chaseharmon/MIT_Course_Catalog · Datasets at Hugging Face

Class Number stringlengths 4 15	Name stringlengths 4 124	Description stringlengths 23 1.14k	Offered bool 2 classes	Term stringclasses 97 values	Level stringclasses 2 values	Units stringclasses 194 values	Prerequisites stringlengths 4 127 ⌀	Equivalents stringlengths 7 63 ⌀	Lab bool 2 classes	Partial Lab bool 2 classes	REST bool 2 classes	GIR stringclasses 7 values	HASS stringclasses 5 values	CI / CI-HW stringclasses 3 values
7.340-7.344	Advanced Undergraduate Seminar	Seminars covering topics of current interest in biology with a focus on how to understand experimental methods and design and how to critically read the primary research literature. Small class size facilitates discussions and interactions with an active research scientist. Students visit research laboratories to see firsthand how biological research is conducted. Contact Biology Education Office for topics.	true	Fall, Spring	Undergraduate	2-0-4 [P/D/F]	7.06 or 7.28	null	false	false	false	False	False	False
7.345-7.349	Advanced Undergraduate Seminar	Seminars covering topics of current interest in biology with a focus on how to understand experimental methods and design and how to critically read the primary research literature. Small class size facilitates discussions and interactions with an active research scientist. Students visit research laboratories to see firsthand how biological research is conducted. Contact Biology Education Office for topics.	true	Fall, Spring	Undergraduate	2-0-4 [P/D/F]	7.06 or 7.28	null	false	false	false	False	False	False
7.35	Human Genetics and Genomics	Upper-level seminar offering in-depth analysis and engaged discussion of primary literature on the dimensions and phenotypic consequences of variation in human genes, chromosomes, and genomes. Topics include the human genome project; pedigree analysis; mutation and selection; linkage and association studies; medical genetics and disease; sex chromosomes and sex differences; the biology of the germ line; epigenetics, imprinting, and transgenerational inheritance; human origins; and evolutionary and population genetics. Students taking graduate version complete additional assignments. Limited to 20 total for versions meeting together.	true	Spring	Undergraduate	3-0-9	7.06, (7.03 and 7.05), or permission of instructor	null	false	false	false	False	False	False
7.36	The CRISPR Revolution: Engineering the Genome for Basic Science and Clinical Medicine (New)	Provides a conceptual and technical understanding of genome editing systems and their research and clinical applications. Focuses on fundamental CRISPR biology in bacteria, methodologies for manipulating the genome with CRISPR, and the application of genome engineering in research and medicine. Combines lectures and literature discussions with critical analysis and assigned readings, with the goal of better understanding how key discoveries were made and how these are applied in the real work. Class work includes brief writing assignments as well as a final research proposal and scientific presentation. Students taking the graduate version explore the subject in greater depth, in part through additional assignments.	true	Fall	Undergraduate	3-0-9	7.06 or permission of instructor	null	false	false	false	False	False	False
7.37[J]	Molecular and Engineering Aspects of Biotechnology	Covers biological and bioengineering principles underlying the development and therapeutic use of recombinant proteins and stem cells; glycoengineering of recombinant proteins; normal and pathological signaling by growth factors and their receptors; receptor trafficking; monoclonal antibodies as therapeutics; protein pharmacology and delivery; stem cell-derived tissues as therapeutics; RNA therapeutics; combinatorial protein engineering; and new antitumor drugs.	true	Spring	Undergraduate	4-0-8	(7.06 and (2.005, 3.012, 5.60, or 20.110)) or permission of instructor	10.441[J], 20.361[J]	false	false	false	False	False	False
7.371	Biological and Engineering Principles Underlying Novel Biotherapeutics	Covers biological and bioengineering principles underlying the development and therapeutic use of recombinant proteins and immune cells. Special attention to monoclonal antibodies and engineered immune system cells as therapeutics; protein- and glyco- engineering to enhance protein function; protein pharmacology and delivery; nucleic acid- based biotherapeutics; generation of functional cells and tissues from embryonic stem cells and iPS cells; and immune cell-cancer cell interactions in cancer immunotherapy.	true	Fall	Undergraduate	4-0-8	7.06	null	false	false	false	False	False	False
7.38	Design Principles of Biological Systems	Introduces students to biological control mechanisms governing decision-making and tools to decipher, model, and perturb these mechanisms. Systems presented include signal transduction, cell cycle control, developmental biology, and the immune system. These systems provide examples of feedback and feedforward control, oscillators, kinetic proofreading, spatial and temporal averaging, and pattern formation. Students taking graduate version complete additional assignments.	true	Fall	Undergraduate	3-0-9	7.06 or permission of instructor	null	false	false	false	False	False	False
7.45	The Hallmarks of Cancer	Provides a comprehensive introduction to the fundamentals of cancer biology and cancer treatment. Topics include cancer genetics, genomics, and epigenetics; familial cancer syndromes; signal transduction, cell cycle control, and apoptosis; cancer metabolism; stem cells and cancer; metastasis; cancer immunology and immunotherapy; conventional and molecularly-targeted therapies; and early detection and prevention. Students taking graduate version complete additional assignments.	true	Fall	Undergraduate	4-0-8	None. Coreq: 7.06	null	false	false	false	False	False	False
7.46	Building with Cells	Focuses on fundamental principles of developmental biology by which cells build organs and organisms. Analyzes the pivotal role of stem cells in tissue maintenance or repair, and in treatment of disease. Explores how to integrate this knowledge with engineering tools to construct functional tissue structures. Students taking graduate version complete additional assignments	true	Fall	Undergraduate	4-0-8	7.03 and 7.05	null	false	false	false	False	False	False
7.458[J]	Advances in Biomanufacturing	Seminar examines how biopharmaceuticals, an increasingly important class of pharmaceuticals, are manufactured. Topics range from fundamental bioprocesses to new technologies to the economics of biomanufacturing. Also covers the impact of globalization on regulation and quality approaches as well as supply chain integrity. Students taking graduate version complete additional assignments.	true	Spring	Undergraduate	1-0-2 [P/D/F]	null	10.03[J]	false	false	false	False	False	False
7.49[J]	Developmental Neurobiology	Considers molecular control of neural specification, formation of neuronal connections, construction of neural systems, and the contributions of experience to shaping brain structure and function. Topics include: neural induction and pattern formation, cell lineage and fate determination, neuronal migration, axon guidance, synapse formation and stabilization, activity-dependent development and critical periods, development of behavior. Students taking graduate version complete additional readings that will be addressed in their mid-term and final exams.	true	Spring	Undergraduate	3-0-9	7.03, 7.05, 9.01, or permission of instructor	9.18[J]	false	false	false	False	False	False
7.390	Practical Internship Experience in Biology	For Course 7, 5-7, and 6-7 students participating in curriculum-related off-campus internship experiences in biology. Before enrolling, students must consult the Biology Education Office for details on procedures and restrictions, and have approval from their faculty advisor. Subject to department approval. Upon completion, the student must submit a write-up of the experience, approved by their faculty advisor.	true	Fall, IAP, Spring, Summer	Undergraduate	0-1-0 [P/D/F]	null	null	false	false	false	False	False	False
7.391	Independent Study in Biology	Program of study or research to be arranged with a department faculty member.	false	Fall, Spring, Summer	Undergraduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
7.392	Independent Study in Biology	Program of study or research to be arranged with a department faculty member.	false	Fall, IAP, Spring	Undergraduate	rranged	null	null	false	false	false	False	False	False
7.393	Independent Study in Genetics	Program of study or research to be arranged with a department faculty member.	false	Fall, Spring	Undergraduate	rranged	null	null	false	false	false	False	False	False
7.394	Independent Study in Biochemistry	Program of study or research to be arranged with a department faculty member.	false	Fall, Spring	Undergraduate	rranged	null	null	false	false	false	False	False	False
7.395	Independent Study in Cell and Molecular Biology	Program of study or research to be arranged with a department faculty member.	false	Fall, Spring	Undergraduate	rranged	null	null	false	false	false	False	False	False
7.396	Independent Study in Experimental Biology	Program of study or research to be arranged with a department faculty member.	false	Fall, IAP, Spring, Fall, IAP, Spring, Fall, Spring, Spring	Graduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
7.C01	Machine Learning in Molecular and Cellular Biology	Introduces machine learning as a tool to understand natural biological systems, with an evolving emphasis on problems in molecular and cellular biology that are being actively advanced using machine learning. Students design, implement, and interpret machine learning approaches to aid in predicting protein structure, probing protein structure/function relationships, and imaging biological systems at scales ranging from the atomic to cellular. Students taking graduate version complete an additional project-based assignment. Students cannot receive credit without completion of the core subject 6.C01.	true	Spring	Undergraduate	2-0-4	Biology (GIR), 6.100A, 6.C01, and 7.05	null	false	false	false	False	False	False
7.S391	Special Subject in Biology	Covers material in various fields of biology not offered by the regular subjects of instruction.	true	Fall, IAP, Spring, Summer	Undergraduate	rranged [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
7.S392	Special Subject in Biology	Covers material in various fields of biology not offered by the regular subjects of instruction.	true	Fall, IAP, Spring	Undergraduate	rranged [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
7.S399	Special Subject in Biology	Covers material in various fields of biology not offered by the regular subjects of instruction.	true	Fall, IAP, Spring	Undergraduate	rranged	Permission of instructor	null	false	false	false	False	False	False
7.UR	Undergraduate Research	Undergraduate research opportunities in the Department of Biology.	true	Fall, IAP, Spring, Summer	Undergraduate	rranged [P/D/F]	Permission of department	null	false	false	false	False	False	False
7.URG	Undergraduate Research	Undergraduate research opportunities in the Department of Biology.	false	Fall, IAP, Spring, Fall, Spring, Spring	Graduate	rranged	Permission of department	null	false	false	false	False	False	False
7.410	Applied Statistics	Provides an introduction to modern applied statistics. Topics include likelihood-based methods for estimation, confidence intervals, and hypothesis-testing; bootstrapping; time series modeling; linear models; nonparametric regression; and model selection. Organized around examples drawn from the recent literature.	true	Spring	Graduate	3-0-9	Permission of instructor	null	false	false	false	False	False	False
7.411	Seminars in Biological Oceanography	Selected topics in biological oceanography.	true	Fall, Spring	Graduate	rranged [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
7.421	Problems in Biological Oceanography	Advanced problems in biological oceanography with assigned reading and consultation.	true	Fall, Spring	Graduate	rranged [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
7.430	Topics in Quantitative Marine Science	Lectures and discussions on quantitative marine ecology. Topics vary from year to year.	true	Fall, Spring	Graduate	2-0-4	Permission of instructor	null	false	false	false	False	False	False
7.431	Topics in Marine Ecology	Lectures and discussions on ecological principles and processes in marine populations, communities, and ecosystems. Topics vary from year to year.	true	Fall, Spring	Graduate	2-0-4	Permission of instructor	null	false	false	false	False	False	False
7.432	Topics in Marine Physiology and Biochemistry	Lectures and discussions on physiological and biochemical processes in marine organisms. Topics vary from year to year.	true	Spring	Graduate	2-0-4	Permission of instructor	null	false	false	false	False	False	False
7.433	Topics in Biological Oceanography	Lectures and discussions on biological oceanography. Topics vary from year to year.	true	Spring	Graduate	2-0-4	Permission of instructor	null	false	false	false	False	False	False
7.434	Topics in Zooplankton Biology	Lectures and discussions on the biology of marine zooplankton. Topics vary from year to year.	true	Fall, Spring	Graduate	2-0-4	Permission of instructor	null	false	false	false	False	False	False
7.435	Topics in Benthic Biology	Lectures and discussions on the biology of marine benthos. Topics vary from year to year.	true	Fall, Spring	Graduate	2-0-4	Permission of instructor	null	false	false	false	False	False	False
7.436	Topics in Phytoplankton Biology	Lectures and discussion on the biology of marine phytoplankton. Topics vary from year to year.	true	Fall, Spring	Graduate	2-0-4	Permission of instructor	null	false	false	false	False	False	False
7.437	Topics in Molecular Biological Oceanography	Lectures and discussion on molecular biological oceanography. Topics vary from year to year.	true	Fall, Spring	Graduate	2-0-4	Permission of instructor	null	false	false	false	False	False	False
7.438	Topics in the Behavior of Marine Animals	Lectures and discussion on the behavioral biology of marine animals. Topics vary from year to year.	true	Fall, Spring	Graduate	2-0-4	Permission of instructor	null	false	false	false	False	False	False
7.439	Topics in Marine Microbiology	Lectures and discussion on the biology of marine prokaryotes. Topics vary from year to year.	true	Spring	Graduate	2-0-4	Permission of instructor	null	false	false	false	False	False	False
7.440	An Introduction to Mathematical Ecology	Covers the basic models of population growth, demography, population interaction (competition, predation, mutualism), food webs, harvesting, and infectious disease, and the mathematical tools required for their analysis. Because these tools are also basic to the analysis of models in biochemistry, physiology, and behavior, subject also broadly relevant to students whose interests are not limited to ecological problems.	true	Spring	Graduate	3-0-9	Calculus I (GIR), 1.018, or permission of instructor	null	false	false	false	False	False	False
7.470	Biological Oceanography	Intended for students with advanced training in biology. Intensive overview of biological oceanography. Major paradigms discussed, and dependence of biological processes in the ocean on physical and chemical aspects of the environment examined. Surveys the diversity of marine habitats, major groups of taxa inhabiting those habitats, and the general biology of the various taxa: the production and consumption of organic material in the ocean, as well as factors controlling those processes. Species diversity, structure of marine food webs, and the flow of energy within different marine habitats are detailed and contrasted.	true	Spring	Graduate	3-0-9	Permission of instructor	null	false	false	false	False	False	False
7.491	Research in Biological Oceanography	Directed research in biological oceanography not leading to graduate thesis and initiated prior to the qualifying exam.	true	Fall, Spring, Summer	Graduate	rranged [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
7.492[J]	Methods and Problems in Microbiology	Students will read and discuss primary literature covering key areas of microbial research with emphasis on methods and approaches used to understand and manipulate microbes. Preference to first-year Microbiology and Biology students.	true	Fall	Graduate	3-0-9	null	1.86[J], 20.445[J]	false	false	false	False	False	False
7.493[J]	Microbial Genetics and Evolution	Covers aspects of microbial genetic and genomic analyses, central dogma, horizontal gene transfer, and evolution.	true	Fall	Graduate	4-0-8	7.03, 7.05, or permission of instructor	1.87[J], 12.493[J], 20.446[J]	false	false	false	False	False	False
7.494	Research Problems in Microbiology	Directed research in the fields of microbial science and engineering.	true	Fall, Spring, Summer	Graduate	rranged [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
7.498	Teaching Experience in Microbiology	For qualified graduate students in the Microbiology graduate program interested in teaching. Classroom or laboratory teaching under the supervision of a faculty member.	true	Fall, Spring	Graduate	rranged [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
7.499	Research Rotations in Microbiology	Introduces students to faculty participating in the interdepartmental Microbiology graduate program through a series of three lab rotations, which provide broad exposure to microbiology research at MIT. Students select a lab for thesis research by the end of their first year. Given the interdisciplinary nature of the program and the many research programs available, students may be able to work jointly with more than one research advisor. Limited to students in the Microbiology graduate program.	true	Fall, Spring	Graduate	rranged [P/D/F]	None. Coreq: 7.492 or 7.493; permission of instructor	null	false	false	false	False	False	False
7.MTHG	Microbiology Graduate Thesis	Program of research leading to the writing of a PhD thesis. To be arranged by the student and the appropriate MIT faculty member.	true	Fall, IAP, Spring, Summer	Graduate	rranged	Permission of instructor	null	false	false	false	False	False	False
7.50	Method and Logic in Molecular Biology	Logic, experimental design and methods in biology, using discussions of the primary literature to discern the principles of biological investigation in making discoveries and testing hypotheses. In collaboration with faculty, students also apply those principles to generate a potential research project, presented in both written and oral form. Limited to Course 7 graduate students.	true	Fall	Graduate	4-0-8	None. Coreq: 7.51 and 7.52; or permission of instructor	null	false	false	false	False	False	False
7.51	Principles of Biochemical Analysis	Principles of protein biochemistry, emphasizing structure, equilibrium studies, kinetics, and experimental design. Topics include macromolecular binding and specificity, allosteric systems, mechanisms of inhibition, enzyme principles, single-molecule studies, structure-function relationships, molecular evolution, and library methods. Case studies examine mechanisms of transcription factors, kinases, molecular machines, and other proteins.	true	Fall	Graduate	6-0-6	Permission of instructor	null	false	false	false	False	False	False
7.52	Genetics for Graduate Students	Principles and approaches of genetic analysis, including Mendelian inheritance and prokaryotic genetics, yeast genetics, developmental genetics, neurogenetics, and human genetics.	true	Fall	Graduate	4-0-8	Permission of instructor	null	false	false	false	False	False	False
7.540[J]	Advances in Chemical Biology	Introduction to current research at the interface of chemistry, biology, and bioengineering. Topics include imaging of biological processes, metabolic pathway engineering, protein engineering, mechanisms of DNA damage, RNA structure and function, macromolecular machines, protein misfolding and disease, metabolomics, and methods for analyzing signaling network dynamics. Lectures are interspersed with class discussions and student presentations based on current literature.	true	Fall	Graduate	3-0-9	5.07, 5.13, 7.06, and permission of instructor	5.54[J], 20.554[J]	false	false	false	False	False	False
7.546[J]	Science and Business of Biotechnology	Covers the new types of drugs and other therapeutics in current practice and under development, the financing and business structures of early-stage biotechnology companies, and the evaluation of their risk/reward profiles. Includes a series of live case studies with industry leaders of both established and emerging biotechnology companies as guest speakers, focusing on the underlying science and engineering as well as core financing and business issues. Students must possess a basic background in cellular and molecular biology.	true	Spring	Graduate	3-0-6	None. Coreq: 15.401; permission of instructor	15.480[J], 20.586[J]	false	false	false	False	False	False
7.548[J]	Advances in Biomanufacturing	Seminar examines how biopharmaceuticals, an increasingly important class of pharmaceuticals, are manufactured. Topics range from fundamental bioprocesses to new technologies to the economics of biomanufacturing. Also covers the impact of globalization on regulation and quality approaches as well as supply chain integrity. Students taking graduate version complete additional assignments.	true	Spring	Graduate	1-0-2	null	10.53[J]	false	false	false	False	False	False
7.549[J]	Case Studies and Strategies in Drug Discovery and Development	Aims to develop appreciation for the stages of drug discovery and development, from target identification, to the submission of preclinical and clinical data to regulatory authorities for marketing approval. Following introductory lectures on the process of drug development, students working in small teams analyze how one of four new drugs or drug candidates traversed the discovery/development landscape. For each case, an outside expert from the sponsoring drug company or pivotal clinical trial principal investigator provides guidance and critiques the teams' presentations to the class.	true	Spring	Graduate	2-0-4	null	15.137[J], 20.486[J], HST.916[J]	false	false	false	False	False	False
7.55	Case Studies in Modern Experimental Design	Focuses on enhancing students' ability to analyze, design and present experiments, emphasizing modern techniques. Class discussions begin with papers that developed or utilized contemporary approaches (e.g., quantitative microscopy, biophysical and molecular genetic methods) to address important problems in biology. Each student prepares one specific aim of a standard research proposal for a project that emphasizes research strategy, experimental design, and writing.	true	Spring	Graduate	2-0-7	Permission of instructor	null	false	false	false	False	False	False
7.571	Quantitative Analysis of Biological Data	Application of probability theory and statistical methods to analyze biological data. Topics include: descriptive and inferential statistics, an introduction to Bayesian statistics, design of quantitative experiments, and methods to analyze high-dimensional datasets. A <em>conceptual</em> understanding of topics is emphasized, and methods are illustrated using the Python programming language. Although a basic understanding of Python is encouraged, no programming experience is required. Students taking the graduate version are expected to explore the subject in greater depth.	true	Spring	Graduate	2-0-4	null	null	false	false	false	False	False	False
7.572	Quantitative Measurements and Modeling of Biological Systems	Quantitative experimental design, data analysis, and modeling for biological systems. Topics include absolute/relative quantification, noise and reproducibility, regression and correlation, and modeling of population growth, gene expression, cellular dynamics, feedback regulation, oscillation. Students taking the graduate version are expected to explore the subject in greater depth.	true	Spring	Graduate	2-0-4	null	null	false	false	false	False	False	False
7.573	Modern Biostatistics	Provides a practical introduction to probability and statistics used in modern biology. Topics covered include discrete and continuous probability distributions, statistical modeling, hypothesis testing, independence, conditional probability, multiple test corrections, nonparametric methods, clustering, correlation, linear regression, principal components analysis with applications to high-throughput DNA sequencing and image data analysis. Homework is in the R programming language, but prior programming experience is not required. Students taking the graduate version are expected to explore the subject in greater depth.	true	Spring	Graduate	2-0-4	7.03 and 7.05	null	false	false	false	False	False	False
7.574	Modern Computational Biology	Introduces modern methods in computational biology, focusing on DNA/RNA/protein analysis. Topics include next-generation DNA sequencing and sequencing data analysis, RNA-seq (bulk and single-cell), and protein dynamics. Students taking the graduate version are expected to explore the subject in greater depth.	true	Spring	Graduate	2-0-4	7.03 and 7.05	null	false	false	false	False	False	False
7.58	Molecular Biology	Detailed analysis of the biochemical mechanisms that control the maintenance, expression, and evolution of prokaryotic and eukaryotic genomes. Topics covered in lecture and readings of relevant literature include: gene regulation, DNA replication, genetic recombination, and mRNA translation. Logic of experimental design and data analysis emphasized. Presentations include both lectures and group discussions of representative papers from the literature. Students taking the graduate version are expected to explore the subject in greater depth.	true	Spring	Graduate	5-0-7	7.03, 7.05, and permission of instructor	null	false	false	false	False	False	False
7.59[J]	Teaching College-Level Science and Engineering	Participatory seminar focuses on the knowledge and skills necessary for teaching science and engineering in higher education. Topics include theories of adult learning; course development; promoting active learning, problemsolving, and critical thinking in students; communicating with a diverse student body; using educational technology to further learning; lecturing; creating effective tests and assignments; and assessment and evaluation. Students research and present a relevant topic of particular interest. Appropriate for both novices and those with teaching experience.	true	Fall	Graduate	2-0-2 [P/D/F]	null	1.95[J], 5.95[J], 8.395[J], 18.094[J]	false	false	false	False	False	False
7.60	Cell Biology: Structure and Functions of the Nucleus	Eukaryotic genome structure, function, and expression, processing of RNA, and regulation of the cell cycle. Emphasis on the techniques and logic used to address important problems in nuclear cell biology. Lectures on broad topic areas in nuclear cell biology and discussions on representative recent papers.	true	Spring	Graduate	3-0-9	7.06 or permission of instructor	null	false	false	false	False	False	False
7.61[J]	Eukaryotic Cell Biology: Principles and Practice	Emphasizes methods and logic used to analyze structure and function of eukaryotic cells in diverse systems (e.g., yeast, fly, worm, mouse, human; development, stem cells, neurons). Combines lectures and in-depth roundtable discussions of literature readings with the active participation of faculty experts. Focuses on membranes (structure, function, traffic), organelles, the cell surface, signal transduction, cytoskeleton, cell motility and extracellular matrix. Ranges from basic studies to applications to human disease, while stressing critical analysis of experimental approaches. Enrollment limited.	true	Fall	Graduate	4-0-8	Permission of instructor	20.561[J]	false	false	false	False	False	False
7.62	Microbial Physiology	Biochemical properties of bacteria and other microorganisms that enable them to grow under a variety of conditions. Interaction between bacteria and bacteriophages. Genetic and metabolic regulation of enzyme action and enzyme formation. Structure and function of components of the bacterial cell envelope. Protein secretion with a special emphasis on its various roles in pathogenesis. Additional topics include bioenergetics, symbiosis, quorum sensing, global responses to DNA damage, and biofilms. Students taking the graduate version are expected to explore the subject in greater depth.	true	Fall	Graduate	4-0-8	7.03, 7.05, and permission of instructor	null	false	false	false	False	False	False
7.63[J]	Immunology	Comprehensive survey of molecular, genetic, and cellular aspects of the immune system. Topics include innate and adaptive immunity; cells and organs of the immune system; hematopoiesis; immunoglobulin, T cell receptor, and major histocompatibility complex (MHC) proteins and genes; development and functions of B and T lymphocytes; immune responses to infections and tumors; hypersensitivity, autoimmunity, and immunodeficiencies. Particular attention to the development and function of the immune system as a whole, as studied by modern methods and techniques. Students taking graduate version explore the subject in greater depth, including study of recent primary literature.	true	Spring	Graduate	5-0-7	7.06 and permission of instructor	20.630[J]	false	false	false	False	False	False
7.64	Molecular Mechanisms, Pathology and Therapy of Human Neuromuscular Disorders	Investigates the molecular and clinical basis of central nervous system and neuromuscular disorders with particular emphasis on strategies for therapeutic intervention. Considers the in-depth analysis of clinical features, pathological mechanisms, and responses to current therapeutic interventions. Covers neurodegenerative diseases, such as Huntington's disease, Parkinson's disease, Alzheimer's disease, Amyotropic Lateral Schlerosis, Frontal Temporal Dementia, and neuromuscular disorders, such as Myotonic Dystrophy, Facio Scapular Humoral Dystrophy, and Duchenne Muscular Dystrophy.	true	Spring	Graduate	3-0-9	Permission of instructor	null	false	false	false	False	False	False
7.65[J]	Molecular and Cellular Neuroscience Core I	Survey and primary literature review of selected major topic areas in molecular and cellular neurobiology. Covers nervous system development, axonal pathfinding, synapse formation and function, synaptic plasticity, ion channels and receptors, cellular neurophysiology, glial cells, sensory transduction, and relevant examples in human disease. Includes lectures and weekly paper write-ups, together with student presentations and discussion of primary literature. A final two-page research write-up is also due at the end of the term.	true	Fall	Graduate	3-0-9	null	9.015[J]	false	false	false	False	False	False
7.66	Molecular Basis of Infectious Disease	Focuses on the principles of host-pathogen interactions with an emphasis on infectious diseases of humans. Presents key concepts of pathogenesis through the study of various human pathogens. Includes critical analysis and discussion of assigned readings. Students taking the graduate version are expected to explore the subject in greater depth.	true	Spring	Graduate	4-0-8	7.06 and permission of instructor	null	false	false	false	False	False	False
7.68[J]	Molecular and Cellular Neuroscience Core II	Survey and primary literature review of major areas in molecular and cellular neurobiology. Covers genetic neurotrophin signaling, adult neurogenesis, G-protein coupled receptor signaling, glia function, epigenetics, neuronal and homeostatic plasticity, neuromodulators of circuit function, and neurological/psychiatric disease mechanisms. Includes lectures and exams, and involves presentation and discussion of primary literature. 9.015 recommended, though the core subjects can be taken in any sequence.	true	Spring	Graduate	3-0-9	Permission of instructor	9.013[J]	false	false	false	False	False	False
7.69[J]	Developmental Neurobiology	Considers molecular control of neural specification, formation of neuronal connections, construction of neural systems, and the contributions of experience to shaping brain structure and function. Topics include: neural induction and pattern formation, cell lineage and fate determination, neuronal migration, axon guidance, synapse formation and stabilization, activity-dependent development and critical periods, development of behavior. In addition to final exam, analysis and presentation of research papers required for final grade. Students taking graduate version complete additional assignments. Students taking graduate version complete additional readings that will be addressed in their mid-term and final exams.	true	Spring	Graduate	3-0-9	9.011 or permission of instructor	9.181[J]	false	false	false	False	False	False
7.70	Regulation of Gene Expression	Seminar examines basic principles of biological regulation of gene expression. Focuses on examples that underpin these principles, as well as those that challenge certain long-held views. Topics covered may include the role of transcription factors, enhancers, DNA modifications, non-coding RNAs, and chromatin structure in the regulation of gene expression and mechanisms for epigenetic inheritance of transcriptional states. Limited to 40.	true	Spring	Graduate	4-0-8	Permission of instructor	null	false	false	false	False	False	False
7.71	Biophysical Technique	Introduces students to modern biophysical methods to study biological systems from atomic, to molecular and cellular scales. Includes an in-depth discussion on the techniques that cover the full resolution range, including X-ray crystallography, electron-, and light microscopy. Discusses other common biophysical techniques for macromolecular characterizations. Lectures cover theoretical principles behind the techniques, and students are given practical laboratory exercises using instrumentation available at MIT. Meets with 5.78 when offered concurrently.	true	Spring	Graduate	5-0-7	5.13, 5.60, (5.07 or 7.05), and permission of instructor	null	false	false	false	False	False	False
7.72	Stem Cells, Regeneration, and Development	Topics include diverse stem cells, such as muscle, intestine, skin, hair and hematopoietic stem cells, as well as pluripotent stem cells. Topics address cell polarity and cell fate; positional information and patterning of development and regeneration; limb, heart and whole body regeneration; stem cell renewal; progenitor cells in development; responses to wounding; and applications of stem cells in development of therapies. Discussions of papers supplement lectures.	true	Spring	Graduate	4-0-8	Permission of instructor	null	false	false	false	False	False	False
7.73	Principles of Chemical Biology	Spanning the fields of biology, chemistry and engineering, class addresses the principles of chemical biology and its application of chemical and physical methods and reagents to the study and manipulation of biological systems. Topics include bioorthogonal reactions and activity-based protein profiling, small molecule inhibitors and chemical genetics, fluorescent probes for biological studies, and unnatural amino acid mutagenesis. Also covers chemical biology approaches for studying dynamic post-translational modification reactions, natural product biosynthesis and mutasynthesis, and high-throughput drug screening. Students taking the graduate version are expected to explore the subject in greater depth.	true	Spring	Graduate	3-0-9	7.05 and permission of instructor	null	false	false	false	False	False	False
7.74[J]	Topics in Biophysics and Physical Biology	Provides broad exposure to research in biophysics and physical biology, with emphasis on the critical evaluation of scientific literature. Weekly meetings include in-depth discussion of scientific literature led by distinct faculty on active research topics. Each session also includes brief discussion of non-research topics including effective presentation skills, writing papers and fellowship proposals, choosing scientific and technical research topics, time management, and scientific ethics.	true	Fall	Graduate	2-0-4 [P/D/F]	null	8.590[J], 20.416[J]	false	false	false	False	False	False
7.75	Human Genetics and Genomics	Upper level seminar offering in-depth analysis and engaged discussion of primary literature on the dimensions and phenotypic consequences of variation in human genes, chromosomes, and genomes. Topics include the human genome project; pedigree analysis; mutation and selection; linkage and association studies; medical genetics and disease; sex chromosomes and sex differences; the biology of the germ line; epigenetics, imprinting, and transgenerational inheritance; human origins; and evolutionary and population genetics. Students taking graduate version complete additional assignments. Limited to 20 total for versions meeting together.	true	Spring	Graduate	3-0-9	7.52 or permission of instructor	null	false	false	false	False	False	False
7.76	Topics in Macromolecular Structure and Function	In-depth analysis and discussion of classic and current literature, with an emphasis on the structure, function, and mechanisms of proteins and other biological macromolecules.	true	Spring	Graduate	3-0-6	Permission of instructor	null	false	false	false	False	False	False
7.77	Nucleic Acids, Structure, Function, Evolution, and Their Interactions with Proteins	Surveys primary literature, focusing on biochemical, biophysical, genetic, and combinatorial approaches for understanding nucleic acids. Topics include the general properties, functions, and structural motifs of DNA and RNA; RNAs as catalysts and as regulators of gene expression; RNA editing and surveillance, and the interaction of nucleic acids with proteins, such as zinc-finger proteins, modification enzymes, aminoacyl-tRNA synthetases and other proteins of the translational machinery. Includes some lectures but is mostly analysis and discussion of current literature in the context of student presentations.	true	Spring	Graduate	3-0-9	7.05, 7.51, or permission of instructor	null	false	false	false	False	False	False
7.80	Fundamentals of Chemical Biology	Spanning the fields of biology, chemistry, and engineering, this class introduces students to the principles of chemical biology and the application of chemical and physical methods and reagents to the study and manipulation of biological systems. Topics include nucleic acid structure, recognition, and manipulation; protein folding and stability, and proteostasis; bioorthogonal reactions and activity-based protein profiling; chemical genetics and small-molecule inhibitor screening; fluorescent probes for biological analysis and imaging; and unnatural amino acid mutagenesis. The class will also discuss the logic of dynamic post-translational modification reactions with an emphasis on chemical biology approaches for studying complex processes including glycosylation, phosphorylation, and lipidation. Students taking the graduate version are expected to explore the subject in greater depth.	true	Spring	Graduate	4-0-8	5.13 and (5.07 or 7.05)	null	false	false	false	False	False	False
7.81[J]	Systems Biology	Introduction to cellular and population-level systems biology with an emphasis on synthetic biology, modeling of genetic networks, cell-cell interactions, and evolutionary dynamics. Cellular systems include genetic switches and oscillators, network motifs, genetic network evolution, and cellular decision-making. Population-level systems include models of pattern formation, cell-cell communication, and evolutionary systems biology. Students taking graduate version explore the subject in more depth.	true	Fall	Graduate	3-0-9	(18.03 and 18.05) or permission of instructor	8.591[J]	false	false	false	False	False	False
7.82	Development, Disease and Therapeutics	Seminar covering the key concepts and technological approaches that are used to study and treat human disease. Topics include human genome variation, germline editing, gene therapy, stem cell derived organoids, human-animal chimeras and the application of these approaches to the study and treatment of major diseases.	true	Spring	Graduate	3-0-9 [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
7.83	Design Principles of Biological Systems	Introduces students to biological control mechanisms governing decision-making and tools to decipher, model, and perturb these mechanisms. Systems presented include signal transduction, cell cycle control, developmental biology, and the immune system. These systems provide examples of feedback and feedforward control, oscillators, kinetic proofreading, spatial and temporal averaging, and pattern formation. Students taking graduate version complete additional assignments.	true	Fall	Graduate	3-0-9	Permission of instructor	null	false	false	false	False	False	False
7.84	Advanced Concepts in Immunology	Provides a comprehensive and intensified understanding of the relevance of the immune system beyond immunity. Focuses on how the immune system intersects with all aspects of body homeostasis/physiology or disease and how the immune system can be manipulated therapeutically. New advances in the intersection of immunology with cancer biology, neurosciences, metabolism, aging, and maternal-fetal immunology or similar explored. Presents new modern methods and techniques applicable beyond immunology. Includes critical analysis and discussion of assigned readings. Students apply principles learned in class to generate a potential research project, presented in a written form. Students taking graduate version complete additional assignments.	true	Spring	Graduate	3-0-9	None. Coreq: 7.63; or permission of instructor	null	false	false	false	False	False	False
7.85	The Hallmarks of Cancer	Provides a comprehensive introduction to the fundamentals of cancer biology and cancer treatment. Topics include cancer genetics, genomics, and epigenetics; familial cancer syndromes; signal transduction, cell cycle control, and apoptosis; cancer metabolism; stem cells and cancer; metastasis; cancer immunology and immunotherapy; conventional and molecularly-targeted therapies; and early detection and prevention. Students taking graduate version complete additional assignments.	true	Fall	Graduate	4-0-8	None. Coreq: 7.06; permission of instructor	null	false	false	false	False	False	False
7.86	Building with Cells	Focuses on fundamental principles of developmental biology by which cells build organs and organisms. Analyzes the pivotal role of stem cells in tissue maintenance or repair, and in treatment of disease. Explores how to integrate this knowledge with engineering tools to construct functional tissue structures. Students taking graduate version complete additional assignments.	true	Fall	Graduate	4-0-8	7.03 and 7.05	null	false	false	false	False	False	False
7.88[J]	Protein Folding in Health and Disease	Focuses on understanding the chemical and biological mechanisms of protein folding, misfolding, aggregation, and quality control. Topics covered include: molecular mechanisms of protein folding; experimental and computational strategies to study protein folding; how cells fold and quality control proteins; protein misfolding and aggregation; proteostasis and human disease; strategies to address protein folding failures in disease; and protein folding in biotechnology development. Provides state-of-the-art understanding of the field, fosters ability to critically assess and use the literature, and empowers students to study and address protein folding issues in their research and beyond.	true	Spring	Graduate	3-0-3	(5.07 or 7.05) and permission of instructor	5.48[J]	false	false	false	False	False	False
7.89[J]	Topics in Computational and Systems Biology	Seminar based on research literature. Papers covered are selected to illustrate important problems and varied approaches in the field of computational and systems biology, and to provide students a framework from which to evaluate new developments. Preference to first-year CSB PhD students.	true	Fall	Graduate	2-0-10	Permission of instructor	CSB.100[J]	false	false	false	False	False	False
7.91	The CRISPR Revolution: Engineering the Genome for Basic Science and Clinical Medicine	Provides a conceptual and technical understanding of genome editing systems and their research and clinical applications. Focuses on fundamental CRISPR biology in bacteria, methodologies for manipulating the genome with CRISPR, and the application of genome engineering in research and medicine. Combines lectures and literature discussions with critical analysis and assigned readings, with the goal of better understanding how key discoveries were made and how these are applied in the real work. Class work includes brief writing assignments as well as a final research proposal and scientific presentation. Students taking the graduate version explore the subject in greater depth, in part through additional assignments.	true	Fall	Graduate	3-0-9	Permission of instructor	null	false	false	false	False	False	False
7.930[J]	Research Experience in Biopharma	Provides exposure to industrial science and develops skills necessary for success in such an environment. Under the guidance of an industrial mentor, students participate in on-site research at a local biopharmaceutical company where they observe and participate in industrial science. Serves as a real-time case study to internalize the factors that shape R&D in industry, including the purpose and scope of a project, key decision points in the past and future, and strategies for execution. Students utilize company resources and work with a scientific team to contribute to the goals of their assigned project; they then present project results to the company and class, emphasizing the logic that dictated their work and their ideas for future directions. Lecture component focuses on professional development.	true	Fall	Graduate	2-10-0	null	20.930[J], CSB.930[J]	false	false	false	False	False	False
7.931	Independent Study in Biology	Program of study or research to be arranged with a department faculty member.	false	Fall, Spring	Graduate	rranged [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
7.932	Independent Study in Biology	Program of study or research to be arranged with a department faculty member.	false	Fall, Spring, Spring	Graduate	rranged	Permission of instructor	null	false	false	false	False	False	False
7.933	Research Rotations in Biology	Introduces students to faculty participating in the Biology graduate program through a series of lab rotations, which provide broad exposure to biology research at MIT. Students select a lab for thesis research by the end of their first year. Limited to students in the Biology graduate program.	true	Fall, Spring	Graduate	rranged [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
7.934	Teaching Experience in Biology	For qualified graduate students in the Biology graduate program interested in teaching. Classroom or laboratory teaching under the supervision of a faculty member.	true	Fall, IAP, Spring	Graduate	rranged [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
7.935	Responsible Conduct in Biology	Sessions focus on the responsible conduct of science. Considers recordkeeping and reporting; roles of mentor and mentee; authorship, review, and confidentiality; resolving conflicts; misfeasance and malfeasance; collaborations, competing interests, and intellectual property; and proper practices in the use of animal and human subjects. Limited to second-year graduate students in Biology.	true	IAP	Graduate	rranged [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
7.936	Professional Development in Biology	Required for course 7 doctoral students to gain professional perspective in career development activities such as internships, scientific meetings, and career and networking events. Written report required upon completion of activities.	true	Fall, IAP, Spring, Summer	Graduate	0-2-0 [P/D/F]	null	null	false	false	false	False	False	False
7.941	Research Problems	Directed research in a field of biological science, but not contributory to graduate thesis.	true	Fall, Summer	Graduate	rranged [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
7.942	Research Problems	Directed research in a field of biological science, but not contributory to graduate thesis.	true	Spring	Graduate	rranged [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
7.95	Cancer Biology	Advanced seminar involving intensive analysis of historical and current developments in cancer biology. Topics address principles of apoptosis, principles of cancer biology, cancer genetics, cancer cell metabolism, tumor immunology, and therapy. Detailed analysis of research literature, including important reports published in recent years. Enrollment limited.	true	Spring	Graduate	3-0-9	7.85 and permission of instructor	null	false	false	false	False	False	False
7.98[J]	Neural Plasticity in Learning and Memory	Examination of the role of neural plasticity during learning and memory of invertebrates and mammals. Detailed critical analysis of the current literature of molecular, cellular, genetic, electrophysiological, and behavioral studies. Student-directed presentations and discussions of original papers supplemented by introductory lectures. Juniors and seniors require instructor's permission.	true	Spring	Graduate	3-0-9	Permission of instructor	9.301[J]	false	false	false	False	False	False
7.C51	Machine Learning in Molecular and Cellular Biology	Introduces machine learning as a tool to understand natural biological systems, with an evolving emphasis on problems in molecular and cellular biology that are being actively advanced using machine learning. Students design, implement, and interpret machine learning approaches to aid in predicting protein structure, probing protein structure/function relationships, and imaging biological systems at scales ranging from the atomic to cellular. Students taking graduate version complete an additional project-based assignment. Students cannot receive credit without completion of the core subject 6.C51.	true	Spring	Graduate	2-0-4	Biology (GIR), 6.100A, 6.C51, and 7.05	null	false	false	false	False	False	False
7.S930	Special Subject in Biology	Covers material in various fields of biology not offered by the regular subjects of instruction.	true	Fall, Spring, Summer	Graduate	rranged [P/D/F]	Permission of instructor	null	false	false	false	False	False	False

7.340-7.344

Advanced Undergraduate Seminar

Seminars covering topics of current interest in biology with a focus on how to understand experimental methods and design and how to critically read the primary research literature. Small class size facilitates discussions and interactions with an active research scientist. Students visit research laboratories to see firsthand how biological research is conducted. Contact Biology Education Office for topics.

true

Fall, Spring

Undergraduate

2-0-4 [P/D/F]

7.06 or 7.28

null

false

False

7.345-7.349

Advanced Undergraduate Seminar

Seminars covering topics of current interest in biology with a focus on how to understand experimental methods and design and how to critically read the primary research literature. Small class size facilitates discussions and interactions with an active research scientist. Students visit research laboratories to see firsthand how biological research is conducted. Contact Biology Education Office for topics.

true

Fall, Spring

Undergraduate

2-0-4 [P/D/F]

7.06 or 7.28

null

false

False

7.35

Human Genetics and Genomics

Upper-level seminar offering in-depth analysis and engaged discussion of primary literature on the dimensions and phenotypic consequences of variation in human genes, chromosomes, and genomes. Topics include the human genome project; pedigree analysis; mutation and selection; linkage and association studies; medical genetics and disease; sex chromosomes and sex differences; the biology of the germ line; epigenetics, imprinting, and transgenerational inheritance; human origins; and evolutionary and population genetics. Students taking graduate version complete additional assignments. Limited to 20 total for versions meeting together.

true

Spring

Undergraduate

3-0-9

7.06, (7.03 and 7.05), or permission of instructor

null

false

False

7.36

The CRISPR Revolution: Engineering the Genome for Basic Science and Clinical Medicine (New)

Provides a conceptual and technical understanding of genome editing systems and their research and clinical applications. Focuses on fundamental CRISPR biology in bacteria, methodologies for manipulating the genome with CRISPR, and the application of genome engineering in research and medicine. Combines lectures and literature discussions with critical analysis and assigned readings, with the goal of better understanding how key discoveries were made and how these are applied in the real work. Class work includes brief writing assignments as well as a final research proposal and scientific presentation. Students taking the graduate version explore the subject in greater depth, in part through additional assignments.

true

Fall

Undergraduate

3-0-9

7.06 or permission of instructor

null

false

False

7.37[J]

Molecular and Engineering Aspects of Biotechnology

Covers biological and bioengineering principles underlying the development and therapeutic use of recombinant proteins and stem cells; glycoengineering of recombinant proteins; normal and pathological signaling by growth factors and their receptors; receptor trafficking; monoclonal antibodies as therapeutics; protein pharmacology and delivery; stem cell-derived tissues as therapeutics; RNA therapeutics; combinatorial protein engineering; and new antitumor drugs.

true

Spring

Undergraduate

4-0-8

(7.06 and (2.005, 3.012, 5.60, or 20.110)) or permission of instructor

10.441[J], 20.361[J]

false

False

7.371

Biological and Engineering Principles Underlying Novel Biotherapeutics

Covers biological and bioengineering principles underlying the development and therapeutic use of recombinant proteins and immune cells. Special attention to monoclonal antibodies and engineered immune system cells as therapeutics; protein- and glyco- engineering to enhance protein function; protein pharmacology and delivery; nucleic acid- based biotherapeutics; generation of functional cells and tissues from embryonic stem cells and iPS cells; and immune cell-cancer cell interactions in cancer immunotherapy.

true

Fall

Undergraduate

4-0-8

7.06

null

false

False

7.38

Design Principles of Biological Systems

Introduces students to biological control mechanisms governing decision-making and tools to decipher, model, and perturb these mechanisms. Systems presented include signal transduction, cell cycle control, developmental biology, and the immune system. These systems provide examples of feedback and feedforward control, oscillators, kinetic proofreading, spatial and temporal averaging, and pattern formation. Students taking graduate version complete additional assignments.

true

Fall

Undergraduate

3-0-9

7.06 or permission of instructor

null

false

False

7.45

The Hallmarks of Cancer

Provides a comprehensive introduction to the fundamentals of cancer biology and cancer treatment. Topics include cancer genetics, genomics, and epigenetics; familial cancer syndromes; signal transduction, cell cycle control, and apoptosis; cancer metabolism; stem cells and cancer; metastasis; cancer immunology and immunotherapy; conventional and molecularly-targeted therapies; and early detection and prevention. Students taking graduate version complete additional assignments.

true

Fall

Undergraduate

4-0-8

None. Coreq: 7.06

null

false

False

7.46

Building with Cells

Focuses on fundamental principles of developmental biology by which cells build organs and organisms. Analyzes the pivotal role of stem cells in tissue maintenance or repair, and in treatment of disease. Explores how to integrate this knowledge with engineering tools to construct functional tissue structures. Students taking graduate version complete additional assignments

true

Fall

Undergraduate

4-0-8

7.03 and 7.05

null

false

False

7.458[J]

Advances in Biomanufacturing

Seminar examines how biopharmaceuticals, an increasingly important class of pharmaceuticals, are manufactured. Topics range from fundamental bioprocesses to new technologies to the economics of biomanufacturing. Also covers the impact of globalization on regulation and quality approaches as well as supply chain integrity. Students taking graduate version complete additional assignments.

true

Spring

Undergraduate

1-0-2 [P/D/F]

null

10.03[J]

false

False

7.49[J]

Developmental Neurobiology

Considers molecular control of neural specification, formation of neuronal connections, construction of neural systems, and the contributions of experience to shaping brain structure and function. Topics include: neural induction and pattern formation, cell lineage and fate determination, neuronal migration, axon guidance, synapse formation and stabilization, activity-dependent development and critical periods, development of behavior. Students taking graduate version complete additional readings that will be addressed in their mid-term and final exams.

true

Spring

Undergraduate

3-0-9

7.03, 7.05, 9.01, or permission of instructor

9.18[J]

false

False

7.390

Practical Internship Experience in Biology

For Course 7, 5-7, and 6-7 students participating in curriculum-related off-campus internship experiences in biology. Before enrolling, students must consult the Biology Education Office for details on procedures and restrictions, and have approval from their faculty advisor. Subject to department approval. Upon completion, the student must submit a write-up of the experience, approved by their faculty advisor.

true

Fall, IAP, Spring, Summer

Undergraduate

0-1-0 [P/D/F]

null

false

False

7.391

Independent Study in Biology

Program of study or research to be arranged with a department faculty member.

false

Fall, Spring, Summer

Undergraduate

rranged [P/D/F]

null

false

False

7.392

Independent Study in Biology

Program of study or research to be arranged with a department faculty member.

false

Fall, IAP, Spring

Undergraduate

rranged

null

false

False

7.393

Independent Study in Genetics

Program of study or research to be arranged with a department faculty member.

false

Fall, Spring

Undergraduate

rranged

null

false

False

7.394

Independent Study in Biochemistry

Program of study or research to be arranged with a department faculty member.

false

Fall, Spring

Undergraduate

rranged

null

false

False

7.395

Independent Study in Cell and Molecular Biology

Program of study or research to be arranged with a department faculty member.

false

Fall, Spring

Undergraduate

rranged

null

false

False

7.396

Independent Study in Experimental Biology

Program of study or research to be arranged with a department faculty member.

false

Fall, IAP, Spring, Fall, IAP, Spring, Fall, Spring, Spring

Graduate

rranged [P/D/F]

null

false

False

7.C01

Machine Learning in Molecular and Cellular Biology

Introduces machine learning as a tool to understand natural biological systems, with an evolving emphasis on problems in molecular and cellular biology that are being actively advanced using machine learning. Students design, implement, and interpret machine learning approaches to aid in predicting protein structure, probing protein structure/function relationships, and imaging biological systems at scales ranging from the atomic to cellular. Students taking graduate version complete an additional project-based assignment. Students cannot receive credit without completion of the core subject 6.C01.

true

Spring

Undergraduate

2-0-4

Biology (GIR), 6.100A, 6.C01, and 7.05

null

false

False

7.S391

Special Subject in Biology

Covers material in various fields of biology not offered by the regular subjects of instruction.

true

Fall, IAP, Spring, Summer

Undergraduate

rranged [P/D/F]

Permission of instructor

null

false

False

7.S392

Special Subject in Biology

Covers material in various fields of biology not offered by the regular subjects of instruction.

true

Fall, IAP, Spring

Undergraduate

rranged [P/D/F]

Permission of instructor

null

false

False

7.S399

Special Subject in Biology

Covers material in various fields of biology not offered by the regular subjects of instruction.

true

Fall, IAP, Spring

Undergraduate

rranged

Permission of instructor

null

false

False

7.UR

Undergraduate Research

Undergraduate research opportunities in the Department of Biology.

true

Fall, IAP, Spring, Summer

Undergraduate

rranged [P/D/F]

Permission of department

null

false

False

7.URG

Undergraduate Research

Undergraduate research opportunities in the Department of Biology.

false

Fall, IAP, Spring, Fall, Spring, Spring

Graduate

rranged

Permission of department

null

false

False

7.410

Applied Statistics

Provides an introduction to modern applied statistics. Topics include likelihood-based methods for estimation, confidence intervals, and hypothesis-testing; bootstrapping; time series modeling; linear models; nonparametric regression; and model selection. Organized around examples drawn from the recent literature.

true

Spring

Graduate

3-0-9

Permission of instructor

null

false

False

7.411

Seminars in Biological Oceanography

Selected topics in biological oceanography.

true

Fall, Spring

Graduate

rranged [P/D/F]

Permission of instructor

null

false

False

7.421

Problems in Biological Oceanography

Advanced problems in biological oceanography with assigned reading and consultation.

true

Fall, Spring

Graduate

rranged [P/D/F]

Permission of instructor

null

false

False

7.430

Topics in Quantitative Marine Science

Lectures and discussions on quantitative marine ecology. Topics vary from year to year.

true

Fall, Spring

Graduate

2-0-4

Permission of instructor

null

false

False

7.431

Topics in Marine Ecology

Lectures and discussions on ecological principles and processes in marine populations, communities, and ecosystems. Topics vary from year to year.

true

Fall, Spring

Graduate

2-0-4

Permission of instructor

null

false

False

7.432

Topics in Marine Physiology and Biochemistry

Lectures and discussions on physiological and biochemical processes in marine organisms. Topics vary from year to year.

true

Spring

Graduate

2-0-4

Permission of instructor

null

false

False

7.433

Topics in Biological Oceanography

Lectures and discussions on biological oceanography. Topics vary from year to year.

true

Spring

Graduate

2-0-4

Permission of instructor

null

false

False

7.434

Topics in Zooplankton Biology

Lectures and discussions on the biology of marine zooplankton. Topics vary from year to year.

true

Fall, Spring

Graduate

2-0-4

Permission of instructor

null

false

False

7.435

Topics in Benthic Biology

Lectures and discussions on the biology of marine benthos. Topics vary from year to year.

true

Fall, Spring

Graduate

2-0-4

Permission of instructor

null

false

False

7.436

Topics in Phytoplankton Biology

Lectures and discussion on the biology of marine phytoplankton. Topics vary from year to year.

true

Fall, Spring

Graduate

2-0-4

Permission of instructor

null

false

False

7.437

Topics in Molecular Biological Oceanography

Lectures and discussion on molecular biological oceanography. Topics vary from year to year.

true

Fall, Spring

Graduate

2-0-4

Permission of instructor

null

false

False

7.438

Topics in the Behavior of Marine Animals

Lectures and discussion on the behavioral biology of marine animals. Topics vary from year to year.

true

Fall, Spring

Graduate

2-0-4

Permission of instructor

null

false

False

7.439

Topics in Marine Microbiology

Lectures and discussion on the biology of marine prokaryotes. Topics vary from year to year.

true

Spring

Graduate

2-0-4

Permission of instructor

null

false

False

7.440

An Introduction to Mathematical Ecology

Covers the basic models of population growth, demography, population interaction (competition, predation, mutualism), food webs, harvesting, and infectious disease, and the mathematical tools required for their analysis. Because these tools are also basic to the analysis of models in biochemistry, physiology, and behavior, subject also broadly relevant to students whose interests are not limited to ecological problems.

true

Spring

Graduate

3-0-9

Calculus I (GIR), 1.018, or permission of instructor

null

false

False

7.470

Biological Oceanography

Intended for students with advanced training in biology. Intensive overview of biological oceanography. Major paradigms discussed, and dependence of biological processes in the ocean on physical and chemical aspects of the environment examined. Surveys the diversity of marine habitats, major groups of taxa inhabiting those habitats, and the general biology of the various taxa: the production and consumption of organic material in the ocean, as well as factors controlling those processes. Species diversity, structure of marine food webs, and the flow of energy within different marine habitats are detailed and contrasted.

true

Spring

Graduate

3-0-9

Permission of instructor

null

false

False

7.491

Research in Biological Oceanography

Directed research in biological oceanography not leading to graduate thesis and initiated prior to the qualifying exam.

true

Fall, Spring, Summer

Graduate

rranged [P/D/F]

Permission of instructor

null

false

False

7.492[J]

Methods and Problems in Microbiology

Students will read and discuss primary literature covering key areas of microbial research with emphasis on methods and approaches used to understand and manipulate microbes. Preference to first-year Microbiology and Biology students.

true

Fall

Graduate

3-0-9

null

1.86[J], 20.445[J]

false

False

7.493[J]

Microbial Genetics and Evolution

Covers aspects of microbial genetic and genomic analyses, central dogma, horizontal gene transfer, and evolution.

true

Fall

Graduate

4-0-8

7.03, 7.05, or permission of instructor

1.87[J], 12.493[J], 20.446[J]

false

False

7.494

Research Problems in Microbiology

Directed research in the fields of microbial science and engineering.

true

Fall, Spring, Summer

Graduate

rranged [P/D/F]

Permission of instructor

null

false

False

7.498

Teaching Experience in Microbiology

For qualified graduate students in the Microbiology graduate program interested in teaching. Classroom or laboratory teaching under the supervision of a faculty member.

true

Fall, Spring

Graduate

rranged [P/D/F]

Permission of instructor

null

false

False

7.499

Research Rotations in Microbiology

Introduces students to faculty participating in the interdepartmental Microbiology graduate program through a series of three lab rotations, which provide broad exposure to microbiology research at MIT. Students select a lab for thesis research by the end of their first year. Given the interdisciplinary nature of the program and the many research programs available, students may be able to work jointly with more than one research advisor. Limited to students in the Microbiology graduate program.

true

Fall, Spring

Graduate

rranged [P/D/F]

None. Coreq: 7.492 or 7.493; permission of instructor

null

false

False

7.MTHG

Microbiology Graduate Thesis

Program of research leading to the writing of a PhD thesis. To be arranged by the student and the appropriate MIT faculty member.

true

Fall, IAP, Spring, Summer

Graduate

rranged

Permission of instructor

null

false

False

7.50

Method and Logic in Molecular Biology

Logic, experimental design and methods in biology, using discussions of the primary literature to discern the principles of biological investigation in making discoveries and testing hypotheses. In collaboration with faculty, students also apply those principles to generate a potential research project, presented in both written and oral form. Limited to Course 7 graduate students.

true

Fall

Graduate

4-0-8

None. Coreq: 7.51 and 7.52; or permission of instructor

null

false

False

7.51

Principles of Biochemical Analysis

Principles of protein biochemistry, emphasizing structure, equilibrium studies, kinetics, and experimental design. Topics include macromolecular binding and specificity, allosteric systems, mechanisms of inhibition, enzyme principles, single-molecule studies, structure-function relationships, molecular evolution, and library methods. Case studies examine mechanisms of transcription factors, kinases, molecular machines, and other proteins.

true

Fall

Graduate

6-0-6

Permission of instructor

null

false

False

7.52

Genetics for Graduate Students

Principles and approaches of genetic analysis, including Mendelian inheritance and prokaryotic genetics, yeast genetics, developmental genetics, neurogenetics, and human genetics.

true

Fall

Graduate

4-0-8

Permission of instructor

null

false

False

7.540[J]

Advances in Chemical Biology

Introduction to current research at the interface of chemistry, biology, and bioengineering. Topics include imaging of biological processes, metabolic pathway engineering, protein engineering, mechanisms of DNA damage, RNA structure and function, macromolecular machines, protein misfolding and disease, metabolomics, and methods for analyzing signaling network dynamics. Lectures are interspersed with class discussions and student presentations based on current literature.

true

Fall

Graduate

3-0-9

5.07, 5.13, 7.06, and permission of instructor

5.54[J], 20.554[J]

false

False

7.546[J]

Science and Business of Biotechnology

Covers the new types of drugs and other therapeutics in current practice and under development, the financing and business structures of early-stage biotechnology companies, and the evaluation of their risk/reward profiles. Includes a series of live case studies with industry leaders of both established and emerging biotechnology companies as guest speakers, focusing on the underlying science and engineering as well as core financing and business issues. Students must possess a basic background in cellular and molecular biology.

true

Spring

Graduate

3-0-6

None. Coreq: 15.401; permission of instructor

15.480[J], 20.586[J]

false

False

7.548[J]

Advances in Biomanufacturing

Seminar examines how biopharmaceuticals, an increasingly important class of pharmaceuticals, are manufactured. Topics range from fundamental bioprocesses to new technologies to the economics of biomanufacturing. Also covers the impact of globalization on regulation and quality approaches as well as supply chain integrity. Students taking graduate version complete additional assignments.

true

Spring

Graduate

1-0-2

null

10.53[J]

false

False

7.549[J]

Case Studies and Strategies in Drug Discovery and Development

Aims to develop appreciation for the stages of drug discovery and development, from target identification, to the submission of preclinical and clinical data to regulatory authorities for marketing approval. Following introductory lectures on the process of drug development, students working in small teams analyze how one of four new drugs or drug candidates traversed the discovery/development landscape. For each case, an outside expert from the sponsoring drug company or pivotal clinical trial principal investigator provides guidance and critiques the teams' presentations to the class.

true

Spring

Graduate

2-0-4

null

15.137[J], 20.486[J], HST.916[J]

false

False

7.55

Case Studies in Modern Experimental Design

Focuses on enhancing students' ability to analyze, design and present experiments, emphasizing modern techniques. Class discussions begin with papers that developed or utilized contemporary approaches (e.g., quantitative microscopy, biophysical and molecular genetic methods) to address important problems in biology. Each student prepares one specific aim of a standard research proposal for a project that emphasizes research strategy, experimental design, and writing.

true

Spring

Graduate

2-0-7

Permission of instructor

null

false

False

7.571

Quantitative Analysis of Biological Data

Application of probability theory and statistical methods to analyze biological data. Topics include: descriptive and inferential statistics, an introduction to Bayesian statistics, design of quantitative experiments, and methods to analyze high-dimensional datasets. A <em>conceptual</em> understanding of topics is emphasized, and methods are illustrated using the Python programming language. Although a basic understanding of Python is encouraged, no programming experience is required. Students taking the graduate version are expected to explore the subject in greater depth.

true

Spring

Graduate

2-0-4

null

false

False

7.572

Quantitative Measurements and Modeling of Biological Systems

Quantitative experimental design, data analysis, and modeling for biological systems. Topics include absolute/relative quantification, noise and reproducibility, regression and correlation, and modeling of population growth, gene expression, cellular dynamics, feedback regulation, oscillation. Students taking the graduate version are expected to explore the subject in greater depth.

true

Spring

Graduate

2-0-4

null

false

False

7.573

Modern Biostatistics

Provides a practical introduction to probability and statistics used in modern biology. Topics covered include discrete and continuous probability distributions, statistical modeling, hypothesis testing, independence, conditional probability, multiple test corrections, nonparametric methods, clustering, correlation, linear regression, principal components analysis with applications to high-throughput DNA sequencing and image data analysis. Homework is in the R programming language, but prior programming experience is not required. Students taking the graduate version are expected to explore the subject in greater depth.

true

Spring

Graduate

2-0-4

7.03 and 7.05

null

false

False

7.574

Modern Computational Biology

Introduces modern methods in computational biology, focusing on DNA/RNA/protein analysis. Topics include next-generation DNA sequencing and sequencing data analysis, RNA-seq (bulk and single-cell), and protein dynamics. Students taking the graduate version are expected to explore the subject in greater depth.

true

Spring

Graduate

2-0-4

7.03 and 7.05

null

false

False

7.58

Molecular Biology

Detailed analysis of the biochemical mechanisms that control the maintenance, expression, and evolution of prokaryotic and eukaryotic genomes. Topics covered in lecture and readings of relevant literature include: gene regulation, DNA replication, genetic recombination, and mRNA translation. Logic of experimental design and data analysis emphasized. Presentations include both lectures and group discussions of representative papers from the literature. Students taking the graduate version are expected to explore the subject in greater depth.

true

Spring

Graduate

5-0-7

7.03, 7.05, and permission of instructor

null

false

False

7.59[J]

Teaching College-Level Science and Engineering

Participatory seminar focuses on the knowledge and skills necessary for teaching science and engineering in higher education. Topics include theories of adult learning; course development; promoting active learning, problemsolving, and critical thinking in students; communicating with a diverse student body; using educational technology to further learning; lecturing; creating effective tests and assignments; and assessment and evaluation. Students research and present a relevant topic of particular interest. Appropriate for both novices and those with teaching experience.

true

Fall

Graduate

2-0-2 [P/D/F]

null

1.95[J], 5.95[J], 8.395[J], 18.094[J]

false

False

7.60

Cell Biology: Structure and Functions of the Nucleus

Eukaryotic genome structure, function, and expression, processing of RNA, and regulation of the cell cycle. Emphasis on the techniques and logic used to address important problems in nuclear cell biology. Lectures on broad topic areas in nuclear cell biology and discussions on representative recent papers.

true

Spring

Graduate

3-0-9

7.06 or permission of instructor

null

false

False

7.61[J]

Eukaryotic Cell Biology: Principles and Practice

Emphasizes methods and logic used to analyze structure and function of eukaryotic cells in diverse systems (e.g., yeast, fly, worm, mouse, human; development, stem cells, neurons). Combines lectures and in-depth roundtable discussions of literature readings with the active participation of faculty experts. Focuses on membranes (structure, function, traffic), organelles, the cell surface, signal transduction, cytoskeleton, cell motility and extracellular matrix. Ranges from basic studies to applications to human disease, while stressing critical analysis of experimental approaches. Enrollment limited.

true

Fall

Graduate

4-0-8

Permission of instructor

20.561[J]

false

False

7.62

Microbial Physiology

Biochemical properties of bacteria and other microorganisms that enable them to grow under a variety of conditions. Interaction between bacteria and bacteriophages. Genetic and metabolic regulation of enzyme action and enzyme formation. Structure and function of components of the bacterial cell envelope. Protein secretion with a special emphasis on its various roles in pathogenesis. Additional topics include bioenergetics, symbiosis, quorum sensing, global responses to DNA damage, and biofilms. Students taking the graduate version are expected to explore the subject in greater depth.

true

Fall

Graduate

4-0-8

7.03, 7.05, and permission of instructor

null

false

False

7.63[J]

Immunology

Comprehensive survey of molecular, genetic, and cellular aspects of the immune system. Topics include innate and adaptive immunity; cells and organs of the immune system; hematopoiesis; immunoglobulin, T cell receptor, and major histocompatibility complex (MHC) proteins and genes; development and functions of B and T lymphocytes; immune responses to infections and tumors; hypersensitivity, autoimmunity, and immunodeficiencies. Particular attention to the development and function of the immune system as a whole, as studied by modern methods and techniques. Students taking graduate version explore the subject in greater depth, including study of recent primary literature.

true

Spring

Graduate

5-0-7

7.06 and permission of instructor

20.630[J]

false

False

7.64

Molecular Mechanisms, Pathology and Therapy of Human Neuromuscular Disorders

Investigates the molecular and clinical basis of central nervous system and neuromuscular disorders with particular emphasis on strategies for therapeutic intervention. Considers the in-depth analysis of clinical features, pathological mechanisms, and responses to current therapeutic interventions. Covers neurodegenerative diseases, such as Huntington's disease, Parkinson's disease, Alzheimer's disease, Amyotropic Lateral Schlerosis, Frontal Temporal Dementia, and neuromuscular disorders, such as Myotonic Dystrophy, Facio Scapular Humoral Dystrophy, and Duchenne Muscular Dystrophy.

true

Spring

Graduate

3-0-9

Permission of instructor

null

false

False

7.65[J]

Molecular and Cellular Neuroscience Core I

Survey and primary literature review of selected major topic areas in molecular and cellular neurobiology. Covers nervous system development, axonal pathfinding, synapse formation and function, synaptic plasticity, ion channels and receptors, cellular neurophysiology, glial cells, sensory transduction, and relevant examples in human disease. Includes lectures and weekly paper write-ups, together with student presentations and discussion of primary literature. A final two-page research write-up is also due at the end of the term.

true

Fall

Graduate

3-0-9

null

9.015[J]

false

False

7.66

Molecular Basis of Infectious Disease

Focuses on the principles of host-pathogen interactions with an emphasis on infectious diseases of humans. Presents key concepts of pathogenesis through the study of various human pathogens. Includes critical analysis and discussion of assigned readings. Students taking the graduate version are expected to explore the subject in greater depth.

true

Spring

Graduate

4-0-8

7.06 and permission of instructor

null

false

False

7.68[J]

Molecular and Cellular Neuroscience Core II

Survey and primary literature review of major areas in molecular and cellular neurobiology. Covers genetic neurotrophin signaling, adult neurogenesis, G-protein coupled receptor signaling, glia function, epigenetics, neuronal and homeostatic plasticity, neuromodulators of circuit function, and neurological/psychiatric disease mechanisms. Includes lectures and exams, and involves presentation and discussion of primary literature. 9.015 recommended, though the core subjects can be taken in any sequence.

true

Spring

Graduate

3-0-9

Permission of instructor

9.013[J]

false

False

7.69[J]

Developmental Neurobiology

Considers molecular control of neural specification, formation of neuronal connections, construction of neural systems, and the contributions of experience to shaping brain structure and function. Topics include: neural induction and pattern formation, cell lineage and fate determination, neuronal migration, axon guidance, synapse formation and stabilization, activity-dependent development and critical periods, development of behavior. In addition to final exam, analysis and presentation of research papers required for final grade. Students taking graduate version complete additional assignments. Students taking graduate version complete additional readings that will be addressed in their mid-term and final exams.

true

Spring

Graduate

3-0-9

9.011 or permission of instructor

9.181[J]

false

False

7.70

Regulation of Gene Expression

Seminar examines basic principles of biological regulation of gene expression. Focuses on examples that underpin these principles, as well as those that challenge certain long-held views. Topics covered may include the role of transcription factors, enhancers, DNA modifications, non-coding RNAs, and chromatin structure in the regulation of gene expression and mechanisms for epigenetic inheritance of transcriptional states. Limited to 40.

true

Spring

Graduate

4-0-8

Permission of instructor

null

false

False

7.71

Biophysical Technique

Introduces students to modern biophysical methods to study biological systems from atomic, to molecular and cellular scales. Includes an in-depth discussion on the techniques that cover the full resolution range, including X-ray crystallography, electron-, and light microscopy. Discusses other common biophysical techniques for macromolecular characterizations. Lectures cover theoretical principles behind the techniques, and students are given practical laboratory exercises using instrumentation available at MIT. Meets with 5.78 when offered concurrently.

true

Spring

Graduate

5-0-7

5.13, 5.60, (5.07 or 7.05), and permission of instructor

null

false

False

7.72

Stem Cells, Regeneration, and Development

Topics include diverse stem cells, such as muscle, intestine, skin, hair and hematopoietic stem cells, as well as pluripotent stem cells. Topics address cell polarity and cell fate; positional information and patterning of development and regeneration; limb, heart and whole body regeneration; stem cell renewal; progenitor cells in development; responses to wounding; and applications of stem cells in development of therapies. Discussions of papers supplement lectures.

true

Spring

Graduate

4-0-8

Permission of instructor

null

false

False

7.73

Principles of Chemical Biology

Spanning the fields of biology, chemistry and engineering, class addresses the principles of chemical biology and its application of chemical and physical methods and reagents to the study and manipulation of biological systems. Topics include bioorthogonal reactions and activity-based protein profiling, small molecule inhibitors and chemical genetics, fluorescent probes for biological studies, and unnatural amino acid mutagenesis. Also covers chemical biology approaches for studying dynamic post-translational modification reactions, natural product biosynthesis and mutasynthesis, and high-throughput drug screening. Students taking the graduate version are expected to explore the subject in greater depth.

true

Spring

Graduate

3-0-9

7.05 and permission of instructor

null

false

False

7.74[J]

Topics in Biophysics and Physical Biology

Provides broad exposure to research in biophysics and physical biology, with emphasis on the critical evaluation of scientific literature. Weekly meetings include in-depth discussion of scientific literature led by distinct faculty on active research topics. Each session also includes brief discussion of non-research topics including effective presentation skills, writing papers and fellowship proposals, choosing scientific and technical research topics, time management, and scientific ethics.

true

Fall

Graduate

2-0-4 [P/D/F]

null

8.590[J], 20.416[J]

false

False

7.75

Human Genetics and Genomics

Upper level seminar offering in-depth analysis and engaged discussion of primary literature on the dimensions and phenotypic consequences of variation in human genes, chromosomes, and genomes. Topics include the human genome project; pedigree analysis; mutation and selection; linkage and association studies; medical genetics and disease; sex chromosomes and sex differences; the biology of the germ line; epigenetics, imprinting, and transgenerational inheritance; human origins; and evolutionary and population genetics. Students taking graduate version complete additional assignments. Limited to 20 total for versions meeting together.

true

Spring

Graduate

3-0-9

7.52 or permission of instructor

null

false

False

7.76

Topics in Macromolecular Structure and Function

In-depth analysis and discussion of classic and current literature, with an emphasis on the structure, function, and mechanisms of proteins and other biological macromolecules.

true

Spring

Graduate

3-0-6

Permission of instructor

null

false

False

7.77

Nucleic Acids, Structure, Function, Evolution, and Their Interactions with Proteins

Surveys primary literature, focusing on biochemical, biophysical, genetic, and combinatorial approaches for understanding nucleic acids. Topics include the general properties, functions, and structural motifs of DNA and RNA; RNAs as catalysts and as regulators of gene expression; RNA editing and surveillance, and the interaction of nucleic acids with proteins, such as zinc-finger proteins, modification enzymes, aminoacyl-tRNA synthetases and other proteins of the translational machinery. Includes some lectures but is mostly analysis and discussion of current literature in the context of student presentations.

true

Spring

Graduate

3-0-9

7.05, 7.51, or permission of instructor

null

false

False

7.80

Fundamentals of Chemical Biology

Spanning the fields of biology, chemistry, and engineering, this class introduces students to the principles of chemical biology and the application of chemical and physical methods and reagents to the study and manipulation of biological systems. Topics include nucleic acid structure, recognition, and manipulation; protein folding and stability, and proteostasis; bioorthogonal reactions and activity-based protein profiling; chemical genetics and small-molecule inhibitor screening; fluorescent probes for biological analysis and imaging; and unnatural amino acid mutagenesis. The class will also discuss the logic of dynamic post-translational modification reactions with an emphasis on chemical biology approaches for studying complex processes including glycosylation, phosphorylation, and lipidation. Students taking the graduate version are expected to explore the subject in greater depth.

true

Spring

Graduate

4-0-8

5.13 and (5.07 or 7.05)

null

false

False

7.81[J]

Systems Biology

Introduction to cellular and population-level systems biology with an emphasis on synthetic biology, modeling of genetic networks, cell-cell interactions, and evolutionary dynamics. Cellular systems include genetic switches and oscillators, network motifs, genetic network evolution, and cellular decision-making. Population-level systems include models of pattern formation, cell-cell communication, and evolutionary systems biology. Students taking graduate version explore the subject in more depth.

true

Fall

Graduate

3-0-9

(18.03 and 18.05) or permission of instructor

8.591[J]

false

False

7.82

Development, Disease and Therapeutics

Seminar covering the key concepts and technological approaches that are used to study and treat human disease. Topics include human genome variation, germline editing, gene therapy, stem cell derived organoids, human-animal chimeras and the application of these approaches to the study and treatment of major diseases.

true

Spring

Graduate

3-0-9 [P/D/F]

Permission of instructor

null

false

False

7.83

Design Principles of Biological Systems

Introduces students to biological control mechanisms governing decision-making and tools to decipher, model, and perturb these mechanisms. Systems presented include signal transduction, cell cycle control, developmental biology, and the immune system. These systems provide examples of feedback and feedforward control, oscillators, kinetic proofreading, spatial and temporal averaging, and pattern formation. Students taking graduate version complete additional assignments.

true

Fall

Graduate

3-0-9

Permission of instructor

null

false

False

7.84

Advanced Concepts in Immunology

Provides a comprehensive and intensified understanding of the relevance of the immune system beyond immunity. Focuses on how the immune system intersects with all aspects of body homeostasis/physiology or disease and how the immune system can be manipulated therapeutically. New advances in the intersection of immunology with cancer biology, neurosciences, metabolism, aging, and maternal-fetal immunology or similar explored. Presents new modern methods and techniques applicable beyond immunology. Includes critical analysis and discussion of assigned readings. Students apply principles learned in class to generate a potential research project, presented in a written form. Students taking graduate version complete additional assignments.

true

Spring

Graduate

3-0-9

None. Coreq: 7.63; or permission of instructor

null

false

False

7.85

The Hallmarks of Cancer

Provides a comprehensive introduction to the fundamentals of cancer biology and cancer treatment. Topics include cancer genetics, genomics, and epigenetics; familial cancer syndromes; signal transduction, cell cycle control, and apoptosis; cancer metabolism; stem cells and cancer; metastasis; cancer immunology and immunotherapy; conventional and molecularly-targeted therapies; and early detection and prevention. Students taking graduate version complete additional assignments.

true

Fall

Graduate

4-0-8

None. Coreq: 7.06; permission of instructor

null

false

False

7.86

Building with Cells

Focuses on fundamental principles of developmental biology by which cells build organs and organisms. Analyzes the pivotal role of stem cells in tissue maintenance or repair, and in treatment of disease. Explores how to integrate this knowledge with engineering tools to construct functional tissue structures. Students taking graduate version complete additional assignments.

true

Fall

Graduate

4-0-8

7.03 and 7.05

null

false

False

7.88[J]

Protein Folding in Health and Disease

Focuses on understanding the chemical and biological mechanisms of protein folding, misfolding, aggregation, and quality control. Topics covered include: molecular mechanisms of protein folding; experimental and computational strategies to study protein folding; how cells fold and quality control proteins; protein misfolding and aggregation; proteostasis and human disease; strategies to address protein folding failures in disease; and protein folding in biotechnology development. Provides state-of-the-art understanding of the field, fosters ability to critically assess and use the literature, and empowers students to study and address protein folding issues in their research and beyond.

true

Spring

Graduate

3-0-3

(5.07 or 7.05) and permission of instructor

5.48[J]

false

False

7.89[J]

Topics in Computational and Systems Biology

Seminar based on research literature. Papers covered are selected to illustrate important problems and varied approaches in the field of computational and systems biology, and to provide students a framework from which to evaluate new developments. Preference to first-year CSB PhD students.

true

Fall

Graduate

2-0-10

Permission of instructor

CSB.100[J]

false

False

7.91

The CRISPR Revolution: Engineering the Genome for Basic Science and Clinical Medicine

Provides a conceptual and technical understanding of genome editing systems and their research and clinical applications. Focuses on fundamental CRISPR biology in bacteria, methodologies for manipulating the genome with CRISPR, and the application of genome engineering in research and medicine. Combines lectures and literature discussions with critical analysis and assigned readings, with the goal of better understanding how key discoveries were made and how these are applied in the real work. Class work includes brief writing assignments as well as a final research proposal and scientific presentation. Students taking the graduate version explore the subject in greater depth, in part through additional assignments.

true

Fall

Graduate

3-0-9

Permission of instructor

null

false

False

7.930[J]

Research Experience in Biopharma

Provides exposure to industrial science and develops skills necessary for success in such an environment. Under the guidance of an industrial mentor, students participate in on-site research at a local biopharmaceutical company where they observe and participate in industrial science. Serves as a real-time case study to internalize the factors that shape R&D in industry, including the purpose and scope of a project, key decision points in the past and future, and strategies for execution. Students utilize company resources and work with a scientific team to contribute to the goals of their assigned project; they then present project results to the company and class, emphasizing the logic that dictated their work and their ideas for future directions. Lecture component focuses on professional development.

true

Fall

Graduate

2-10-0

null

20.930[J], CSB.930[J]

false

False

7.931

Independent Study in Biology

Program of study or research to be arranged with a department faculty member.

false

Fall, Spring

Graduate

rranged [P/D/F]

Permission of instructor

null

false

False

7.932

Independent Study in Biology

Program of study or research to be arranged with a department faculty member.

false

Fall, Spring, Spring

Graduate

rranged

Permission of instructor

null

false

False

7.933

Research Rotations in Biology

Introduces students to faculty participating in the Biology graduate program through a series of lab rotations, which provide broad exposure to biology research at MIT. Students select a lab for thesis research by the end of their first year. Limited to students in the Biology graduate program.

true

Fall, Spring

Graduate

rranged [P/D/F]

Permission of instructor

null

false

False

7.934

Teaching Experience in Biology

For qualified graduate students in the Biology graduate program interested in teaching. Classroom or laboratory teaching under the supervision of a faculty member.

true

Fall, IAP, Spring

Graduate

rranged [P/D/F]

Permission of instructor

null

false

False

7.935

Responsible Conduct in Biology

Sessions focus on the responsible conduct of science. Considers recordkeeping and reporting; roles of mentor and mentee; authorship, review, and confidentiality; resolving conflicts; misfeasance and malfeasance; collaborations, competing interests, and intellectual property; and proper practices in the use of animal and human subjects. Limited to second-year graduate students in Biology.

true

IAP

Graduate

rranged [P/D/F]

Permission of instructor

null

false

False

7.936

Professional Development in Biology

Required for course 7 doctoral students to gain professional perspective in career development activities such as internships, scientific meetings, and career and networking events. Written report required upon completion of activities.

true

Fall, IAP, Spring, Summer

Graduate

0-2-0 [P/D/F]

null

false

False

7.941

Research Problems

Directed research in a field of biological science, but not contributory to graduate thesis.

true

Fall, Summer

Graduate

rranged [P/D/F]

Permission of instructor

null

false

False

7.942

Research Problems

Directed research in a field of biological science, but not contributory to graduate thesis.

true

Spring

Graduate

rranged [P/D/F]

Permission of instructor

null

false

False

7.95

Cancer Biology

Advanced seminar involving intensive analysis of historical and current developments in cancer biology. Topics address principles of apoptosis, principles of cancer biology, cancer genetics, cancer cell metabolism, tumor immunology, and therapy. Detailed analysis of research literature, including important reports published in recent years. Enrollment limited.

true

Spring

Graduate

3-0-9

7.85 and permission of instructor

null

false

False

7.98[J]

Neural Plasticity in Learning and Memory

Examination of the role of neural plasticity during learning and memory of invertebrates and mammals. Detailed critical analysis of the current literature of molecular, cellular, genetic, electrophysiological, and behavioral studies. Student-directed presentations and discussions of original papers supplemented by introductory lectures. Juniors and seniors require instructor's permission.

true

Spring

Graduate

3-0-9

Permission of instructor

9.301[J]

false

False

7.C51

Machine Learning in Molecular and Cellular Biology

Introduces machine learning as a tool to understand natural biological systems, with an evolving emphasis on problems in molecular and cellular biology that are being actively advanced using machine learning. Students design, implement, and interpret machine learning approaches to aid in predicting protein structure, probing protein structure/function relationships, and imaging biological systems at scales ranging from the atomic to cellular. Students taking graduate version complete an additional project-based assignment. Students cannot receive credit without completion of the core subject 6.C51.

true

Spring

Graduate

2-0-4

Biology (GIR), 6.100A, 6.C51, and 7.05

null

false

False

7.S930

Special Subject in Biology

Covers material in various fields of biology not offered by the regular subjects of instruction.

true

Fall, Spring, Summer

Graduate

rranged [P/D/F]

Permission of instructor

null

false

False