Datasets:

bigbio

/

scicite

like 1

Follow

BigScience Biomedical Datasets 126

4fa6bc9e73e52f4e7a4f165b2f4799eb05c31aa2>fc6f38bd4724635723ffe8518f2be1a8f3085ea5_13

4fa6bc9e73e52f4e7a4f165b2f4799eb05c31aa2

Still, the majority of speech apraxia cases do not seem to carry causal mutations in FOXP2, BCL11A or ERC1 [6, 11, 12].

d8a0715ca3e004b4e92f4ebf02ef39c45106ec50>15d47a35e929ec108f47d8dcfd07b2de0c064b10_1

d8a0715ca3e004b4e92f4ebf02ef39c45106ec50

, 2002) and hydroxypropyl methylcellulose (HPMC) (Kushida and Gotoda, 2013; Miyazaki et al., 2011) or enteric polymers such as hydroxypropyl methylcellulose phthalate (HPMCP) (Miyazaki et al.

560c67b8d5c6e4b2809fbbd308d373366241ea86>b0fe8d2727db77f58bc430fef29aba3308ecd3f2_17

560c67b8d5c6e4b2809fbbd308d373366241ea86

Our previous report showed that the corresponding lysine residue of T. thermophilus acyl-CoA synthetase was also propionylated (Okanishi et al. 2014).

731f4b9498ec9276c76f8bf1e3c32a50eb9394ab>a4cf4bb41fb0b6fa978fd1456e86308218c8e882_10

731f4b9498ec9276c76f8bf1e3c32a50eb9394ab

The non-trivial baselines were two n-gram models, adopted from previous goal recognition work (Blaylock and Allen 2003; Mott et al. 2006).

4d9170a8daa2f40530580a24e8490f569eaf15d7>d6eaf36357406cc26c09d36fc88d8974ba49807d_5

4d9170a8daa2f40530580a24e8490f569eaf15d7

suggested that there was little evidence of the contribution of methylation to downregulation of miR-99a [10].

84ec5cac47cae049137ac5b4a945324c7f1db71a>a563aac4a9f97ca6424b89c6ce534094263ca911_11

84ec5cac47cae049137ac5b4a945324c7f1db71a

However, the real contribution may be substantially greater than this if, as has been shown previously, respondents tend to over-report their physical activity using IPAQ [28].

a7351077ac15746925f8b846ca1f396c2a7e06fc>a97bddd90d80b36b6a9d8ab9214c8d80e584cd5d_5

a7351077ac15746925f8b846ca1f396c2a7e06fc

SIFT uses DoG function to identify the potential features and it uses 128-dimensional vector to store the feature vector.

448760e5c8eb9268abab275ab995400fcf8c94de>5ac7acc8b972ef64be1227e1d51252ab2ec47701_6

448760e5c8eb9268abab275ab995400fcf8c94de

014 roviding important information for surgical management nd postoperative outcomes for patients with ERM.(5,6) pectral-domain OCT (SD-OCT; also known as Fourieromain or high-speed OCT) is a new technology that has een demonstrated recently.

e3450e8ca6d743f04a1ad41297ab59eeb82299b4>b5fcda6fd9a47d7ef14b8e3e8c80c00fde1b990a_0

e3450e8ca6d743f04a1ad41297ab59eeb82299b4

Unlike Bcl-2, which is highly expressed in naïve and memory T cells and rapidly downregulated after T cell activation, Mcl-1 expression is strongly induced after TCR stimulation (Dunkle et al., 2011; Opferman et al., 2003).

098b03fa2d4f68c227d8046720bcbe170497618c>8fde490964c88088536693cbe2077a49aa34eca0_0

098b03fa2d4f68c227d8046720bcbe170497618c

multiple equilibria, see Albanesi et al. (2003), King and Wolman (2004) and Blake and Kirsanova (2012), and a simple New Keynesian model is not appropriate to investigate many consequences of policy delegation.

1c4f0ef8445e44f2b3155bc1e9597b64a53160ca>cd9427fb58862d2aa21c522ef2b070ac26100af2_0

1c4f0ef8445e44f2b3155bc1e9597b64a53160ca

The apparent disparity between physiologic and neurologic/ fetotoxic effects of PCP on mortality and morbidity is consistent with previous studies of PCP [20,29,36].

cfb8d1580c6b099ddb7e575b48b35868eb2d1c03>3b05b86247b92bcac943e77fd2ae3a5c1e770f7b_0

cfb8d1580c6b099ddb7e575b48b35868eb2d1c03

These results are in agreement with phylogenies previously reported for AGT sequences (Chen et al., 2008;Wong and Takei, 2011; Umasuthan et al., 2012).

be9a51c999f8cb2514e16ee00b7fc5d47f53fea7>45ff42e8ed2d8e7bb29919d87bf647b20cfea6fc_3

be9a51c999f8cb2514e16ee00b7fc5d47f53fea7

We compared these patient experiences to those of patients with chronic disease that had received in-person post-test genomic counseling in a parent study randomized controlled trial (RCT) [18].

2ac4af430442bf68bd401e613e9df5b29df4c7aa>f1f4c4f5925215ab27570f1040b1b9c95b507948_2

2ac4af430442bf68bd401e613e9df5b29df4c7aa

Specifically, we compare our methods against V-MDAV [35] because it is the most similar method to MDAV and its variant CBFS.

86eb5358afd5e968fb6674934eb4b1a52a45ceec>1947fa607eb4f60ea2c26cf0bd789618734d94ef_0

86eb5358afd5e968fb6674934eb4b1a52a45ceec

The clinical trial protocol and the flow cytometry staining and analysis procedures used to acquire data in this study have been described in detail elsewhere [8,33].

8735aab66f4b9bf85e187df23a806a1c00ae7e91>6dc497b7048b936dd0b1907ac49be2ad519f8b23_0

8735aab66f4b9bf85e187df23a806a1c00ae7e91

Down’s syndrome cell adhesion molecule (Dscam) has been shown to regulate dendrite self-avoidance inDrosophila (Hughes et al., 2007;Matthews et al., 2007; Soba et al., 2007) and mouse (Fuerst et al.

21dbf449ff5b39e1dc4b65fb87eaa7e8abc3ae83>b8d851c0cdeb3996ce634a2f75c9f30bd91389cb_2

21dbf449ff5b39e1dc4b65fb87eaa7e8abc3ae83

…of corticospinal projections from the site of stimulation, indexed by reduced amplitude of motor evoked potentials in relaxed hand muscles (Chen et al., 1997; Maeda et al., 2000; Touge et al., 2001; Romero et al., 2002; Tsuji and Rothwell, 2002). rTMS at 1 Hz reduces the amplitude of the…

65d4de92fa86bfc182feced6c440382d9bc8d4e2>540ce47e26a5dd033bfb19a9d4429c739f7dd611_5

65d4de92fa86bfc182feced6c440382d9bc8d4e2

QUERI researchers’ use of HIT was concentrated in five distinct areas: (1) clinical decision support systems (CDSS); (2) HIT tools targeted for specific users; (3) telehealth applications; (4) design and maintenance of VA-wide databases; (5) integration and innovative use of extant VA-wide data (Table 2).

dcb5d895640dd00da0d95686b9832ec4457df1cf>2b2e1988c794a5362bd48f3204ec565725d11c0a_3

dcb5d895640dd00da0d95686b9832ec4457df1cf

This was followed by multiple pediatric case reports [9, 13, 15, 21, 23] and combined adult and pediatric series [16, 24, 27].

d9d512655e9ef7bf1d2898150c1ad7e2964717db>c5a23b594780b11d0671e98624b52c3c97ff3fb6_4

d9d512655e9ef7bf1d2898150c1ad7e2964717db

These domains comprise verbal fluency (Triggs et al., 1999; Fabre et al., 2004), attentional control (Vanderhasselt et al., 2009), reaction time (O’Connor et al., 2005; Bloch et al., 2008; Vanderhasselt et al., 2009), executive functions/working memory (Martis et al., 2003; Bloch et al., 2008),…

b45e9c37ce7d2264d52fad7714f537c8bb4c2ee2>daf7dea2d63b94db589a516c297f9867ff1d26f7_2

b45e9c37ce7d2264d52fad7714f537c8bb4c2ee2

The epidemic curves in the Montreal network occasionally exhibit multiple peaks, driven by underlying community structure [56].

28362d02d8050a32d988122d469cd48b68d904ab>e60d620109d2c26c56aec1f8f042fe30c9333092_1

28362d02d8050a32d988122d469cd48b68d904ab

A similar degree of desensitization was found in adolescent animals, a developmental time period in which the PFC is vulnerable for long-term adaptations induced by nicotine (Counotte et al., 2011b; Goriounova and Mansvelder, 2012a).

01860852775e86decfd6358a7ee469cef8d1487e>bc93349c6b16c1a27f8531d35aabedac62f72e0e_0

01860852775e86decfd6358a7ee469cef8d1487e

Interregional GABAergic neurons have been described also in the adult isocortex (Gonchar et al., 1995; Fabri and Manzoni, 1996; Jinno and Kosaka, 2004; Tomioka et al., 2005; Apergis- Schoute et al., 2007).

af5d6fe5daa2b7ec7482a2e5fbe27929a1f14de7>f75e422caae42a7fabd1e6117a72bed4d54cc709_8

af5d6fe5daa2b7ec7482a2e5fbe27929a1f14de7

…degree of FA unsaturation in skeletal muscle membrane PLs has been shown to correlate positively with insulin sensitivity (Borkman et al., 1993; Pan et al., 1995), whereas the proportion of 16:0 in both skeletal muscle PLs and TGs correlated negatively with insulin sensitivity (Vessby et al.,…

e62486151d4cdce40cfc63b3e6a0d5344e755388>a415d8d67d6e604038256e4de700466fc1acedba_3

e62486151d4cdce40cfc63b3e6a0d5344e755388

However, luciferase gene expression from the IFN-stimulated Mx1 promoter or the SV40 promoter was reduced by PR(1-80)Tx(80-239) but not by Tx(1-80)PR(81-230) (Fig.

2827092a537f0f9bd91505569c95a9280dfeffa5>5d62b0f89d694e6c7fd7e9b9e1e763b59b189f82_3

2827092a537f0f9bd91505569c95a9280dfeffa5

Since a NO donor relaxed the pylorus in vitro (17) , NO could be the putative NANC inhibitory neurotransmitte r at the pylorus.

7defa9a85a97751fbb94a982d0e3ddc0a0fa14f0>02a2201ea91687ee01a868451a79cddca194f9e9_7

7defa9a85a97751fbb94a982d0e3ddc0a0fa14f0

With neurodisruption techniques, it is now established that both SEF (Stuphorn and Schall, 2006) and IFG (Chambers et al., 2006, 2007) are critical for inhibitory control.

1f67735acd308c13fc4225265d6fae0d38561a4c>09e94bf6d4c553a350b6c501912f47e526c9bd17_2

1f67735acd308c13fc4225265d6fae0d38561a4c

As the T99 mutant was rendered unable to grow on 4-CP by an insertion of a transposon into a hydroxyquinol 1,2-dioxygenase gene, the results suggest that cleavage of hydroxyquinol is a vital part of degradation of 4-NP and 4-BP as well as of 4-CP (Nordin et al. 2005).

3df2451a1d7cc15c131bda91aa286acc37b37fbe>4e14f99e3730f8240149893b3181e62b7a7c04e8_0

3df2451a1d7cc15c131bda91aa286acc37b37fbe

These results appear consistent with PCR amplification bias favoring GCneutral content as previously documented for RNA-seq data (7, 17, 65).

0b37ac4deff5ecdf1ea165551c454f30f2e2716e>5f1c1f1ae2bad91e1cfa45e29df8295430dc95fc_0

0b37ac4deff5ecdf1ea165551c454f30f2e2716e

Nowadays, there are only a few studies that have a systemic view on these accidents (Bentley 2008) and which try, by using detailed analysis (Gao and Abeysekera 2004, Leclercq and Thouy 2004, Bentley et al. 2005, 2006, Derosier 2005), to enlighten contributing factors and root causes involved in…

b9b5e0040ebe59586fdf426a1af642bc3d29fd60>4263868c3cefb055f798455b7e84984e92bd8b29_0

b9b5e0040ebe59586fdf426a1af642bc3d29fd60

…I analyzed these data using a multi-level mixed-effects linear regression (GLMM, lme package in R software, 2.7.2, Foundation for Statistical Computing, R Development Core Team 2008), which uses t-tests to test the null hypothesis that a coefficient equals 0 (Bolker et al. 2009; Crawley 2007).

a3ab23f7c76decce6b45696fb09ef8ea538df866>03a7146d3b138976303eabebbf6b9cb04172c5ac_0

a3ab23f7c76decce6b45696fb09ef8ea538df866

It has been previously reported that chronic exposure to glucocorticoid can inhibit gonadotropin (LH and FSH) secretion as evidence by decrease responsiveness to administered GnRH and subnormal plasma testosterone.(16) LH is the hormone involved in the regulation of the steroidogenic acute regulatory (StAR) protein that deliver cholesterol to inner mitochondria for steroidogenesis in the Leydig cell.

271adbb419c95de9b4634a630082299b1a40ecc9>979f71be62cb9612690e46494dd65a6ce8db05e2_2

271adbb419c95de9b4634a630082299b1a40ecc9

On the other hand, the conservative treatment is more often complicated by re-rupture of the Achilles tendon [14, 16, 31].

a2ee878f61f002360c8e14fb00f370e04ae55c2e>6c0ee4328c9bef9d3f94ff45976711a3737c19f5_4

a2ee878f61f002360c8e14fb00f370e04ae55c2e

Amplicon preparation, sequencing and data analysis were conducted for all 44 samples as described previously (Hospodsky et al., 2012).

bf76273127eb57c35ffb2c708e3df7e5f9e9115b>fc5c9fde1703d262d0208928a4549aef67706d4f_3

bf76273127eb57c35ffb2c708e3df7e5f9e9115b

The cause is the direct effect of the antigen-antibody complex that triggers an inflammatory cascade mostly mediated by cytokines Th1 [17, 19].

c2fc5a359d12b3fbf7bc7a0262032369dcca6f3b>7f8cc06f8b9b184bbe667f41cdb5f51dea5836b6_0

c2fc5a359d12b3fbf7bc7a0262032369dcca6f3b

Nevertheless, podocytes have been shown to possess a differentiated amino acid transport system [73] including vesicular glutamate transporter [74, 75], and recent findings reveal more and more similarities between podocytes and neuronal cells.

b2ed3cc8f4621e47413f56cb328ca15aaff6bb00>None_0

b2ed3cc8f4621e47413f56cb328ca15aaff6bb00

Our results are in agreement with the findings of a study in Brazil which also calculated low internal radiation doses for granite industry workers (Estellita et al 2010).

33ce87f465e800c0fd5b078641a663a02fc1451e>7556064a9a5192a0df0160539f4ba5ee11b3c2f2_7

33ce87f465e800c0fd5b078641a663a02fc1451e

Previous studies indicate that jellyfish planulae have different substrate choices and settlement preferences between natural and artificial materials (Holst & Jarms, 2007; Hoover & Purcell, 2009; Duarte et al., 2012).

8ad6f4477cfeaa135e44c473b34f04ff0c58e04f>25abfe33c3460d63f1b9695695f3dfc15da1e2c7_5

8ad6f4477cfeaa135e44c473b34f04ff0c58e04f

Our proof borrows heavily from the work of Hori, Herbst and Page [5], in which they give a detailed physical argument for a generalisation of Orlov’s result.

9ff6db42efd365601a002bf43e53fe0a132099c0>df0f4951a1f285d9639ef5590260dbc61f204e9b_2

9ff6db42efd365601a002bf43e53fe0a132099c0

The coordinated formation of each of these components is crucial to synaptic function, and genetic studies have revealed multiple conserved pathways that control their development (Collins and DiAntonio, 2007; Harris and Littleton, 2015; Menon et al., 2013).

45701ff05d3ed583a658f18aa998944c1d4eee7a>f89d87e5f4d58e9bb7d576ec6ae34a84240b9c5e_6

45701ff05d3ed583a658f18aa998944c1d4eee7a

The average magnitude of the NBR increases with increasing stimulus intensity and duration (Klingner et al., 2010; Shmuel et al., 2002), suggesting that NBR reflects neuronal inhibition required to optimise task performance, by reducing sensitivity and allocation of processing resources to the unattended or irrelevant part of the sensory field.

2b6f7a4b0a17fbe26bd2c5a86c209aefe9ab90cb>37d4f42e18a8d092a646dd7f378c6232d2dc9a1d_3

2b6f7a4b0a17fbe26bd2c5a86c209aefe9ab90cb

…for multiple bands is that chick brain contains at least two BgtR subtypes because of the expression of a8 subunits (Schoepfer et al., 1990; Gotti et al., 1992, 1994; Keyser et al., 1993). a8 subunits, which are highly homologous to a7 subunits, are not found in mammals (Elgoyhen et al.,…

9ce776353adb946702980fe4b5c39fccd4867b65>5c943f4b843f7cc6a14d8a8a60fb1f36f0930daf_1

9ce776353adb946702980fe4b5c39fccd4867b65

Even though many studies about complications following transpedicular instrumentation have been reported [2, 11, 17, 20], the possibility of adjacent superior facet joint violation that may lead to instability, which can bring about adjacent segmental degeneration, has not been studied in detail.

ac98889274074aaffe68806613f94400764cc392>e79c496d57be7fd821df67996a40c5579ed81450_2

ac98889274074aaffe68806613f94400764cc392

Several studies revealed redundant and essential roles of both, class I and II HDACs, in multiple levels of development and tissue patterning (De Rubertis et al., 1996; Shi and Mello 1998; Lagger et al. 2002; Brunmeir et al., 2009; Pillai et al., 2004).

21bd7d69cc8b712ccb6fc542c09bc4401dd43570>f400a5c8b531455faae6ed2bfac2093fad8c6c4d_0

21bd7d69cc8b712ccb6fc542c09bc4401dd43570

TPC, TFC, FRAP, DPPH, and ORAC values were slightly different from, but comparable to, values in other reports (Cardador-Martinez et al., 2002; Heimler et al., 2005; Xu et al., 2007).

b9f994187b3953bb4ba99b08697bbf0023eede33>4feb0f5510707d867363861379a12c01e7ac9181_2

b9f994187b3953bb4ba99b08697bbf0023eede33

In preliminary implementations of SSEhunter, the identified structural features have been used to establish virus evolutionary relationships (Baker et al., 2005) and compare ion channel structures (Ludtke et al.

2e01fd3af50f2f962f8b98714255a3abb9ad70a5>4898abe63e8cce53cd50415f7bc86faad0ff9061_5

2e01fd3af50f2f962f8b98714255a3abb9ad70a5

Because previous work [10, 9, 5] has found strong diurnal patterns in traffic matrices, the third generation methods we study assume that when flow monitors are turned on, they remain on for 24 hours.

0f84c971755c6d9321b071c4ed1ee640329da199>0f764f578269760d51d8f888100e9e3cf00a0e5c_1

0f84c971755c6d9321b071c4ed1ee640329da199

Chen (2001) developed a new FMADM approach for resolving the DC location selection problem under fuzzy environments based on a stepwise ranking procedure.

04e959adbd781234e5d32b697360f0ed72c97325>62d0a9a77ec3056185d85e8f0cc04b07b72981fc_0

04e959adbd781234e5d32b697360f0ed72c97325

Chlorhexidine has previously demonstrated an antibacterial spectrum that includes most of the microorganisms present in the oral cavity, such as Gram-positive and Gram-negative bacteria, bacterial spores, lipophilic viruses, yeasts and dermatophytes [7].

dd0f9c1a4bbc3458d03f3b3d070ecb1b86bd232b>76df956618732c2a7813a09924d997af6b743b7a_7

dd0f9c1a4bbc3458d03f3b3d070ecb1b86bd232b

This database has been updated with a yeast three-hybrid (Y3H) screen for MADS-domain proteins (Immink et al., 2009) using SEP3 as the third interactor.

ccb47434223fcbd343e5f9c891fce890247b4982>3c676680d78d9ff2b44bb565185e05d51c6da902_1

ccb47434223fcbd343e5f9c891fce890247b4982

…94 Hart et al. 2003 [17] Manual postop xray 60 70 Hart et al. 2003 [17] Manual postop xray 60 93 Matsumoto et al. 2004 [27] Manual postop xray 30 67 Tillett et al. 1988 [42] Manual (IM) postop xray 25 92 Tillett et al. 1988 [42] Manual (IM) postop xray 25 92 Tillett et al. 1988 [42] Manual (EM)…

e934e9795fa0a7a69d861bd19c988bd0b027f746>c2acbe1582e1147d4fe4aa9ca1d8473cefe40b6f_4

e934e9795fa0a7a69d861bd19c988bd0b027f746

A 3-day duration of UUO was used, as both AT1 and AT2 receptors are abundant in the kidney at this age and renal AT2 expression falls rapidly in the neonatal period (27, 48).

69b6f12f183acc83abda96fc73a67e2f14b06fd6>cbaa08a512344a4389f1f86394030098c4c94201_3

69b6f12f183acc83abda96fc73a67e2f14b06fd6

We reasoned that drugs that alter chromatin, such as 50Aza and TSA, might be effective at disrupting Cdkn1c expression when epigenetic marks are consolidated (Bhogal et al., 2004; Umlauf et al., 2004).

0f811605238713a03a80e3b2c7ee0b4209648985>3b27aa570198f8dc86c4a0aaf4befe1bdac3aa3c_0

0f811605238713a03a80e3b2c7ee0b4209648985

Insulin sensitivity was measured using the insulin sensitivity index of Matsuda, a wellestablished measure of whole-body insulin sensitivity [16].

00eea3644491b0fcf74c49aa211fa2a24a6e3d3e>2271b873cf8e52856c38eae82751d2b1421007c5_4

00eea3644491b0fcf74c49aa211fa2a24a6e3d3e

The discovery and characterization of new tick-protective antigens is important to improve existing vaccines for the control of cattle tick infestations (de la Fuente et al. 2007a).

0388ab26736d8c5cbb4ae7a309699bb1c5ca780a>72671f894477b6f275504d3e8187845ca363fe4d_1

0388ab26736d8c5cbb4ae7a309699bb1c5ca780a

SM/J individuals tend to be more responsive to the effect of a high-fat diet in relation to body weight, fat depot weight, organ weight, basal glucose levels, and triglyceride levels [23,24].

599de37e6628fd9e2f42eff08de73e85fc9e3e10>d55c95cedf9904a2776b682518c24b4d4d96bec7_15

599de37e6628fd9e2f42eff08de73e85fc9e3e10

spatially localized faulting that characterizes ribbon structures [Hansen and Willis, 1996, 1998, and references therein; Ghent and Hansen, 1999].

ac5fb99eda6b95e9703bb3d93417df5f7373e662>e9891d090394b105cc1a6a85ccf55253ca96728c_1

ac5fb99eda6b95e9703bb3d93417df5f7373e662

The proportion of laboratory confirmed cases (n = 3634) among clinically diagnosed cases (10,966) is about 30% [25].

c89c24eeb1d89b053434636c27d263c19bd3f3d1>705be404cc29f8bc30fbfc45f5ff79657a037b90_0

c89c24eeb1d89b053434636c27d263c19bd3f3d1

Thirdly, ErbB-3 is characterized by a defective mechanism of clearance from the cell surface (Baulida et al., 1996; Pinkas-Kramarski et al., 1996): instead of ligand-induced internalization and degradation in lysosomes, a mechanism shared by many growth factor receptors (Sorkin and Waters, 1993), ErbB-3 is destined primarily to enter the recycling pathway (Waterman et al.

88edbd25bbcb41311a5eb7553c9439c72f7bbc3f>8934adb4658ebb3061494086087f5428699feb3d_3

88edbd25bbcb41311a5eb7553c9439c72f7bbc3f

Then, the 29 pixels whose NDVI values were greater than 0 and less than 0.2 were seen as non-vegetation pixels (Tsai et al., 2007; Noujdina and Ustin, 2008).

db486cf03240d6c95e37c5f0c07aa8fdee83e7c0>82fdcd159acec2029a3168d22546ebd684c83a4c_0

db486cf03240d6c95e37c5f0c07aa8fdee83e7c0

As shown recently, a different member of the Krueppel-like factor family KLF4 demonstrated a potent antiapoptotic effect upon HDACi treatment which was mediated in part by direct binding and transcriptional upregulation of p57 followed by inhibition of the stress response phosphorylation pathway [42].

4dce430c34595c89fc878bd0c47f64f4ef2feb47>b04f0343c6feff16f8d846c2ca840f5416c2d7fc_9

4dce430c34595c89fc878bd0c47f64f4ef2feb47

…isoforms, despite the use of different experimental endpoints such as production of inositol phosphates (Brauner-Osborne and Krogsgaard-Larsen 1999), competitive binding (Green et al. 2000; Kaupmann et al. 1998a; Malitschek et al. 1998) or coupling to Kir3 channels (Kaupmann et al. 1998a).

a8631ba39f7b793821f3826561c75c8760c63ecc>8171e6651c80359e878f31d290825064a7430c9c_1

a8631ba39f7b793821f3826561c75c8760c63ecc

It was found in (Hulse et al. 2007) that the effectiveness of re-sampling for imbalanced learning depends on the evaluation metrics and base learning algorithms.

4445cba251a0c983b76acb84d3c48ca8713c65b9>b83fc70119b548fbd5ad03093eb3add669c8716a_2

4445cba251a0c983b76acb84d3c48ca8713c65b9

Thus we selected BG01 and HUES-7, which were independentlyderived at BresaGen (Mitalipova et al., 2003) and Harvard University (Cowan et al., 2004) using different embryo culture, inner cell mass isolation, hESC culture and hESC passaging methods.

9c9f73003a613a0dee6200f126ff6edce0698087>1c5920abffd5b81e806791fee2aa00a8c49dacf5_2

9c9f73003a613a0dee6200f126ff6edce0698087

We tested different classes of corrector molecules such as corr-2b, corr-3a, corr-4a, corr-4b (Pedemonte et al., 2005), VRT-532 (Wang et al., 2006), and VRT-325 (Loo et al., 2005) for their abilities to inhibit cross-linking of L339C (TM6)/F728C (TM7).

b15d584464aabf4634e16b765db97cbf617b4318>5dbe84872b42cb6167d3b601fdf68b4eb2d7f5d9_0

b15d584464aabf4634e16b765db97cbf617b4318

To demonstrate the effectiveness and applicability of the proposed approach, we generated independent and anticorrelated data sets by using the same way that has been used to generate the datasets in [5].

5f417cb6e084469b2d73711e22fba968129f376c>822d893bc364223159884c77225e2aec6f42b5e8_0

5f417cb6e084469b2d73711e22fba968129f376c

Cross-talk between JA and SA signalling has been described in response to various attackers (Beckers and Spoel, 2006; Stout et al., 2006; Koornneef and Pieterse, 2008).

7ec102746b50af4549ff328e649f7c9c875bcd2f>3da8310618b8d9488ab6d6ee10bfcce927a47891_1

7ec102746b50af4549ff328e649f7c9c875bcd2f

Six cortical fields each contained a separate representation of sound fre- quency (2–32 kHz), and the range of BFs mapped in all regions covered the range of pinna-related frequency and ILD cues in the rat (Koka et al., 2008; Tollin and Koka, 2009).

b603e41fe01e780dc3320ff0245005e193afe17e>fa7c45877a011892020fb5362cef514266ec8802_2

b603e41fe01e780dc3320ff0245005e193afe17e

SNX27 however, possesses a unique PDZ domain involved in alternative cargo trafficking (Cai et al., 2011; Gallon et al., 2014; Lauffer et al., 2010; Lunn et al., 2007; Steinberg et al., 2013; Temkin et al., 2011; Valdes et al., 2011; Wang et al., 2013), and our results now suggest an additional unique property of this protein with respect to lipid headgroup association, interacting with PtdInsP species not bound by the other family members.

cf82d977a64226a15cca9fc0eea7de1e0078ce29>efe167e81022b9fb2b41ea7de996515c26f94838_18

cf82d977a64226a15cca9fc0eea7de1e0078ce29

Because antibiotic inhibitory interactions can be highly specific among Streptomyces isolates (Davelos et al., 2004a; Vetsigian et al., 2011), the benefits of producing a single antibiotic may vary across communities.

91fbf2dde0effb33bfc88008decf43476dbb08ed>06e8eab4c7673fe38fd7dfea8879712a71e3a537_2

91fbf2dde0effb33bfc88008decf43476dbb08ed

We demonstrate that a spatial registration strategy of pooling all data disregarding disease status or scanner (study site and/or MFS) produces results with the greatest validity in terms of biological plausibility (Frisoni et al., 2010).

ee07dc6478c8399acbd07ec4a6d4c1fd5d17e455>028fcece1dd0472dbe12dc00ac3f77161643b98b_5

ee07dc6478c8399acbd07ec4a6d4c1fd5d17e455

…of a relatively larger area or volume (Alidaee et al., 2009; Beard et al., 2006; Bertuccelli et al., 2004; Gancet et al., 2005; Kovacina et al., 2002; Kuiper and Nadjm-Tehrani, 2006; Lawrence et al., 2004; Merino et al., 2006; Parunak et al., 2005; Richards et al., 2002; Sauter et al., 2005).

e05b26ad09151f4a5906b933ec809042b3c3699a>4817870f65d589e91410d0abbe420b16cf490f65_0

e05b26ad09151f4a5906b933ec809042b3c3699a

This result is consistent with the reported trend of providers ordering testing of more genes per patient.(25)

0eae0a403f24f8ff891d923b4937c32925c9367d>0dc2e84b91c3078be63471aa396019a1d6db033a_0

0eae0a403f24f8ff891d923b4937c32925c9367d

the additional foreground 1SVMs help our algorithm remembering the detected foreground appearance, and as a result, lead to better performance than previous work using only local background models such as [18, 5].

68150da5b1ef20cf9ab8baa217f8588ba1cabcc6>e531b9821e39c1e1aa2df1641774ba31af736913_0

68150da5b1ef20cf9ab8baa217f8588ba1cabcc6

Those with alcohol dependence ever in lifetime met at least three symptoms of maladaptive pattern of alcohol use leading to clinically significant impairment or distress (Sheehan et al., 1998; American Psychiatric Association, 2000).

fc7ea9adaeed2e4bdab43680a5520375d652ac7a>77e9ac044b4b6ec83072633cde0d5367213e035d_0

fc7ea9adaeed2e4bdab43680a5520375d652ac7a

lalandi transcriptome sequences (YTK002, YTK008, YTK011, YTK017 and YTK019) [3] and three loci (Sdu21, Sdu32 and Sdu46) validated from the literature [18, 19] were used to genotype the experiment fish for parentage analysis in this study.

55c48343a8b4a4bdd74d1c93b2b5181216faffbd>033e3fe75da26d8d3dd3cb0f99640181655e6746_1

55c48343a8b4a4bdd74d1c93b2b5181216faffbd

Recent papers [6], [14], [15] show that spatial max and average pooling of feature maps output by intermediate convolutional layers is an effective representation, and higher performance can be achieved compared to using fully connected layers.

3f9329351c516e7547a1f0680d1b6153b0cfd9a1>7a5a34fc4b4d812b86e96f218f408b4b555f656a_4

3f9329351c516e7547a1f0680d1b6153b0cfd9a1

2, as well as our implementation of the algorithm introduced in [16], is freely available at http://www.

2b17452f6a3f4091902d181399299538b299bf14>c1bb9e5e9c34fc42c66382fb0215a2ee0d588201_1

2b17452f6a3f4091902d181399299538b299bf14

…neural network connectivity between brain regions increasingly has been proposed as a key characteristic underlying memory deficits in amnestic mild cognitive impairment (aMCI), which has a high risk of conversion to Alzheimer's disease (AD) (Bai et al., 2009a, 2009b; Sorg et al., 2007).

1e11c6990fcdafb27cfec935b00526257ef2de14>e4176d76459bf7ae2601a8746620899ba349aae2_2

1e11c6990fcdafb27cfec935b00526257ef2de14

It has been reported that various mechanisms such as telomere shortening, histone modification, DNA methylation and miRNA expression affect the proliferation and differentiation of MSCs, resulting in cell senescence (Bonab et al., 2006; Noer et al., 2006; Wagner et al., 2008; Zhang et al., 2008; Bork et al., 2010).

56c2794eba69df4549556ed24833df76ede12f45>833bba2167563b8b083480009caeaa24dc4f507a_0

56c2794eba69df4549556ed24833df76ede12f45

The contamination of ground and surface water by As from soils and sediments represent significant threats to human health (WHO 2004) and, consequently, it is essential to fully understand the transport characteristics of solid phase As (Zhang and Selim 2005).

48d24a4c63f06b306636115311fa35061198ec83>3de03b9725894afb73d6d59a5e9f060ed4003dc7_1

48d24a4c63f06b306636115311fa35061198ec83

This co-activation of the tongue protrudor and retractor muscles is particularly significant, as this has only been reported in the isolated rodent UAW [3].

cf41558802e944b52306037ebf4e21989526193c>501d99e392783e4acafb220136d32ea68a921282_0

cf41558802e944b52306037ebf4e21989526193c

We trained the ve di erent merged architectures described in gure 2c-2g ve times for ResNet-164 and for DenseNet100-BC.

aa2cd9d04362b7c84602e3fd6b0b0d91b945fb87>932de154c10090d21334811fd0b867ebb9d9dcff_2

aa2cd9d04362b7c84602e3fd6b0b0d91b945fb87

We need to look at the sign of a few derivatives to identify the impact of an increase in risk, which implies some calculations (Nishimura and Ozaki, 2007): sign of 2

23d24382c737a9c5c33681a1dbc405205eb081c6>2041cf896a34f537bbb1bb017a602944ea503840_5

23d24382c737a9c5c33681a1dbc405205eb081c6

Mutations in ATRX result in loss of ATRX protein by immunostaining and are thought to mediate loss of function (1).

28767016435c869e1d3216eec91fcf0795babb70>4da9dc98c630fb2d09fcee4d6e22e7ea9fc1c1bc_0

28767016435c869e1d3216eec91fcf0795babb70

Pupillometry has been proposed as a simple and sensitive tool to detect subclinical autonomic dysfunction [30,31].

1c6b446bc13a454686b6c3872a78fa9c0760677b>815bd94807ff43a3f3a4f361e5b21e3f7a63556d_14

1c6b446bc13a454686b6c3872a78fa9c0760677b

…back-propagation learning, Mixture-ofExperts (ME) model (Jacobs et al., 1991; Jordan & Jacobs, 1994; Jordan & Xu, 1995) and its alternative model (Xu, 1998a; Xu et al., 1995), as well as normalized RBF nets (Moody & Darken, 1989; Nowlan, 1990; Xu et al., 1994) and its extensions (Xu, 1998a), but…

a45ef83360eb53c5afd80c1ef69be5a85ba4acdc>a630d74b6376217a1e51f6c3f22c781bb04c3ce1_0

a45ef83360eb53c5afd80c1ef69be5a85ba4acdc

Furthermore TGFβ is the only inhibitor of myogenesis that does not stimulate myoblast proliferation (Florini et al., 1986; Massague et al., 1986; Olson et al., 1986).

b8a18619f2a81108397e4fbd5faba89e29755dc0>94660605276e5907b7eddc185f931fd9dc8e483e_1

b8a18619f2a81108397e4fbd5faba89e29755dc0

The Illumina platform and Roche GS-FLX are an effective combination to call SNPs when lacking a reference genome [17–20], but additional labor, time and cost are required to build a rough reference with GS-FLX.

666c9839fda634f9f74f411f985ab0980c1d7263>256ad51b5cddf2652a66def737f0d07ef6dca496_2

666c9839fda634f9f74f411f985ab0980c1d7263

The risk of death of PWA, as compared to non-PWA, was estimated using sex-and agestandardized mortality ratios (SMRs).17 SMRs were calculated as the ratio between the observed number of deceased PWA who had a specific can er to the expected one, estimated on the basis of sex- and age-specific (quinquennia) mortality rates among non-PWA, multiplied by the person-years at risk among PWA.

2b3978e4aabbcc87cfd4e7363ec7c93be38c55fd>8919a3f010f0daba47aa01783956acbadd41a9e7_1

2b3978e4aabbcc87cfd4e7363ec7c93be38c55fd

Ecological parameters of WNV transmission have yet to be clearly defined in tropical ecosystems typical of the Caribbean Basin countries.(1) Serosurveys of free-ranging birds in several countries have identified infections in numerous species of

85e766e708cac537f272621e1d8d1e641279806c>9bd8a440cfb92cc5f7f45d88cce6f9d651b98237_5

85e766e708cac537f272621e1d8d1e641279806c

This approach is a modified version of the dynamic bioclimate envelope model developed by Cheung et al. (2008a).

745c4f69c160823911589db740f1efbc61e88ab7>0f973badc6a5bfb01d1a30913104d6e197fc2fff_0

745c4f69c160823911589db740f1efbc61e88ab7

Cysteine to serine mutation of WhiB1 was generated by overlapping extension PCR using a primer pair consisting of wild type [23] and appropriately mutated primer as mentioned in the Table 2 (Additional file 2).

7dda92d7dbb1a5f7fc78bba6f81890b3832cb2d6>e6f6fdef07ca7e5a96e0c7d8619bb9171e9eb60a_0

7dda92d7dbb1a5f7fc78bba6f81890b3832cb2d6

A type I T-cell gene signature that promotes both the generation and tumor infiltration of cytotoxic T cells has been shown to be associated with an improved clinical outcome in a variety of tumor types (2, 3).

6ed0e052d39e7f66d6d45d005d6f4401dfd0bbc2>7aa6cb7dce4dc601ce5f6d657ed889a4a4b39879_3

6ed0e052d39e7f66d6d45d005d6f4401dfd0bbc2

The literature describes substantial variation in dentists’ assessments of clinical, community, and behavioral factors that influence their decisions to provide a particular restorative treatment for their patients (21-23).

7506a6aaa7154354ee7b145fd5b1de3d3c7fd873>a036ac52a271a45f0244a4f95ce4026c57e394b1_0

7506a6aaa7154354ee7b145fd5b1de3d3c7fd873

In studies that report intakes as frequency, we converted a serving size as 80 g according to other meta-analysis [15, 16].

785d26e6592278f48c9eb68eb1e3388788c76b32>35c27b0c0db73af7303c0a95efa90479afb04fed_1

785d26e6592278f48c9eb68eb1e3388788c76b32

In addition, PTH-induced release of calcium from bone is substantially impaired in the presence of hypomagnesaemia, as magnesium depletion interferes with the generation of cAMP in response to PTH [2, 3].

b60bd6086848ab2d21bf0589e5d02aa8748a0d82>932e47c83f4466cac2f37e3ad80e13fabd6ca423_0

b60bd6086848ab2d21bf0589e5d02aa8748a0d82

We also used an example based MT (EBMT) system [31] [32] which was developed by Joshi et al.

09e2dda605728b604d0eecd254c00119ff0a2140>c4dadcc767979eea395074469143b23f161de3df_6

09e2dda605728b604d0eecd254c00119ff0a2140

Ultimately, telomerase-deficient cells undergo replicative senescence, a process in which the majority of cells in the culture cease to grow, and a variety of deleterious genome-destabilizing events increase in frequency (Chen and Kolodner, 1999; Hackett et al., 2001; DuBois et al., 2002; Hackett and Greider, 2003; Mieczkowski et al., 2003; Meyer and Bailis, 2007).

cf1b8ce9d2649e20f51eeb7494724b71197a5f65>6a982d6236c6efcf59dc6d9e451b1321db49f7ea_0

cf1b8ce9d2649e20f51eeb7494724b71197a5f65

As in previous studies, injury severity was stratified using the discharge diagnosis ICD-9ebased ICISS scoring system, which has been shown to outperform other scoring systems in predicting injury mortality and is particularly suited for the study of administrative databases.(8,9,12,13) The definition of severely injured patients was chosen to match that in several preceding studies that focused on the survival advantage of severely injured patients treated at DTCs in Florida.