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stringlengths 15
19
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stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
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|---|---|---|---|---|---|---|
split_0_train_3100 | split_0_train_3100 | [
{
"id": "split_0_train_3100_passage",
"type": "progene_text",
"text": [
"In this work we were able to expand our previous analysis for Asr2 and investigated the coding regions of the four known Asr paralogous genes in seven tomato species from different geographic locations ."
],
"offsets": [
[
0,
203
]
]
}
]
| [
{
"id": "split_0_train_4982_entity",
"type": "progene_text",
"text": [
"Asr2"
],
"offsets": [
[
62,
66
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],
"normalized": []
},
{
"id": "split_0_train_4983_entity",
"type": "progene_text",
"text": [
"Asr"
],
"offsets": [
[
121,
124
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3101 | split_0_train_3101 | [
{
"id": "split_0_train_3101_passage",
"type": "progene_text",
"text": [
"In addition , we performed a phylogenetic analysis on ASR proteins ."
],
"offsets": [
[
0,
68
]
]
}
]
| [
{
"id": "split_0_train_4984_entity",
"type": "progene_text",
"text": [
"ASR"
],
"offsets": [
[
54,
57
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3102 | split_0_train_3102 | [
{
"id": "split_0_train_3102_passage",
"type": "progene_text",
"text": [
"The first conclusion drawn from this work is that tomato ASR proteins cluster together in the tree ."
],
"offsets": [
[
0,
100
]
]
}
]
| [
{
"id": "split_0_train_4985_entity",
"type": "progene_text",
"text": [
"ASR"
],
"offsets": [
[
57,
60
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3103 | split_0_train_3103 | [
{
"id": "split_0_train_3103_passage",
"type": "progene_text",
"text": [
"This observation can be explained by a scenario of concerted evolution or birth and death of genes ."
],
"offsets": [
[
0,
100
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3104 | split_0_train_3104 | [
{
"id": "split_0_train_3104_passage",
"type": "progene_text",
"text": [
"Secondly , our study showed that Asr1 is highly conserved at both replacement and synonymous sites within the genus Lycopersicon ."
],
"offsets": [
[
0,
130
]
]
}
]
| [
{
"id": "split_0_train_4986_entity",
"type": "progene_text",
"text": [
"Asr1"
],
"offsets": [
[
33,
37
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3105 | split_0_train_3105 | [
{
"id": "split_0_train_3105_passage",
"type": "progene_text",
"text": [
"ASR1 protein sequence conservation might be associated with its multiple functions in different tissues while the low rate of synonymous substitutions suggests that silent variation in Asr1 is selectively constrained , which is probably related to its high expression levels ."
],
"offsets": [
[
0,
276
]
]
}
]
| [
{
"id": "split_0_train_4987_entity",
"type": "progene_text",
"text": [
"ASR1"
],
"offsets": [
[
0,
4
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],
"normalized": []
},
{
"id": "split_0_train_4988_entity",
"type": "progene_text",
"text": [
"Asr1"
],
"offsets": [
[
185,
189
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3106 | split_0_train_3106 | [
{
"id": "split_0_train_3106_passage",
"type": "progene_text",
"text": [
"Finally , we found that Asr1 activation under water stress is not conserved between Lycopersicon species ."
],
"offsets": [
[
0,
106
]
]
}
]
| [
{
"id": "split_0_train_4989_entity",
"type": "progene_text",
"text": [
"Asr1"
],
"offsets": [
[
24,
28
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3107 | split_0_train_3107 | [
{
"id": "split_0_train_3107_passage",
"type": "progene_text",
"text": [
"Regulation of hepatic steroid receptors and enzymes by the 3beta-hydroxysteroid dehydrogenase inhibitor trilostane ."
],
"offsets": [
[
0,
116
]
]
}
]
| [
{
"id": "split_0_train_4990_entity",
"type": "progene_text",
"text": [
"steroid receptors"
],
"offsets": [
[
22,
39
]
],
"normalized": []
},
{
"id": "split_0_train_4991_entity",
"type": "progene_text",
"text": [
"3beta-hydroxysteroid dehydrogenase"
],
"offsets": [
[
59,
93
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3108 | split_0_train_3108 | [
{
"id": "split_0_train_3108_passage",
"type": "progene_text",
"text": [
"Therapies designed to treat hypercortisolism have usually sought to reduce circulating glucocorticoid concentrations , however the local tissue endocrine environment could be an alternative target ."
],
"offsets": [
[
0,
198
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3109 | split_0_train_3109 | [
{
"id": "split_0_train_3109_passage",
"type": "progene_text",
"text": [
"The 3beta-hydroxysteroid dehydrogenase Delta5 - 4 isomerase ( 3beta-HSD ) inhibitor trilostane is of interest , since , although it is only moderately and transiently effective in reducing circulating steroid , it is remarkably effective in alleviating Cushing 's symptoms in veterinary applications ."
],
"offsets": [
[
0,
301
]
]
}
]
| [
{
"id": "split_0_train_4992_entity",
"type": "progene_text",
"text": [
"3beta-hydroxysteroid dehydrogenase Delta5 - 4 isomerase"
],
"offsets": [
[
4,
59
]
],
"normalized": []
},
{
"id": "split_0_train_4993_entity",
"type": "progene_text",
"text": [
"3beta-HSD"
],
"offsets": [
[
62,
71
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3110 | split_0_train_3110 | [
{
"id": "split_0_train_3110_passage",
"type": "progene_text",
"text": [
"To seek alternative modes of action , male Wistar rats were treated with trilostane ."
],
"offsets": [
[
0,
85
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3111 | split_0_train_3111 | [
{
"id": "split_0_train_3111_passage",
"type": "progene_text",
"text": [
"Although final circulating corticosteroid concentrations were unaffected , liver 11beta-hydroxysteroid dehydrogenase type 2 ( 11beta - HSD2 ) transcription and translation was significantly increased , whereas 3beta-HSD was not affected either in liver or adrenal ."
],
"offsets": [
[
0,
265
]
]
}
]
| [
{
"id": "split_0_train_4994_entity",
"type": "progene_text",
"text": [
"11beta-hydroxysteroid dehydrogenase type 2"
],
"offsets": [
[
81,
123
]
],
"normalized": []
},
{
"id": "split_0_train_4995_entity",
"type": "progene_text",
"text": [
"11beta - HSD2"
],
"offsets": [
[
126,
139
]
],
"normalized": []
},
{
"id": "split_0_train_4996_entity",
"type": "progene_text",
"text": [
"3beta-HSD"
],
"offsets": [
[
210,
219
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3112 | split_0_train_3112 | [
{
"id": "split_0_train_3112_passage",
"type": "progene_text",
"text": [
"Glucocorticoid receptor ( GR ) mRNA was down - regulated , and mineralocorticoid receptor ( MR ) up - regulated by trilostane treatment : no changes in 11beta-HSD1 mRNA were observed ."
],
"offsets": [
[
0,
184
]
]
}
]
| [
{
"id": "split_0_train_4997_entity",
"type": "progene_text",
"text": [
"Glucocorticoid receptor"
],
"offsets": [
[
0,
23
]
],
"normalized": []
},
{
"id": "split_0_train_4998_entity",
"type": "progene_text",
"text": [
"GR"
],
"offsets": [
[
26,
28
]
],
"normalized": []
},
{
"id": "split_0_train_4999_entity",
"type": "progene_text",
"text": [
"mineralocorticoid receptor"
],
"offsets": [
[
63,
89
]
],
"normalized": []
},
{
"id": "split_0_train_5000_entity",
"type": "progene_text",
"text": [
"MR"
],
"offsets": [
[
92,
94
]
],
"normalized": []
},
{
"id": "split_0_train_5001_entity",
"type": "progene_text",
"text": [
"11beta-HSD1"
],
"offsets": [
[
152,
163
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3113 | split_0_train_3113 | [
{
"id": "split_0_train_3113_passage",
"type": "progene_text",
"text": [
"Trilostane also had no direct effect on GR response element - mediated gene transcription ."
],
"offsets": [
[
0,
91
]
]
}
]
| [
{
"id": "split_0_train_5002_entity",
"type": "progene_text",
"text": [
"GR"
],
"offsets": [
[
40,
42
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3114 | split_0_train_3114 | [
{
"id": "split_0_train_3114_passage",
"type": "progene_text",
"text": [
"The results show that the tissue endocrine environment is affected by trilostane treatment in the absence of sustained changes in circulating corticosteroid ."
],
"offsets": [
[
0,
158
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3115 | split_0_train_3115 | [
{
"id": "split_0_train_3115_passage",
"type": "progene_text",
"text": [
"The combination of increased 11beta-HSD2 and reduced GR expression in target organs could be expected to ameliorate the effects of excess glucocorticoid , suggesting new therapeutic approaches ."
],
"offsets": [
[
0,
194
]
]
}
]
| [
{
"id": "split_0_train_5003_entity",
"type": "progene_text",
"text": [
"11beta-HSD2"
],
"offsets": [
[
29,
40
]
],
"normalized": []
},
{
"id": "split_0_train_5004_entity",
"type": "progene_text",
"text": [
"GR"
],
"offsets": [
[
53,
55
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3116 | split_0_train_3116 | [
{
"id": "split_0_train_3116_passage",
"type": "progene_text",
"text": [
"IL-18 expression in pigs following infection with Mycoplasma hyopneumoniae ."
],
"offsets": [
[
0,
76
]
]
}
]
| [
{
"id": "split_0_train_5005_entity",
"type": "progene_text",
"text": [
"IL-18"
],
"offsets": [
[
0,
5
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3117 | split_0_train_3117 | [
{
"id": "split_0_train_3117_passage",
"type": "progene_text",
"text": [
"Little is known about the detail of the immune response during infection of pigs with Mycoplasma hyopneumoniae ( Mhp ) ."
],
"offsets": [
[
0,
120
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3118 | split_0_train_3118 | [
{
"id": "split_0_train_3118_passage",
"type": "progene_text",
"text": [
"To further understand this important porcine pathogen , we examined the interleukin-18 ( IL - 18 ) response in experimentally infected piglets ."
],
"offsets": [
[
0,
144
]
]
}
]
| [
{
"id": "split_0_train_5006_entity",
"type": "progene_text",
"text": [
"interleukin-18"
],
"offsets": [
[
72,
86
]
],
"normalized": []
},
{
"id": "split_0_train_5007_entity",
"type": "progene_text",
"text": [
"IL - 18"
],
"offsets": [
[
89,
96
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3119 | split_0_train_3119 | [
{
"id": "split_0_train_3119_passage",
"type": "progene_text",
"text": [
"We found that large amounts of IL-18 were produced in the bronchoalveolar lavage fluids ( BALF ) of pigs experimentally infected with Mhp ."
],
"offsets": [
[
0,
139
]
]
}
]
| [
{
"id": "split_0_train_5008_entity",
"type": "progene_text",
"text": [
"IL-18"
],
"offsets": [
[
31,
36
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3120 | split_0_train_3120 | [
{
"id": "split_0_train_3120_passage",
"type": "progene_text",
"text": [
"However , the concentration of interferon-gamma ( IFN-gamma ) in the same BALF was negatively correlated with that of IL-18 ."
],
"offsets": [
[
0,
125
]
]
}
]
| [
{
"id": "split_0_train_5009_entity",
"type": "progene_text",
"text": [
"interferon-gamma"
],
"offsets": [
[
31,
47
]
],
"normalized": []
},
{
"id": "split_0_train_5010_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
50,
59
]
],
"normalized": []
},
{
"id": "split_0_train_5011_entity",
"type": "progene_text",
"text": [
"IL-18"
],
"offsets": [
[
118,
123
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3121 | split_0_train_3121 | [
{
"id": "split_0_train_3121_passage",
"type": "progene_text",
"text": [
"The antibody response against Mhp was found to be associated with the IL-18 concentration in the BALF ."
],
"offsets": [
[
0,
103
]
]
}
]
| [
{
"id": "split_0_train_5012_entity",
"type": "progene_text",
"text": [
"IL-18"
],
"offsets": [
[
70,
75
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3122 | split_0_train_3122 | [
{
"id": "split_0_train_3122_passage",
"type": "progene_text",
"text": [
"Immunohistochemical staining revealed that both IL-18 and IL-18 receptor alpha chain ( IL-18Ralpha ) were present in macrophages and plasma cells in the lungs of Mhp - infected pigs ."
],
"offsets": [
[
0,
183
]
]
}
]
| [
{
"id": "split_0_train_5013_entity",
"type": "progene_text",
"text": [
"IL-18"
],
"offsets": [
[
48,
53
]
],
"normalized": []
},
{
"id": "split_0_train_5014_entity",
"type": "progene_text",
"text": [
"IL-18 receptor alpha chain"
],
"offsets": [
[
58,
84
]
],
"normalized": []
},
{
"id": "split_0_train_5015_entity",
"type": "progene_text",
"text": [
"IL-18Ralpha"
],
"offsets": [
[
87,
98
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3123 | split_0_train_3123 | [
{
"id": "split_0_train_3123_passage",
"type": "progene_text",
"text": [
"Lung mononuclear cells isolated from pneumonic lesions secreted IL-18 and prostaglandin E(2) ( PGE(2) ) in vitro , and PGE(2) production was enhanced by stimulation with IL-18 ."
],
"offsets": [
[
0,
177
]
]
}
]
| [
{
"id": "split_0_train_5016_entity",
"type": "progene_text",
"text": [
"IL-18"
],
"offsets": [
[
64,
69
]
],
"normalized": []
},
{
"id": "split_0_train_5017_entity",
"type": "progene_text",
"text": [
"IL-18"
],
"offsets": [
[
170,
175
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3124 | split_0_train_3124 | [
{
"id": "split_0_train_3124_passage",
"type": "progene_text",
"text": [
"These results indicate that IL-18 produced in the pig lung contributes to the development of innate and acquired immune responses against Mhp as a proinflammatory cytokine rather than as an IFN-gamma - inducing factor and may be involved in immunomodulation in pigs ."
],
"offsets": [
[
0,
267
]
]
}
]
| [
{
"id": "split_0_train_5018_entity",
"type": "progene_text",
"text": [
"IL-18"
],
"offsets": [
[
28,
33
]
],
"normalized": []
},
{
"id": "split_0_train_5019_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
163,
171
]
],
"normalized": []
},
{
"id": "split_0_train_5020_entity",
"type": "progene_text",
"text": [
"IFN-gamma - inducing factor"
],
"offsets": [
[
190,
217
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3125 | split_0_train_3125 | [
{
"id": "split_0_train_3125_passage",
"type": "progene_text",
"text": [
"Influence of interleukin IL-2 and IL-12 + IL-18 on surface expression of immunoglobulin - like receptors KIR2DL1 , KIR2DL2 , and KIR3DL2 in natural killer cells ."
],
"offsets": [
[
0,
162
]
]
}
]
| [
{
"id": "split_0_train_5021_entity",
"type": "progene_text",
"text": [
"interleukin"
],
"offsets": [
[
13,
24
]
],
"normalized": []
},
{
"id": "split_0_train_5022_entity",
"type": "progene_text",
"text": [
"IL-2"
],
"offsets": [
[
25,
29
]
],
"normalized": []
},
{
"id": "split_0_train_5023_entity",
"type": "progene_text",
"text": [
"IL-12"
],
"offsets": [
[
34,
39
]
],
"normalized": []
},
{
"id": "split_0_train_5024_entity",
"type": "progene_text",
"text": [
"IL-18"
],
"offsets": [
[
42,
47
]
],
"normalized": []
},
{
"id": "split_0_train_5025_entity",
"type": "progene_text",
"text": [
"immunoglobulin - like receptors"
],
"offsets": [
[
73,
104
]
],
"normalized": []
},
{
"id": "split_0_train_5026_entity",
"type": "progene_text",
"text": [
"KIR2DL1"
],
"offsets": [
[
105,
112
]
],
"normalized": []
},
{
"id": "split_0_train_5027_entity",
"type": "progene_text",
"text": [
"KIR2DL2"
],
"offsets": [
[
115,
122
]
],
"normalized": []
},
{
"id": "split_0_train_5028_entity",
"type": "progene_text",
"text": [
"KIR3DL2"
],
"offsets": [
[
129,
136
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3126 | split_0_train_3126 | [
{
"id": "split_0_train_3126_passage",
"type": "progene_text",
"text": [
"Natural killer ( NK ) cells express killer cell inhibitory receptors ( KIRs ) that recognize polymorphic class I MHC molecules ."
],
"offsets": [
[
0,
128
]
]
}
]
| [
{
"id": "split_0_train_5029_entity",
"type": "progene_text",
"text": [
"KIRs"
],
"offsets": [
[
71,
75
]
],
"normalized": []
},
{
"id": "split_0_train_5030_entity",
"type": "progene_text",
"text": [
"class I MHC"
],
"offsets": [
[
105,
116
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3127 | split_0_train_3127 | [
{
"id": "split_0_train_3127_passage",
"type": "progene_text",
"text": [
"In the present study , we analyze the modulatory effect of IL-2 alone or a combination of IL-12 with IL-18 on surface expression of killer cell immunoglobulin - like receptors KIR2DL1 , KIR2DL2 , and KIR3DL2 in NK cells ."
],
"offsets": [
[
0,
221
]
]
}
]
| [
{
"id": "split_0_train_5031_entity",
"type": "progene_text",
"text": [
"IL-2"
],
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59,
63
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],
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},
{
"id": "split_0_train_5032_entity",
"type": "progene_text",
"text": [
"IL-12"
],
"offsets": [
[
90,
95
]
],
"normalized": []
},
{
"id": "split_0_train_5033_entity",
"type": "progene_text",
"text": [
"IL-18"
],
"offsets": [
[
101,
106
]
],
"normalized": []
},
{
"id": "split_0_train_5034_entity",
"type": "progene_text",
"text": [
"killer cell immunoglobulin - like receptors"
],
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[
132,
175
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],
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},
{
"id": "split_0_train_5035_entity",
"type": "progene_text",
"text": [
"KIR2DL1"
],
"offsets": [
[
176,
183
]
],
"normalized": []
},
{
"id": "split_0_train_5036_entity",
"type": "progene_text",
"text": [
"KIR2DL2"
],
"offsets": [
[
186,
193
]
],
"normalized": []
},
{
"id": "split_0_train_5037_entity",
"type": "progene_text",
"text": [
"KIR3DL2"
],
"offsets": [
[
200,
207
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3128 | split_0_train_3128 | [
{
"id": "split_0_train_3128_passage",
"type": "progene_text",
"text": [
"Thus , it was found that IL-2 causes a significant increase in the proportion of cells with given studied receptors ."
],
"offsets": [
[
0,
117
]
]
}
]
| [
{
"id": "split_0_train_5038_entity",
"type": "progene_text",
"text": [
"IL-2"
],
"offsets": [
[
25,
29
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3129 | split_0_train_3129 | [
{
"id": "split_0_train_3129_passage",
"type": "progene_text",
"text": [
"Stimulation by a mixture of IL-12 and IL-18 caused significant increase in the fraction of cells with the KIR2DL1 and KIR2DL2 , however no significant change in the percentage of cells with KIR3DL2 receptor on their surface was observed ."
],
"offsets": [
[
0,
238
]
]
}
]
| [
{
"id": "split_0_train_5039_entity",
"type": "progene_text",
"text": [
"IL-12"
],
"offsets": [
[
28,
33
]
],
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},
{
"id": "split_0_train_5040_entity",
"type": "progene_text",
"text": [
"IL-18"
],
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[
38,
43
]
],
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},
{
"id": "split_0_train_5041_entity",
"type": "progene_text",
"text": [
"KIR2DL1"
],
"offsets": [
[
106,
113
]
],
"normalized": []
},
{
"id": "split_0_train_5042_entity",
"type": "progene_text",
"text": [
"KIR2DL2"
],
"offsets": [
[
118,
125
]
],
"normalized": []
},
{
"id": "split_0_train_5043_entity",
"type": "progene_text",
"text": [
"KIR3DL2"
],
"offsets": [
[
190,
197
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3130 | split_0_train_3130 | [
{
"id": "split_0_train_3130_passage",
"type": "progene_text",
"text": [
"The results of the study show the presence of KIRs on both resting and activated NK cells , this may suggest that KIRs have also an important role in the regulatory processes after activation of this subpopulation of cells ."
],
"offsets": [
[
0,
224
]
]
}
]
| [
{
"id": "split_0_train_5044_entity",
"type": "progene_text",
"text": [
"KIRs"
],
"offsets": [
[
46,
50
]
],
"normalized": []
},
{
"id": "split_0_train_5045_entity",
"type": "progene_text",
"text": [
"KIRs"
],
"offsets": [
[
114,
118
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3131 | split_0_train_3131 | [
{
"id": "split_0_train_3131_passage",
"type": "progene_text",
"text": [
"Characteristics of inhibitors in mild / moderate haemophilia A ."
],
"offsets": [
[
0,
64
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3132 | split_0_train_3132 | [
{
"id": "split_0_train_3132_passage",
"type": "progene_text",
"text": [
"Patients with mild or moderate haemophilia A usually have a mild bleeding disorder requiring only occasional treatment with factor VIII ( FVIII ) concentrates ."
],
"offsets": [
[
0,
160
]
]
}
]
| [
{
"id": "split_0_train_5046_entity",
"type": "progene_text",
"text": [
"factor VIII"
],
"offsets": [
[
124,
135
]
],
"normalized": []
},
{
"id": "split_0_train_5047_entity",
"type": "progene_text",
"text": [
"FVIII"
],
"offsets": [
[
138,
143
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3133 | split_0_train_3133 | [
{
"id": "split_0_train_3133_passage",
"type": "progene_text",
"text": [
"The frequency of inhibitor development in such patients has been the subject of several recent surveys , which significantly modified our appreciation of this complication ."
],
"offsets": [
[
0,
173
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3134 | split_0_train_3134 | [
{
"id": "split_0_train_3134_passage",
"type": "progene_text",
"text": [
"Studies of the anti - FVIII antibodies provided an explanation for the different bleeding phenotypes observed in mild / moderate haemophilia A patients with inhibitors ."
],
"offsets": [
[
0,
169
]
]
}
]
| [
{
"id": "split_0_train_5048_entity",
"type": "progene_text",
"text": [
"FVIII"
],
"offsets": [
[
22,
27
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3135 | split_0_train_3135 | [
{
"id": "split_0_train_3135_passage",
"type": "progene_text",
"text": [
"Antibodies distinguishing between the patient 's mutant FVIII and the normal wild - type FVIII were characterized , in addition to antibodies inhibiting completely or only partially FVIII activity ."
],
"offsets": [
[
0,
198
]
]
}
]
| [
{
"id": "split_0_train_5049_entity",
"type": "progene_text",
"text": [
"FVIII"
],
"offsets": [
[
56,
61
]
],
"normalized": []
},
{
"id": "split_0_train_5050_entity",
"type": "progene_text",
"text": [
"FVIII"
],
"offsets": [
[
89,
94
]
],
"normalized": []
},
{
"id": "split_0_train_5051_entity",
"type": "progene_text",
"text": [
"FVIII"
],
"offsets": [
[
182,
187
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3136 | split_0_train_3136 | [
{
"id": "split_0_train_3136_passage",
"type": "progene_text",
"text": [
"T lymphocytes recognizing FVIII and likely involved in the development of the immune response to FVIII were successfully identified ."
],
"offsets": [
[
0,
133
]
]
}
]
| [
{
"id": "split_0_train_5052_entity",
"type": "progene_text",
"text": [
"FVIII"
],
"offsets": [
[
26,
31
]
],
"normalized": []
},
{
"id": "split_0_train_5053_entity",
"type": "progene_text",
"text": [
"FVIII"
],
"offsets": [
[
97,
102
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3137 | split_0_train_3137 | [
{
"id": "split_0_train_3137_passage",
"type": "progene_text",
"text": [
"The FVIII peptides recognized by those FVIII - specific cells bind to many major histocompatibility complex ( MHC ) class II molecules , which may provide an explanation for the lack of strong association between MHC haplotypes and inhibitor development ."
],
"offsets": [
[
0,
255
]
]
}
]
| [
{
"id": "split_0_train_5054_entity",
"type": "progene_text",
"text": [
"FVIII"
],
"offsets": [
[
4,
9
]
],
"normalized": []
},
{
"id": "split_0_train_5055_entity",
"type": "progene_text",
"text": [
"FVIII"
],
"offsets": [
[
39,
44
]
],
"normalized": []
},
{
"id": "split_0_train_5056_entity",
"type": "progene_text",
"text": [
"major histocompatibility complex ( MHC ) class II"
],
"offsets": [
[
75,
124
]
],
"normalized": []
},
{
"id": "split_0_train_5057_entity",
"type": "progene_text",
"text": [
"MHC"
],
"offsets": [
[
213,
216
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3138 | split_0_train_3138 | [
{
"id": "split_0_train_3138_passage",
"type": "progene_text",
"text": [
"Although these studies have advanced our understanding of the conditions leading to inhibitor development , further work is required to determine whether the mode of FVIII administration significantly influences inhibitor development ."
],
"offsets": [
[
0,
235
]
]
}
]
| [
{
"id": "split_0_train_5058_entity",
"type": "progene_text",
"text": [
"FVIII"
],
"offsets": [
[
166,
171
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3139 | split_0_train_3139 | [
{
"id": "split_0_train_3139_passage",
"type": "progene_text",
"text": [
"Further studies of the genetic factors are also required to fully understand the mechanisms leading to inhibitor development in patients with mild / moderate haemophilia A ."
],
"offsets": [
[
0,
173
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3140 | split_0_train_3140 | [
{
"id": "split_0_train_3140_passage",
"type": "progene_text",
"text": [
"Discovery and characterization of a Ca2+-independent phosphatidylethanolamine N-acyltransferase generating the anandamide precursor and its congeners ."
],
"offsets": [
[
0,
151
]
]
}
]
| [
{
"id": "split_0_train_5059_entity",
"type": "progene_text",
"text": [
"Ca2+-independent phosphatidylethanolamine N-acyltransferase"
],
"offsets": [
[
36,
95
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3141 | split_0_train_3141 | [
{
"id": "split_0_train_3141_passage",
"type": "progene_text",
"text": [
"N-Acylphosphatidylethanolamines ( NAPEs ) are precursors of bioactive N - acylethanolamines , including the endocannabinoid anandamide ."
],
"offsets": [
[
0,
136
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3142 | split_0_train_3142 | [
{
"id": "split_0_train_3142_passage",
"type": "progene_text",
"text": [
"In animal tissues , NAPE is formed by transfer of a fatty acyl chain at the sn - 1 position of glycerophospholipids to the amino group of phosphatidylethanolamine ( PE ) , and this reaction is believed to be the principal rate - limiting step in N - acylethanolamine synthesis ."
],
"offsets": [
[
0,
278
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3143 | split_0_train_3143 | [
{
"id": "split_0_train_3143_passage",
"type": "progene_text",
"text": [
"However , the Ca2+ - dependent , membrane - associated N-acyltransferase ( NAT ) responsible for this reaction has not yet been cloned ."
],
"offsets": [
[
0,
136
]
]
}
]
| [
{
"id": "split_0_train_5060_entity",
"type": "progene_text",
"text": [
"N-acyltransferase"
],
"offsets": [
[
55,
72
]
],
"normalized": []
},
{
"id": "split_0_train_5061_entity",
"type": "progene_text",
"text": [
"NAT"
],
"offsets": [
[
75,
78
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3144 | split_0_train_3144 | [
{
"id": "split_0_train_3144_passage",
"type": "progene_text",
"text": [
"In this study , on the basis of the functional similarity of NAT to lecithin - retinol acyltransferase ( LRAT ) , we examined a possible PE N - acylation activity in two rat LRAT homologous proteins ."
],
"offsets": [
[
0,
200
]
]
}
]
| [
{
"id": "split_0_train_5062_entity",
"type": "progene_text",
"text": [
"NAT"
],
"offsets": [
[
61,
64
]
],
"normalized": []
},
{
"id": "split_0_train_5063_entity",
"type": "progene_text",
"text": [
"lecithin - retinol acyltransferase"
],
"offsets": [
[
68,
102
]
],
"normalized": []
},
{
"id": "split_0_train_5064_entity",
"type": "progene_text",
"text": [
"LRAT"
],
"offsets": [
[
105,
109
]
],
"normalized": []
},
{
"id": "split_0_train_5065_entity",
"type": "progene_text",
"text": [
"LRAT"
],
"offsets": [
[
174,
178
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3145 | split_0_train_3145 | [
{
"id": "split_0_train_3145_passage",
"type": "progene_text",
"text": [
"Upon overexpression in COS-7 cells , one protein , named rat LRAT - like protein ( RLP ) - 1 , catalyzed transfer of a radioactive acyl group from phosphatidylcholine ( PC ) to PE , resulting in the formation of radioactive NAPE ."
],
"offsets": [
[
0,
230
]
]
}
]
| [
{
"id": "split_0_train_5066_entity",
"type": "progene_text",
"text": [
"LRAT - like protein ( RLP ) - 1"
],
"offsets": [
[
61,
92
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3146 | split_0_train_3146 | [
{
"id": "split_0_train_3146_passage",
"type": "progene_text",
"text": [
"However , the RLP-1 activity was detected mainly in the cytosolic rather than membrane fraction and was little stimulated by Ca2 + ."
],
"offsets": [
[
0,
132
]
]
}
]
| [
{
"id": "split_0_train_5067_entity",
"type": "progene_text",
"text": [
"RLP-1"
],
"offsets": [
[
14,
19
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3147 | split_0_train_3147 | [
{
"id": "split_0_train_3147_passage",
"type": "progene_text",
"text": [
"Moreover , RLP-1 did not show selectivity with respect to the sn-1 and sn - 2 positions of PC as an acyl donor and therefore could generate N - arachidonoyl - PE ( anandamide precursor ) from 2 - arachidonoyl - PC and PE ."
],
"offsets": [
[
0,
222
]
]
}
]
| [
{
"id": "split_0_train_5068_entity",
"type": "progene_text",
"text": [
"RLP-1"
],
"offsets": [
[
11,
16
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3148 | split_0_train_3148 | [
{
"id": "split_0_train_3148_passage",
"type": "progene_text",
"text": [
"In contrast , under the same assay conditions , partially purified NAT from rat brain was highly Ca2 + - dependent , membrane - associated , and specific for the sn - 1 - acyl group of PC ."
],
"offsets": [
[
0,
189
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3149 | split_0_train_3149 | [
{
"id": "split_0_train_3149_passage",
"type": "progene_text",
"text": [
"RLP-1 mRNA was expressed predominantly in testis among various rat tissues , and the testis cytosol exhibited an RLP - 1 - like activity ."
],
"offsets": [
[
0,
138
]
]
}
]
| [
{
"id": "split_0_train_5069_entity",
"type": "progene_text",
"text": [
"RLP-1"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_5070_entity",
"type": "progene_text",
"text": [
"RLP - 1"
],
"offsets": [
[
113,
120
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3150 | split_0_train_3150 | [
{
"id": "split_0_train_3150_passage",
"type": "progene_text",
"text": [
"These results reveal that RLP-1 can function as a PE N-acyltransferase , catalytically distinguishable from the known Ca2 + - dependent NAT ."
],
"offsets": [
[
0,
141
]
]
}
]
| [
{
"id": "split_0_train_5071_entity",
"type": "progene_text",
"text": [
"RLP-1"
],
"offsets": [
[
26,
31
]
],
"normalized": []
},
{
"id": "split_0_train_5072_entity",
"type": "progene_text",
"text": [
"N-acyltransferase"
],
"offsets": [
[
53,
70
]
],
"normalized": []
},
{
"id": "split_0_train_5073_entity",
"type": "progene_text",
"text": [
"NAT"
],
"offsets": [
[
136,
139
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3151 | split_0_train_3151 | [
{
"id": "split_0_train_3151_passage",
"type": "progene_text",
"text": [
"A large - scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis - risk genes ."
],
"offsets": [
[
0,
125
]
]
}
]
| [
{
"id": "split_0_train_5074_entity",
"type": "progene_text",
"text": [
"IL12B"
],
"offsets": [
[
51,
56
]
],
"normalized": []
},
{
"id": "split_0_train_5075_entity",
"type": "progene_text",
"text": [
"IL23R"
],
"offsets": [
[
92,
97
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3152 | split_0_train_3152 | [
{
"id": "split_0_train_3152_passage",
"type": "progene_text",
"text": [
"We performed a multitiered , case - control association study of psoriasis in three independent sample sets of white North American individuals ( 1 , 446 cases and 1 , 432 controls ) with 25,215 genecentric single - nucleotide polymorphisms ( SNPs ) and found a highly significant association with an IL12B 3' - untranslated - region SNP ( rs3212227 ) , confirming the results of a small Japanese study ."
],
"offsets": [
[
0,
404
]
]
}
]
| [
{
"id": "split_0_train_5076_entity",
"type": "progene_text",
"text": [
"IL12B"
],
"offsets": [
[
301,
306
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3153 | split_0_train_3153 | [
{
"id": "split_0_train_3153_passage",
"type": "progene_text",
"text": [
"This SNP was significant in all three sample sets ( odds ratio [ OR ] ( common ) 0.64 , combined P [ Pcomb ] = 7.85x10 ( - 10 ) ) ."
],
"offsets": [
[
0,
131
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3154 | split_0_train_3154 | [
{
"id": "split_0_train_3154_passage",
"type": "progene_text",
"text": [
"A Monte Carlo simulation to address multiple testing suggests that this association is not a type I error ."
],
"offsets": [
[
0,
107
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3155 | split_0_train_3155 | [
{
"id": "split_0_train_3155_passage",
"type": "progene_text",
"text": [
"The coding regions of IL12B were resequenced in 96 individuals with psoriasis , and 30 additional IL12B - region SNPs were genotyped ."
],
"offsets": [
[
0,
134
]
]
}
]
| [
{
"id": "split_0_train_5077_entity",
"type": "progene_text",
"text": [
"IL12B"
],
"offsets": [
[
22,
27
]
],
"normalized": []
},
{
"id": "split_0_train_5078_entity",
"type": "progene_text",
"text": [
"IL12B"
],
"offsets": [
[
98,
103
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3156 | split_0_train_3156 | [
{
"id": "split_0_train_3156_passage",
"type": "progene_text",
"text": [
"Haplotypes were estimated , and genotype - conditioned analyses identified a second risk allele ( rs6887695 ) located approximately 60 kb upstream of the IL12B coding region that exhibited association with psoriasis after adjustment for rs3212227 ."
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[
0,
248
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]
| [
{
"id": "split_0_train_5079_entity",
"type": "progene_text",
"text": [
"IL12B"
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[
154,
159
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}
]
| []
| []
| []
|
split_0_train_3157 | split_0_train_3157 | [
{
"id": "split_0_train_3157_passage",
"type": "progene_text",
"text": [
"Together , these two SNPs mark a common IL12B risk haplotype ( OR ( common ) 1.40 , Pcomb = 8.11x10 ( - 9 ) ) and a less frequent protective haplotype ( OR ( common ) 0.58 , Pcomb = 5.65x10 ( - 12 ) ) , which were statistically significant in all three studies ."
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[
0,
262
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}
]
| [
{
"id": "split_0_train_5080_entity",
"type": "progene_text",
"text": [
"IL12B"
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[
40,
45
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}
]
| []
| []
| []
|
split_0_train_3158 | split_0_train_3158 | [
{
"id": "split_0_train_3158_passage",
"type": "progene_text",
"text": [
"Since IL12B encodes the common IL-12p40 subunit of IL-12 and IL-23 , we individually genotyped 17 SNPs in the genes encoding the other chains of these cytokines ( IL12A and IL23A ) and their receptors ( IL12RB1 , IL12RB2 , and IL23R ) ."
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[
0,
236
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}
]
| [
{
"id": "split_0_train_5081_entity",
"type": "progene_text",
"text": [
"IL12B"
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[
6,
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{
"id": "split_0_train_5082_entity",
"type": "progene_text",
"text": [
"IL-12p40"
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[
31,
39
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},
{
"id": "split_0_train_5083_entity",
"type": "progene_text",
"text": [
"IL-12"
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[
51,
56
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},
{
"id": "split_0_train_5084_entity",
"type": "progene_text",
"text": [
"IL-23"
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[
61,
66
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{
"id": "split_0_train_5085_entity",
"type": "progene_text",
"text": [
"cytokines"
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[
151,
160
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"normalized": []
},
{
"id": "split_0_train_5086_entity",
"type": "progene_text",
"text": [
"IL12A"
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[
163,
168
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},
{
"id": "split_0_train_5087_entity",
"type": "progene_text",
"text": [
"IL23A"
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[
173,
178
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{
"id": "split_0_train_5088_entity",
"type": "progene_text",
"text": [
"IL12RB1"
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[
203,
210
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},
{
"id": "split_0_train_5089_entity",
"type": "progene_text",
"text": [
"IL12RB2"
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[
213,
220
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},
{
"id": "split_0_train_5090_entity",
"type": "progene_text",
"text": [
"IL23R"
],
"offsets": [
[
227,
232
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3159 | split_0_train_3159 | [
{
"id": "split_0_train_3159_passage",
"type": "progene_text",
"text": [
"Haplotype analyses identified two IL23R missense SNPs that together mark a common psoriasis - associated haplotype in all three studies ( OR ( common ) 1.44 , Pcomb = 3.13x10 (-6) ) ."
],
"offsets": [
[
0,
183
]
]
}
]
| [
{
"id": "split_0_train_5091_entity",
"type": "progene_text",
"text": [
"IL23R"
],
"offsets": [
[
34,
39
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3160 | split_0_train_3160 | [
{
"id": "split_0_train_3160_passage",
"type": "progene_text",
"text": [
"Individuals homozygous for both the IL12B and the IL23R predisposing haplotypes have an increased risk of disease ( OR ( common ) 1.66 , Pcomb = 1.33x10(-8) ) ."
],
"offsets": [
[
0,
160
]
]
}
]
| [
{
"id": "split_0_train_5092_entity",
"type": "progene_text",
"text": [
"IL12B"
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"offsets": [
[
36,
41
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],
"normalized": []
},
{
"id": "split_0_train_5093_entity",
"type": "progene_text",
"text": [
"IL23R"
],
"offsets": [
[
50,
55
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3161 | split_0_train_3161 | [
{
"id": "split_0_train_3161_passage",
"type": "progene_text",
"text": [
"These data , and the previous observation that administration of an antibody specific for the IL - 12p40 subunit to patients with psoriasis is highly efficacious , suggest that these genes play a fundamental role in psoriasis pathogenesis ."
],
"offsets": [
[
0,
240
]
]
}
]
| [
{
"id": "split_0_train_5094_entity",
"type": "progene_text",
"text": [
"IL - 12p40"
],
"offsets": [
[
94,
104
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3162 | split_0_train_3162 | [
{
"id": "split_0_train_3162_passage",
"type": "progene_text",
"text": [
"Pyrin - only protein 2 modulates NF-kappaB and disrupts ASC : CLR interactions ."
],
"offsets": [
[
0,
80
]
]
}
]
| [
{
"id": "split_0_train_5095_entity",
"type": "progene_text",
"text": [
"Pyrin - only protein 2"
],
"offsets": [
[
0,
22
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],
"normalized": []
},
{
"id": "split_0_train_5096_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
33,
42
]
],
"normalized": []
},
{
"id": "split_0_train_5097_entity",
"type": "progene_text",
"text": [
"ASC"
],
"offsets": [
[
56,
59
]
],
"normalized": []
},
{
"id": "split_0_train_5098_entity",
"type": "progene_text",
"text": [
"CLR"
],
"offsets": [
[
62,
65
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3163 | split_0_train_3163 | [
{
"id": "split_0_train_3163_passage",
"type": "progene_text",
"text": [
"NF-kappaB is pivotal for transactivation of cell - cycle regulatory , cytokine , and adhesion molecule genes and is dysregulated in many cancers , neurodegenerative disorders , and inflammatory diseases ."
],
"offsets": [
[
0,
204
]
]
}
]
| [
{
"id": "split_0_train_5099_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "split_0_train_5100_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
70,
78
]
],
"normalized": []
},
{
"id": "split_0_train_5101_entity",
"type": "progene_text",
"text": [
"adhesion molecule"
],
"offsets": [
[
85,
102
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3164 | split_0_train_3164 | [
{
"id": "split_0_train_3164_passage",
"type": "progene_text",
"text": [
"Proteins with pyrin and/or caspase recruitment domains have roles in apoptosis , innate immunity , and inflammation ."
],
"offsets": [
[
0,
117
]
]
}
]
| [
{
"id": "split_0_train_5102_entity",
"type": "progene_text",
"text": [
"caspase"
],
"offsets": [
[
27,
34
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3165 | split_0_train_3165 | [
{
"id": "split_0_train_3165_passage",
"type": "progene_text",
"text": [
"Many pyrin domain ( PYD ) proteins modulate NF-kappaB activity as well as participate in assembling both the perinuclear \" apoptotic speck \" and the pro - IL1beta / IL-18 - converting inflammasome complex ."
],
"offsets": [
[
0,
206
]
]
}
]
| [
{
"id": "split_0_train_5103_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
44,
53
]
],
"normalized": []
},
{
"id": "split_0_train_5104_entity",
"type": "progene_text",
"text": [
"IL1beta"
],
"offsets": [
[
155,
162
]
],
"normalized": []
},
{
"id": "split_0_train_5105_entity",
"type": "progene_text",
"text": [
"IL-18"
],
"offsets": [
[
165,
170
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3166 | split_0_train_3166 | [
{
"id": "split_0_train_3166_passage",
"type": "progene_text",
"text": [
"\" Pyrin - only \" proteins ( POP ) are attractive as negative regulators of PYD - mediated functions and one such protein , POP1 , has been reported ."
],
"offsets": [
[
0,
149
]
]
}
]
| [
{
"id": "split_0_train_5106_entity",
"type": "progene_text",
"text": [
"Pyrin - only \" proteins"
],
"offsets": [
[
2,
25
]
],
"normalized": []
},
{
"id": "split_0_train_5107_entity",
"type": "progene_text",
"text": [
"POP"
],
"offsets": [
[
28,
31
]
],
"normalized": []
},
{
"id": "split_0_train_5108_entity",
"type": "progene_text",
"text": [
"POP1"
],
"offsets": [
[
123,
127
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3167 | split_0_train_3167 | [
{
"id": "split_0_train_3167_passage",
"type": "progene_text",
"text": [
"We report the identification and initial characterization of a second POP ."
],
"offsets": [
[
0,
75
]
]
}
]
| [
{
"id": "split_0_train_5109_entity",
"type": "progene_text",
"text": [
"POP"
],
"offsets": [
[
70,
73
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3168 | split_0_train_3168 | [
{
"id": "split_0_train_3168_passage",
"type": "progene_text",
"text": [
"POP2 is a 294 nt single exon gene located on human chromosome 3 encoding a 97 - aa protein with sequence and predicted structural similarity to other PYDs ."
],
"offsets": [
[
0,
156
]
]
}
]
| [
{
"id": "split_0_train_5110_entity",
"type": "progene_text",
"text": [
"POP2"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3169 | split_0_train_3169 | [
{
"id": "split_0_train_3169_passage",
"type": "progene_text",
"text": [
"Highly similar to PYDs in CATERPILLER ( CLR , NLR , NALP ) family proteins , POP2 is less like the prototypic pyrin and ASC PYDs ."
],
"offsets": [
[
0,
130
]
]
}
]
| [
{
"id": "split_0_train_5111_entity",
"type": "progene_text",
"text": [
"CATERPILLER ( CLR , NLR , NALP ) family"
],
"offsets": [
[
26,
65
]
],
"normalized": []
},
{
"id": "split_0_train_5112_entity",
"type": "progene_text",
"text": [
"POP2"
],
"offsets": [
[
77,
81
]
],
"normalized": []
},
{
"id": "split_0_train_5113_entity",
"type": "progene_text",
"text": [
"ASC"
],
"offsets": [
[
120,
123
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3170 | split_0_train_3170 | [
{
"id": "split_0_train_3170_passage",
"type": "progene_text",
"text": [
"POP2 is expressed principally in peripheral blood leukocytes and displays both cytoplasmic and nuclear expression patterns in transfected cells ."
],
"offsets": [
[
0,
145
]
]
}
]
| [
{
"id": "split_0_train_5114_entity",
"type": "progene_text",
"text": [
"POP2"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3171 | split_0_train_3171 | [
{
"id": "split_0_train_3171_passage",
"type": "progene_text",
"text": [
"TNF-alpha - stimulated and p65 ( RelA ) - induced NF-kappaB - dependent gene transcription is inhibited by POP2 in vitro by a mechanism involving changes in NF-kappaB nuclear import or distribution ."
],
"offsets": [
[
0,
199
]
]
}
]
| [
{
"id": "split_0_train_5115_entity",
"type": "progene_text",
"text": [
"TNF-alpha"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "split_0_train_5116_entity",
"type": "progene_text",
"text": [
"p65"
],
"offsets": [
[
27,
30
]
],
"normalized": []
},
{
"id": "split_0_train_5117_entity",
"type": "progene_text",
"text": [
"RelA"
],
"offsets": [
[
33,
37
]
],
"normalized": []
},
{
"id": "split_0_train_5118_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
50,
59
]
],
"normalized": []
},
{
"id": "split_0_train_5119_entity",
"type": "progene_text",
"text": [
"POP2"
],
"offsets": [
[
107,
111
]
],
"normalized": []
},
{
"id": "split_0_train_5120_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
157,
166
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3172 | split_0_train_3172 | [
{
"id": "split_0_train_3172_passage",
"type": "progene_text",
"text": [
"While colocalizing with ASC in perinuclear specks , POP2 also inhibits the formation of specks by the CLR protein CIAS1 / NALP3 ."
],
"offsets": [
[
0,
129
]
]
}
]
| [
{
"id": "split_0_train_5121_entity",
"type": "progene_text",
"text": [
"ASC"
],
"offsets": [
[
24,
27
]
],
"normalized": []
},
{
"id": "split_0_train_5122_entity",
"type": "progene_text",
"text": [
"POP2"
],
"offsets": [
[
52,
56
]
],
"normalized": []
},
{
"id": "split_0_train_5123_entity",
"type": "progene_text",
"text": [
"CLR"
],
"offsets": [
[
102,
105
]
],
"normalized": []
},
{
"id": "split_0_train_5124_entity",
"type": "progene_text",
"text": [
"CIAS1"
],
"offsets": [
[
114,
119
]
],
"normalized": []
},
{
"id": "split_0_train_5125_entity",
"type": "progene_text",
"text": [
"NALP3"
],
"offsets": [
[
122,
127
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3173 | split_0_train_3173 | [
{
"id": "split_0_train_3173_passage",
"type": "progene_text",
"text": [
"Together , these observations demonstrate that POP2 is a negative regulator of NF-kappaB activity that may influence the assembly of PYD - dependent complexes ."
],
"offsets": [
[
0,
160
]
]
}
]
| [
{
"id": "split_0_train_5126_entity",
"type": "progene_text",
"text": [
"POP2"
],
"offsets": [
[
47,
51
]
],
"normalized": []
},
{
"id": "split_0_train_5127_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
79,
88
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3174 | split_0_train_3174 | [
{
"id": "split_0_train_3174_passage",
"type": "progene_text",
"text": [
"Differential regulation of BACE1 promoter activity by nuclear factor - kappaB in neurons and glia upon exposure to beta-amyloid peptides ."
],
"offsets": [
[
0,
138
]
]
}
]
| [
{
"id": "split_0_train_5128_entity",
"type": "progene_text",
"text": [
"BACE1"
],
"offsets": [
[
27,
32
]
],
"normalized": []
},
{
"id": "split_0_train_5129_entity",
"type": "progene_text",
"text": [
"nuclear factor - kappaB"
],
"offsets": [
[
54,
77
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3175 | split_0_train_3175 | [
{
"id": "split_0_train_3175_passage",
"type": "progene_text",
"text": [
"The brains of Alzheimer 's disease ( AD ) patients display cerebrovascular and parenchymal deposits of beta - amyloid ( A beta ) peptides , which are derived by proteolytic processing by the beta - site APP - cleaving enzyme 1 ( BACE1 ) of the amyloid precursor protein ( APP ) ."
],
"offsets": [
[
0,
279
]
]
}
]
| [
{
"id": "split_0_train_5130_entity",
"type": "progene_text",
"text": [
"beta - site APP - cleaving enzyme 1"
],
"offsets": [
[
191,
226
]
],
"normalized": []
},
{
"id": "split_0_train_5131_entity",
"type": "progene_text",
"text": [
"BACE1"
],
"offsets": [
[
229,
234
]
],
"normalized": []
},
{
"id": "split_0_train_5132_entity",
"type": "progene_text",
"text": [
"amyloid precursor protein"
],
"offsets": [
[
244,
269
]
],
"normalized": []
},
{
"id": "split_0_train_5133_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
272,
275
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3176 | split_0_train_3176 | [
{
"id": "split_0_train_3176_passage",
"type": "progene_text",
"text": [
"The rat BACE1 promoter has a nuclear factor - kappaB ( NF-kappaB ) binding site ."
],
"offsets": [
[
0,
81
]
]
}
]
| [
{
"id": "split_0_train_5134_entity",
"type": "progene_text",
"text": [
"BACE1"
],
"offsets": [
[
8,
13
]
],
"normalized": []
},
{
"id": "split_0_train_5135_entity",
"type": "progene_text",
"text": [
"nuclear factor - kappaB"
],
"offsets": [
[
29,
52
]
],
"normalized": []
},
{
"id": "split_0_train_5136_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
55,
64
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3177 | split_0_train_3177 | [
{
"id": "split_0_train_3177_passage",
"type": "progene_text",
"text": [
"Deletion studies with a BACE1 promoter / luciferase reporter suggest that the NF-kappaB binding DNA consensus sequence plays a suppressor role , when occupied by NF - kappaB , in the regulation of neuronal brain BACE1 expression ."
],
"offsets": [
[
0,
230
]
]
}
]
| [
{
"id": "split_0_train_5137_entity",
"type": "progene_text",
"text": [
"BACE1"
],
"offsets": [
[
24,
29
]
],
"normalized": []
},
{
"id": "split_0_train_5138_entity",
"type": "progene_text",
"text": [
"luciferase"
],
"offsets": [
[
41,
51
]
],
"normalized": []
},
{
"id": "split_0_train_5139_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
78,
87
]
],
"normalized": []
},
{
"id": "split_0_train_5140_entity",
"type": "progene_text",
"text": [
"NF - kappaB"
],
"offsets": [
[
162,
173
]
],
"normalized": []
},
{
"id": "split_0_train_5141_entity",
"type": "progene_text",
"text": [
"BACE1"
],
"offsets": [
[
212,
217
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3178 | split_0_train_3178 | [
{
"id": "split_0_train_3178_passage",
"type": "progene_text",
"text": [
"Here we characterize a signal transduction pathway that may be responsible for the increases in A beta associated with AD ."
],
"offsets": [
[
0,
123
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3179 | split_0_train_3179 | [
{
"id": "split_0_train_3179_passage",
"type": "progene_text",
"text": [
"We propose that the transcription factor NF-kappaB acts as a repressor in neurons but as an activator of BACE1 transcription in activated astrocytes present in the CNS under chronic stress , a feature present in the AD brain ."
],
"offsets": [
[
0,
226
]
]
}
]
| [
{
"id": "split_0_train_5142_entity",
"type": "progene_text",
"text": [
"transcription factor"
],
"offsets": [
[
20,
40
]
],
"normalized": []
},
{
"id": "split_0_train_5143_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
41,
50
]
],
"normalized": []
},
{
"id": "split_0_train_5144_entity",
"type": "progene_text",
"text": [
"BACE1"
],
"offsets": [
[
105,
110
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3180 | split_0_train_3180 | [
{
"id": "split_0_train_3180_passage",
"type": "progene_text",
"text": [
"The activated astrocytic stimulation of BACE1 may in part account for increased BACE1 transcription and subsequent processing of Ab eta in a cell - specific manner in the aged and AD brain ."
],
"offsets": [
[
0,
190
]
]
}
]
| [
{
"id": "split_0_train_5145_entity",
"type": "progene_text",
"text": [
"BACE1"
],
"offsets": [
[
40,
45
]
],
"normalized": []
},
{
"id": "split_0_train_5146_entity",
"type": "progene_text",
"text": [
"BACE1"
],
"offsets": [
[
80,
85
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3181 | split_0_train_3181 | [
{
"id": "split_0_train_3181_passage",
"type": "progene_text",
"text": [
"As measured by reporter gene promoter constructs and endogenous BACE1 protein expression , a functional NF-kappaB site was stimulatory in activated astrocytes and A beta - exposed neuronal cells and repressive in neuronal and nonactivated astrocytic cells ."
],
"offsets": [
[
0,
257
]
]
}
]
| [
{
"id": "split_0_train_5147_entity",
"type": "progene_text",
"text": [
"BACE1"
],
"offsets": [
[
64,
69
]
],
"normalized": []
},
{
"id": "split_0_train_5148_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
104,
113
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3182 | split_0_train_3182 | [
{
"id": "split_0_train_3182_passage",
"type": "progene_text",
"text": [
"Given the evidence for increased levels of activated astrocytes in the aged brain , the age - and AD - associated increases in NF-kappaB in brain may be significant contributors to increases in A beta , acting as a positive feedback loop of chronic inflammation , astrocyte activation , increased p65 / p50 activation of BACE1 transcription , and further inflammation ."
],
"offsets": [
[
0,
369
]
]
}
]
| [
{
"id": "split_0_train_5149_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
127,
136
]
],
"normalized": []
},
{
"id": "split_0_train_5150_entity",
"type": "progene_text",
"text": [
"p65"
],
"offsets": [
[
297,
300
]
],
"normalized": []
},
{
"id": "split_0_train_5151_entity",
"type": "progene_text",
"text": [
"p50"
],
"offsets": [
[
303,
306
]
],
"normalized": []
},
{
"id": "split_0_train_5152_entity",
"type": "progene_text",
"text": [
"BACE1"
],
"offsets": [
[
321,
326
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3183 | split_0_train_3183 | [
{
"id": "split_0_train_3183_passage",
"type": "progene_text",
"text": [
"Increased frequencies of activating natural killer receptors are associated with liver injury in individuals who do not eliminate hepatitis C virus ."
],
"offsets": [
[
0,
149
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3184 | split_0_train_3184 | [
{
"id": "split_0_train_3184_passage",
"type": "progene_text",
"text": [
"This study was designed to investigate the role of killer immunoglobulin - like receptor ( KIR ) genes in the outcome of hepatitis C virus ( HCV ) infection ."
],
"offsets": [
[
0,
158
]
]
}
]
| [
{
"id": "split_0_train_5153_entity",
"type": "progene_text",
"text": [
"killer immunoglobulin - like receptor"
],
"offsets": [
[
51,
88
]
],
"normalized": []
},
{
"id": "split_0_train_5154_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
91,
94
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3185 | split_0_train_3185 | [
{
"id": "split_0_train_3185_passage",
"type": "progene_text",
"text": [
"In patients who cleared the virus ( HCV RNA - ) we found a decrease of 2DL2 ( P = 0.04 ) , and 2DS2 ( P = 0.014 ) accompanied by an increase of 2DS5 ( P = 0.04 ) ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_5155_entity",
"type": "progene_text",
"text": [
"2DL2"
],
"offsets": [
[
71,
75
]
],
"normalized": []
},
{
"id": "split_0_train_5156_entity",
"type": "progene_text",
"text": [
"2DS2"
],
"offsets": [
[
95,
99
]
],
"normalized": []
},
{
"id": "split_0_train_5157_entity",
"type": "progene_text",
"text": [
"2DS5"
],
"offsets": [
[
144,
148
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3186 | split_0_train_3186 | [
{
"id": "split_0_train_3186_passage",
"type": "progene_text",
"text": [
"Those RNA + patients with elevated levels of hepatic transaminases ( HCV RNA + elevated alanine aminotransferase ) showed an increased frequency of 2DS3 ( P = 0.018 ) ."
],
"offsets": [
[
0,
168
]
]
}
]
| [
{
"id": "split_0_train_5158_entity",
"type": "progene_text",
"text": [
"transaminases"
],
"offsets": [
[
53,
66
]
],
"normalized": []
},
{
"id": "split_0_train_5159_entity",
"type": "progene_text",
"text": [
"alanine aminotransferase"
],
"offsets": [
[
88,
112
]
],
"normalized": []
},
{
"id": "split_0_train_5160_entity",
"type": "progene_text",
"text": [
"2DS3"
],
"offsets": [
[
148,
152
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3187 | split_0_train_3187 | [
{
"id": "split_0_train_3187_passage",
"type": "progene_text",
"text": [
"Additionally , in cirrhotic patients we found an increased frequency of individuals having two copies of 3DS1 and HLA-Bw4 ( P = 0.016 ) ."
],
"offsets": [
[
0,
137
]
]
}
]
| [
{
"id": "split_0_train_5161_entity",
"type": "progene_text",
"text": [
"3DS1"
],
"offsets": [
[
105,
109
]
],
"normalized": []
},
{
"id": "split_0_train_5162_entity",
"type": "progene_text",
"text": [
"HLA-Bw4"
],
"offsets": [
[
114,
121
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3188 | split_0_train_3188 | [
{
"id": "split_0_train_3188_passage",
"type": "progene_text",
"text": [
"We conclude that higher natural killer cytotoxicity might be associated with a worse progression of the HCV infection ."
],
"offsets": [
[
0,
119
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3189 | split_0_train_3189 | [
{
"id": "split_0_train_3189_passage",
"type": "progene_text",
"text": [
"Laboratory assessment of hypercoagulable state ."
],
"offsets": [
[
0,
48
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3190 | split_0_train_3190 | [
{
"id": "split_0_train_3190_passage",
"type": "progene_text",
"text": [
"A study in a group of patients with venous thromboembolism born in Chioggia ."
],
"offsets": [
[
0,
77
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3191 | split_0_train_3191 | [
{
"id": "split_0_train_3191_passage",
"type": "progene_text",
"text": [
"AIM :"
],
"offsets": [
[
0,
5
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3192 | split_0_train_3192 | [
{
"id": "split_0_train_3192_passage",
"type": "progene_text",
"text": [
"Authors performed a Laboratory assessment for thrombophilia risk factors in a group of patients with previous deep venous thrombosis ."
],
"offsets": [
[
0,
134
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3193 | split_0_train_3193 | [
{
"id": "split_0_train_3193_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3194 | split_0_train_3194 | [
{
"id": "split_0_train_3194_passage",
"type": "progene_text",
"text": [
"123 consecutive patients were considered ."
],
"offsets": [
[
0,
42
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3195 | split_0_train_3195 | [
{
"id": "split_0_train_3195_passage",
"type": "progene_text",
"text": [
"The following parameters were investigated by using commercially available methods : PT , aPTT , TT , Fibrinogen , D-Dimer , Anti thrombin 3 ( AT ) , Protein C ( PC ) , Protein S ( PS ) , activated C protein ( APC ) resistance , Lupus anticoagulant ( LA ) , FV Leiden ( G1691a mutation ) , Prothrombin G20210A mutation , MTHFR mutation ( G677T mutation ) , anti Prothrombin auto - antibodies ( PR ) IgG and IgM , anti Beta 2 glycoprotein 1 ( B2GP1 ) auto - antibodies IgG and IgM , anti Cardiolipin ( CL ) auto - antibodies IgG and IgM , homocysteine ."
],
"offsets": [
[
0,
552
]
]
}
]
| [
{
"id": "split_0_train_5163_entity",
"type": "progene_text",
"text": [
"Fibrinogen"
],
"offsets": [
[
102,
112
]
],
"normalized": []
},
{
"id": "split_0_train_5164_entity",
"type": "progene_text",
"text": [
"thrombin"
],
"offsets": [
[
130,
138
]
],
"normalized": []
},
{
"id": "split_0_train_5165_entity",
"type": "progene_text",
"text": [
"Protein C"
],
"offsets": [
[
150,
159
]
],
"normalized": []
},
{
"id": "split_0_train_5166_entity",
"type": "progene_text",
"text": [
"PC"
],
"offsets": [
[
162,
164
]
],
"normalized": []
},
{
"id": "split_0_train_5167_entity",
"type": "progene_text",
"text": [
"Protein S"
],
"offsets": [
[
169,
178
]
],
"normalized": []
},
{
"id": "split_0_train_5168_entity",
"type": "progene_text",
"text": [
"PS"
],
"offsets": [
[
181,
183
]
],
"normalized": []
},
{
"id": "split_0_train_5169_entity",
"type": "progene_text",
"text": [
"C protein"
],
"offsets": [
[
198,
207
]
],
"normalized": []
},
{
"id": "split_0_train_5170_entity",
"type": "progene_text",
"text": [
"Prothrombin"
],
"offsets": [
[
290,
301
]
],
"normalized": []
},
{
"id": "split_0_train_5171_entity",
"type": "progene_text",
"text": [
"MTHFR"
],
"offsets": [
[
321,
326
]
],
"normalized": []
},
{
"id": "split_0_train_5172_entity",
"type": "progene_text",
"text": [
"Prothrombin"
],
"offsets": [
[
362,
373
]
],
"normalized": []
},
{
"id": "split_0_train_5173_entity",
"type": "progene_text",
"text": [
"IgG"
],
"offsets": [
[
399,
402
]
],
"normalized": []
},
{
"id": "split_0_train_5174_entity",
"type": "progene_text",
"text": [
"IgM"
],
"offsets": [
[
407,
410
]
],
"normalized": []
},
{
"id": "split_0_train_5175_entity",
"type": "progene_text",
"text": [
"Beta 2 glycoprotein 1"
],
"offsets": [
[
418,
439
]
],
"normalized": []
},
{
"id": "split_0_train_5176_entity",
"type": "progene_text",
"text": [
"B2GP1"
],
"offsets": [
[
442,
447
]
],
"normalized": []
},
{
"id": "split_0_train_5177_entity",
"type": "progene_text",
"text": [
"IgG"
],
"offsets": [
[
468,
471
]
],
"normalized": []
},
{
"id": "split_0_train_5178_entity",
"type": "progene_text",
"text": [
"IgM"
],
"offsets": [
[
476,
479
]
],
"normalized": []
},
{
"id": "split_0_train_5179_entity",
"type": "progene_text",
"text": [
"IgG"
],
"offsets": [
[
524,
527
]
],
"normalized": []
},
{
"id": "split_0_train_5180_entity",
"type": "progene_text",
"text": [
"IgM"
],
"offsets": [
[
532,
535
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3196 | split_0_train_3196 | [
{
"id": "split_0_train_3196_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3197 | split_0_train_3197 | [
{
"id": "split_0_train_3197_passage",
"type": "progene_text",
"text": [
"In the 123 patients considered we observed : two AT deficiency , one PC deficiencies , one PS deficiency , 60 FV Leiden mutation ( six homozygous ) , 1 Prothrombin gene mutations ( heterozygous ) , 71 MTHFR mutations ( 15 homozygous ) ."
],
"offsets": [
[
0,
236
]
]
}
]
| [
{
"id": "split_0_train_5181_entity",
"type": "progene_text",
"text": [
"PC"
],
"offsets": [
[
69,
71
]
],
"normalized": []
},
{
"id": "split_0_train_5182_entity",
"type": "progene_text",
"text": [
"PS"
],
"offsets": [
[
91,
93
]
],
"normalized": []
},
{
"id": "split_0_train_5183_entity",
"type": "progene_text",
"text": [
"Prothrombin"
],
"offsets": [
[
152,
163
]
],
"normalized": []
},
{
"id": "split_0_train_5184_entity",
"type": "progene_text",
"text": [
"MTHFR"
],
"offsets": [
[
201,
206
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3198 | split_0_train_3198 | [
{
"id": "split_0_train_3198_passage",
"type": "progene_text",
"text": [
"Study of anti phospholipid auto antibodies showed 10 patients positive for LA , 9 for anti CL antibodies ( 6IgG and 3IgM ) , 10 for anti B2GP1 antibody ( 5 IgG and 5IgM ) , 3 for anti PR antibody ( IgG ) ."
],
"offsets": [
[
0,
205
]
]
}
]
| [
{
"id": "split_0_train_5185_entity",
"type": "progene_text",
"text": [
"B2GP1"
],
"offsets": [
[
137,
142
]
],
"normalized": []
},
{
"id": "split_0_train_5186_entity",
"type": "progene_text",
"text": [
"IgG"
],
"offsets": [
[
156,
159
]
],
"normalized": []
},
{
"id": "split_0_train_5187_entity",
"type": "progene_text",
"text": [
"5IgM"
],
"offsets": [
[
164,
168
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3199 | split_0_train_3199 | [
{
"id": "split_0_train_3199_passage",
"type": "progene_text",
"text": [
"Thirty nine patients showed hyper homocysteinemia ."
],
"offsets": [
[
0,
51
]
]
}
]
| []
| []
| []
| []
|
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