_0_train_3352_passage",
"type": "progene_text",
"text": [
"Moreover , the treatment of RLPK with acid phosphatase did not reduce its in vitro kinase activity ."
],
"offsets": [
[
0,
100
]
]
}
]
| [
{
"id": "split_0_train_5449_entity",
"type": "progene_text",
"text": [
"RLPK"
],
"offsets": [
[
28,
32
]
],
"normalized": []
},
{
"id": "split_0_train_5450_entity",
"type": "progene_text",
"text": [
"acid phosphatase"
],
"offsets": [
[
38,
54
]
],
"normalized": []
},
{
"id": "split_0_train_5451_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
83,
89
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3353 | split_0_train_3353 | [
{
"id": "split_0_train_3353_passage",
"type": "progene_text",
"text": [
"These data suggest that RLPK is structurally similar to previously isolated RSKs , but its regulatory mechanism may be distinct from either p70 ( RSK ) or p90(RSK)s ."
],
"offsets": [
[
0,
166
]
]
}
]
| [
{
"id": "split_0_train_5452_entity",
"type": "progene_text",
"text": [
"RLPK"
],
"offsets": [
[
24,
28
]
],
"normalized": []
},
{
"id": "split_0_train_5453_entity",
"type": "progene_text",
"text": [
"RSKs"
],
"offsets": [
[
76,
80
]
],
"normalized": []
},
{
"id": "split_0_train_5454_entity",
"type": "progene_text",
"text": [
"p70 ( RSK )"
],
"offsets": [
[
140,
151
]
],
"normalized": []
},
{
"id": "split_0_train_5455_entity",
"type": "progene_text",
"text": [
"p90(RSK)s"
],
"offsets": [
[
155,
164
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3354 | split_0_train_3354 | [
{
"id": "split_0_train_3354_passage",
"type": "progene_text",
"text": [
"Cardiovascular and pharmacokinetic interactions between nicorandil and adjunctive propranolol , atenolol or diltiazem in conscious dogs ."
],
"offsets": [
[
0,
137
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3355 | split_0_train_3355 | [
{
"id": "split_0_train_3355_passage",
"type": "progene_text",
"text": [
"In support of clinical antianginal studies , the vasodilator nicorandil ( NIC ) was combined with the beta-adrenergic receptor antagonists propranolol ( PRO ) and atenolol ( ATN ) and with the calcium channel blocker diltiazem ( DTZ ) to determine their cardiovascular and pharmacokinetic interactions ."
],
"offsets": [
[
0,
303
]
]
}
]
| [
{
"id": "split_0_train_5456_entity",
"type": "progene_text",
"text": [
"beta-adrenergic receptor"
],
"offsets": [
[
102,
126
]
],
"normalized": []
},
{
"id": "split_0_train_5457_entity",
"type": "progene_text",
"text": [
"calcium channel"
],
"offsets": [
[
193,
208
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3356 | split_0_train_3356 | [
{
"id": "split_0_train_3356_passage",
"type": "progene_text",
"text": [
"Beagle dogs were chronically cannulated to record mean arterial pressure , heart rate , and the lead II electrocardiogram under conscious conditions ."
],
"offsets": [
[
0,
150
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3357 | split_0_train_3357 | [
{
"id": "split_0_train_3357_passage",
"type": "progene_text",
"text": [
"Oral NIC ( 1 , 3 , and 10 mg / kg ) was coadministered with i.v. PRO ( 5.0 mg / kg ) or ATN ( 7.5 mg / kg ) , both of which lessened NIC's reflex tachycardia ."
],
"offsets": [
[
0,
159
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3358 | split_0_train_3358 | [
{
"id": "split_0_train_3358_passage",
"type": "progene_text",
"text": [
"ECG rhythm remained normal , but both beta-blockers restricted high dose NIC 's QTc prolongation and ST segment depression ."
],
"offsets": [
[
0,
124
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3359 | split_0_train_3359 | [
{
"id": "split_0_train_3359_passage",
"type": "progene_text",
"text": [
"Intravenous DTZ ( 5 - 23 micrograms / kg / min ) did not affect i.v. NIC's hypotensive profile ( 10 - 80 micrograms / kg / min ) but attenuated its tachycardia , whereas NIC-reversed DTZ's PR interval shortening and frequency of ectopic beats ."
],
"offsets": [
[
0,
244
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3360 | split_0_train_3360 | [
{
"id": "split_0_train_3360_passage",
"type": "progene_text",
"text": [
"Similar cardiovascular interactions were seen with chronic oral DTZ ( 10 mg / kg / day ) + NIC ( 3.0 or 7.5 mg / kg ) ."
],
"offsets": [
[
0,
119
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3361 | split_0_train_3361 | [
{
"id": "split_0_train_3361_passage",
"type": "progene_text",
"text": [
"Plasma analysis confirmed that none of the adjuncts affected NIC 's disposition nor its concentration - dependent hypotensive response profile ."
],
"offsets": [
[
0,
144
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3362 | split_0_train_3362 | [
{
"id": "split_0_train_3362_passage",
"type": "progene_text",
"text": [
"These studies establish the cardiovascular effects of NIC when combined with PRO , ATN or DTZ in dogs , and outline paradigms useful for evaluating such antianginal drug combinations ."
],
"offsets": [
[
0,
184
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3363 | split_0_train_3363 | [
{
"id": "split_0_train_3363_passage",
"type": "progene_text",
"text": [
"Analysis of two cosmid clones from chromosome 4 of Drosophila melanogaster reveals two new genes amid an unusual arrangement of repeated sequences ."
],
"offsets": [
[
0,
148
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3364 | split_0_train_3364 | [
{
"id": "split_0_train_3364_passage",
"type": "progene_text",
"text": [
"Chromosome 4 from Drosophila melanogaster has several unusual features that distinguish it from the other chromosomes ."
],
"offsets": [
[
0,
119
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3365 | split_0_train_3365 | [
{
"id": "split_0_train_3365_passage",
"type": "progene_text",
"text": [
"These include a diffuse appearance in salivary gland polytene chromosomes , an absence of recombination , and the variegated expression of P-element transgenes ."
],
"offsets": [
[
0,
161
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3366 | split_0_train_3366 | [
{
"id": "split_0_train_3366_passage",
"type": "progene_text",
"text": [
"As part of a larger project to understand these properties , we are assembling a physical map of this chromosome ."
],
"offsets": [
[
0,
114
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3367 | split_0_train_3367 | [
{
"id": "split_0_train_3367_passage",
"type": "progene_text",
"text": [
"Here we report the sequence of two cosmids representing approximately 5 % of the polytenized region ."
],
"offsets": [
[
0,
101
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3368 | split_0_train_3368 | [
{
"id": "split_0_train_3368_passage",
"type": "progene_text",
"text": [
"Both cosmid clones contain numerous repeated DNA sequences , as identified by cross hybridization with labeled genomic DNA , BLAST searches , and dot matrix analysis , which are positioned between and within the transcribed sequences ."
],
"offsets": [
[
0,
235
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3369 | split_0_train_3369 | [
{
"id": "split_0_train_3369_passage",
"type": "progene_text",
"text": [
"The repetitive sequences include three copies of the mobile element Hoppel , one copy of the mobile element HB , and 18 DINE repeats ."
],
"offsets": [
[
0,
134
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3370 | split_0_train_3370 | [
{
"id": "split_0_train_3370_passage",
"type": "progene_text",
"text": [
"DINE is a novel , short repeated sequence dispersed throughout both cosmid sequences ."
],
"offsets": [
[
0,
86
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3371 | split_0_train_3371 | [
{
"id": "split_0_train_3371_passage",
"type": "progene_text",
"text": [
"One cosmid includes the previously described cubitus interruptus ( ci ) gene and two new genes : that a gene with a predicted amino acid sequence similar to ribosomal protein S3a which is consistent with the Minute(4) 101 locus thought to be in the region , and a novel member of the protein family that includes plexin and met - hepatocyte growth factor receptor ."
],
"offsets": [
[
0,
365
]
]
}
]
| [
{
"id": "split_0_train_5458_entity",
"type": "progene_text",
"text": [
"cubitus interruptus"
],
"offsets": [
[
45,
64
]
],
"normalized": []
},
{
"id": "split_0_train_5459_entity",
"type": "progene_text",
"text": [
"ci"
],
"offsets": [
[
67,
69
]
],
"normalized": []
},
{
"id": "split_0_train_5460_entity",
"type": "progene_text",
"text": [
"ribosomal protein S3a"
],
"offsets": [
[
157,
178
]
],
"normalized": []
},
{
"id": "split_0_train_5461_entity",
"type": "progene_text",
"text": [
"plexin"
],
"offsets": [
[
313,
319
]
],
"normalized": []
},
{
"id": "split_0_train_5462_entity",
"type": "progene_text",
"text": [
"met"
],
"offsets": [
[
324,
327
]
],
"normalized": []
},
{
"id": "split_0_train_5463_entity",
"type": "progene_text",
"text": [
"hepatocyte growth factor receptor"
],
"offsets": [
[
330,
363
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3372 | split_0_train_3372 | [
{
"id": "split_0_train_3372_passage",
"type": "progene_text",
"text": [
"The other cosmid contains only the two short 5'-most exons from the zinc-finger-homolog-2 ( zfh-2 ) gene ."
],
"offsets": [
[
0,
106
]
]
}
]
| [
{
"id": "split_0_train_5464_entity",
"type": "progene_text",
"text": [
"zinc-finger-homolog-2"
],
"offsets": [
[
68,
89
]
],
"normalized": []
},
{
"id": "split_0_train_5465_entity",
"type": "progene_text",
"text": [
"zfh-2"
],
"offsets": [
[
92,
97
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3373 | split_0_train_3373 | [
{
"id": "split_0_train_3373_passage",
"type": "progene_text",
"text": [
"This is the first extensive sequence analysis of noncoding DNA from chromosome 4 ."
],
"offsets": [
[
0,
82
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3374 | split_0_train_3374 | [
{
"id": "split_0_train_3374_passage",
"type": "progene_text",
"text": [
"The distribution of the various repeats suggests its organization is similar to the beta-heterochromatic regions near the base of the major chromosome arms ."
],
"offsets": [
[
0,
157
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3375 | split_0_train_3375 | [
{
"id": "split_0_train_3375_passage",
"type": "progene_text",
"text": [
"Such a pattern may account for the diffuse banding of the polytene chromosome 4 and the variegation of many P-element transgenes on the chromosome ."
],
"offsets": [
[
0,
148
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3376 | split_0_train_3376 | [
{
"id": "split_0_train_3376_passage",
"type": "progene_text",
"text": [
"Fibroblast growth factor-8 expression is regulated by intronic engrailed and Pbx1 - binding sites ."
],
"offsets": [
[
0,
99
]
]
}
]
| [
{
"id": "split_0_train_5466_entity",
"type": "progene_text",
"text": [
"Fibroblast growth factor-8"
],
"offsets": [
[
0,
26
]
],
"normalized": []
},
{
"id": "split_0_train_5467_entity",
"type": "progene_text",
"text": [
"Pbx1"
],
"offsets": [
[
77,
81
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3377 | split_0_train_3377 | [
{
"id": "split_0_train_3377_passage",
"type": "progene_text",
"text": [
"Fibroblast growth factor-8 ( FGF8 ) plays a critical role in vertebrate development and is expressed normally in temporally and spatially restricted regions of the vertebrate embryo ."
],
"offsets": [
[
0,
183
]
]
}
]
| [
{
"id": "split_0_train_5468_entity",
"type": "progene_text",
"text": [
"Fibroblast growth factor-8"
],
"offsets": [
[
0,
26
]
],
"normalized": []
},
{
"id": "split_0_train_5469_entity",
"type": "progene_text",
"text": [
"FGF8"
],
"offsets": [
[
29,
33
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3378 | split_0_train_3378 | [
{
"id": "split_0_train_3378_passage",
"type": "progene_text",
"text": [
"We now report on the identification of regions of Fgf8 important for its transcriptional regulation in murine ES cell - derived embryoid bodies ."
],
"offsets": [
[
0,
145
]
]
}
]
| [
{
"id": "split_0_train_5470_entity",
"type": "progene_text",
"text": [
"Fgf8"
],
"offsets": [
[
50,
54
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3379 | split_0_train_3379 | [
{
"id": "split_0_train_3379_passage",
"type": "progene_text",
"text": [
"Stable transfection of ES cells , using a human growth hormone reporter gene , was employed to identify regions of the Fgf8 gene with promoter / enhancer activity ."
],
"offsets": [
[
0,
164
]
]
}
]
| [
{
"id": "split_0_train_5471_entity",
"type": "progene_text",
"text": [
"growth hormone"
],
"offsets": [
[
48,
62
]
],
"normalized": []
},
{
"id": "split_0_train_5472_entity",
"type": "progene_text",
"text": [
"Fgf8"
],
"offsets": [
[
119,
123
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3380 | split_0_train_3380 | [
{
"id": "split_0_train_3380_passage",
"type": "progene_text",
"text": [
"A 2-kilobase 5' region of Fgf8 was shown to contain promoter activity ."
],
"offsets": [
[
0,
71
]
]
}
]
| [
{
"id": "split_0_train_5473_entity",
"type": "progene_text",
"text": [
"Fgf8"
],
"offsets": [
[
26,
30
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3381 | split_0_train_3381 | [
{
"id": "split_0_train_3381_passage",
"type": "progene_text",
"text": [
"A 0.8 - kilobase fragment derived from the large intron of Fgf8 was found to enhance human growth hormone expressed from the Fgf8 promoter 3 - 4 - fold in an orientation dependent manner ."
],
"offsets": [
[
0,
188
]
]
}
]
| [
{
"id": "split_0_train_5474_entity",
"type": "progene_text",
"text": [
"Fgf8"
],
"offsets": [
[
59,
63
]
],
"normalized": []
},
{
"id": "split_0_train_5475_entity",
"type": "progene_text",
"text": [
"growth hormone"
],
"offsets": [
[
91,
105
]
],
"normalized": []
},
{
"id": "split_0_train_5476_entity",
"type": "progene_text",
"text": [
"Fgf8"
],
"offsets": [
[
125,
129
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3382 | split_0_train_3382 | [
{
"id": "split_0_train_3382_passage",
"type": "progene_text",
"text": [
"The intronic fragment contains DNA - binding sites for the AP2 , Pbx1 , and Engrailed transcription factors ."
],
"offsets": [
[
0,
109
]
]
}
]
| [
{
"id": "split_0_train_5477_entity",
"type": "progene_text",
"text": [
"AP2"
],
"offsets": [
[
59,
62
]
],
"normalized": []
},
{
"id": "split_0_train_5478_entity",
"type": "progene_text",
"text": [
"Pbx1"
],
"offsets": [
[
65,
69
]
],
"normalized": []
},
{
"id": "split_0_train_5479_entity",
"type": "progene_text",
"text": [
"Engrailed"
],
"offsets": [
[
76,
85
]
],
"normalized": []
},
{
"id": "split_0_train_5480_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
86,
107
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3383 | split_0_train_3383 | [
{
"id": "split_0_train_3383_passage",
"type": "progene_text",
"text": [
"Gel shift and Western blot experiments documented the presence of these transcription factors in nuclear extracts from ES cell embryoid bodies ."
],
"offsets": [
[
0,
144
]
]
}
]
| [
{
"id": "split_0_train_5481_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
72,
93
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3384 | split_0_train_3384 | [
{
"id": "split_0_train_3384_passage",
"type": "progene_text",
"text": [
"In vitro mutagenesis of the Engrailed or Pbx1 site demonstrated that these sites modulate the activity of the intronic fragment ."
],
"offsets": [
[
0,
129
]
]
}
]
| [
{
"id": "split_0_train_5482_entity",
"type": "progene_text",
"text": [
"Engrailed"
],
"offsets": [
[
28,
37
]
],
"normalized": []
},
{
"id": "split_0_train_5483_entity",
"type": "progene_text",
"text": [
"Pbx1"
],
"offsets": [
[
41,
45
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3385 | split_0_train_3385 | [
{
"id": "split_0_train_3385_passage",
"type": "progene_text",
"text": [
"In addition , in vitro mutagenesis of both Engrailed and Pbx1 sites indicated that other unidentified sites are responsible for the transcriptional enhancement observed with the intronic fragment ."
],
"offsets": [
[
0,
197
]
]
}
]
| [
{
"id": "split_0_train_5484_entity",
"type": "progene_text",
"text": [
"Engrailed"
],
"offsets": [
[
43,
52
]
],
"normalized": []
},
{
"id": "split_0_train_5485_entity",
"type": "progene_text",
"text": [
"Pbx1"
],
"offsets": [
[
57,
61
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3386 | split_0_train_3386 | [
{
"id": "split_0_train_3386_passage",
"type": "progene_text",
"text": [
"Discovery of three novel orphan G-protein - coupled receptors ."
],
"offsets": [
[
0,
63
]
]
}
]
| [
{
"id": "split_0_train_5486_entity",
"type": "progene_text",
"text": [
"G-protein - coupled receptors"
],
"offsets": [
[
32,
61
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3387 | split_0_train_3387 | [
{
"id": "split_0_train_3387_passage",
"type": "progene_text",
"text": [
"We have discovered three novel human genes , GPR34 , GPR44 , and GPR45 , encoding family A G - protein - coupled receptors ( GPCRs ) ."
],
"offsets": [
[
0,
134
]
]
}
]
| [
{
"id": "split_0_train_5487_entity",
"type": "progene_text",
"text": [
"GPR34"
],
"offsets": [
[
45,
50
]
],
"normalized": []
},
{
"id": "split_0_train_5488_entity",
"type": "progene_text",
"text": [
"GPR44"
],
"offsets": [
[
53,
58
]
],
"normalized": []
},
{
"id": "split_0_train_5489_entity",
"type": "progene_text",
"text": [
"GPR45"
],
"offsets": [
[
65,
70
]
],
"normalized": []
},
{
"id": "split_0_train_5490_entity",
"type": "progene_text",
"text": [
"G - protein - coupled receptors"
],
"offsets": [
[
91,
122
]
],
"normalized": []
},
{
"id": "split_0_train_5491_entity",
"type": "progene_text",
"text": [
"GPCRs"
],
"offsets": [
[
125,
130
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3388 | split_0_train_3388 | [
{
"id": "split_0_train_3388_passage",
"type": "progene_text",
"text": [
"The receptor encoded by GPR34 is most similar to the P2Y receptor subfamily , while the receptor encoded by GPR44 is most similar to chemoattractant receptors ."
],
"offsets": [
[
0,
160
]
]
}
]
| [
{
"id": "split_0_train_5492_entity",
"type": "progene_text",
"text": [
"GPR34"
],
"offsets": [
[
24,
29
]
],
"normalized": []
},
{
"id": "split_0_train_5493_entity",
"type": "progene_text",
"text": [
"P2Y receptor subfamily"
],
"offsets": [
[
53,
75
]
],
"normalized": []
},
{
"id": "split_0_train_5494_entity",
"type": "progene_text",
"text": [
"GPR44"
],
"offsets": [
[
108,
113
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3389 | split_0_train_3389 | [
{
"id": "split_0_train_3389_passage",
"type": "progene_text",
"text": [
"The receptor encoded by GPR45 is the mammalian orthologue of a putative lysophosphatidic acid receptor from Xenopus laevis ."
],
"offsets": [
[
0,
124
]
]
}
]
| [
{
"id": "split_0_train_5495_entity",
"type": "progene_text",
"text": [
"GPR45"
],
"offsets": [
[
24,
29
]
],
"normalized": []
},
{
"id": "split_0_train_5496_entity",
"type": "progene_text",
"text": [
"lysophosphatidic acid receptor"
],
"offsets": [
[
72,
102
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3390 | split_0_train_3390 | [
{
"id": "split_0_train_3390_passage",
"type": "progene_text",
"text": [
"Partial sequence of GPR34 was discovered during a search of the GenBank database of expressed sequence tags ( ESTs ) ."
],
"offsets": [
[
0,
118
]
]
}
]
| [
{
"id": "split_0_train_5497_entity",
"type": "progene_text",
"text": [
"GPR34"
],
"offsets": [
[
20,
25
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3391 | split_0_train_3391 | [
{
"id": "split_0_train_3391_passage",
"type": "progene_text",
"text": [
"This sequence information was used both to isolate the full - length translational open reading frame from a human genomic library and to assemble a contig from additional GPR34 EST cDNAs ."
],
"offsets": [
[
0,
189
]
]
}
]
| [
{
"id": "split_0_train_5498_entity",
"type": "progene_text",
"text": [
"GPR34"
],
"offsets": [
[
172,
177
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3392 | split_0_train_3392 | [
{
"id": "split_0_train_3392_passage",
"type": "progene_text",
"text": [
"Northern blot and in situ hybridization analyses revealed GPR34 mRNA transcripts in several human and rat brain regions ."
],
"offsets": [
[
0,
121
]
]
}
]
| [
{
"id": "split_0_train_5499_entity",
"type": "progene_text",
"text": [
"GPR34"
],
"offsets": [
[
58,
63
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3393 | split_0_train_3393 | [
{
"id": "split_0_train_3393_passage",
"type": "progene_text",
"text": [
"Also , we used polymerase chain reaction ( PCR ) to amplify human genomic DNA using degenerate oligonucleotides designed from sequences encoding transmembrane domains 3 and 7 of opioid and somatostatin receptors ."
],
"offsets": [
[
0,
213
]
]
}
]
| [
{
"id": "split_0_train_5500_entity",
"type": "progene_text",
"text": [
"opioid and somatostatin receptors"
],
"offsets": [
[
178,
211
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3394 | split_0_train_3394 | [
{
"id": "split_0_train_3394_passage",
"type": "progene_text",
"text": [
"Two PCR products partially encoding novel GPCRs , named GPR44 and GPR45 , were discovered and used to isolate the full - length translational open reading frames from a human genomic library ."
],
"offsets": [
[
0,
192
]
]
}
]
| [
{
"id": "split_0_train_5501_entity",
"type": "progene_text",
"text": [
"GPCRs"
],
"offsets": [
[
42,
47
]
],
"normalized": []
},
{
"id": "split_0_train_5502_entity",
"type": "progene_text",
"text": [
"GPR44"
],
"offsets": [
[
56,
61
]
],
"normalized": []
},
{
"id": "split_0_train_5503_entity",
"type": "progene_text",
"text": [
"GPR45"
],
"offsets": [
[
66,
71
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3395 | split_0_train_3395 | [
{
"id": "split_0_train_3395_passage",
"type": "progene_text",
"text": [
"Both GPR44 and GPR45 are expressed in the central nervous system and periphery ."
],
"offsets": [
[
0,
80
]
]
}
]
| [
{
"id": "split_0_train_5504_entity",
"type": "progene_text",
"text": [
"GPR44"
],
"offsets": [
[
5,
10
]
],
"normalized": []
},
{
"id": "split_0_train_5505_entity",
"type": "progene_text",
"text": [
"GPR45"
],
"offsets": [
[
15,
20
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3396 | split_0_train_3396 | [
{
"id": "split_0_train_3396_passage",
"type": "progene_text",
"text": [
"For chromosomal localization , fluorescence in situ hybridization analysis was performed to assign GPR34 to chromosomes 4p12 and Xp11 ."
],
"offsets": [
[
0,
135
]
]
}
]
| [
{
"id": "split_0_train_5506_entity",
"type": "progene_text",
"text": [
"GPR34"
],
"offsets": [
[
99,
104
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3397 | split_0_train_3397 | [
{
"id": "split_0_train_3397_passage",
"type": "progene_text",
"text": [
"3 , GPR44 to chromosome 11q12 - q13.3 , and GPR45 to chromosome 2q11. 1-q12 ."
],
"offsets": [
[
0,
77
]
]
}
]
| [
{
"id": "split_0_train_5507_entity",
"type": "progene_text",
"text": [
"GPR44"
],
"offsets": [
[
4,
9
]
],
"normalized": []
},
{
"id": "split_0_train_5508_entity",
"type": "progene_text",
"text": [
"GPR45"
],
"offsets": [
[
44,
49
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3398 | split_0_train_3398 | [
{
"id": "split_0_train_3398_passage",
"type": "progene_text",
"text": [
"unr , a cellular cytoplasmic RNA - binding protein with five cold - shock domains , is required for internal initiation of translation of human rhinovirus RNA ."
],
"offsets": [
[
0,
160
]
]
}
]
| [
{
"id": "split_0_train_5509_entity",
"type": "progene_text",
"text": [
"unr"
],
"offsets": [
[
0,
3
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3399 | split_0_train_3399 | [
{
"id": "split_0_train_3399_passage",
"type": "progene_text",
"text": [
"Initiation of translation of the animal picornavirus RNAs occurs via a mechanism of direct ribosome entry , which requires a segment of the 5' UTR of the RNA , known as the internal ribosome entry site ( IRES ) ."
],
"offsets": [
[
0,
212
]
]
}
]
| []
| []
| []
| []
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.