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split_0_train_3500 | split_0_train_3500 | [
{
"id": "split_0_train_3500_passage",
"type": "progene_text",
"text": [
"In contrast , neither P159 , a Pro - containing analog of K159 that presents a kink around proline but with intact epitope conformation , nor the truncated analogs encompassing the epitope , were inhibitors of IN ."
],
"offsets": [
[
0,
214
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]
}
]
| [
{
"id": "split_0_train_5741_entity",
"type": "progene_text",
"text": [
"IN"
],
"offsets": [
[
210,
212
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3501 | split_0_train_3501 | [
{
"id": "split_0_train_3501_passage",
"type": "progene_text",
"text": [
"While the activity of antibodies is restricted to recognition of the sole epitope portion , that of the antigenic K159 likely requires interactions of the peptide with the whole 147 - 175 segment in the protein [ Sourgen F. , Maroun , R.G. , Fr�¨re , V. , Bouziane , A. , Auclair , C. , Troalen , F. & Fermandjian , S. ( 1996 ) Eur. J. Biochem. 240 , 765 - 773 ] ."
],
"offsets": [
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0,
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]
}
]
| []
| []
| []
| []
|
split_0_train_3502 | split_0_train_3502 | [
{
"id": "split_0_train_3502_passage",
"type": "progene_text",
"text": [
"Actually , of all tested peptides only K159 was found to fulfill condition of minimal number of helical heptads to achieve the formation of a stable coiled - coil structure with the IN 147 - 175 segment ."
],
"offsets": [
[
0,
204
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}
]
| [
{
"id": "split_0_train_5742_entity",
"type": "progene_text",
"text": [
"IN"
],
"offsets": [
[
182,
184
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3503 | split_0_train_3503 | [
{
"id": "split_0_train_3503_passage",
"type": "progene_text",
"text": [
"The binding of antibodies and of the antigenic peptide to this segment of IN hampers the binding of IN to its DNA substrates in filter - binding assays ."
],
"offsets": [
[
0,
153
]
]
}
]
| [
{
"id": "split_0_train_5743_entity",
"type": "progene_text",
"text": [
"IN"
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"offsets": [
[
74,
76
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"normalized": []
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{
"id": "split_0_train_5744_entity",
"type": "progene_text",
"text": [
"IN"
],
"offsets": [
[
100,
102
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3504 | split_0_train_3504 | [
{
"id": "split_0_train_3504_passage",
"type": "progene_text",
"text": [
"This appears to be the main effect leading to inhibition of integration ."
],
"offsets": [
[
0,
73
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3505 | split_0_train_3505 | [
{
"id": "split_0_train_3505_passage",
"type": "progene_text",
"text": [
"Quantitative analysis of filter - binding assay curves indicates that two antibody molecules react with IN implying that the enzyme is dimeric within these experimental conditions ."
],
"offsets": [
[
0,
181
]
]
}
]
| [
{
"id": "split_0_train_5745_entity",
"type": "progene_text",
"text": [
"IN"
],
"offsets": [
[
104,
106
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3506 | split_0_train_3506 | [
{
"id": "split_0_train_3506_passage",
"type": "progene_text",
"text": [
"Together , present data provide an insight into the structure - function relationship for the 147 - 175 peptide domain of the enzyme ."
],
"offsets": [
[
0,
134
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3507 | split_0_train_3507 | [
{
"id": "split_0_train_3507_passage",
"type": "progene_text",
"text": [
"They also strongly suggest that the functional enzyme is dimeric ."
],
"offsets": [
[
0,
66
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]
}
]
| []
| []
| []
| []
|
split_0_train_3508 | split_0_train_3508 | [
{
"id": "split_0_train_3508_passage",
"type": "progene_text",
"text": [
"Results could help to assess models for binding of peptide fragments to IN and to develop stronger inhibitors ."
],
"offsets": [
[
0,
111
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]
}
]
| [
{
"id": "split_0_train_5746_entity",
"type": "progene_text",
"text": [
"IN"
],
"offsets": [
[
72,
74
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3509 | split_0_train_3509 | [
{
"id": "split_0_train_3509_passage",
"type": "progene_text",
"text": [
"Moreover , K159 antibodies when expressed in vivo might exhibit useful inhibitory properties ."
],
"offsets": [
[
0,
94
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3510 | split_0_train_3510 | [
{
"id": "split_0_train_3510_passage",
"type": "progene_text",
"text": [
"Genes coding for phosphotransacetylase and acetate kinase in Sinorhizobium meliloti are in an operon that is inducible by phosphate stress and controlled by phoB ."
],
"offsets": [
[
0,
163
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]
}
]
| [
{
"id": "split_0_train_5747_entity",
"type": "progene_text",
"text": [
"phosphotransacetylase"
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"offsets": [
[
17,
38
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"normalized": []
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{
"id": "split_0_train_5748_entity",
"type": "progene_text",
"text": [
"acetate kinase"
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[
43,
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"normalized": []
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{
"id": "split_0_train_5749_entity",
"type": "progene_text",
"text": [
"phoB"
],
"offsets": [
[
157,
161
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3511 | split_0_train_3511 | [
{
"id": "split_0_train_3511_passage",
"type": "progene_text",
"text": [
"Recent work in this laboratory has shown that the gene coding for acetate kinase ( ackA ) in Sinorhizobium meliloti is up - regulated in response to phosphate limitation ."
],
"offsets": [
[
0,
171
]
]
}
]
| [
{
"id": "split_0_train_5750_entity",
"type": "progene_text",
"text": [
"acetate kinase"
],
"offsets": [
[
66,
80
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"normalized": []
},
{
"id": "split_0_train_5751_entity",
"type": "progene_text",
"text": [
"ackA"
],
"offsets": [
[
83,
87
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3512 | split_0_train_3512 | [
{
"id": "split_0_train_3512_passage",
"type": "progene_text",
"text": [
"Characterization of the region surrounding ackA revealed that it is adjacent to pta , which codes for phosphotransacetylase , and that these two genes are part of an operon composed of at least two additional genes in the following order : an open reading frame ( orfA ) , pta , ackA , and the partial sequence of a gene with an inferred peptide that has a high degree of homology to enoyl - ACP reductase ( fabI ) ."
],
"offsets": [
[
0,
416
]
]
}
]
| [
{
"id": "split_0_train_5752_entity",
"type": "progene_text",
"text": [
"ackA"
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"offsets": [
[
43,
47
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"normalized": []
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{
"id": "split_0_train_5753_entity",
"type": "progene_text",
"text": [
"pta"
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[
80,
83
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"normalized": []
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{
"id": "split_0_train_5754_entity",
"type": "progene_text",
"text": [
"phosphotransacetylase"
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[
102,
123
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],
"normalized": []
},
{
"id": "split_0_train_5755_entity",
"type": "progene_text",
"text": [
"orfA"
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"offsets": [
[
264,
268
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],
"normalized": []
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{
"id": "split_0_train_5756_entity",
"type": "progene_text",
"text": [
"pta"
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[
273,
276
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"normalized": []
},
{
"id": "split_0_train_5757_entity",
"type": "progene_text",
"text": [
"ackA"
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"offsets": [
[
279,
283
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],
"normalized": []
},
{
"id": "split_0_train_5758_entity",
"type": "progene_text",
"text": [
"enoyl - ACP reductase"
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"offsets": [
[
384,
405
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],
"normalized": []
},
{
"id": "split_0_train_5759_entity",
"type": "progene_text",
"text": [
"fabI"
],
"offsets": [
[
408,
412
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3513 | split_0_train_3513 | [
{
"id": "split_0_train_3513_passage",
"type": "progene_text",
"text": [
"Experiments combining enzyme assays , a chromosomal lacZ : : ackA transcriptional fusion , complementation analysis with cosmid subclones , and the creation of mutations in pta and ackA all indicated that the orfA - pta - ackA - fabI genes are cotranscribed in response to phosphate starvation ."
],
"offsets": [
[
0,
295
]
]
}
]
| [
{
"id": "split_0_train_5760_entity",
"type": "progene_text",
"text": [
"lacZ"
],
"offsets": [
[
52,
56
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],
"normalized": []
},
{
"id": "split_0_train_5761_entity",
"type": "progene_text",
"text": [
"ackA"
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"offsets": [
[
61,
65
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{
"id": "split_0_train_5762_entity",
"type": "progene_text",
"text": [
"pta"
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[
173,
176
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],
"normalized": []
},
{
"id": "split_0_train_5763_entity",
"type": "progene_text",
"text": [
"ackA"
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[
181,
185
]
],
"normalized": []
},
{
"id": "split_0_train_5764_entity",
"type": "progene_text",
"text": [
"orfA"
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"offsets": [
[
209,
213
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],
"normalized": []
},
{
"id": "split_0_train_5765_entity",
"type": "progene_text",
"text": [
"pta"
],
"offsets": [
[
216,
219
]
],
"normalized": []
},
{
"id": "split_0_train_5766_entity",
"type": "progene_text",
"text": [
"ackA"
],
"offsets": [
[
222,
226
]
],
"normalized": []
},
{
"id": "split_0_train_5767_entity",
"type": "progene_text",
"text": [
"fabI"
],
"offsets": [
[
229,
233
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3514 | split_0_train_3514 | [
{
"id": "split_0_train_3514_passage",
"type": "progene_text",
"text": [
"Primer extension was used to map the position of the phosphate starvation - inducible transcriptional start sites upstream of orfA ."
],
"offsets": [
[
0,
132
]
]
}
]
| [
{
"id": "split_0_train_5768_entity",
"type": "progene_text",
"text": [
"orfA"
],
"offsets": [
[
126,
130
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3515 | split_0_train_3515 | [
{
"id": "split_0_train_3515_passage",
"type": "progene_text",
"text": [
"The start sites were found to be preceded by a sequence having similarity to PHO boxes from other phosphate - regulated genes in S. meliloti and to the consensus PHO box in Escherichia coli ."
],
"offsets": [
[
0,
191
]
]
}
]
| [
{
"id": "split_0_train_5769_entity",
"type": "progene_text",
"text": [
"PHO"
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"offsets": [
[
77,
80
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],
"normalized": []
},
{
"id": "split_0_train_5770_entity",
"type": "progene_text",
"text": [
"PHO"
],
"offsets": [
[
162,
165
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3516 | split_0_train_3516 | [
{
"id": "split_0_train_3516_passage",
"type": "progene_text",
"text": [
"Introduction of a phoB mutation in the wild - type strain eliminated elevated levels of acetate kinase and phosphotransacetylase activities in response to phosphate limitation and also eliminated the phosphate stress - induced up - regulation of the ackA : : lacZ fusion ."
],
"offsets": [
[
0,
272
]
]
}
]
| [
{
"id": "split_0_train_5771_entity",
"type": "progene_text",
"text": [
"phoB"
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"offsets": [
[
18,
22
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"normalized": []
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{
"id": "split_0_train_5772_entity",
"type": "progene_text",
"text": [
"acetate kinase"
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"offsets": [
[
88,
102
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],
"normalized": []
},
{
"id": "split_0_train_5773_entity",
"type": "progene_text",
"text": [
"phosphotransacetylase"
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"offsets": [
[
107,
128
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{
"id": "split_0_train_5774_entity",
"type": "progene_text",
"text": [
"ackA"
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"offsets": [
[
250,
254
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{
"id": "split_0_train_5775_entity",
"type": "progene_text",
"text": [
"lacZ"
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"offsets": [
[
259,
263
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3517 | split_0_train_3517 | [
{
"id": "split_0_train_3517_passage",
"type": "progene_text",
"text": [
"Mutations in either ackA alone or both pta and ackA did not affect the nodulation or nitrogen fixation phenotype of S. meliloti ."
],
"offsets": [
[
0,
129
]
]
}
]
| [
{
"id": "split_0_train_5776_entity",
"type": "progene_text",
"text": [
"ackA"
],
"offsets": [
[
20,
24
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"normalized": []
},
{
"id": "split_0_train_5777_entity",
"type": "progene_text",
"text": [
"pta"
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"offsets": [
[
39,
42
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],
"normalized": []
},
{
"id": "split_0_train_5778_entity",
"type": "progene_text",
"text": [
"ackA"
],
"offsets": [
[
47,
51
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3518 | split_0_train_3518 | [
{
"id": "split_0_train_3518_passage",
"type": "progene_text",
"text": [
"Human thyroid cancer cells as a source of iso - genic , iso - phenotypic cell lines with or without functional p53 ."
],
"offsets": [
[
0,
116
]
]
}
]
| [
{
"id": "split_0_train_5779_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
111,
114
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3519 | split_0_train_3519 | [
{
"id": "split_0_train_3519_passage",
"type": "progene_text",
"text": [
"Differentiated thyroid carcinomas ( in contrast to the rarer anaplastic form ) are unusual among human cancers in displaying a remarkably low frequency of p53 mutation and appear to retain wild - type ( wt ) p53 function as assessed by the response of derived cell lines to DNA damage ."
],
"offsets": [
[
0,
286
]
]
}
]
| [
{
"id": "split_0_train_5780_entity",
"type": "progene_text",
"text": [
"p53"
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"offsets": [
[
155,
158
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"normalized": []
},
{
"id": "split_0_train_5781_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
208,
211
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3520 | split_0_train_3520 | [
{
"id": "split_0_train_3520_passage",
"type": "progene_text",
"text": [
"Using one such cell line , K1 , we have tested the effect of experimental abrogation of p53 function by generating matched sub - clones stably expressing either a neo control gene , a dominant - negative mutant p53 ( 143ala ) or human papilloma virus protein HPV16 E6 ."
],
"offsets": [
[
0,
269
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]
}
]
| [
{
"id": "split_0_train_5782_entity",
"type": "progene_text",
"text": [
"p53"
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"offsets": [
[
88,
91
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"normalized": []
},
{
"id": "split_0_train_5783_entity",
"type": "progene_text",
"text": [
"p53"
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"offsets": [
[
211,
214
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"normalized": []
},
{
"id": "split_0_train_5784_entity",
"type": "progene_text",
"text": [
"E6"
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"offsets": [
[
265,
267
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3521 | split_0_train_3521 | [
{
"id": "split_0_train_3521_passage",
"type": "progene_text",
"text": [
"Loss of p53 function in the latter two groups was confirmed by abolition of p53 - dependent ' stress ' responses including induction of the cyclin / CDK inhibitor p21WAF1 and G1 / S arrest following DNA - damage ."
],
"offsets": [
[
0,
213
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]
}
]
| [
{
"id": "split_0_train_5785_entity",
"type": "progene_text",
"text": [
"p53"
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"offsets": [
[
8,
11
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},
{
"id": "split_0_train_5786_entity",
"type": "progene_text",
"text": [
"p53"
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"offsets": [
[
76,
79
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],
"normalized": []
},
{
"id": "split_0_train_5787_entity",
"type": "progene_text",
"text": [
"cyclin / CDK inhibitor"
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"offsets": [
[
140,
162
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},
{
"id": "split_0_train_5788_entity",
"type": "progene_text",
"text": [
"p21WAF1"
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"offsets": [
[
163,
170
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3522 | split_0_train_3522 | [
{
"id": "split_0_train_3522_passage",
"type": "progene_text",
"text": [
"In contrast , no change was detected in the phenotype of 'unstressed' clones , with respect to any of the following parameters : proliferation rate in monolayer , serum - dependence for proliferation or survival , tumorigenicity , cellular morphology , or tissue - specific differentiation markers ."
],
"offsets": [
[
0,
299
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3523 | split_0_train_3523 | [
{
"id": "split_0_train_3523_passage",
"type": "progene_text",
"text": [
"The K1 line therefore represents a ' neutral ' background with respect to p53 function , permitting the derivation of functionally p53 + or - clones which are not only iso-genic but also iso - phenotypic ."
],
"offsets": [
[
0,
205
]
]
}
]
| [
{
"id": "split_0_train_5789_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
74,
77
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],
"normalized": []
},
{
"id": "split_0_train_5790_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
131,
134
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3524 | split_0_train_3524 | [
{
"id": "split_0_train_3524_passage",
"type": "progene_text",
"text": [
"Such a panel should be an ideal tool with which to test the p53 - dependence of cellular stress responses , particularly the sensitivity to potential therapeutic agents , free from the confounding additional phenotypic differences which usually accompany loss of p53 function ."
],
"offsets": [
[
0,
277
]
]
}
]
| [
{
"id": "split_0_train_5791_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
60,
63
]
],
"normalized": []
},
{
"id": "split_0_train_5792_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
263,
266
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3525 | split_0_train_3525 | [
{
"id": "split_0_train_3525_passage",
"type": "progene_text",
"text": [
"The results also further support the hypothesis that p53 mutation alone is not sufficient to drive progression of thyroid cancer to the aggressive anaplastic form ."
],
"offsets": [
[
0,
164
]
]
}
]
| [
{
"id": "split_0_train_5793_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
53,
56
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3526 | split_0_train_3526 | [
{
"id": "split_0_train_3526_passage",
"type": "progene_text",
"text": [
"A 42 - kDa glycoprotein from chicken egg - envelope , an avian homolog of the ZPC family glycoproteins in mammalian Zona pellucida ."
],
"offsets": [
[
0,
132
]
]
}
]
| [
{
"id": "split_0_train_5794_entity",
"type": "progene_text",
"text": [
"ZPC family"
],
"offsets": [
[
78,
88
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3527 | split_0_train_3527 | [
{
"id": "split_0_train_3527_passage",
"type": "progene_text",
"text": [
"Its first identification , cDNA cloning and granulosa cell - specific expression ."
],
"offsets": [
[
0,
82
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3528 | split_0_train_3528 | [
{
"id": "split_0_train_3528_passage",
"type": "progene_text",
"text": [
"A glycoprotein with molecular mass of 42 kDa was identified as the major component of the chicken egg - envelope , the filamentous , extracellular matrix known as the perivitelline layer ."
],
"offsets": [
[
0,
188
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3529 | split_0_train_3529 | [
{
"id": "split_0_train_3529_passage",
"type": "progene_text",
"text": [
"By using a DNA probe amplified with degenerative primers derived from the protein 's partial amino acid sequences , a cDNA clone encoding the egg-envelope 42 - kDa glycoprotein ( gp42 ) was isolated from a hen 's ovary cDNA library ."
],
"offsets": [
[
0,
233
]
]
}
]
| [
{
"id": "split_0_train_5795_entity",
"type": "progene_text",
"text": [
"gp42"
],
"offsets": [
[
179,
183
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3530 | split_0_train_3530 | [
{
"id": "split_0_train_3530_passage",
"type": "progene_text",
"text": [
"The gp42 open reading frame encoded 435 amino acid residues , including a putative signal peptide of 20 amino acids ."
],
"offsets": [
[
0,
117
]
]
}
]
| [
{
"id": "split_0_train_5796_entity",
"type": "progene_text",
"text": [
"gp42"
],
"offsets": [
[
4,
8
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3531 | split_0_train_3531 | [
{
"id": "split_0_train_3531_passage",
"type": "progene_text",
"text": [
"The deduced amino acid sequence of gp42 showed significant similarity to egg - envelope glycoproteins of the ZPC family of several other vertebrate species , including human ZP3 , mouse ZP3 , Xenopus laevis gp43 and medaka ( Oryzias latipes ) ZI3 ( LS-F ) , which play important roles for sperm - egg interaction ."
],
"offsets": [
[
0,
314
]
]
}
]
| [
{
"id": "split_0_train_5797_entity",
"type": "progene_text",
"text": [
"ZPC family"
],
"offsets": [
[
109,
119
]
],
"normalized": []
},
{
"id": "split_0_train_5798_entity",
"type": "progene_text",
"text": [
"ZP3"
],
"offsets": [
[
174,
177
]
],
"normalized": []
},
{
"id": "split_0_train_5799_entity",
"type": "progene_text",
"text": [
"ZP3"
],
"offsets": [
[
186,
189
]
],
"normalized": []
},
{
"id": "split_0_train_5800_entity",
"type": "progene_text",
"text": [
"gp43"
],
"offsets": [
[
207,
211
]
],
"normalized": []
},
{
"id": "split_0_train_5801_entity",
"type": "progene_text",
"text": [
"ZI3"
],
"offsets": [
[
243,
246
]
],
"normalized": []
},
{
"id": "split_0_train_5802_entity",
"type": "progene_text",
"text": [
"LS-F"
],
"offsets": [
[
249,
253
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3532 | split_0_train_3532 | [
{
"id": "split_0_train_3532_passage",
"type": "progene_text",
"text": [
"A single N-glycosylation site present in chicken gp42 is conserved among all five of these proteins : carbohydrate analysis of gp42 revealed the presence of a complex type glycan chain at this site ."
],
"offsets": [
[
0,
199
]
]
}
]
| [
{
"id": "split_0_train_5803_entity",
"type": "progene_text",
"text": [
"gp42"
],
"offsets": [
[
49,
53
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3533 | split_0_train_3533 | [
{
"id": "split_0_train_3533_passage",
"type": "progene_text",
"text": [
"N - terminal sequence analysis of the mature polypeptide suggests that C - terminal processing of the pro - protein occurs during synthesis and secretion ."
],
"offsets": [
[
0,
155
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3534 | split_0_train_3534 | [
{
"id": "split_0_train_3534_passage",
"type": "progene_text",
"text": [
"The 1.4 - kb gp42 transcript was detected only in follicles , and was found to be accumulated in granulosa cells in a manner dependent on ovarian follicular development ."
],
"offsets": [
[
0,
170
]
]
}
]
| [
{
"id": "split_0_train_5804_entity",
"type": "progene_text",
"text": [
"gp42"
],
"offsets": [
[
13,
17
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3535 | split_0_train_3535 | [
{
"id": "split_0_train_3535_passage",
"type": "progene_text",
"text": [
"Furthermore , a metabolically radio - labeled gp42 was immunopreciptated from both cell lysate and culture supernatant of the granulosa cells with specific anti - gp42 antibody , suggesting granulosa cell - specific synthesis and secretion of the glycoprotein ."
],
"offsets": [
[
0,
261
]
]
}
]
| [
{
"id": "split_0_train_5805_entity",
"type": "progene_text",
"text": [
"gp42"
],
"offsets": [
[
46,
50
]
],
"normalized": []
},
{
"id": "split_0_train_5806_entity",
"type": "progene_text",
"text": [
"gp42"
],
"offsets": [
[
163,
167
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3536 | split_0_train_3536 | [
{
"id": "split_0_train_3536_passage",
"type": "progene_text",
"text": [
"Supravalvular aortic stenosis : a splice site mutation within the elastin gene results in reduced expression of two aberrantly spliced transcripts ."
],
"offsets": [
[
0,
148
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3537 | split_0_train_3537 | [
{
"id": "split_0_train_3537_passage",
"type": "progene_text",
"text": [
"We have screened the elastin gene for mutations responsible for supravalvular aortic stenosis ( SVAS ) in two large , independently collected families with isolated ( nonsyndromic ) SVAS ."
],
"offsets": [
[
0,
188
]
]
}
]
| [
{
"id": "split_0_train_5807_entity",
"type": "progene_text",
"text": [
"elastin"
],
"offsets": [
[
21,
28
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3538 | split_0_train_3538 | [
{
"id": "split_0_train_3538_passage",
"type": "progene_text",
"text": [
"By single - strand conformation polymorphism and heteroduplex analysis , we have identified a C to G transversion within the acceptor splice site of exon 16 in SVAS patients from both families ."
],
"offsets": [
[
0,
194
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3539 | split_0_train_3539 | [
{
"id": "split_0_train_3539_passage",
"type": "progene_text",
"text": [
"This mutation segregates in both families with high penetrance of SVAS , and all affected individuals carry the mutation ."
],
"offsets": [
[
0,
122
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3540 | split_0_train_3540 | [
{
"id": "split_0_train_3540_passage",
"type": "progene_text",
"text": [
"Haplotype analysis by using closely linked polymorphisms , including a previously unreported BfaI restriction fragment length polymorphism within the 3'-UTR of the elastin gene , indicates that the mutations found in the two apparently non - overlapping kindreds are identical by descent ."
],
"offsets": [
[
0,
289
]
]
}
]
| [
{
"id": "split_0_train_5808_entity",
"type": "progene_text",
"text": [
"BfaI"
],
"offsets": [
[
93,
97
]
],
"normalized": []
},
{
"id": "split_0_train_5809_entity",
"type": "progene_text",
"text": [
"elastin"
],
"offsets": [
[
164,
171
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3541 | split_0_train_3541 | [
{
"id": "split_0_train_3541_passage",
"type": "progene_text",
"text": [
"To study the effect of the mutation on the expression of the mutant allele , we have established a primary skin fibroblast culture from one of the affected individuals ."
],
"offsets": [
[
0,
169
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3542 | split_0_train_3542 | [
{
"id": "split_0_train_3542_passage",
"type": "progene_text",
"text": [
"Reverse transcription / polymerase chain reaction analysis of elastin mRNA species indicates that the mutation results in two abnormal elastin mRNA species ."
],
"offsets": [
[
0,
157
]
]
}
]
| [
{
"id": "split_0_train_5810_entity",
"type": "progene_text",
"text": [
"elastin"
],
"offsets": [
[
62,
69
]
],
"normalized": []
},
{
"id": "split_0_train_5811_entity",
"type": "progene_text",
"text": [
"elastin"
],
"offsets": [
[
135,
142
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3543 | split_0_train_3543 | [
{
"id": "split_0_train_3543_passage",
"type": "progene_text",
"text": [
"One mutant elastin mRNA is generated by the activation of a cryptic splice site that lies within intron 15 and that adds 44 bp of intronic sequence to the sequence encoded by exon 16 ."
],
"offsets": [
[
0,
184
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3544 | split_0_train_3544 | [
{
"id": "split_0_train_3544_passage",
"type": "progene_text",
"text": [
"This insertion creates a frame shift that results in a 59-amino-acid-long abnormal protein sequence and leads to a termination codon in the mRNA sequence encoded by exon 17 ."
],
"offsets": [
[
0,
174
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3545 | split_0_train_3545 | [
{
"id": "split_0_train_3545_passage",
"type": "progene_text",
"text": [
"The smaller abnormal mRNA species arises as a consequence of the skipping of exon 16 ."
],
"offsets": [
[
0,
86
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3546 | split_0_train_3546 | [
{
"id": "split_0_train_3546_passage",
"type": "progene_text",
"text": [
"This study demonstrates , for the first time , the expression of mutant alleles of the elastin gene in patients with isolated SVAS ."
],
"offsets": [
[
0,
132
]
]
}
]
| [
{
"id": "split_0_train_5812_entity",
"type": "progene_text",
"text": [
"elastin"
],
"offsets": [
[
87,
94
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3547 | split_0_train_3547 | [
{
"id": "split_0_train_3547_passage",
"type": "progene_text",
"text": [
"Expression cloning and characterization of PREB ( prolactin regulatory element binding ) , a novel WD motif DNA - binding protein with a capacity to regulate prolactin promoter activity ."
],
"offsets": [
[
0,
187
]
]
}
]
| [
{
"id": "split_0_train_5813_entity",
"type": "progene_text",
"text": [
"PREB"
],
"offsets": [
[
43,
47
]
],
"normalized": []
},
{
"id": "split_0_train_5814_entity",
"type": "progene_text",
"text": [
"prolactin regulatory element binding"
],
"offsets": [
[
50,
86
]
],
"normalized": []
},
{
"id": "split_0_train_5815_entity",
"type": "progene_text",
"text": [
"prolactin"
],
"offsets": [
[
158,
167
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3548 | split_0_train_3548 | [
{
"id": "split_0_train_3548_passage",
"type": "progene_text",
"text": [
"Previous studies have implied that a transcription factor(s) other than Pit-1 is involved in homeostatic regulation of PRL promoter activity via Pit-1 - binding elements ."
],
"offsets": [
[
0,
171
]
]
}
]
| [
{
"id": "split_0_train_5816_entity",
"type": "progene_text",
"text": [
"transcription factor(s)"
],
"offsets": [
[
37,
60
]
],
"normalized": []
},
{
"id": "split_0_train_5817_entity",
"type": "progene_text",
"text": [
"Pit-1"
],
"offsets": [
[
72,
77
]
],
"normalized": []
},
{
"id": "split_0_train_5818_entity",
"type": "progene_text",
"text": [
"PRL"
],
"offsets": [
[
119,
122
]
],
"normalized": []
},
{
"id": "split_0_train_5819_entity",
"type": "progene_text",
"text": [
"Pit-1"
],
"offsets": [
[
145,
150
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3549 | split_0_train_3549 | [
{
"id": "split_0_train_3549_passage",
"type": "progene_text",
"text": [
"One such element , 1P , was employed to clone from a rat pituitary cDNA expression library a novel 417 - amino acid WD protein , designated PREB ( PRL regulatory element binding ) protein ."
],
"offsets": [
[
0,
189
]
]
}
]
| [
{
"id": "split_0_train_5820_entity",
"type": "progene_text",
"text": [
"PREB"
],
"offsets": [
[
140,
144
]
],
"normalized": []
},
{
"id": "split_0_train_5821_entity",
"type": "progene_text",
"text": [
"PRL regulatory element binding"
],
"offsets": [
[
147,
177
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3550 | split_0_train_3550 | [
{
"id": "split_0_train_3550_passage",
"type": "progene_text",
"text": [
"PREB contains two PQ - rich potential transactivation domains , but no apparent DNA - binding motif , and exhibits sequence - specific binding to site 1P , to a site nonidentical to that for Pit-1 ."
],
"offsets": [
[
0,
198
]
]
}
]
| [
{
"id": "split_0_train_5822_entity",
"type": "progene_text",
"text": [
"PREB"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_5823_entity",
"type": "progene_text",
"text": [
"Pit-1"
],
"offsets": [
[
191,
196
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3551 | split_0_train_3551 | [
{
"id": "split_0_train_3551_passage",
"type": "progene_text",
"text": [
"The PREB gene ( or a related gene ) is conserved , as an apparently single copy , in rat , human , fly , and yeast ."
],
"offsets": [
[
0,
116
]
]
}
]
| [
{
"id": "split_0_train_5824_entity",
"type": "progene_text",
"text": [
"PREB"
],
"offsets": [
[
4,
8
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3552 | split_0_train_3552 | [
{
"id": "split_0_train_3552_passage",
"type": "progene_text",
"text": [
"A single approximately 1.9 - kb PREB transcript accumulates in GH3 rat pituitary cells , to levels similar to Pit-1 mRNA ."
],
"offsets": [
[
0,
122
]
]
}
]
| [
{
"id": "split_0_train_5825_entity",
"type": "progene_text",
"text": [
"PREB"
],
"offsets": [
[
32,
36
]
],
"normalized": []
},
{
"id": "split_0_train_5826_entity",
"type": "progene_text",
"text": [
"Pit-1"
],
"offsets": [
[
110,
115
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3553 | split_0_train_3553 | [
{
"id": "split_0_train_3553_passage",
"type": "progene_text",
"text": [
"PREB transcripts were detected in all human tissues examined , but the observation of tissue - specific multiple transcript patterns suggests the possibility of tissue - specific alternative splicing ."
],
"offsets": [
[
0,
201
]
]
}
]
| [
{
"id": "split_0_train_5827_entity",
"type": "progene_text",
"text": [
"PREB"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3554 | split_0_train_3554 | [
{
"id": "split_0_train_3554_passage",
"type": "progene_text",
"text": [
"RT - PCR analysis of human brain tumor RNA samples suggested region - specific expression of PREB transcripts in brain ."
],
"offsets": [
[
0,
120
]
]
}
]
| [
{
"id": "split_0_train_5828_entity",
"type": "progene_text",
"text": [
"PREB"
],
"offsets": [
[
93,
97
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3555 | split_0_train_3555 | [
{
"id": "split_0_train_3555_passage",
"type": "progene_text",
"text": [
"Western and immunocytochemical analysis implied that PREB accumulates specifically in GH3 cell nuclei ."
],
"offsets": [
[
0,
103
]
]
}
]
| [
{
"id": "split_0_train_5829_entity",
"type": "progene_text",
"text": [
"PREB"
],
"offsets": [
[
53,
57
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3556 | split_0_train_3556 | [
{
"id": "split_0_train_3556_passage",
"type": "progene_text",
"text": [
"Transient transfection employing PREB - negative C6 rat glial cells showed that PREB is as active as , and additive with , Pit-1 in transactivation of a PRL promoter construct , and that PREB , but not Pit-1 , can mediate transcriptional activation by protein kinase A ( PKA ) ."
],
"offsets": [
[
0,
278
]
]
}
]
| [
{
"id": "split_0_train_5830_entity",
"type": "progene_text",
"text": [
"PREB"
],
"offsets": [
[
33,
37
]
],
"normalized": []
},
{
"id": "split_0_train_5831_entity",
"type": "progene_text",
"text": [
"PREB"
],
"offsets": [
[
80,
84
]
],
"normalized": []
},
{
"id": "split_0_train_5832_entity",
"type": "progene_text",
"text": [
"Pit-1"
],
"offsets": [
[
123,
128
]
],
"normalized": []
},
{
"id": "split_0_train_5833_entity",
"type": "progene_text",
"text": [
"PRL"
],
"offsets": [
[
153,
156
]
],
"normalized": []
},
{
"id": "split_0_train_5834_entity",
"type": "progene_text",
"text": [
"PREB"
],
"offsets": [
[
187,
191
]
],
"normalized": []
},
{
"id": "split_0_train_5835_entity",
"type": "progene_text",
"text": [
"Pit-1"
],
"offsets": [
[
202,
207
]
],
"normalized": []
},
{
"id": "split_0_train_5836_entity",
"type": "progene_text",
"text": [
"protein kinase A"
],
"offsets": [
[
252,
268
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"normalized": []
},
{
"id": "split_0_train_5837_entity",
"type": "progene_text",
"text": [
"PKA"
],
"offsets": [
[
271,
274
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3557 | split_0_train_3557 | [
{
"id": "split_0_train_3557_passage",
"type": "progene_text",
"text": [
"Expression in GH3 cells of a GAL4 - PREB fusion protein both strongly transactivated a 5XGAL indicator construct and yielded a further stimulation of expression of this construct by coexpressed PKA , implying that PREB can mediate both basal and PKA - stimulated transcriptional responses in pituitary cells ."
],
"offsets": [
[
0,
309
]
]
}
]
| [
{
"id": "split_0_train_5838_entity",
"type": "progene_text",
"text": [
"GAL4"
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[
29,
33
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},
{
"id": "split_0_train_5839_entity",
"type": "progene_text",
"text": [
"PREB"
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[
36,
40
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],
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},
{
"id": "split_0_train_5840_entity",
"type": "progene_text",
"text": [
"PKA"
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[
194,
197
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"normalized": []
},
{
"id": "split_0_train_5841_entity",
"type": "progene_text",
"text": [
"PREB"
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[
214,
218
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{
"id": "split_0_train_5842_entity",
"type": "progene_text",
"text": [
"PKA"
],
"offsets": [
[
246,
249
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3558 | split_0_train_3558 | [
{
"id": "split_0_train_3558_passage",
"type": "progene_text",
"text": [
"These observations imply that PREB will prove to play a significant transcriptional regulatory role , both in the pituitary and in other organs in which transcripts of its gene are expressed ."
],
"offsets": [
[
0,
192
]
]
}
]
| [
{
"id": "split_0_train_5843_entity",
"type": "progene_text",
"text": [
"PREB"
],
"offsets": [
[
30,
34
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3559 | split_0_train_3559 | [
{
"id": "split_0_train_3559_passage",
"type": "progene_text",
"text": [
"An aggregate level analysis of the socioeconomic correlates of drink driving offenders ."
],
"offsets": [
[
0,
88
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3560 | split_0_train_3560 | [
{
"id": "split_0_train_3560_passage",
"type": "progene_text",
"text": [
"Research within urban sociology and social geography has discussed the relation between the spatial or aggregate level distribution of various social and demographic variables and a wide range of social problems ."
],
"offsets": [
[
0,
213
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3561 | split_0_train_3561 | [
{
"id": "split_0_train_3561_passage",
"type": "progene_text",
"text": [
"This paper takes the spirit of these studies as a starting point and applies methods of social area analysis to study drink driving offender rates within the Sunshine Coast - Brisbane - Gold Coast conurbation ."
],
"offsets": [
[
0,
210
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3562 | split_0_train_3562 | [
{
"id": "split_0_train_3562_passage",
"type": "progene_text",
"text": [
"The major findings of the paper are that at the aggregate level there is a strong correlation between rates of drink driving offenders and particular social and demographic factors ."
],
"offsets": [
[
0,
182
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3563 | split_0_train_3563 | [
{
"id": "split_0_train_3563_passage",
"type": "progene_text",
"text": [
"As such the findings support existing studies that have identified given social characteristics of drink drivers ."
],
"offsets": [
[
0,
114
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3564 | split_0_train_3564 | [
{
"id": "split_0_train_3564_passage",
"type": "progene_text",
"text": [
"In addition , the findings also illustrate the need to consider a range of aggregate social and demographic variables in future research ."
],
"offsets": [
[
0,
138
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3565 | split_0_train_3565 | [
{
"id": "split_0_train_3565_passage",
"type": "progene_text",
"text": [
"Elevated plasma levels of glucagon - like peptide-1 after oral glucose ingestion in patients with pancreatic diabetes ."
],
"offsets": [
[
0,
119
]
]
}
]
| [
{
"id": "split_0_train_5844_entity",
"type": "progene_text",
"text": [
"glucagon - like peptide-1"
],
"offsets": [
[
26,
51
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3566 | split_0_train_3566 | [
{
"id": "split_0_train_3566_passage",
"type": "progene_text",
"text": [
"OBJECTIVE :"
],
"offsets": [
[
0,
11
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3567 | split_0_train_3567 | [
{
"id": "split_0_train_3567_passage",
"type": "progene_text",
"text": [
"The purpose of the present study was to evaluate plasma glucagon - like peptide-1 ( GLP-1 ) responses after oral glucose ingestion in patients with chronic pancreatitis and to clarify how GLP-1 secretion relates to pancreatic diabetes ."
],
"offsets": [
[
0,
236
]
]
}
]
| [
{
"id": "split_0_train_5845_entity",
"type": "progene_text",
"text": [
"glucagon - like peptide-1"
],
"offsets": [
[
56,
81
]
],
"normalized": []
},
{
"id": "split_0_train_5846_entity",
"type": "progene_text",
"text": [
"GLP-1"
],
"offsets": [
[
84,
89
]
],
"normalized": []
},
{
"id": "split_0_train_5847_entity",
"type": "progene_text",
"text": [
"GLP-1"
],
"offsets": [
[
188,
193
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3568 | split_0_train_3568 | [
{
"id": "split_0_train_3568_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3569 | split_0_train_3569 | [
{
"id": "split_0_train_3569_passage",
"type": "progene_text",
"text": [
"An oral glucose tolerance test ( OGTT ) was performed in 17 patients with chronic pancreatitis ."
],
"offsets": [
[
0,
96
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3570 | split_0_train_3570 | [
{
"id": "split_0_train_3570_passage",
"type": "progene_text",
"text": [
"Plasma glucose , immunoreactive insulin ( IRI ) , C-peptide , glucagon , and GLP-1 levels at each time point during OGTT were measured ."
],
"offsets": [
[
0,
136
]
]
}
]
| [
{
"id": "split_0_train_5848_entity",
"type": "progene_text",
"text": [
"insulin"
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"offsets": [
[
32,
39
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],
"normalized": []
},
{
"id": "split_0_train_5849_entity",
"type": "progene_text",
"text": [
"C-peptide"
],
"offsets": [
[
50,
59
]
],
"normalized": []
},
{
"id": "split_0_train_5850_entity",
"type": "progene_text",
"text": [
"glucagon"
],
"offsets": [
[
62,
70
]
],
"normalized": []
},
{
"id": "split_0_train_5851_entity",
"type": "progene_text",
"text": [
"GLP-1"
],
"offsets": [
[
77,
82
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3571 | split_0_train_3571 | [
{
"id": "split_0_train_3571_passage",
"type": "progene_text",
"text": [
"The diagnosis of chronic pancreatitis was made by the findings of endoscopic retrograde pancreatography ( ERP ) : evident dilation of the main pancreatic duct with or without pancreatolithiasis ."
],
"offsets": [
[
0,
195
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3572 | split_0_train_3572 | [
{
"id": "split_0_train_3572_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3573 | split_0_train_3573 | [
{
"id": "split_0_train_3573_passage",
"type": "progene_text",
"text": [
"The patients were divided into three groups according to the World Health Organization classification of diabetes based on plasma glucose levels after OGTT ."
],
"offsets": [
[
0,
157
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3574 | split_0_train_3574 | [
{
"id": "split_0_train_3574_passage",
"type": "progene_text",
"text": [
"The groups were : normal ( three patients ) , impaired glucose tolerant ( IGT ) ( six patients ) , and diabetic ( DM ) ( eight patients ) ."
],
"offsets": [
[
0,
139
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3575 | split_0_train_3575 | [
{
"id": "split_0_train_3575_passage",
"type": "progene_text",
"text": [
"In the DM group , IRI and C-peptide response levels after oral glucose ingestion were significantly reduced as compared with those of the normal and IGT groups ."
],
"offsets": [
[
0,
161
]
]
}
]
| [
{
"id": "split_0_train_5852_entity",
"type": "progene_text",
"text": [
"C-peptide"
],
"offsets": [
[
26,
35
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3576 | split_0_train_3576 | [
{
"id": "split_0_train_3576_passage",
"type": "progene_text",
"text": [
"No significant glucagon responses to oral glucose ingestion were found in the three groups ."
],
"offsets": [
[
0,
92
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3577 | split_0_train_3577 | [
{
"id": "split_0_train_3577_passage",
"type": "progene_text",
"text": [
"In contrast , plasma GLP-1 levels were significantly elevated after oral glucose ingestion in the DM groups as compared with normal and IGT groups ."
],
"offsets": [
[
0,
148
]
]
}
]
| [
{
"id": "split_0_train_5853_entity",
"type": "progene_text",
"text": [
"GLP-1"
],
"offsets": [
[
21,
26
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3578 | split_0_train_3578 | [
{
"id": "split_0_train_3578_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3579 | split_0_train_3579 | [
{
"id": "split_0_train_3579_passage",
"type": "progene_text",
"text": [
"The present study affords evidence that plasma GLP-1 levels become elevated with development of pancreatic diabetes , although the precise mechanism of this elevation remains undetermined ."
],
"offsets": [
[
0,
189
]
]
}
]
| [
{
"id": "split_0_train_5854_entity",
"type": "progene_text",
"text": [
"GLP-1"
],
"offsets": [
[
47,
52
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3580 | split_0_train_3580 | [
{
"id": "split_0_train_3580_passage",
"type": "progene_text",
"text": [
"p53 down - regulates human matrix metalloproteinase-1 ( Collagenase-1 ) gene expression ."
],
"offsets": [
[
0,
89
]
]
}
]
| [
{
"id": "split_0_train_5855_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_5856_entity",
"type": "progene_text",
"text": [
"matrix metalloproteinase-1"
],
"offsets": [
[
27,
53
]
],
"normalized": []
},
{
"id": "split_0_train_5857_entity",
"type": "progene_text",
"text": [
"Collagenase-1"
],
"offsets": [
[
56,
69
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3581 | split_0_train_3581 | [
{
"id": "split_0_train_3581_passage",
"type": "progene_text",
"text": [
"Recent studies show that the p53 tumor suppressor protein is overexpressed in rheumatoid arthritis ( RA ) synovium and that somatic mutations previously identified in human tumors are present in RA synovium ( Firestein , G. S. , Echeverri , F. , Yeo , M. , Zvaifler , N. J. , and Green , D. R. ( 1997 ) Proc. Natl. Acad. Sci. U. S. A. 94 , 10895 - 10900 ; Firestein , G. S. , Nguyen , K. , Aupperle , K. R. , Yeo , M. , Boyle , D. L. , and Zvaifler , N. J. ( 1996 ) Am. J. Pathol. 149 , 2143 - 2151 ; Reme , T. , Travaglio , A. , Gueydon , E. , Adla , L. , Jorgensen , C. , and Sany , J. ( 1998 ) Clin. Exp. Immunol. 111 , 353 - 3581 ) ."
],
"offsets": [
[
0,
637
]
]
}
]
| [
{
"id": "split_0_train_5858_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
29,
32
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3582 | split_0_train_3582 | [
{
"id": "split_0_train_3582_passage",
"type": "progene_text",
"text": [
"We hypothesize that the abnormality of p53 seen in RA synovium may contribute to joint degeneration through the regulation of human matrix metalloproteinase-1 ( hMMP-1 , collagenase-1 ) gene expression ."
],
"offsets": [
[
0,
203
]
]
}
]
| [
{
"id": "split_0_train_5859_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
39,
42
]
],
"normalized": []
},
{
"id": "split_0_train_5860_entity",
"type": "progene_text",
"text": [
"matrix metalloproteinase-1"
],
"offsets": [
[
132,
158
]
],
"normalized": []
},
{
"id": "split_0_train_5861_entity",
"type": "progene_text",
"text": [
"hMMP-1"
],
"offsets": [
[
161,
167
]
],
"normalized": []
},
{
"id": "split_0_train_5862_entity",
"type": "progene_text",
"text": [
"collagenase-1"
],
"offsets": [
[
170,
183
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3583 | split_0_train_3583 | [
{
"id": "split_0_train_3583_passage",
"type": "progene_text",
"text": [
"Transcription assays were performed with luciferase reporters driven by the promoter of the hMMP-1 gene or by a minimal promoter containing tandem repeats of the consensus binding sequence for activator protein-1 , cotransfected with p53 - expressing plasmids ."
],
"offsets": [
[
0,
261
]
]
}
]
| [
{
"id": "split_0_train_5863_entity",
"type": "progene_text",
"text": [
"luciferase"
],
"offsets": [
[
41,
51
]
],
"normalized": []
},
{
"id": "split_0_train_5864_entity",
"type": "progene_text",
"text": [
"hMMP-1"
],
"offsets": [
[
92,
98
]
],
"normalized": []
},
{
"id": "split_0_train_5865_entity",
"type": "progene_text",
"text": [
"activator protein-1"
],
"offsets": [
[
193,
212
]
],
"normalized": []
},
{
"id": "split_0_train_5866_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
234,
237
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3584 | split_0_train_3584 | [
{
"id": "split_0_train_3584_passage",
"type": "progene_text",
"text": [
"The results revealed that (i) wild - type ( wt ) p53 down - regulated the promoter activity of hMMP-1 in a dose - dependent fashion ; (ii) four of six p53 mutants ( commonly found in human cancers ) lost this repression activity ; and (iii) this p53 repression activity was mediated at least in part by the activator protein-1 sites found in the hMMP-1 promoter ."
],
"offsets": [
[
0,
363
]
]
}
]
| [
{
"id": "split_0_train_5867_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
49,
52
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],
"normalized": []
},
{
"id": "split_0_train_5868_entity",
"type": "progene_text",
"text": [
"hMMP-1"
],
"offsets": [
[
95,
101
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],
"normalized": []
},
{
"id": "split_0_train_5869_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
151,
154
]
],
"normalized": []
},
{
"id": "split_0_train_5870_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
246,
249
]
],
"normalized": []
},
{
"id": "split_0_train_5871_entity",
"type": "progene_text",
"text": [
"activator protein-1"
],
"offsets": [
[
307,
326
]
],
"normalized": []
},
{
"id": "split_0_train_5872_entity",
"type": "progene_text",
"text": [
"hMMP-1"
],
"offsets": [
[
346,
352
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3585 | split_0_train_3585 | [
{
"id": "split_0_train_3585_passage",
"type": "progene_text",
"text": [
"These findings were further confirmed by Northern analysis ."
],
"offsets": [
[
0,
60
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3586 | split_0_train_3586 | [
{
"id": "split_0_train_3586_passage",
"type": "progene_text",
"text": [
"The down - regulation of hMMP-1 gene expression by endogenous wt - p53 was shown by treatment of U2-OS cells , a wt - p53 - containing osteogenic sarcoma line , and Saos-2 cells , a p53 - negative osteogenic sarcoma line , with etoposide , a potent inducer of p53 expression ."
],
"offsets": [
[
0,
276
]
]
}
]
| [
{
"id": "split_0_train_5873_entity",
"type": "progene_text",
"text": [
"hMMP-1"
],
"offsets": [
[
25,
31
]
],
"normalized": []
},
{
"id": "split_0_train_5874_entity",
"type": "progene_text",
"text": [
"p53"
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"offsets": [
[
67,
70
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],
"normalized": []
},
{
"id": "split_0_train_5875_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
118,
121
]
],
"normalized": []
},
{
"id": "split_0_train_5876_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
182,
185
]
],
"normalized": []
},
{
"id": "split_0_train_5877_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
260,
263
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3587 | split_0_train_3587 | [
{
"id": "split_0_train_3587_passage",
"type": "progene_text",
"text": [
"p53 , activated by etoposide , appears to block hMMP-1 promoter activity induced by etoposide in U2-OS cells ."
],
"offsets": [
[
0,
110
]
]
}
]
| [
{
"id": "split_0_train_5878_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
0,
3
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],
"normalized": []
},
{
"id": "split_0_train_5879_entity",
"type": "progene_text",
"text": [
"hMMP-1"
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"offsets": [
[
48,
54
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3588 | split_0_train_3588 | [
{
"id": "split_0_train_3588_passage",
"type": "progene_text",
"text": [
"In summary , we have shown for the first time that the hMMP-1 gene is a p53 target gene , subject to p53 repression ."
],
"offsets": [
[
0,
117
]
]
}
]
| [
{
"id": "split_0_train_5880_entity",
"type": "progene_text",
"text": [
"hMMP-1"
],
"offsets": [
[
55,
61
]
],
"normalized": []
},
{
"id": "split_0_train_5881_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
72,
75
]
],
"normalized": []
},
{
"id": "split_0_train_5882_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
101,
104
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3589 | split_0_train_3589 | [
{
"id": "split_0_train_3589_passage",
"type": "progene_text",
"text": [
"Because MMP-1 is principally responsible for the irreversible destruction of collagen in articular tissue in RA , abnormality of p53 may contribute to joint degeneration through the regulation of MMP-1 expression ."
],
"offsets": [
[
0,
214
]
]
}
]
| [
{
"id": "split_0_train_5883_entity",
"type": "progene_text",
"text": [
"MMP-1"
],
"offsets": [
[
8,
13
]
],
"normalized": []
},
{
"id": "split_0_train_5884_entity",
"type": "progene_text",
"text": [
"collagen"
],
"offsets": [
[
77,
85
]
],
"normalized": []
},
{
"id": "split_0_train_5885_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
129,
132
]
],
"normalized": []
},
{
"id": "split_0_train_5886_entity",
"type": "progene_text",
"text": [
"MMP-1"
],
"offsets": [
[
196,
201
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3590 | split_0_train_3590 | [
{
"id": "split_0_train_3590_passage",
"type": "progene_text",
"text": [
"The response of Nigerian West African Dwarf goats to experimental infections with Haemonchus contortus ."
],
"offsets": [
[
0,
104
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3591 | split_0_train_3591 | [
{
"id": "split_0_train_3591_passage",
"type": "progene_text",
"text": [
"One option for controlling haemonchosis in warm pastoral regions is improvement of resistance by selective breeding ."
],
"offsets": [
[
0,
117
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3592 | split_0_train_3592 | [
{
"id": "split_0_train_3592_passage",
"type": "progene_text",
"text": [
"Variation in acquired immunity to H. contortus and immunological correlates of infection were studied in West African Dwarf ( WAD ) goats ."
],
"offsets": [
[
0,
139
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3593 | split_0_train_3593 | [
{
"id": "split_0_train_3593_passage",
"type": "progene_text",
"text": [
"Following exposure to 5000 L3 , 63 per cent of the inoculum established but 77 per cent of established worms were expelled by week 5 ."
],
"offsets": [
[
0,
134
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3594 | split_0_train_3594 | [
{
"id": "split_0_train_3594_passage",
"type": "progene_text",
"text": [
"All infected animals were anaemic ( day 14 ) ."
],
"offsets": [
[
0,
46
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3595 | split_0_train_3595 | [
{
"id": "split_0_train_3595_passage",
"type": "progene_text",
"text": [
"When exposed to 2000L3 , 36 per cent of the inoculum was still present ( day 35 ) with no loss by day 49 ."
],
"offsets": [
[
0,
106
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3596 | split_0_train_3596 | [
{
"id": "split_0_train_3596_passage",
"type": "progene_text",
"text": [
"Persisting primary infection worms survived a superimposed challenge ( day 35 ) , but their growth was slowed and resistance to challenge was significant ."
],
"offsets": [
[
0,
155
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3597 | split_0_train_3597 | [
{
"id": "split_0_train_3597_passage",
"type": "progene_text",
"text": [
"Most goats showed eosinophilia and parasite - specific IgG responses to primary infection , but only eosinophilia increased after challenge ."
],
"offsets": [
[
0,
141
]
]
}
]
| [
{
"id": "split_0_train_5887_entity",
"type": "progene_text",
"text": [
"IgG"
],
"offsets": [
[
55,
58
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3598 | split_0_train_3598 | [
{
"id": "split_0_train_3598_passage",
"type": "progene_text",
"text": [
"No consistent associations were found between parasite burden and any immunological measures of infection , but parasite egg counts showed considerable variation ."
],
"offsets": [
[
0,
163
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3599 | split_0_train_3599 | [
{
"id": "split_0_train_3599_passage",
"type": "progene_text",
"text": [
"Overall , our results suggest that resistant genotypes exist among the WAD goat population ."
],
"offsets": [
[
0,
92
]
]
}
]
| []
| []
| []
| []
|
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