id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_4100
|
split_0_train_4100
|
[
{
"id": "split_0_train_4100_passage",
"type": "progene_text",
"text": [
"In Brassica , two self - incompatibility genes , encoding SLG ( S locus glycoprotein ) and SRK ( S-receptor kinase ) , are located at the S locus and expressed in the stigma ."
],
"offsets": [
[
0,
175
]
]
}
] |
[
{
"id": "split_0_train_6451_entity",
"type": "progene_text",
"text": [
"SLG"
],
"offsets": [
[
58,
61
]
],
"normalized": []
},
{
"id": "split_0_train_6452_entity",
"type": "progene_text",
"text": [
"S locus glycoprotein"
],
"offsets": [
[
64,
84
]
],
"normalized": []
},
{
"id": "split_0_train_6453_entity",
"type": "progene_text",
"text": [
"SRK"
],
"offsets": [
[
91,
94
]
],
"normalized": []
},
{
"id": "split_0_train_6454_entity",
"type": "progene_text",
"text": [
"S-receptor kinase"
],
"offsets": [
[
97,
114
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4101
|
split_0_train_4101
|
[
{
"id": "split_0_train_4101_passage",
"type": "progene_text",
"text": [
"Recent molecular analysis has revealed that the S locus is highly polymorphic and contains several genes , i.e. , SLG , SRK , the as - yet - unidentified pollen S gene(s) , and other linked genes ."
],
"offsets": [
[
0,
197
]
]
}
] |
[
{
"id": "split_0_train_6455_entity",
"type": "progene_text",
"text": [
"SLG"
],
"offsets": [
[
114,
117
]
],
"normalized": []
},
{
"id": "split_0_train_6456_entity",
"type": "progene_text",
"text": [
"SRK"
],
"offsets": [
[
120,
123
]
],
"normalized": []
},
{
"id": "split_0_train_6457_entity",
"type": "progene_text",
"text": [
"S gene(s)"
],
"offsets": [
[
161,
170
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4102
|
split_0_train_4102
|
[
{
"id": "split_0_train_4102_passage",
"type": "progene_text",
"text": [
"In the present study , we searched for expressed sequences in a 76 - kb SLG / SRK region of the S(9) haplotype of Brassica campestris ( syn. rapa ) and identified 10 genes in addition to the four previously identified ( SLG(9) , SRK(9) , SAE1 , and SLL2 ) in this haplotype ."
],
"offsets": [
[
0,
275
]
]
}
] |
[
{
"id": "split_0_train_6458_entity",
"type": "progene_text",
"text": [
"SLG"
],
"offsets": [
[
72,
75
]
],
"normalized": []
},
{
"id": "split_0_train_6459_entity",
"type": "progene_text",
"text": [
"SRK"
],
"offsets": [
[
78,
81
]
],
"normalized": []
},
{
"id": "split_0_train_6460_entity",
"type": "progene_text",
"text": [
"SLG(9)"
],
"offsets": [
[
220,
226
]
],
"normalized": []
},
{
"id": "split_0_train_6461_entity",
"type": "progene_text",
"text": [
"SRK(9)"
],
"offsets": [
[
229,
235
]
],
"normalized": []
},
{
"id": "split_0_train_6462_entity",
"type": "progene_text",
"text": [
"SAE1"
],
"offsets": [
[
238,
242
]
],
"normalized": []
},
{
"id": "split_0_train_6463_entity",
"type": "progene_text",
"text": [
"SLL2"
],
"offsets": [
[
249,
253
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4103
|
split_0_train_4103
|
[
{
"id": "split_0_train_4103_passage",
"type": "progene_text",
"text": [
"This gene density ( 1 gene / 5.4 kb ) suggests that the S locus is embedded in a gene - rich region of the genome ."
],
"offsets": [
[
0,
115
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4104
|
split_0_train_4104
|
[
{
"id": "split_0_train_4104_passage",
"type": "progene_text",
"text": [
"The average G + C content in this region is 32.6 % ."
],
"offsets": [
[
0,
52
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4105
|
split_0_train_4105
|
[
{
"id": "split_0_train_4105_passage",
"type": "progene_text",
"text": [
"An En / Spm - type transposon - like element was found downstream of SLG(9) ."
],
"offsets": [
[
0,
77
]
]
}
] |
[
{
"id": "split_0_train_6464_entity",
"type": "progene_text",
"text": [
"SLG(9)"
],
"offsets": [
[
69,
75
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4106
|
split_0_train_4106
|
[
{
"id": "split_0_train_4106_passage",
"type": "progene_text",
"text": [
"Among the genes we identified that had not previously been found to be linked to the S locus were genes encoding a small cysteine - rich protein , a J - domain protein , and an antisilencing protein ( ASF1 ) homologue ."
],
"offsets": [
[
0,
219
]
]
}
] |
[
{
"id": "split_0_train_6465_entity",
"type": "progene_text",
"text": [
"small cysteine - rich protein"
],
"offsets": [
[
115,
144
]
],
"normalized": []
},
{
"id": "split_0_train_6466_entity",
"type": "progene_text",
"text": [
"J - domain protein"
],
"offsets": [
[
149,
167
]
],
"normalized": []
},
{
"id": "split_0_train_6467_entity",
"type": "progene_text",
"text": [
"antisilencing protein"
],
"offsets": [
[
177,
198
]
],
"normalized": []
},
{
"id": "split_0_train_6468_entity",
"type": "progene_text",
"text": [
"ASF1"
],
"offsets": [
[
201,
205
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4107
|
split_0_train_4107
|
[
{
"id": "split_0_train_4107_passage",
"type": "progene_text",
"text": [
"The small cysteine - rich protein was similar to a pollen coat protein , named PCP-A1 , which had previously been shown to bind SLG ."
],
"offsets": [
[
0,
133
]
]
}
] |
[
{
"id": "split_0_train_6469_entity",
"type": "progene_text",
"text": [
"small cysteine - rich protein"
],
"offsets": [
[
4,
33
]
],
"normalized": []
},
{
"id": "split_0_train_6470_entity",
"type": "progene_text",
"text": [
"PCP-A1"
],
"offsets": [
[
79,
85
]
],
"normalized": []
},
{
"id": "split_0_train_6471_entity",
"type": "progene_text",
"text": [
"SLG"
],
"offsets": [
[
128,
131
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4108
|
split_0_train_4108
|
[
{
"id": "split_0_train_4108_passage",
"type": "progene_text",
"text": [
"Experiences with vaccination and epidemiological investigations on an anthrax outbreak in Australia in 1997 ."
],
"offsets": [
[
0,
109
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4109
|
split_0_train_4109
|
[
{
"id": "split_0_train_4109_passage",
"type": "progene_text",
"text": [
"Between January and February 1997 , there was a severe outbreak of anthrax on 83 properties in north - central Victoria , Australia ."
],
"offsets": [
[
0,
133
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4110
|
split_0_train_4110
|
[
{
"id": "split_0_train_4110_passage",
"type": "progene_text",
"text": [
"Vaccination was used as a major tool to control the outbreak by establishing a vaccination buffer zone 30 km by 20 km ."
],
"offsets": [
[
0,
119
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4111
|
split_0_train_4111
|
[
{
"id": "split_0_train_4111_passage",
"type": "progene_text",
"text": [
"In all , 78 , 649 cattle in 457 herds were vaccinated in a three week program ."
],
"offsets": [
[
0,
79
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4112
|
split_0_train_4112
|
[
{
"id": "split_0_train_4112_passage",
"type": "progene_text",
"text": [
"In the face of the outbreak , there was a delay before vaccination was able to stop deaths ."
],
"offsets": [
[
0,
92
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4113
|
split_0_train_4113
|
[
{
"id": "split_0_train_4113_passage",
"type": "progene_text",
"text": [
"In the 10 days following vaccination 144 cases of confirmed anthrax occurred and 38 cases occurred more than 10 days after vaccination ."
],
"offsets": [
[
0,
136
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4114
|
split_0_train_4114
|
[
{
"id": "split_0_train_4114_passage",
"type": "progene_text",
"text": [
"When all cattle on at - risk properties were revaccinated in October and early November 1997 , there were only two confirmed cases of anthrax in vaccinated seven and nine month old calves in the following anthrax season ."
],
"offsets": [
[
0,
221
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4115
|
split_0_train_4115
|
[
{
"id": "split_0_train_4115_passage",
"type": "progene_text",
"text": [
"Investigations into the epidemiology of the outbreak were unable to establish a single major association for the spread of the disease by flies , biting insects , carrion scavengers , wind , manufactured feed , milk factory tanker routes , veterinary visits , animal treatments , movements of personnel between farms or burning of carcases ."
],
"offsets": [
[
0,
341
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4116
|
split_0_train_4116
|
[
{
"id": "split_0_train_4116_passage",
"type": "progene_text",
"text": [
"The weather conditions in the outbreak area were part of a long dry spell with periods of high daily and night temperatures , continuing high humidity over the period and higher than normal soil temperatures ."
],
"offsets": [
[
0,
209
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4117
|
split_0_train_4117
|
[
{
"id": "split_0_train_4117_passage",
"type": "progene_text",
"text": [
"It is possible that extensive earth works in the district involving irrigated pasture renovation and water channel and drainage renovation could have disturbed old anthrax graves ."
],
"offsets": [
[
0,
180
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4118
|
split_0_train_4118
|
[
{
"id": "split_0_train_4118_passage",
"type": "progene_text",
"text": [
"It is postulated that these works released spores that were dispersed in the preceding wet winter across poorly drained areas that formed the axis for the outbreak ."
],
"offsets": [
[
0,
165
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4119
|
split_0_train_4119
|
[
{
"id": "split_0_train_4119_passage",
"type": "progene_text",
"text": [
"The earth moving renovations establishing irrigation in the area were conducted in the late 1890s , and before the occurrence of anthrax outbreaks were recorded ."
],
"offsets": [
[
0,
162
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4120
|
split_0_train_4120
|
[
{
"id": "split_0_train_4120_passage",
"type": "progene_text",
"text": [
"The axis of the outbreak was the major stock route for cattle and sheep moving from southern Victoria to northern Victoria and southern New South Wales , and undoubtedly there would have been extensive anthrax outbreaks before vaccine became available in the 1890s ."
],
"offsets": [
[
0,
266
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4121
|
split_0_train_4121
|
[
{
"id": "split_0_train_4121_passage",
"type": "progene_text",
"text": [
"In respect of other outbreaks , the events in Victoria most resembled outbreaks of anthrax recorded in the United States of America in the 1950s , 1960s and 1970s ."
],
"offsets": [
[
0,
164
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4122
|
split_0_train_4122
|
[
{
"id": "split_0_train_4122_passage",
"type": "progene_text",
"text": [
"Diet , cholesterol and coronary heart disease ."
],
"offsets": [
[
0,
47
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4123
|
split_0_train_4123
|
[
{
"id": "split_0_train_4123_passage",
"type": "progene_text",
"text": [
"A perspective ."
],
"offsets": [
[
0,
15
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4124
|
split_0_train_4124
|
[
{
"id": "split_0_train_4124_passage",
"type": "progene_text",
"text": [
"After pioneering , scattered observations in the context of the so - called geographical pathology , collected during the first part of this century , a systematic approach into the search of causality of the association between diet and coronary heart disease has characterized the past 50 years ."
],
"offsets": [
[
0,
298
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4125
|
split_0_train_4125
|
[
{
"id": "split_0_train_4125_passage",
"type": "progene_text",
"text": [
"The possible link of eating habits leading to a diet high in calories , total fat , saturated fatty acids and cholesterol , to coronary events , through the mediation of serum cholesterol , represents the classic diet - heart theory ."
],
"offsets": [
[
0,
234
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4126
|
split_0_train_4126
|
[
{
"id": "split_0_train_4126_passage",
"type": "progene_text",
"text": [
"This theory is supported by results from ecological analyses , prospective studies , animal experiments , clinical observations , controlled trials , biochemical and nutritional studies ."
],
"offsets": [
[
0,
187
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4127
|
split_0_train_4127
|
[
{
"id": "split_0_train_4127_passage",
"type": "progene_text",
"text": [
"This traditional view of the problem has partly changed recently and a number of other dietary components in the possibly causal chain have emerged , with effects not necessarily involving serum cholesterol and lipids ."
],
"offsets": [
[
0,
219
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4128
|
split_0_train_4128
|
[
{
"id": "split_0_train_4128_passage",
"type": "progene_text",
"text": [
"The role of other nutrients in the atherosclerotic process and of precipitating factors ( e.g. vitamins , anti - oxidants , fibre , sub - categories of fatty acids , phytosterols , flavonoids , etc. ) has been identified but is not always fully understood ."
],
"offsets": [
[
0,
257
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4129
|
split_0_train_4129
|
[
{
"id": "split_0_train_4129_passage",
"type": "progene_text",
"text": [
"At the same time other blood lipids , other blood components and other pathways have been identified between diet and coronary outcomes ."
],
"offsets": [
[
0,
137
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4130
|
split_0_train_4130
|
[
{
"id": "split_0_train_4130_passage",
"type": "progene_text",
"text": [
"New challenges are open for future research since the association of diet with coronary disease is not as simple and linear as supposed ."
],
"offsets": [
[
0,
137
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4131
|
split_0_train_4131
|
[
{
"id": "split_0_train_4131_passage",
"type": "progene_text",
"text": [
"The main issues are the need to explain a number of still unknown mechanisms , to determine which \" natural diet \" carries the minimum coronary risk and whether \" new \" foods produced by modern technology are really needed to contrast this epidemic ."
],
"offsets": [
[
0,
250
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4132
|
split_0_train_4132
|
[
{
"id": "split_0_train_4132_passage",
"type": "progene_text",
"text": [
"Sp3 , but not Sp1 , mediates the transcriptional activation of the p21 / WAF1 / Cip1 gene promoter by histone deacetylase inhibitor ."
],
"offsets": [
[
0,
133
]
]
}
] |
[
{
"id": "split_0_train_6472_entity",
"type": "progene_text",
"text": [
"Sp3"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_6473_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
14,
17
]
],
"normalized": []
},
{
"id": "split_0_train_6474_entity",
"type": "progene_text",
"text": [
"p21"
],
"offsets": [
[
67,
70
]
],
"normalized": []
},
{
"id": "split_0_train_6475_entity",
"type": "progene_text",
"text": [
"WAF1"
],
"offsets": [
[
73,
77
]
],
"normalized": []
},
{
"id": "split_0_train_6476_entity",
"type": "progene_text",
"text": [
"Cip1"
],
"offsets": [
[
80,
84
]
],
"normalized": []
},
{
"id": "split_0_train_6477_entity",
"type": "progene_text",
"text": [
"histone deacetylase"
],
"offsets": [
[
102,
121
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4133
|
split_0_train_4133
|
[
{
"id": "split_0_train_4133_passage",
"type": "progene_text",
"text": [
"We previously reported that both sodium butyrate and trichostatin A ( TSA ) , both of which are known as inhibitors of histone deacetylase , arrest human tumor cells at G1 and G2-M and activate the cyclin - dependent kinase inhibitor , the p21 / WAF1 / Cip1 gene promoter , through the Sp1 sites ."
],
"offsets": [
[
0,
297
]
]
}
] |
[
{
"id": "split_0_train_6478_entity",
"type": "progene_text",
"text": [
"histone deacetylase"
],
"offsets": [
[
119,
138
]
],
"normalized": []
},
{
"id": "split_0_train_6479_entity",
"type": "progene_text",
"text": [
"cyclin - dependent kinase inhibitor"
],
"offsets": [
[
198,
233
]
],
"normalized": []
},
{
"id": "split_0_train_6480_entity",
"type": "progene_text",
"text": [
"p21"
],
"offsets": [
[
240,
243
]
],
"normalized": []
},
{
"id": "split_0_train_6481_entity",
"type": "progene_text",
"text": [
"WAF1"
],
"offsets": [
[
246,
250
]
],
"normalized": []
},
{
"id": "split_0_train_6482_entity",
"type": "progene_text",
"text": [
"Cip1"
],
"offsets": [
[
253,
257
]
],
"normalized": []
},
{
"id": "split_0_train_6483_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
286,
289
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4134
|
split_0_train_4134
|
[
{
"id": "split_0_train_4134_passage",
"type": "progene_text",
"text": [
"In this study , we identified Sp1 and Sp3 as major factors binding to the Sp1 sites of the p21 / WAF1 / Cip1 promoter in MG63 cells through electrophoretic mobility shift assays and showed that TSA treatment did not change their binding activities ."
],
"offsets": [
[
0,
249
]
]
}
] |
[
{
"id": "split_0_train_6484_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
30,
33
]
],
"normalized": []
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},
{
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101
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{
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"type": "progene_text",
"text": [
"Cip1"
],
"offsets": [
[
104,
108
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4135
|
split_0_train_4135
|
[
{
"id": "split_0_train_4135_passage",
"type": "progene_text",
"text": [
"However , GAL4 - Sp3 but not GAL4 - Sp1 fusion protein supported the TSA - mediated gene induction from a luciferase reporter plasmid driven by five GAL4 DNA - binding sites ."
],
"offsets": [
[
0,
175
]
]
}
] |
[
{
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10,
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{
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17,
20
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},
{
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29,
33
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},
{
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"type": "progene_text",
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36,
39
]
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},
{
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"type": "progene_text",
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106,
116
]
],
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},
{
"id": "split_0_train_6495_entity",
"type": "progene_text",
"text": [
"GAL4"
],
"offsets": [
[
149,
153
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4136
|
split_0_train_4136
|
[
{
"id": "split_0_train_4136_passage",
"type": "progene_text",
"text": [
"Moreover , the ectopic expression of dominant negative Sp3 repressed the enhancement by TSA of the p21 / WAF1 / Cip1 promoter and Sp1 site - driven promoter ."
],
"offsets": [
[
0,
158
]
]
}
] |
[
{
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"type": "progene_text",
"text": [
"Sp3"
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55,
58
]
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},
{
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"type": "progene_text",
"text": [
"p21"
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99,
102
]
],
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},
{
"id": "split_0_train_6498_entity",
"type": "progene_text",
"text": [
"WAF1"
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105,
109
]
],
"normalized": []
},
{
"id": "split_0_train_6499_entity",
"type": "progene_text",
"text": [
"Cip1"
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112,
116
]
],
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},
{
"id": "split_0_train_6500_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
130,
133
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4137
|
split_0_train_4137
|
[
{
"id": "split_0_train_4137_passage",
"type": "progene_text",
"text": [
"Taken together , these results suggest that histone deacetylase inhibitor up - regulates p21 / WAF1 / Cip1 transcription by Sp3 but not by Sp1 ."
],
"offsets": [
[
0,
144
]
]
}
] |
[
{
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"type": "progene_text",
"text": [
"histone deacetylase"
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[
44,
63
]
],
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},
{
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"type": "progene_text",
"text": [
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89,
92
]
],
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},
{
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"type": "progene_text",
"text": [
"WAF1"
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95,
99
]
],
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},
{
"id": "split_0_train_6504_entity",
"type": "progene_text",
"text": [
"Cip1"
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102,
106
]
],
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},
{
"id": "split_0_train_6505_entity",
"type": "progene_text",
"text": [
"Sp3"
],
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[
124,
127
]
],
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},
{
"id": "split_0_train_6506_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
139,
142
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4138
|
split_0_train_4138
|
[
{
"id": "split_0_train_4138_passage",
"type": "progene_text",
"text": [
"NuA4 , an essential transcription adaptor / histone H4 acetyltransferase complex containing Esa1p and the ATM - related cofactor Tra1p ."
],
"offsets": [
[
0,
136
]
]
}
] |
[
{
"id": "split_0_train_6507_entity",
"type": "progene_text",
"text": [
"NuA4"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_6508_entity",
"type": "progene_text",
"text": [
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],
"offsets": [
[
44,
80
]
],
"normalized": []
},
{
"id": "split_0_train_6509_entity",
"type": "progene_text",
"text": [
"Esa1p"
],
"offsets": [
[
92,
97
]
],
"normalized": []
},
{
"id": "split_0_train_6510_entity",
"type": "progene_text",
"text": [
"ATM"
],
"offsets": [
[
106,
109
]
],
"normalized": []
},
{
"id": "split_0_train_6511_entity",
"type": "progene_text",
"text": [
"Tra1p"
],
"offsets": [
[
129,
134
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4139
|
split_0_train_4139
|
[
{
"id": "split_0_train_4139_passage",
"type": "progene_text",
"text": [
"Post - translational acetylation of histone H4 N - terminal tail in chromatin has been associated with several nuclear processes including transcription ."
],
"offsets": [
[
0,
154
]
]
}
] |
[
{
"id": "split_0_train_6512_entity",
"type": "progene_text",
"text": [
"histone H4"
],
"offsets": [
[
36,
46
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4140
|
split_0_train_4140
|
[
{
"id": "split_0_train_4140_passage",
"type": "progene_text",
"text": [
"We report the purification and characterization of a native multisubunit complex ( NuA4 ) from yeast that acetylates nucleosomal histone H4 ."
],
"offsets": [
[
0,
141
]
]
}
] |
[
{
"id": "split_0_train_6513_entity",
"type": "progene_text",
"text": [
"NuA4"
],
"offsets": [
[
83,
87
]
],
"normalized": []
},
{
"id": "split_0_train_6514_entity",
"type": "progene_text",
"text": [
"histone H4"
],
"offsets": [
[
129,
139
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4141
|
split_0_train_4141
|
[
{
"id": "split_0_train_4141_passage",
"type": "progene_text",
"text": [
"NuA4 has an apparent molecular mass of 1.3 MDa ."
],
"offsets": [
[
0,
48
]
]
}
] |
[
{
"id": "split_0_train_6515_entity",
"type": "progene_text",
"text": [
"NuA4"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4142
|
split_0_train_4142
|
[
{
"id": "split_0_train_4142_passage",
"type": "progene_text",
"text": [
"All four conserved lysines of histone H4 can be acetylated by NuA4 ."
],
"offsets": [
[
0,
68
]
]
}
] |
[
{
"id": "split_0_train_6516_entity",
"type": "progene_text",
"text": [
"histone H4"
],
"offsets": [
[
30,
40
]
],
"normalized": []
},
{
"id": "split_0_train_6517_entity",
"type": "progene_text",
"text": [
"NuA4"
],
"offsets": [
[
62,
66
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4143
|
split_0_train_4143
|
[
{
"id": "split_0_train_4143_passage",
"type": "progene_text",
"text": [
"We have identified the catalytic subunit of the complex as the product of ESA1 , an essential gene required for cell cycle progression in yeast ."
],
"offsets": [
[
0,
145
]
]
}
] |
[
{
"id": "split_0_train_6518_entity",
"type": "progene_text",
"text": [
"ESA1"
],
"offsets": [
[
74,
78
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4144
|
split_0_train_4144
|
[
{
"id": "split_0_train_4144_passage",
"type": "progene_text",
"text": [
"Antibodies against Esa1p specifically immunoprecipitate NuA4 activity whereas the complex purified from a temperature - sensitive esa1 mutant loses its acetyltransferase activity at the restrictive temperature ."
],
"offsets": [
[
0,
211
]
]
}
] |
[
{
"id": "split_0_train_6519_entity",
"type": "progene_text",
"text": [
"Esa1p"
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"offsets": [
[
19,
24
]
],
"normalized": []
},
{
"id": "split_0_train_6520_entity",
"type": "progene_text",
"text": [
"NuA4"
],
"offsets": [
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56,
60
]
],
"normalized": []
},
{
"id": "split_0_train_6521_entity",
"type": "progene_text",
"text": [
"esa1"
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"offsets": [
[
130,
134
]
],
"normalized": []
},
{
"id": "split_0_train_6522_entity",
"type": "progene_text",
"text": [
"acetyltransferase"
],
"offsets": [
[
152,
169
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4145
|
split_0_train_4145
|
[
{
"id": "split_0_train_4145_passage",
"type": "progene_text",
"text": [
"Additionally , we have identified another subunit of the complex as the product of TRA1 , an ATM - related essential gene homologous to human TRRAP , an essential cofactor for c-Myc - and E2F - mediated oncogenic transformation ."
],
"offsets": [
[
0,
229
]
]
}
] |
[
{
"id": "split_0_train_6523_entity",
"type": "progene_text",
"text": [
"TRA1"
],
"offsets": [
[
83,
87
]
],
"normalized": []
},
{
"id": "split_0_train_6524_entity",
"type": "progene_text",
"text": [
"ATM"
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"offsets": [
[
93,
96
]
],
"normalized": []
},
{
"id": "split_0_train_6525_entity",
"type": "progene_text",
"text": [
"TRRAP"
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"offsets": [
[
142,
147
]
],
"normalized": []
},
{
"id": "split_0_train_6526_entity",
"type": "progene_text",
"text": [
"c-Myc"
],
"offsets": [
[
176,
181
]
],
"normalized": []
},
{
"id": "split_0_train_6527_entity",
"type": "progene_text",
"text": [
"E2F"
],
"offsets": [
[
188,
191
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4146
|
split_0_train_4146
|
[
{
"id": "split_0_train_4146_passage",
"type": "progene_text",
"text": [
"Finally , the ability of NuA4 to stimulate GAL4 - VP16 - driven transcription from chromatin templates in vitro is also lost in the temperature - sensitive esa1 mutant ."
],
"offsets": [
[
0,
169
]
]
}
] |
[
{
"id": "split_0_train_6528_entity",
"type": "progene_text",
"text": [
"NuA4"
],
"offsets": [
[
25,
29
]
],
"normalized": []
},
{
"id": "split_0_train_6529_entity",
"type": "progene_text",
"text": [
"GAL4"
],
"offsets": [
[
43,
47
]
],
"normalized": []
},
{
"id": "split_0_train_6530_entity",
"type": "progene_text",
"text": [
"VP16"
],
"offsets": [
[
50,
54
]
],
"normalized": []
},
{
"id": "split_0_train_6531_entity",
"type": "progene_text",
"text": [
"esa1"
],
"offsets": [
[
156,
160
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4147
|
split_0_train_4147
|
[
{
"id": "split_0_train_4147_passage",
"type": "progene_text",
"text": [
"The function of the essential Esa1 protein as the HAT subunit of NuA4 and the presence of Tra1p , a putative transcription activator - interacting subunit , supports an essential link between nuclear H4 acetylation , transcriptional regulation and cell cycle control ."
],
"offsets": [
[
0,
268
]
]
}
] |
[
{
"id": "split_0_train_6532_entity",
"type": "progene_text",
"text": [
"Esa1"
],
"offsets": [
[
30,
34
]
],
"normalized": []
},
{
"id": "split_0_train_6533_entity",
"type": "progene_text",
"text": [
"HAT"
],
"offsets": [
[
50,
53
]
],
"normalized": []
},
{
"id": "split_0_train_6534_entity",
"type": "progene_text",
"text": [
"NuA4"
],
"offsets": [
[
65,
69
]
],
"normalized": []
},
{
"id": "split_0_train_6535_entity",
"type": "progene_text",
"text": [
"Tra1p"
],
"offsets": [
[
90,
95
]
],
"normalized": []
},
{
"id": "split_0_train_6536_entity",
"type": "progene_text",
"text": [
"H4"
],
"offsets": [
[
200,
202
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4148
|
split_0_train_4148
|
[
{
"id": "split_0_train_4148_passage",
"type": "progene_text",
"text": [
"Evidence for neutrophil activation in occupational asthma ."
],
"offsets": [
[
0,
59
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4149
|
split_0_train_4149
|
[
{
"id": "split_0_train_4149_passage",
"type": "progene_text",
"text": [
"In order to evaluate the role of neutrophils in the pathogenesis of occupational asthma ( OA ) , 15 toluene diisocyanate ( TDI ) - asthma and six grain dust - asthma patients were recruited ."
],
"offsets": [
[
0,
191
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4150
|
split_0_train_4150
|
[
{
"id": "split_0_train_4150_passage",
"type": "progene_text",
"text": [
"Controls were the same number of subjects showing negative bronchoprovocation test ( BPT ) and six house dust mite - sensitive asthma ."
],
"offsets": [
[
0,
135
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4151
|
split_0_train_4151
|
[
{
"id": "split_0_train_4151_passage",
"type": "progene_text",
"text": [
"Bronchoscopic biopsy specimens were stained with monoclonal antibodies to mast cell ( AA1 ) , eosinophil ( EG2 ) , pan T cell ( CD3 ) and neutrophil ( NE ) ."
],
"offsets": [
[
0,
157
]
]
}
] |
[
{
"id": "split_0_train_6537_entity",
"type": "progene_text",
"text": [
"CD3"
],
"offsets": [
[
128,
131
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4152
|
split_0_train_4152
|
[
{
"id": "split_0_train_4152_passage",
"type": "progene_text",
"text": [
"Serum neutrophil chemotactic activity ( NCA ) was measured before and 10-420 min after BPT ."
],
"offsets": [
[
0,
92
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4153
|
split_0_train_4153
|
[
{
"id": "split_0_train_4153_passage",
"type": "progene_text",
"text": [
"Sputum interleukin-8 ( IL-8 ) and myeloperoxidase ( MPO ) were also measured ."
],
"offsets": [
[
0,
78
]
]
}
] |
[
{
"id": "split_0_train_6538_entity",
"type": "progene_text",
"text": [
"interleukin-8"
],
"offsets": [
[
7,
20
]
],
"normalized": []
},
{
"id": "split_0_train_6539_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
23,
27
]
],
"normalized": []
},
{
"id": "split_0_train_6540_entity",
"type": "progene_text",
"text": [
"myeloperoxidase"
],
"offsets": [
[
34,
49
]
],
"normalized": []
},
{
"id": "split_0_train_6541_entity",
"type": "progene_text",
"text": [
"MPO"
],
"offsets": [
[
52,
55
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4154
|
split_0_train_4154
|
[
{
"id": "split_0_train_4154_passage",
"type": "progene_text",
"text": [
"There was a significant increase of NE + cells as well as AA1 + and EG2+ cells in grain dust - and TDI - asthma compared with house dust - sensitive asthma ( P < 0.05 ) ."
],
"offsets": [
[
0,
170
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4155
|
split_0_train_4155
|
[
{
"id": "split_0_train_4155_passage",
"type": "progene_text",
"text": [
"Neutrophil + cells and AA1 + cells showed a significant correlation in TDI-asthma ( r = 0.73 , P = 0.02 ) ."
],
"offsets": [
[
0,
107
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4156
|
split_0_train_4156
|
[
{
"id": "split_0_train_4156_passage",
"type": "progene_text",
"text": [
"Serum NCA was significantly increased at 10 min after BPT and decreased at 60 min in subjects with TDI - asthma ."
],
"offsets": [
[
0,
113
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4157
|
split_0_train_4157
|
[
{
"id": "split_0_train_4157_passage",
"type": "progene_text",
"text": [
"In grain dust - asthma , serum NCA increased at 30 min and decreased at 240 min after BPT ( P < 0.05 ) ."
],
"offsets": [
[
0,
104
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4158
|
split_0_train_4158
|
[
{
"id": "split_0_train_4158_passage",
"type": "progene_text",
"text": [
"Sputum IL-8 and MPO were significantly increased after BPT in both TDI - and grain dust - asthma ( P < 0.05 ) ."
],
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[
0,
111
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]
}
] |
[
{
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7,
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{
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"type": "progene_text",
"text": [
"MPO"
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[
16,
19
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}
] |
[] |
[] |
[] |
split_0_train_4159
|
split_0_train_4159
|
[
{
"id": "split_0_train_4159_passage",
"type": "progene_text",
"text": [
"These findings suggested that neutrophils in the lungs might contribute to bronchoconstriction induced by either TDI or grain dust ."
],
"offsets": [
[
0,
132
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4160
|
split_0_train_4160
|
[
{
"id": "split_0_train_4160_passage",
"type": "progene_text",
"text": [
"The possible involvement of IL-8 in activation of neutrophils was also suggested ."
],
"offsets": [
[
0,
82
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]
}
] |
[
{
"id": "split_0_train_6544_entity",
"type": "progene_text",
"text": [
"IL-8"
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"offsets": [
[
28,
32
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4161
|
split_0_train_4161
|
[
{
"id": "split_0_train_4161_passage",
"type": "progene_text",
"text": [
"Overexpressed BCL6 ( LAZ3 ) oncoprotein triggers apoptosis , delays S phase progression and associates with replication foci ."
],
"offsets": [
[
0,
126
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]
}
] |
[
{
"id": "split_0_train_6545_entity",
"type": "progene_text",
"text": [
"BCL6"
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14,
18
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{
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"type": "progene_text",
"text": [
"LAZ3"
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[
21,
25
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4162
|
split_0_train_4162
|
[
{
"id": "split_0_train_4162_passage",
"type": "progene_text",
"text": [
"One of the most frequent genetic abnormalities associated with non Hodgkin lymphoma is the structural alteration of the 5' non coding / regulatory region of the BCL6 ( LAZ3 ) protooncogene ."
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[
0,
190
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]
}
] |
[
{
"id": "split_0_train_6547_entity",
"type": "progene_text",
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161,
165
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{
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"type": "progene_text",
"text": [
"LAZ3"
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[
168,
172
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}
] |
[] |
[] |
[] |
split_0_train_4163
|
split_0_train_4163
|
[
{
"id": "split_0_train_4163_passage",
"type": "progene_text",
"text": [
"BCL6 encodes a POZ / Zn finger protein , a structure similar to that of many Drosophila developmental regulators and to another protein involved in a human hematopoietic malignancy , PLZF ."
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[
0,
189
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]
}
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[
{
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"type": "progene_text",
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0,
4
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{
"id": "split_0_train_6550_entity",
"type": "progene_text",
"text": [
"PLZF"
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[
183,
187
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4164
|
split_0_train_4164
|
[
{
"id": "split_0_train_4164_passage",
"type": "progene_text",
"text": [
"BCL6 is a sequence specific transcriptional repressor controlling germinal center formation and T cell dependent immune response ."
],
"offsets": [
[
0,
130
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]
}
] |
[
{
"id": "split_0_train_6551_entity",
"type": "progene_text",
"text": [
"BCL6"
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"offsets": [
[
0,
4
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4165
|
split_0_train_4165
|
[
{
"id": "split_0_train_4165_passage",
"type": "progene_text",
"text": [
"Although the expression of BCL6 negatively correlates with cellular proliferation in different cell types , the influence of BCL6 on cell growth and survival is currently unknown so that the way its deregulation may contribute to cancer remains elusive ."
],
"offsets": [
[
0,
254
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]
}
] |
[
{
"id": "split_0_train_6552_entity",
"type": "progene_text",
"text": [
"BCL6"
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[
27,
31
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{
"id": "split_0_train_6553_entity",
"type": "progene_text",
"text": [
"BCL6"
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"offsets": [
[
125,
129
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4166
|
split_0_train_4166
|
[
{
"id": "split_0_train_4166_passage",
"type": "progene_text",
"text": [
"To directly address this issue , we used a tetracycline - regulated system in human U2OS osteosarcoma cells and thus found that BCL6 mediates growth suppression associated with impaired S phase progression and apoptosis ."
],
"offsets": [
[
0,
221
]
]
}
] |
[
{
"id": "split_0_train_6554_entity",
"type": "progene_text",
"text": [
"BCL6"
],
"offsets": [
[
128,
132
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4167
|
split_0_train_4167
|
[
{
"id": "split_0_train_4167_passage",
"type": "progene_text",
"text": [
"Interestingly , overexpressed BCL6 can colocalize with sites of ongoing DNA synthesis , suggesting that it may directly interfere with S phase initiation and/or progression ."
],
"offsets": [
[
0,
174
]
]
}
] |
[
{
"id": "split_0_train_6555_entity",
"type": "progene_text",
"text": [
"BCL6"
],
"offsets": [
[
30,
34
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4168
|
split_0_train_4168
|
[
{
"id": "split_0_train_4168_passage",
"type": "progene_text",
"text": [
"In contrast , the isolated Zn finger region of BCL6 , which binds BCL6 target sequence but lacks transcriptional repression activity , slows , but does not suppress , U2OS cell growth , is less efficient at delaying S phase progression , and does not trigger apoptosis ."
],
"offsets": [
[
0,
270
]
]
}
] |
[
{
"id": "split_0_train_6556_entity",
"type": "progene_text",
"text": [
"BCL6"
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"offsets": [
[
47,
51
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{
"id": "split_0_train_6557_entity",
"type": "progene_text",
"text": [
"BCL6"
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"offsets": [
[
66,
70
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4169
|
split_0_train_4169
|
[
{
"id": "split_0_train_4169_passage",
"type": "progene_text",
"text": [
"Thus , for a large part , the effects of BCL6 overexpression on cell growth and survival depend on its ability to engage protein / protein interactions with itself and/or its transcriptional corepressors ."
],
"offsets": [
[
0,
205
]
]
}
] |
[
{
"id": "split_0_train_6558_entity",
"type": "progene_text",
"text": [
"BCL6"
],
"offsets": [
[
41,
45
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4170
|
split_0_train_4170
|
[
{
"id": "split_0_train_4170_passage",
"type": "progene_text",
"text": [
"That BCL6 restricts cell growth suggests that its deregulation upon structural alterations may alleviate negative controls on the cell cycle and cell survival ."
],
"offsets": [
[
0,
160
]
]
}
] |
[
{
"id": "split_0_train_6559_entity",
"type": "progene_text",
"text": [
"BCL6"
],
"offsets": [
[
5,
9
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4171
|
split_0_train_4171
|
[
{
"id": "split_0_train_4171_passage",
"type": "progene_text",
"text": [
"Solution conformation of the (+)-trans-anti-benzo[g]chrysene-dA adduct opposite dT in a DNA duplex ."
],
"offsets": [
[
0,
100
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4172
|
split_0_train_4172
|
[
{
"id": "split_0_train_4172_passage",
"type": "progene_text",
"text": [
"The solution structure of the adduct derived from the covalent bonding of the fjord region (+)-(11S, 12R , 13R , 14S ) stereoisomer of anti - 11 , 12 - dihydroxy - 13 , 14 - epoxy - 11 , 12 , 13 , 14 - tetrahydrobenzo [ g ] chrysene , (+) - anti - B[g]CDE , to the exocyclic N(6) amino group of the adenine residue dA6 , ( designated (+) - trans-anti -(B[g]C)dA6) , positioned opposite a thymine residue dT17 in the DNA sequence context d(C1-T2 - C3 - T4 - C5 - ( B [ g ] C ) A6 - C7 - T8 - T9 - C10 - C11 ) ."
],
"offsets": [
[
0,
509
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4173
|
split_0_train_4173
|
[
{
"id": "split_0_train_4173_passage",
"type": "progene_text",
"text": [
"d(G12-G13-A14-A15-G16-T17-G18-A19-G20 ++ +-A21-G22 ) ( designated ( B[g]C ) dA. dT 11-mer duplex ) , has been studied using structural information derived from NMR data in combination with molecular dynamics ( MD ) calculations ."
],
"offsets": [
[
0,
229
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4174
|
split_0_train_4174
|
[
{
"id": "split_0_train_4174_passage",
"type": "progene_text",
"text": [
"The solution structure of the ( + ) - trans - anti - ( B[g]C ) dA.dT 11-mer duplex has been determined using an MD protocol where both interproton distance and dihedral angle restraints deduced from NOESY and COSY spectra are used during the refinement process , followed by additional relaxation matrix refinement to the observed NOESY intensities to account for spin diffusion effects ."
],
"offsets": [
[
0,
388
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4175
|
split_0_train_4175
|
[
{
"id": "split_0_train_4175_passage",
"type": "progene_text",
"text": [
"The results established that the covalently attached benzo[g]chrysene ring intercalates into the DNA helix directed towards the 5' - side of the modified strand and stacks predominantly with dT17 when intercalated between dC5.dG18 and ( B[g]C ) dA6.dT17 base - pairs ."
],
"offsets": [
[
0,
268
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4176
|
split_0_train_4176
|
[
{
"id": "split_0_train_4176_passage",
"type": "progene_text",
"text": [
"All base - pairs , including the modified ( B[g]C ) dA6.dT17 base-pair , are aligned through Watson - Crick pairing as in normal B - DNA ."
],
"offsets": [
[
0,
138
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4177
|
split_0_train_4177
|
[
{
"id": "split_0_train_4177_passage",
"type": "progene_text",
"text": [
"In addition , the potential strain associated with the highly sterically hindered fjord region of the aromatic portion of the benzo[g]chrysenyl ring is relieved through the adoption of a non - planar , propeller - like geometry within the chrysenyl ring system ."
],
"offsets": [
[
0,
262
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4178
|
split_0_train_4178
|
[
{
"id": "split_0_train_4178_passage",
"type": "progene_text",
"text": [
"This conformation shares common structural features with the related ( + ) - trans - anti - ( B[c]Ph ) dA adduct in the identical base sequence context , derived from the fjord region (+)-(1S,2R,3R,4S)-3 , 4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene stereoisomer , in which intercalation is also observed towards the 5' - side of the modified dA6.dT17 base - pair ."
],
"offsets": [
[
0,
382
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4179
|
split_0_train_4179
|
[
{
"id": "split_0_train_4179_passage",
"type": "progene_text",
"text": [
"Cloning and mutational analysis of the Leptomonas seymouri U5 snRNA gene : function of the Sm site in core RNP formation and nuclear localization ."
],
"offsets": [
[
0,
147
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4180
|
split_0_train_4180
|
[
{
"id": "split_0_train_4180_passage",
"type": "progene_text",
"text": [
"We have cloned the single - copy gene for the trans - spliceosomal U5 snRNA from the trypanosomatid species Leptomonas seymouri , using U5 RNA affinity selection and cDNA cloning ."
],
"offsets": [
[
0,
180
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4181
|
split_0_train_4181
|
[
{
"id": "split_0_train_4181_passage",
"type": "progene_text",
"text": [
"Sequence comparison revealed that the trans - spliceosomal U5 RNAs from trypanosomatid species share certain characteristic features ."
],
"offsets": [
[
0,
134
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4182
|
split_0_train_4182
|
[
{
"id": "split_0_train_4182_passage",
"type": "progene_text",
"text": [
"Interestingly , the affinity selection procedure yielded - in addition to the bona fide U5 RNA-a closely related small RNA , which can be folded into the same secondary structure , but carries three changes in the loop sequence ."
],
"offsets": [
[
0,
229
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4183
|
split_0_train_4183
|
[
{
"id": "split_0_train_4183_passage",
"type": "progene_text",
"text": [
"This raises the possibility that there may be a larger family of U5 - like RNAs in trypanosomes ."
],
"offsets": [
[
0,
97
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4184
|
split_0_train_4184
|
[
{
"id": "split_0_train_4184_passage",
"type": "progene_text",
"text": [
"To study the U5 snRNP assembly and function in trypanosomes we have established a stable expression system in L.seymouri ."
],
"offsets": [
[
0,
122
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4185
|
split_0_train_4185
|
[
{
"id": "split_0_train_4185_passage",
"type": "progene_text",
"text": [
"Two cell lines have been generated that express U5 RNAs with mutations in the Sm site , resulting in a defect of core snRNP formation ."
],
"offsets": [
[
0,
135
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4186
|
split_0_train_4186
|
[
{
"id": "split_0_train_4186_passage",
"type": "progene_text",
"text": [
"In addition , the U5 Sm - mutant RNAs behaved differently in cell fractionation , implying a defect in nuclear localization ."
],
"offsets": [
[
0,
125
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4187
|
split_0_train_4187
|
[
{
"id": "split_0_train_4187_passage",
"type": "progene_text",
"text": [
"In sum , this demonstrates for the first time that the Sm site of trypanosome snRNAs contributes an essential element for stable core RNP assembly and may be important for nuclear localization , in analogy to the Sm site function of cis - spliceosomal snRNAs in higher eucaryotes ."
],
"offsets": [
[
0,
281
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4188
|
split_0_train_4188
|
[
{
"id": "split_0_train_4188_passage",
"type": "progene_text",
"text": [
"Re - expression of SPR1 in breast cancer cells by phorbol 12-myristate 13-acetate ( PMA ) or UV irradiation is mediated by the AP-1 binding site in the SPR1 promoter ."
],
"offsets": [
[
0,
167
]
]
}
] |
[
{
"id": "split_0_train_6560_entity",
"type": "progene_text",
"text": [
"SPR1"
],
"offsets": [
[
19,
23
]
],
"normalized": []
},
{
"id": "split_0_train_6561_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
127,
131
]
],
"normalized": []
},
{
"id": "split_0_train_6562_entity",
"type": "progene_text",
"text": [
"SPR1"
],
"offsets": [
[
152,
156
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4189
|
split_0_train_4189
|
[
{
"id": "split_0_train_4189_passage",
"type": "progene_text",
"text": [
"BACKGROUND :"
],
"offsets": [
[
0,
12
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4190
|
split_0_train_4190
|
[
{
"id": "split_0_train_4190_passage",
"type": "progene_text",
"text": [
"Invasive tumor cells are characterized by multiple phenotypic changes as a result of the large number of cDNAs being differentially expressed in tumor cells compared to normal progenitors ."
],
"offsets": [
[
0,
189
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4191
|
split_0_train_4191
|
[
{
"id": "split_0_train_4191_passage",
"type": "progene_text",
"text": [
"Expression genetics focuses on changes at the RNA level with the aim of identifying functionally important genes whose aberrant expression in cancer cells is regulated at the level of transcription ."
],
"offsets": [
[
0,
199
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4192
|
split_0_train_4192
|
[
{
"id": "split_0_train_4192_passage",
"type": "progene_text",
"text": [
"These genes were named class II genes and are distinguished from class I genes , which are characterized by genomic mutations , deletions , or other alterations ."
],
"offsets": [
[
0,
162
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4193
|
split_0_train_4193
|
[
{
"id": "split_0_train_4193_passage",
"type": "progene_text",
"text": [
"Reversal of the tumor cell phenotype accompanying normalization of the expression of such genes may be exploited therapeutically if gene expression can be specifically modulated by drugs or other treatments ."
],
"offsets": [
[
0,
208
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4194
|
split_0_train_4194
|
[
{
"id": "split_0_train_4194_passage",
"type": "progene_text",
"text": [
"Considering that genes are coordinately regulated in complex networks , it is likely that the expression of multiple genes can be simultaneously modulated in tumor cells by drugs acting on the signal transduction pathway that regulates their expression ."
],
"offsets": [
[
0,
254
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4195
|
split_0_train_4195
|
[
{
"id": "split_0_train_4195_passage",
"type": "progene_text",
"text": [
"The SPR1 gene is associated with differentiation and its expression is down - regulated or inactivated in malignant cells ."
],
"offsets": [
[
0,
123
]
]
}
] |
[
{
"id": "split_0_train_6563_entity",
"type": "progene_text",
"text": [
"SPR1"
],
"offsets": [
[
4,
8
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4196
|
split_0_train_4196
|
[
{
"id": "split_0_train_4196_passage",
"type": "progene_text",
"text": [
"Analysis of the SPR1 promoter showed that down - regulation of SPR1 expression in breast tumor cells occurs at the level of transcription ."
],
"offsets": [
[
0,
139
]
]
}
] |
[
{
"id": "split_0_train_6564_entity",
"type": "progene_text",
"text": [
"SPR1"
],
"offsets": [
[
16,
20
]
],
"normalized": []
},
{
"id": "split_0_train_6565_entity",
"type": "progene_text",
"text": [
"SPR1"
],
"offsets": [
[
63,
67
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4197
|
split_0_train_4197
|
[
{
"id": "split_0_train_4197_passage",
"type": "progene_text",
"text": [
"SPR1 presents an example of class II genes , since its expression was up - regulated in tumor cells by phorbol 12-myristate 13-acetate ( PMA ) or by ultraviolet ( UV ) irradiation ."
],
"offsets": [
[
0,
181
]
]
}
] |
[
{
"id": "split_0_train_6566_entity",
"type": "progene_text",
"text": [
"SPR1"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4198
|
split_0_train_4198
|
[
{
"id": "split_0_train_4198_passage",
"type": "progene_text",
"text": [
"MATERIALS AND METHODS :"
],
"offsets": [
[
0,
23
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4199
|
split_0_train_4199
|
[
{
"id": "split_0_train_4199_passage",
"type": "progene_text",
"text": [
"The SPR1 gene was identified by differential display on the basis of its reduced or absent expression in human breast tumor cell lines compared to normal mammary epithelial cell strains ."
],
"offsets": [
[
0,
187
]
]
}
] |
[
{
"id": "split_0_train_6567_entity",
"type": "progene_text",
"text": [
"SPR1"
],
"offsets": [
[
4,
8
]
],
"normalized": []
}
] |
[] |
[] |
[] |
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