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BigScience Biomedical Datasets 126

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…nervous system (heart rate, blood pressure, etc.), it is a direct measure of sympathetic activity that is relatively free of any influence of somatic symptoms (respiratory cycles or muscle tone) [Geer, 1966; Corah and Pantera, 1968; West et al., 1983; Jiménez, 1995; Lundgren et al., 2001].

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In another study in the NHS and HPFS (59), we found that lifestyle factors closely related to energy expenditure, such as physical activity and television watching, also interacted with the genetic obesity risk score in relation to BMI, and stronger genetic eff ects were observed in those with low physical activity or more hours of television watching.

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ms attributed to DRA [17], the remaining 59% of this flux would therefore be paracellular and passive.

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They comprised 136 strains isolated from clinical environments; 42 strains isolated from intertidal sand contaminated by Prestige’s crude oil [23]; 50 strains from our laboratory collection, which have been previously studied by multilocus sequence analysis, MLSA [6, 20, 22]; and strain PE, which was isolated from a bioreactor seeded with the commercial compound Putidoil®.

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This study provided further evidence that VTC is a sensitive measure of instability that may act as a control variable in the regulation of upright standing posture (Slobounov et al. 1998; Van Wegen et al. 2001, 2002; Haibach et al. 2007).

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The degree of coronary stenosis was classified from 5 to 0 as follows: 5 for total occlusion, 4 for 75–99 % stenosis, 3 for 50–74 % stenosis, 2 for 25–49 % stenosis, 1 for up to 24 % stenosis, and 0 for no atherosclerosis [4].

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The known homologous proteins for this matrix were taken from the Database of Aligned Protein Structures (DAPS) (Murzin et al., 1995; Holm and Sander, 1996; Berman et al., 2000; Mallick et al., 2001).

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Its NMR data (Tables 1 and 2) also showed great similarity to those of AGI-B4 [7] except for a change in the chemical shift of H-2 (from δH 4.

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The vertical line marks the 6 kHz boundary that was arbitrarily set for manually distinguishing between flat and chevron syllables. et al., 2008; Young et al., 2010; Wohr et al., 2011b) or stress level (Rupniak et al., 2000).

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This is consistent with previously reported results (Levinowitz et al., 1998; Rutkowski and Miller, 2003; Ilari and Habibi, 2015).

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Microscopic evaluation of the brain of the US 2006 H-type BSE case was limited to the obex and complicated by freeze artifact, precluding a definitive microscopic interpretation [18].

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[30,31] using data from the ART Cohort Collaboration and considering new AIDS defining disease or death from any causes as a composite endpoint.

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Coronary flow rate was adjusted to achieve a mean coronary perfusion pressure of 110 mm Hg in hearts from aortic stenosis rats and 75 mm Hg in hearts from control rats, and was then held constant, achieving comparable myocardial perfusion rates per gram of LV tissue in all groups (8,10).

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We fit the LCJ, LCJc, and LCJsym to simulated data derived from each parameter configuration and LCJ decision rule, and to simulated data derived from one parameter configuration using the LCJc and LCJsym decision rules.

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By clustering with lowly aggressive close kin (King 1989a,b; Viblanc et al. 2010; Arnaud, Dobson & Murie 2012), breeding females may decrease the time/energy cost of maintaining territorial boundaries (Festa-Bianchet & Boag 1982; Murie & Harris 1988), which could ultimately lead to increases in net…

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We run our tracking method on 12 challenging video sequences from prior work [5, 6, 7, 3, 2].

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…label, the amount of dye loss from the loaded vesicles was assessed by stimulating the endplates with 1 s trains of either 10 or 100 Hz, with 1 s alternating periods of rest, a pattern that approximates the way in which these junctions would be activated in vivo (Gorassini et al., 2000) (Fig.

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23The fact that players with intermediating roles arise endogenously is in contrast with other models of intermediation, where intermediaries are exogenously assigned to their role, as for example in Rubinstein and Wolinsky (1987), and Blume et al. (2009).

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In comparison, the effect of Skp1 modification on culmination implied inhibition of Skp1 breakdown activity toward a hypothetical activator [10,11], and the effects on cyst formation (assessed morphologically) above suggested activation of breakdown activity toward an activator.

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DOI: 10.7554/eLife.08828 16 of 27 that normally induces dramatic mitochondrial fission (Korobova et al., 2013, 2014).

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Our findings utilizing human materials are consistent with previous studies in murine FHF models in which the administration of anti-Fas antibody resulted in massive hepatocyte destruction (4).

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The system was tested on the 20Newsgroups data set [2] by employing the topic grouping suggested in [4].

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Swi1-Swi3 are evolutionally conserved (Tof1-Csm3 in budding yeast and Tim1-Tipin in metazoan), and these proteins physically interact with Mrc1 (4, 13, 41, 45) and are known to be required for stabilization of stalled replication fork and induction of replication checkpoint (7, 31).

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Sessions were conducted at the same time of day for each participant after a 4-hr postprandial period during which no food was consumed, in accordance with previous studies including that of Carter et al. (2004). Participants were instructed to abstain from alcohol, caffeine, tobacco, and exercise during the 24-hr period before each visit.

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The face database used for building the models was provided by the Max-Planck Institute for Biological Cybernetics in Tuebingen, Germany [3].

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…2000; Wang et al. 2001; Boddaert et al. 2003; Ceponiene et al. 2003; Jansson-Verkasalo et al. 2003; Rapin and Dunn 2003; Rosenhall et al. 2003; Boddaert et al. 2004; Gervais et al. 2004; Kasai et al. 2005; Kujala et al. 2005; Lepisto et al. 2005, 2006; Korpilahti et al. 2006; Tharpe et al. 2006).

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Our results showed that the mean area of blastocysts that did implant and those that did not wasn’t statistically significant, in agreement with previous papers [28] suggesting that blastocysts of similar area have the same implantation potential.

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Similar discrepancies between PCR and culturing methods have been found by other authors (4,8,11) and may result from a low estimate of DNA in the CFU method from unculturable or slow-growing bacteria, nonviable cells, or free DNA.

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Wood and Shepherd (2010), in particular, reported a selective decrease of excitatory input onto layer 2/3 pyramidal neurons, with no change in inhibitory drive.

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For example, Kawato et al. (1990) suggested that movement trajectories can be projected using critical via-points through which the trajectory has to pass at a certain time, rather than in terms of the moment-by-moment dynamics of the implemented movement trajectory.

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Accordingly, time-to-contact measures may yield information about dynamic stability in balance (Patton et al. 1999; Van Wegen et al. 2001; 2002; Haibach et al. 2007) and serve as a ‘‘detector/predictor’’ of future instability.

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However, the broad substrate specificity of the AtPLT5 and the unchanged phenotype of Atplt5-knock-out plants make it difficult to speculate on the physiological role of AtPLT5 (Klepek et al. 2005; Reinders et al. 2005).

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In agreement with other studies (Hakkola et al., 1994; McKinnon et al., 1991; RodriguezAntona et al., 2001; Schweikl et al., 1993), CYP1A2 mRNA expression was detectable in all samples, although it was below the limit of quantitation in two samples.

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We have previously shown that turkey livers possess orthologs to human P450 1A2 and 3A4 which efficiently bioactivate AFB1 to exo-AFBO (Rawal et al., 2010b, 2009; Klein et al., 2000; Yip and Coulombe, 2006).

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Moreover, recent findings in Drosophila suggest that the Y chromosome has an important role in male fitness and also contributes to adaptive phenotypic variation through a regulatory role of Y-linked polymorphic elements in gene expression (Lemos et al., 2008).

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The I-QoL is a 22-item measure of quality of life, specific to stress, urge and mixed incontinence [17, 18].

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1% to 3% of all gastrointestinal neoplasms, with an incidence of 1-20 per million and up to 30% of these are considered malignant [1,3,4].

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, 2009), this synteny was also observed in Salmo salar (Pendás et al., 1994), Oncorhynchus mykiss (Móran et al.

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Multi-kinase inhibitors including imatinib, which blocks RTKs such as c-Kit and PDGFR, have been used in sarcoma clinical trials with modest success [22].

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The viral VP4, VP6, VP7 and NSP4 genes were amplified with primer sets Con3/Con2, JRG7/JRG8 or GEN-VP6F/GEN-VP6R, Beg9-End9 and JRG30/JRG31, respectively (Gouvea et al., 1990; Gentsch et al., 1992; Matthijnssens et al., 2006; Esona et al.; 2009; Mijatovic-Rustempasic et al., 2011), and subjected to direct sequencing using the same PCR primers.

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Our results are in agreement with other studies which reported the presence of plasticizer residues in water stored in bottles [10,12].

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Bayesian (e.g., Brown, Fearn, and Haque 1999; Daniels and Kass 2001) and minimax approaches (Dey and Srinivasan 1985) have been proposed to regularize ̂ by shrinking sample eigenvalues.

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Participants were then investigated on separate days for assessment of whole-body glucose disposal using euglycaemic–hyperinsulinaemic clamps as detailed previously [28].

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b) The average volume-weighted mean glandular volume (VV gl) was performed using the point sampled intercept method [34], that estimates the volume, giving greater chance of volume estimation to structures of greater size.

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We included the latter criterion to mitigate negative responses to questions regarding TB symptoms from women who had just learned their HIV test results [13].

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…and glucose and then were tested, within 10 min of their collection , (a) with the modified Griess nitrite method (Cruickshank & Moyes, 1914; Smith et al., 1961; Smith & Schmidt, 1962), (b) with the glucose consumption detecting test (Scherst6n & Fritz, 1967; Schersten, Fritz & Kohler, 1967).

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Delta Ct values were calculated by subtracting themean Ct of each discriminating gene triplicate from the geometric mean of the three endogenous control genes’ mean Ct values [5].

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…report a lack of significant differences between organically and conventionally grown food in terms of safety and nutritional value, suggesting that crops and livestock products produced in both farming systems are comparable with regard to their nutrient content (Smith-Spangler et al. 2012).

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We evaluate our method over both real and synthetic RDF datasets, and compare our approach with the state-of-the-art distributed RDF systems, including a cloud-based approach (EAGRE [48]), two partition-based approaches (GraphPartition [22] and TripleGroup [28]), two memory-based systems (TriAD [18] and Trinity.

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Although our cohort also consisted of treatment naïve patients with symptom duration of less than six months, we found that IL-21 levels were not elevated in RA patients compared to healthy controls, a finding which is in contrast to the results of other authors (Rasmussen et al. 2010).

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We hypothesize that our observations can be explained by the fact that inactivated X chromosomes can be reactivated as the result of ageing and decreased levels of 5-methyldeoxycytidine (Wareham et al 1987; Wilson et al 1987).

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It has an amino acid sequence close to that of the galanin receptor family (40% identity), although it does not bind either galanin or galanin-like peptide (Lee et al., 1999).

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2012) and Korean (Jeong et al. 2013) herpetofauna and the formation of the “Cold Code” consortium (Murphy et al.

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…to road (Fortin et al. 2005), habitat diversity (Boyce, Mao & Merrill 2003), habitat openness (e.g. Creel & Winnie 2005; Proffitt et al. 2009), snowpack and elk density (e.g. Gower et al. 2009; Proffitt et al. 2015), and predation risk from wolves (e.g. Creel & Winnie 2005; Gower et al. 2009).

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For example, the novel PKCε and PKCδ isoforms were shown to mediate the inhibitory effect of phorbol ester PMA and serotonin on Cl−/OH− exchange, respectively [24, 38], in Caco2 cells.

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We assessed participants’ dehumanization of Arabs by using the Ascent scale of blatant dehumanization (Kteily et al., 2015).

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We observed a monotonically decreased mean activation in node 1 with higher hyperactivity, providing no evidence for a U-shaped model between hyperactivity and BOLD response (20) (Fig.

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There are multiple techniques for identifying protein coding genes that are involved in cancer because mutations that occur in protein coding genes can result in missense mutations, and methods have been developed for identifying which of these mutations are drivers as opposed to simply passengers (Carter et al., 2009; Kaminker et al., 2007; Youn & Simon, 2011).

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This result is consistent with previous studies conducted with nonspecific and specific inhibitors of cysteine proteases (34, 35).

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General symptoms of anxiety and depression were evaluated by the Hamilton Anxiety Rating Scale (HARS; Hamilton, 1959) and the Hamilton Rating Scale for Depression (HRSD; Hamilton, 1960), administered by IEs in accordance with the Structured Interview Guide for the Hamilton Anxiety and Depression Rating Scale (SIGH-A and SIGH-D, respectively; Shear, Vander Bilt, & Rucci, 2001; Williams, 1988), and the self-report Beck Depression Inventory (BDI-II; Beck, Steer, & Brown, 1996) and Beck Anxiety Inventory (BAI; Beck, Epstein, Brown,& Steer, 1988; Beck& Steer, 1990; Steer, Ranieri, Beck, & Clark, 1993).

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In addition, these vaccines may also prevent or reduce transmission of pathogens by reducing tick populations and/or affecting tick vector capacity (de la Fuente et al. 1998, 2007a; Rodríguez Valle et al. 2004).

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The APP response has been observed in common pig infections (Grau-Roma et al., 2009; Pomorska-Mól et al., 2011a, b) but it is not known whether infection with H1N2 swine influenza virus (SIV) also induces an APP response.

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1994; Fora et al. 1996). During the final third of gestation in fetal sheep, Fora et al. (Fora et al. 1996) reported that ovine fetal anterior pituitary cells exhibit a progressive decline in ACTH1–39 release in response to CRH, while AVP-induced ACTH release increases. This is supported by the findings of Lu et al., (1994) that CRH binding sites in the anterior pituitary declined during late gestation in the ovine fetus.

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Both approaches can be applied in a blind manner [3, 7] or by using training symbols [1].

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Other proteins, including synaptotagmin (Matthew et al., 1981) and SV2 (Buckley and Kelly, 1985; Bajjalieh et al., 1992), are components of both small clear synaptic vesicles and large, dense-core vesicles (Kelly, 1993).

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There are some large case series that have reported a low risk of stroke after AF ablation.(39) Although the stroke rate is low in

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The drift was removed because it would produce exaggerated standard deviation (SD) of force values not representative of the fluctuations of interest (39,46).

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Recent work has shown that opportunistic routing is an efficient way to achieve low-latency yet energy-efficient data collection in WSN [24, 26, 38].

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We also apply attribute selection and select the most informative 2,000 terms using Information Gain as described in Altınel et al. (2013, 2014a, 2014b), Ganiz et al., 2009, (2011) and Poyraz et al. (2012, 2014).

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Induction of the complement cascade in the brain, particularly in myeloid-derived cells such as microglia/monocytes, has been shown to be a potentially damaging event in aging and disease [28,29,30,31].

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The late Pleistocene encompassed several Croll–Milankovitch climate cycles that would be expected to produce deep phylogeographic structure in marine species (Avise, 2000).

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However, in humans, MMAIII/V and DMAIII/V are the most relevant metabolites (Cohen et al., 2006; Tapio and Grosche, 2006).

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Cardiac manifestations include atrial or ventricular tachycardia, premature contractions, a prolonged QT interval and torsades de pointes [2].

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The procedures used to evaluate the incidence of fractures are described in detail in the original reports [9, 10, 13].

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As Caldwell and Nittrouer (2013) note, voicing contrasts for consonants may be relatively more resistant to hearing loss than other phonemic distinctions, a fact that has likely contributed to the results we found regarding how well bilingual children with CIs were able to match their peers’ productions when it came to initial stop voicing.

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In many species, rhythmic movements have been proved to be the output of dedicated neural circuitries, the Central Pattern Generator(s) (CPGs1) (Marder, 2000; Marder and Bucher, 2001).

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Despite its abundance in soil, inorganic P (Pi) is least bioavailable for plant uptake due to adsorption, precipitation and conversion to organic forms (Rengel and Marschner 2005).

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We choose a well-studied parallel task scheduling of DAG, DLS (Dynamic Level Scheduling)([33]), as a baseline in our experiments.

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This article aims to identify the putative mechanisms governing changes of activity observed in thalamic cells after cortical inactivation based on earlier experiments and suggested network topologies with special reference to our previous work (Waleszczyk et al. 2005) as one of the few studies investigating the effect of the cortex inactivation on both excitatory and inhibitory cells.

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The United States National Lung Screening Trial (NLST) has reported an encouraging 20% reduction in lung cancer mortality with low-dose CT screening over chest X-ray screening [5].

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The average value of observed heterozygosity in this study is close to that obtained by Yamamoto et al. (2003) at 0.5, and is also congruent with results using isoenzymes (Huang et al. 1994; Pereira-Lorenzo et al. 2006).

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In this experiment, we tested whether lexical competition as reflected in the Gender Number interaction is restricted to freestanding morphemes, as suggested by Schiller and Caramazza (2003), or whether it also occurs for bound morphemes like adjective inflections, as suggested by the results of Schriefers (1993). Participants produced noun phrases consisting of an adjective with a bound gender-marked suffix (exhibiting the same distributional properties over gender classes and number, singular vs.

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…human health [Dockery et al., 1993; Krewski et al., 2003] and visibility [Seinfeld and Pandis, 2006] and can also influence Earth’s energy balance either directly [Intergovernmental Panel on Climate Change, 2007] or through the modification of cloud properties [Twomey, 1977; Albrecht, 1989].

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One study addressed elevated serum cortisol [28], and another reported significant changes in female hormones and leptin [30] during fasting.

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This compares favourably with results reported previously in those treated with open reduction and internal fixation [1, 13].

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The c-met protooncogene encodes a receptor tyrosine kinase that has been identified as a receptor for hepatocyte growth factor/scatter factor (HGF/SF) [77].

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The action of this saline on VSMN spike rate, membrane resistance, and premotor activity was discussed in a previous report (Krans and Chapple 2005).

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PED protein has also been found to be overexpressed in skeletal muscle, adipose tissue, and fibroblasts from type 2 diabetic individuals (1).

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…(1997) model gave us new, logically coherent, but largely ungrounded explanations for describing a previously-identified pattern of change, while Orlikowski (1996) gave us new, grounded, but as yet logically uncertain explanations for both identified and (at that point) unidentified patterns…

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Axelsson et al. (2012) and Auton et al. (2013) obtained estimates of Ne for dogs that differed 4-fold, and Freedman et al. (2014) detected very large changes in effective population size since the time of domestication and in different wolf lineages.

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All four infants had multi-organ dysfunction syndrome [3]; their underlying diagnoses were complex congenital heart disease (two infants), left ventricular non-compaction cardiomyopathy, and congenital dyserythropoietic anemia, respectively.

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Following previous studies [18], for the purposes of these analyses patients were combined regardless of treatment group assignment in the clinical trial.

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The role of receptor phosphorylation and β-arrestin binding in the internalization of M2 AChR and other muscarinic receptor subtypes remains controversial [66].

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across different stages of their life cycle and thus have been proposed as possible causes of jellyfish blooms (Richardson et al., 2009; Dong et al., 2010; Purcell, 2012; Duarte et al., 2012).

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Given that Pro is one of the low-molecular organic osmolytes, Pro accumulation is frequently considered an evaluating parameter for the osmotic adjustment capability of plants under salt stress (Verbruggen and Hermans 2008).

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This last observation is in line with another study that showed that the number and size of polyps influence test accuracy for detection of advanced adenomas [16].

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An ideal day for scheduling OPU was defined by the administration of hCG on the day when at least three follicles reached the size of 17 mm, or with one day of delay (protocol charts 0 and +1), regardless of the type of protocol used, as supported by previous reports (3,9).

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HPLC-UV methods which use PP and LLE as pretreatments were developed to determine baicalin and baicalein in rat and human urine samples (Lai et al., 2003a, b; Di et al., 2006; Zhang et al., 2006; Gao et al., 2007; Zeng et al., 2010).

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The main parameter in muddy, shallow water environments, where food-supply is much higher than in the deep-sea, is the availability of oxygen [van der Zwaan et al., 1999; Jorissen et al., 2007].

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In humans, this phenomenon is manifested in reduced motivation for work, friends, family, and monetary gain (e.g., Goldstein et al., 2006, 2008; Jones, Casswell, & Zhang, 1995; Nair et al., 1997; SantolariaFernandez et al., 1995).