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2.75k
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5.51k
AlphaFoldDB
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P02651
APOA4_RAT
Apolipoprotein A4
Rattus
MFLKAVVLTVALVAITGTQAEVTSDQVANVMWDYFTQLSNNAKEAVEQLQKTDVTQQLNTLFQDKLGNINTYADDLQNKLVPFAVQLSGHLTKETERVREEIQKELEDLRANMMPHANKVSQMFGDNVQKLQEHLRPYATDLQAQINAQTQDMKRQLTPYIQRMQTTIQDNVENLQSSMVPFANELKEKFNQNMEGLKGQLTPRANELKATIDQNLEDLRSRLAPLAEGVQEKLNHQMEGLAFQMKKNAEELQTKVSTNIDQLQKNLAPLVEDVQSKLKGNTEGLQKSLEDLNKQLDQQVEVFRRAVEPLGDKFNMALVQQMEKFRQQLGSDSGDVESHLSFLEKNLREKVSSFMSTLQKKGSPDQPLALPLPEQVQEQVQEQVQPKPLES
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
P02651
A8G797
PEBB_PROM2
Phycoerythrobilin:ferredoxin oxidoreductase
Prochlorococcus
MLIKDTIFYRPDWRWHIFLKYLTNNLSKYNCLEKIIPSEYSYKDSTYGSKKSKKNVNLCTWGVTHKKRIQFARAVCINSPKYSVLNFLIIPNTIYNVPFFGVDFVSLPNIYLLVLDFQPSLKIQNQYNNQLLEKLIKLKNHCHSSLPLAEEMSVDVARFFSPGAIWSKLPKEERSDFLIANQLYTSFKEYLDLYLEILFESKEVNIDLQKELINGQNNYLNYRRDNDPARPMLSSLFGKEFTESLIKEVLFTT
Catalyzes the two-electron reduction of the C2 and C3(1) diene system of 15,16-dihydrobiliverdin.
A8G797
Q02QU5
MNMC_PSEAB
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Pseudomonas
MSDFQHAQLDWDENGQPLSRAFGDVYFSRHSGLNETRHVFLATNRLAERFAALGDGEVLCIGETGFGTGLNFLCAWQLFEQVAPAGARLEFVSVEKFPLAAADLRRALALWPELAPWSEALLGQYLAVHPGFQRLAFAGGRIGLTLLLGDALECLPQLDARVDAWFLDGFAPAKNPDMWSPALFAELARLSAPQATLGTFTSAGFVRRGLIEAGFAMQRVPGYGQKREMLGGTYQGPPANAGKPWYARPAPHAGRRAALVVGGGLAGCASAASLAARGWQVTLIERHPGLAREASGNPQGVLYLKLSAHGTPLSRLVLSGFGHTRRLLERLRRGHDWDACGVLQLAFDAKEAQRQAQLAAAFPADLLHGLDREQAERLAGVALPAGGLFYPEAGWVHPPALCQALAATPGITLLSGRAVRLRREGDDWCAYAGDECLARAPLAILATAADIRDFPPAAELPLKRIRGQVTRLPATPQSRALRTVVCAEGYVAPPRGDEHTLGASFDFKSEDLAPTLAEHQGNLELLREISPDLLQRLGADDLPLERLEGRAAFRCTSPDYLPLVGPLAERAAFDEAYAVLARDARQVPERACPWLPGLYLNSGHGSRGLISAPLSGELLAAWICGEPLPLPRAVAEACHPNRFLLRDLVRGQRG
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
Q02QU5
P13678
KPC3_DROME
dPKC98F
Sophophora
MFTGKLQIKVCEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVDESHFDRATTRPKTFDPVWNEQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISFEDLMQSETAVQDLWVNLEPQGKIHVIIELKNRTDKAKAEAVVEHTVAVNKEFKERAGFNRRRGAMRRRVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDKQQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSFRSCALSVDSLATSTTTMTSGYNSSSCMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNPKFGPERKVY
PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
P13678
Q1RJJ2
YIDD_RICBR
Putative membrane protein insertion efficiency factor
belli group
MTRILLLLLTFYRYFISPLLGGNNCRFYPTCSKYAKEALNTHGGIKGLWLIFKRIIKCQPLCDGGYDPVPLTK
Could be involved in insertion of integral membrane proteins into the membrane.
Q1RJJ2
P12626
ANFA_AZOVI
Nitrogen fixation protein AnfA
Azotobacter
MSDQATFEFDTDYFVEEFSHCFTGECRVKMLPILYKISQIITGNADLADALSIVLGVMQQHLKMQRGIVTLYDMRAETIFIHDSFGLTEEEKKRGIYAVGEGITGKVVETGKAIVARRLQEHPDFLGRTRVSRNGKAKAAFFCVPIMRAQKVLGTIAAERVYMNPRLLKQDVELLTMIATMIAPLVELYLIENIERVRLENENRRLKHALKERFKPSNIIGNSKPMQEVYELIHKVASTKATVLILGESGVGKELVANAIHYNSPNAEAALVTSNCAPLPENLAESELFGHEKGSFTGALTMHKGCFEQADGGTIFLDEVGELSPTVQAKLVRVLQNRTFERVGGSKPVKVDVRIIAATNRNLVEMVEQGTFREDLYYRLNVFPITVPPLRERGSDVIALADHFVSAFSRENGKNVKRISTPALNMLMSYHWPGNVRELENVMERAVILSDDDVIHSYNLPPSLQTSKESGTAFGLTLEEKIKAVECEMIVEALKNSSGHIGEAAKELGLARRMLGVRMERYGISYKSFSRYA
AnfA is essential for nitrogen fixation under Mo- and V-deficient conditions. It is required for the regulation of nitrogenase 3 transcription. Interacts with sigma-54.
P12626
Q8ZPZ4
MNMA_SALTY
tRNA-specific 2-thiouridylase MnmA
Salmonella
MSESPKKVIVGMSGGVDSSVSAWLLQQQGYQVEGLFMKNWEEDDGEEYCTAAADLADAQAVCDKLGIELHTVNFAAEYWDNVFELFLEEYKAGRTPNPDILCNKEIKFKAFLEFAAEDLGADYIATGHYVRRADVNGKSRLLRGLDGNKDQSYFLYTLGHEQIAQSLFPVGELEKPQVRKIAEDLGLVTAKKKDSTGICFIGERKFRDFLGRYLPAQPGKIITVDGDEIGEHQGLMYHTLGQRKGLGIGGTKDGSEDPWYVVDKDVENNVLIVAQGHEHPRLMSVGLIAQQLHWVDREPFTGTLRCTVKTRYRQTDIPCTINALNDDRIEVIFDEPVAAVTPGQSAVFYSGEVCLGGGIIEQRLPLTV
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs.
Q8ZPZ4
B9E9J2
RL4_MACCJ
50S ribosomal protein L4
Macrococcus
MANYDVLKVDGTKAGSIELNDNVFGIEPNQHVLFEAINLQRASMRQGTHAVKNRSAVSGGGRKPWKQKGTGRARQGTIRAPQWRGGGIVFGPTPRSYSYKMPKKMRRLALRSALSAKVQENAFTVLESLTFDAPKTKEFKNMTTTLELPKKVLFVVEAEDVNVALSARNIPGVTVITTTGLNVLDIVHANQVVMTKGAVEKVEEVLG
Forms part of the polypeptide exit tunnel.
B9E9J2
Q93YV6
2A5K_ARATH
Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform
Arabidopsis
MFKQFLSKLPRKSSKSDSGELNRSSSGPVSSPVQRSGTSGGGSGPVRSNSGKRMSSAVFPASVVAGIEPLVPFKDVPSSEKLNLFVSKVSLCCVTFDFSDPGKNSIEKDVKRQTLLELLDFVASGSVKFTEPAILAMCRMCAVNLFRVFPPNYRSSSGGENDDDEPMFDPAWPHLQIVYDLLLKFITSPCLDAKVAKKYLDHAFIVRLLDLFDSEDPRERECLKTILHRVYGKFMVHRPFVRKSMSNIFYRFVFETEKHSGIAELLEIFGSIVSGFALPLKEEHKIFLWRVLIPLHKPKSVGNYFQQLSYCITQFIDKEPKLGSVVIKGLLKFWPITNSQKEVMFLGEVEEIVEAMSVMEFQKIMVPLFLRIACCVTSSHFQVSERALFLWNNDQIVNLIGHNRQAILPIMFTALEKNAQNHWNQSVLNLTLNVRKMFCEMDEALFMSCHARFKEDEAKQCSAAEKRKEVWARLENAASMKPITGKTAVLVTPRATSIAC
The B regulatory subunit may modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment.
Q93YV6
Q5L5H5
IF1_CHLAB
Translation initiation factor IF-1
Chlamydia
MAKKEDTIVLEGRVKELLPGMHFKILLENGMPVTAHLCGKMRMSNIRLLVGDRVTVEMSAYDLTKARVVYRHR
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
Q5L5H5
C6DYJ5
SYT_GEOSM
Threonyl-tRNA synthetase
unclassified Geobacter
MNEINVTLPDGSQRPLPAGASIFDLAASIGAGLAKAAIAGKIDGNLVDLNTPLADGARVEIVTEKSPEALEIIRHSTSHLMAQAVKALFPQAKVTIGPAIETGFYYDFDVDHPFTPEDLEKIEEKMRELAKADLKIERRELTSADAIALFKGMGEDYKVELIEDLGADKVSLYSQGDFVDLCRGPHLPKTSYIKAFKLTSIAGAYWRGDEKRAMLQRVYGTAFGDKKELEAYLARIEEAKKRDHRKLGRELDLFSFNDEVGAGLVIWHPKGAMLRTILEDFERKEHLKRGYDIVLGPQILKTELWQRSGHYENYRENMYFTTVDEQSYGVKPMNCLAHMMIYRSQLRSYRDLPLRYFELGTVHRHERAGVLHGLLRVRGFTQDDAHILCTPDQLDAEIKGVIQFVTEVMGIFGFEFEMELSTRPEKSIGSDDAWELATSALLNALKDSGRPYEINEGDGAFYGPKIDIKLRDALDRRWQCATIQCDFTLPERFDLTYVDADGEKKRPVMVHRVILGAIERFIGVLIEHFAGNFPTWLAPVQATIVTVTDNQIPYAQAAFDKLRAAGIRVQKDFRNEKLGFKIREAQLQKIPYMLVVGDKEVESGMLAPRFRDGKNLESMTPEQFITFIENEVKSYK
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
C6DYJ5
B8J9V9
RRF_ANAD2
Ribosome-releasing factor
Anaeromyxobacter
MGTIADDILDDLHGRILKTLDQLRTELAAVRTGRASLHLLDNVRVDYYGTPTPLNQVATLSVPEARLIVVKPWEKSMIPPIEKAIRDGNLGLNPMSDKDLVRVPIPALTEERRKEIVKQVKHKGEEHKIAVRNVRREAKELIEVAEKDGDISGDDAEKALEKMQKETDDGVKKIDEIVAAKEKDVLQV
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
B8J9V9
Q2RI73
AROC_MOOTA
5-enolpyruvylshikimate-3-phosphate phospholyase
Moorella
MLRYLTAGESHGRGLSVIVEGLPAGVPLTDGDINTWLTRRQGGYGRGGRMAIERDQAEILAGVRGGLTLGSPIALFIANRDWENWQEIMAPGPEARAARVVTRPRPGHADLAGGLKYHQADLRNILERASARETAARVAAGAVAAVLLKELAIELAFHVVRIGPVEVREQVDWEAACRAVESPVYCADPEAGRAMVAAIEEARQQGDTLGGVVEVLARGVPAGLGSHVHWDRRLDGRLAQALMSIPAIKGVEIGAGFRVAALPGSRAHDAIAYRKGQGFYHPTNRAGGLEGGLTNGETLVLRAAMKPIPTLMHPLPSVDLVTKQPATASIERSDVCAVPAAAVVAAAAVAWVLAGAILEQFGGDYLPVIQERLAAYRQYLQEI
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
Q2RI73
O22456
SEP3_ARATH
Agamous-like MADS-box protein AGL9
Arabidopsis
MGRGRVELKRIENKINRQVTFAKRRNGLLKKAYELSVLCDAEVALIIFSNRGKLYEFCSSSSMLRTLERYQKCNYGAPEPNVPSREALAVELSSQQEYLKLKERYDALQRTQRNLLGEDLGPLSTKELESLERQLDSSLKQIRALRTQFMLDQLNDLQSKERMLTETNKTLRLRLADGYQMPLQLNPNQEEVDHYGRHHHQQQQHSQAFFQPLECEPILQIGYQGQQDGMGAGPSVNNYMLGWLPYDTNSI
Probable transcription factor active in inflorescence development and floral organogenesis. Functions with SEPALLATA1/AGL2 and SEPALLATA2/AGL4 to ensure proper development of petals, stamens and carpels and to prevent the indeterminate growth of the flower meristem. Interacts with APETALA1, AGAMOUS or APETALA3/PISTILLATA to form complexes, that could be involved in genes regulation during floral meristem development . Binds specifically to the CArG box DNA sequence 5'-CC (A/T)6 GG-3' .
O22456
Q6DW73
DGDG2_LOTJA
Digalactosyldiacylglycerol synthase 2, chloroplastic
Lotus
MGKKQHIAIFTTASLPWLTGTAVNPLFRAAYLSKDGERDVTLVIPWLSLKDQALVYPNNITFASPSEHEKYIRQWLEERVGFTSGFSIKFYPGKFSRDKRSILAVGDISEVIPDKEADIAVLEEPEHLTWFHHGKRWKTKFRLVIGIIHTNYLEYVKREKNGQMQAFLLKYLNNWVVGIYCHKVIRLSAATQDYSGSIVCNVHGVNPKFLEIGKKKREQQQNGDQAFTKGAYFIGKMVWSKGYKELLHLFKNHQKELSALEVDLFGSGEDSDEVQKAAKKLEMAVRVHPARDHADALFHDYKLFLNPSTTDVVCTTTAEALAMGKIVVCANHCSNEFFKQFPNCWTFDESKGFVQLILKALAEEPAQLTDAQRHDLSWEAATERFLKAAELDKPFEKKLSRSTSIYMSTSLNLQQTVDDASAYVHHVASGFEISRRMFGAIPGSLKPDEELSKELGLSDSGRK
Involved in the synthesis of diacylglycerol galactolipids that are specifically found in thylakoid membranes. Specific for alpha-glycosidic linkages.
Q6DW73
Q49588
PSTB_MYCIT
Phosphate-transporting ATPase
Mycobacterium avium complex (MAC)
MRREQQLPAAVAAPVADGGQLMRAVDLTLGFGPKTVLEQVSLDFPARSVTTLLGPTGSGKTTFLRTLNRMNDKVSGFRHSGDVLLGGRTIFADRDLMEFRRSVGMLFQRPNPFPMSIMDNVVAGVRAHKMAPRKQFKTVAEARLTEVGLWDAVKDRLGDSPFRLSGGQQQLLCLARALAVNPDVLLLDEPTSSLDPTTTEKIEGLIRSLADRLTVIMVTHDLAQAARTGDRTAFFFEGRLVEEGPTKHLFLSPQHEETVRYFAPFRPAQGSDRGSSQTAGVAESQ
Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
Q49588
F4HU58
TAD1_ARATH
tRNA-specific adenosine-37 deaminase TAD1
Arabidopsis
MEEDWGKTVSEKVISAYMSLPKKGKPQGREVTVLSAFLVSSPSQDPKVIALGTGTKCVSGSLLSPRGDIVNDSHAEVVARRALIRFFYSEIQRMQLTSGKSNEAKRQRIDSETSSILESADSSCPGEVKYKLKSGCLLHLYISQLPCGYASTSSPLYALKKIPSTQVDDSLLVQASDICSSRHSDVPEIGSNSNKGNGSQVADMVQRKPGRGETTLSVSCSDKIARWNVLGVQGALLYQVLQPVYISTITVGQSLHSPDNFSLADHLRRSLYERILPLSDELLTSFRLNKPLFFVAPVPPSEFQHSETAQATLTCGYSLCWNYSGLHEVILGTTGRKQGTSAKGALYPSTQSSICKQRLLELFLKETHGHKRESSKSKKSYRELKNKATEYYLMSKIFKGKYPFNNWLRKPLNCEDFLIN
Involved in RNA editing. Catalyzes the specific deamination of adenosine-37 in the cytosolic tRNA-Ala. Generates inosine at the position 3'-adjacent to the anticodon tRNA-Ala.
F4HU58
Q02953
HSF_SCHPO
Heat shock transcription factor
Schizosaccharomyces
MIQTASTISSNGGTNQGMESSSANSPEMNGTQNSMSVGMSGSGSSQNRKITQFSNKLYNMVNDSSTDSLIRWSDRGDSFLVIGHEDFAKLVLPRYFKHNNFSSFVRQLNMYGFHKVPHIQQGVLQSDSPNELLEFANPNFQRDQPELLCLVTRKKAGSQPVEESNTSLDMSTISSELQNIRIQQMNLSNELSRIQVDNAALWQENMENRERQRRHQETIDKILRFLASVYLDGKQKPPSKVMPKSRRLLLEAKYPTVSPTNEPSAHSRPSPQGTTANSSSASISSLHNTTPDGEGKYRSVQNGRALNYVSSFNSDSHSPKDYISQSYTNEPGLKKESADSFNNSIDSYISPNQSPNTDVPSLNRDDTTDPKVVNTGDIINMLDDANSIEGSNMNSLSPLLFDYPNSLYPVNNTSSEQHHNSYRGSVSNSQPSGNLSESTNLQPVQPVDYMSNSNPSYGSYNAEDQLTNFHPGYAMDQKRISKLSDGITKQDQNIQALADILGIPLGDGKIDDAGFSANSPTNLNLPVSSDLDSVLNIPPNEDVFPDSNPVFDEFTNISNLTSPIEASNGNTFGSNPVSLPNQQKSVNPSLMTVSSPRQVRKKRKSSIGA
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. Also required for growth at normal temperatures.
Q02953
P10176
COX8A_HUMAN
Cytochrome c oxidase subunit 8-2
Homo
MSVLTPLLLRGLTGSARRLPVPRAKIHSLPPEGKLGIMELAVGLTSCFVTFLLPAGWILSHLETYRRPE
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
P10176
C6A5J6
NADK_THESM
ATP-dependent NAD kinase
Thermococcus
MKFGIVARRDREEALKLAYRVYDFLKVNNYEVYVDEEAYIHFPHFSSEDVLSLKKMDVDMIIAIGGDGTVLRVEHNTSKDIPILAVNMGTLGFLAEIEPAETFFAISRILEGDYFIDERMKIRVFVEDVSIPDALNDVVILTSIPGKVTHLKYYVDGELAEDIRADGLIISTPTGSTAYALSAGGPLVDPRLHAILLVPLAPVALTARPLVVPDCSSIEIEVLTEREIVLTVDGQFYTQLPSNLKIRVEKSPRKTKFVRFSERIYPKYTLKIKKKF
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
C6A5J6
O74499
LSM7_SCHPO
U6 snRNA-associated Sm-like protein LSm7
Schizosaccharomyces
MSSLQKRPGPGNSSQPTERPRKESILDLSRYQDQRIQATFTGGRQITGILKGFDQLMNLVLDDVEEQLRNPEDGKLTGAIRKLGLVVVRGTTLVLIAPMDGSEEIPNPFVQAE
Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. Probable component of the spliceosome.
O74499
A2QLJ9
ATG9_ASPNC
Autophagy-related protein 9
Aspergillus subgen. Circumdati
MMTSNILSRFLPPNGSPSVYETIRQHDNHSDASDVEERAGMAFEDEHGDRFSDRELEDALADAGRDDSPGPSEPFLPRSPPTKRDEGGFLKAGSRRRKFSRSGRIHAASPRHKFDDSDDDVPPSLLVEGDQDDDDVLRSKLPPPPRSIDPPNVEPPPRPSPRDDRVHWEAARDRLPLHDTNRRAHHASLWSAGYPNLALVDPKEKALWMWANVENLDNFLKEVYTYFLGNGIWSILLNRVLSLLTFAFVVGFSIFLTNCIDYHKVRGSRTLDDILIQKCTKQMSMSATFLLWLLSFFWIGKAFQYLLDIRRLKHMHDFYHYLLGISDAEIQSISWQEVVSRLMTLRDSNPATAGAVSAKHRKFMGSQSKQRMDAHDIANRLMRKENYLIALINKDILDLTLPIPFLRNRQLFSRTLEWNINLCIMDYVFNEQGQVRTLFLKDTHRRALSEGLRRRFMFAGIMNIFVAPFIVVYFMMHYFFRYFNEYKKNPSQIGSRQYTPLAEWKFREFNELWHLFERRVNMSYPFASRYVDQFPKDKMVQFAGFVAFVSGALASVLALASVVDPELFLGFEITHDRTVLFYLGVFGSIWAVAQGLVPEETNVFDPEYALLEVINFTHYFPGHWKGRLHSDDVRKDFAVLYQMKIVIFLEEILSMIFTPFILWFSLPKCSDRLIDFFREFTVHVDGMGYLCSFAVFDFKKGTNVISQGDTGRRDAARQDLRADYFSTKDGKMLASYYGFLDNYGANPRSGHPSTKRQFHPPPTFPTLGSPSAIEMGNFGDRPAAAGLMGQQSTYGAAPRFGPAGMGDHLSPAPSMLLDPHHQPSASGFRSTHRANPYPRYRASRPPPTISDPIEDEDPPAGKGRSAVKSSPGVGSSGGGIGTSDSNLGESWRMNLVGDEVEEEDEGGENVDTLAGGGGVLGLIQQFQKVNQDNRGRTTVGI
Phospholipid scramblase involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through atg2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Required for mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machineries are required for anterograde trafficking to the PAS during either the Cvt pathway or bulk autophagy and for retrograde trafficking.
A2QLJ9
Q10271
ARB2_SCHPO
Argonaute-binding protein 2
Schizosaccharomyces
MFRKKKSRVLQRDVNFGNCLEDMNLQITNDFYLRKLNAPNELYEFQVTKDKEYNEKFYFAVLDHVYSWTLQNSLLTRISIPLESSPSEPHSWIYATRNWQTNENGIVIIIQSMSHPLIWSNRNLREGDVRRATVLDVIAKCTEKKLSVVIFSPSALLWDQSINFPRTTRYFTSQGLQITKKSIIKDVETPESYVSIGLNYVMSNSVSTKIHFVGSEYGSYLLNSYLDLNWKKFSGKAGAILLIMNMSINEELHDPDYVSYLIEHARNYLPSHEPCRHLMNSIMTESGIPNFSAGKYIDEFYDYIGDVLLEMIALDTNTSKS
A member of the argonaute siRNA chaperone (ARC) complex which is required for histone H3K9 methylation, heterochromatin assembly and siRNA generation. The ARC complex contains mostly double-stranded siRNA. Inhibits the release of the siRNA passenger strand from ago1 together with arb1.
Q10271
B0BZK7
ATP61_ACAM1
F-ATPase subunit 6 1
Acaryochloris
MPLASLEVGQHLYWQIGGLKVHGQVLITSWIVIGILVIVSVLATRKVERIPSGLQNFMEYALEFVRDLTKNQIGEKEYRPWVPFIGTLFLFIFVSNWSGALFPWKLISLPEGELAAPTNDINTTVALALCTSFVYFYAGFRKKGLGYFRKYIEPTPVLLPIAILEDFTKPLSLSFRLFGNILADELVVAVLVLLVPLIVPLPVMLLGLFTSGIQALVFATLAGAYIHESLEGHGEEEEAH
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
B0BZK7
B3EGP4
RECA_CHLL2
Recombinase A
Chlorobium
MNMDTNDKEKKNEGIDPAKLKQLNLAVDALEKQFGKGAIMRLGDGSAVMQVQSISTGSMTLDFALGVGGLPRGRVAEIYGPESSGKTTLALHVIAEAQKEGGIAAIVDAEHAFDPSYARKLGVDINALLISQPESGEQALTIVETLVRSGAVDVVVVDSVAALVPQAELEGEMGDSVVGLQARLMSQALRKLTGAISKSSAVCIFINQLRDKIGVMYGSPETTTGGKALKFYASIRLDIRKIAQIKDGDEIVGNRTKVKVVKNKVAPPFKSAEFDILYGEGISAMGELVDLAVEFGVVKKSGSWFSFGQEKLGQGRESAKKALREDHALFQQVYIQVRELMTGTAEIING
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
B3EGP4
B9KJ95
LIPB_ANAMF
Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase
Anaplasma
MSLLGFPVEWRVSDGMVDYKAALDFMTSRVDGILEGRESEMVWLLEHPSVYTAGVSAKDGELLSENKFQVVRTTRGGKYSYHGPGQRVVYVMLHLGRRDKRDVRLYVRNLGLWVVGTLAEFGIDSHFDDDNTGVWVQYSRQAKKIAAFGIAIRRWVTYHGFSVNISTDLGCYSGIVPCGIAGSHVTSLQDLGVTVPFEEFDAVLQQKFDTIFLQ
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
B9KJ95
Q60CS4
RSMG_METCA
16S rRNA 7-methylguanosine methyltransferase
Methylococcus
MLERGLSELGSDAGGDQRERLLRFLELLRKWNRVYSLTAIEDPCEGVRLHLLDSLSIASFLHGRRVLDVGTGPGLPGIPLAIVQPERRFVLLDCNAKKIRFVRQAVIELGLANVVPVQARIESFTDAEGFDCVLARAYASLAEIWTDAAPLLRTGGTVLALKGRRPEAELGDLPAGVAVGIHRLRVPGVEAERHLAELKPTGQDS
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
Q60CS4
O74974
UTP25_SCHPO
U three protein 25
Schizosaccharomyces
MAIESDLDGASMDELAGKSYEALLYLMNKNKKRKPEKKDDKEKSSKKVQKKNKVIESLNEMEVEMEDENENENDEQEAIQYYINVESQDADETLHQEAQDSSEDPFHQHFDYDDSEVIKNSIAAYDEGKLCKSIEESKLGVSQSFFPDVTKRLPCSCLSEIKNIDDLGLKQRILDSYKKQKPSGQLTSMQIELAKAMFNYQDVFFTNMSMKSHKLGTSLLALHALNHVFKTRDRVLKNSARISQNPELEFRDQGYTRPKVLILLPTRNSAFEFINLLISYSGTNQVENRKRFDNEFSIEKEVISEKKPEDFRYLFSGNTDDMFRLGVKFTRKTVKLFSQFYNSDIIVASPLGLRLAIGNKGDKKRDLDYLSSIEIAMVDQAHALVMQNWEHIECIFDELNGLPKEAHGCDFSRVRPWYLDQQARYMRQTILFSQYNNLDINSFFSHYMSNIAGKVKFRSLLHGVLNRLGYKVTQTFVRISVDSIIKVPDARFSYFTGSILVQLKKYSQSGILVYIPSYFDFVRVRNYMDEEGINYSAISEYSSVSDMTRARNLFYQGRTNIMLYTERAHHFRRFDFRGVKAVVMYGPPTNPQFYVELVRMPMRTISEGNLDSDAAKCRIMYTKFDSICLEGIVGYQRVSNMCHGKHEVFEFL
DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
O74974
Q65JA8
HFQ_BACLD
RNA-binding protein Hfq
Bacillus
MKSINIQDQFLNQIRKENTFVTVFLLNGFQLRGQVKGFDNFTVLIESEGKQQLIYKHAISTFAPQKNVQLELE
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.
Q65JA8
Q9UUC7
CTU2_SCHPO
Cytoplasmic tRNA 2-thiolation protein 2
Schizosaccharomyces
MQNTALDNSADSKCSKCDNKATVLTKSDAVCDSCFVRRIENKIRRQFELVRPNLQGRKSKRAMLAISGGISSMAMLETANYLSKYRDDNYRPMFDELLAVHFQWGTDSAVAKTIEESISKNYPKCPFKVIGEAELLNRTIATDSRGNIEINADNEKFNPEVISSLASRQDLLYRIRDKLLVSYARKANCDTIVFGDSGTTIAARVLELVAEGRGFAIPWYTSVCSKLPNCDTFLLRPLREVLSSDLKSYMNIKGLAFCDSLIEARPNTIHGVTESYFSSLNDTFPSLVSTVVKMSSKLHVPSTEAICTICNLPMQEDAETWLQKTTVEHPDSVEGIKNQNVCYGCSVSLKSLKGTLHIPDIEKEGI
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ctu1 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Q9UUC7
C0ZAH1
HEM3_BREBN
Pre-uroporphyrinogen synthase
Brevibacillus
MGKWKVGTRRSKLALTQTNWVVDKLKGFAPEADFELHEIVTKGDRILDVTLSKVGGKGLFVKEIEQSLFDKETDFAVHSLKDMPAELPDGLVIGAIPKRVDPRDVLLSKDGKTLDELPQGALVGTSSLRRSSQILAYRPDIQIESLRGNIDTRMRKLAEGNFDAIILAAAGLERVNFEGEISQFLPVEISLPAVGQGALAIECRADDEETLALLKQFDDAPTRLAVSAERSFLHKLQGGCQVPIGAYATVGENNEITLTGMVGSPDGKQMFKNTATGQDPLALGIQVAEALLAQGAGDVLAEVLRENEQ
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
C0ZAH1
Q58445
RPO1N_METJA
Mja rpoA1 intein
Methanocaldococcus
MERYEIPKEIGEIMFGLLSPDYIRQMSVAKIVTPDTYDEDGYPIDGGLMDTRLGVIDPGLVCKTCGGRIGECPGHFGHIELAKPVIHIGFAKTIYKILKAVCPHCGRVAISETKRKEILEKMEKLERDGGNKWEVCEEVYKEASKVTICPHCGEIKYDIKFEKPTTYYRIDGNEEKTLTPSDVREILEKIPDEDCILLGLNPEVARPEWMVLTVLPVPPVTVRPSITLETGERSEDDLTHKLVDIIRINNRLEENIEGGAPNLIIEDLWNLLQYHVNTYFDNEAPGIPPAKHRSGRPLKTLAQRLKGKEGRFRYNLAGKRVNFSSRTVISPDPCLSINEVGVPEVVAKELTVPEKVTKYNIERIRQLLRNGSEKHPGVNYVIRKMIGRDGTEQEYKVKITESNKDFWAENIREGDIVERHLMDGDIVLYNRQPSLHRMSIMAHRVRVLPYRTFRHNLCVCVDGDTTVLLDGKLIKIKDLEDKWKDVKVLTSDDLNPKLTSLSKYWKLNADEYGKKIYKIKTELGREIIATEDHPFYTTNGRKRCGELKVGDEVIIYPNDFPMFEDDNRVIVDEEKIKKVINNIGGTYKNKIINELKDRKLIPLTYNDQKASILARIVGHVMGDGSLIINNKNSRVVFRGDIEDLKTIKEDLKELGYDGEEIKLHEGETEITDYNGKKRIIKGKGYSFEVRKKSLCILLKALGCVGGDKTKKMYGIPNWIKTAPKYIKKEFLSAYFGSELTTPKIRNHGTSFKELSFKIAKIEEIFDEDRFIKDIKEMLKEFGIELKVRVEEGNLRKDGYKTKVYVASIYNHKEFFGRIGYTYANKKETLARYAYEYLLTKEKYLKDRNIKKLENNTKFITFDKFIKEKCLKNGFVKEKIVSIEETKVDYVYDITTISETHNFIANGFLTGNCPPYNADFDGDEMNLHVPQSEEARAEAEALMLVEKHILSPRFGGPIIGAIHDFISGAYLLTSNYFTKDEATLILRSGGIKDELWEPDKVENGVPLYSGKKIFSKALPKGLNLRYKAKICRKCDVCKKEECEYDAYVVIKDGELIKGVIDKNGYGAEAGLILHTIVKEFGPEAGRKFLDSATKMAIRAVMLRGFTTGIDDEDLPEEALKEIEKVLDEAEEKVKEIIEKYERGELELLPGLNLEESREAYISNVLREARDKAGAIAERYLGLDNHAVIMAVTGARGNILNLTQMAACLGQQSVRGKRIFRGYRGRVLPHFEKGDLGARSHGFVRSSYKKGLSPTEFFFHAMGGREGLVDQAVRTAQSGYMQRRLINALQDLKTEFDGTVRDSRGIMIQFKYGEDGIDPMLADRGKAVNIDRIIDKVKMKYNQ
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
Q58445
P61721
RISB_CORDI
6,7-dimethyl-8-ribityllumazine synthase
Corynebacterium
MSKEGLPNVSSVAGAGLVVGIVSATWNEKICNQLHAEAIRTAKDCGAKVIETRVIGALELPIVVQKLAQTCDAVVANGCVIKGGTPHFDYVCDSVTEGLTRIALDSGVPVGNGVLTTLNEEQAIDRAGFDGSTENKGAEATIAAMHTALVLRDLP
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
P61721
Q2GB76
MURA_NOVAD
UDP-N-acetylglucosamine enolpyruvyl transferase
Novosphingobium
MDKIIIRGGKRLSGAVPVSGAKNSALTLLPCALLTDEPVTLRNLPRLADIDGFQHLMNQFGVSTSIAGARPEDFGRVMTLQATRLTSTVAPYDLVRKMRASILVLGPMLARAGEATVSLPGGCAIGNRPIDLHLKALEALGAQIELAAGYVRAIAPDGGLPGGRYSFPVVSVGATENALMAAVLAKGKSTLHNAAREPEIVDLCNLLVAMGAQIEGIGTSDLTIHGVDRLHGATYMVMPDRIEAGSYACAAAITGGEVMLNGARIEDMEATVQALRDAGVHVEPRKGGIYVAADGPLKPVTISTAPYPGFATDMQAQLMAMLCLAHGSSVLTETIFENRYMHVPELNRMGARIETKGRTAVVHGVEKLTGAEVMATDLRASMSLVIAGLAAEGETQVHRLYHLDRGYERLEEKLSLLGAEIERVGGD
Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
Q2GB76
Q8LFU0
NFYAA_ARATH
Nuclear transcription factor Y subunit A-10
Arabidopsis
MQTEELLSPPQTPWWNAFGSQPLTTESLSGEASDSFTGVKAVTTEAEQGVVDKQTSTTLFTFSPGGEKSSRDVPKPHVAFAMQSACFEFGFAQPMMYTKHPHVEQYYGVVSAYGSQRSSGRVMIPLKMETEEDGTIYVNSKQYHGIIRRRQSRAKAEKLSRCRKPYMHHSRHLHAMRRPRGSGGRFLNTKTADAAKQSKPSNSQSSEVFHPENETINSSREANESNLSDSAVTSMDYFLSSSAYSPGGMVMPIKWNAAAMDIGCCKLNI
Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
Q8LFU0
Q6P0U0
NAGA_DANRE
Amidohydrolase domain-containing protein 2
Danio
MPSNKSVSDAPITQFVNCRILKNHKLQWEDLWVREGKILNPEKLFFDEQGFADHRVDCENKIIAPGFIDVQLNGGYGIDFSQASSDIRGGVALVAKKILEHGVTSFCPTLVTSPPHIYHKVIPELRVQDGGPEGAGVLGIHLEGPFISEEKRGAHPPKFLRTFQSGGVADLMETYGQLENVAMVTLAPELTNSAAAIHELSSRGITVSVGHSMADLSQAEEAVQNGATFITHLFNAMLPFHHRDPGIVGLLTSDRIPPGRTVYYGMIADGIHTHPAALRIAHRAHPAGLVLVTDAVTAMGLPPGRHTLGQQQIDIQGLHAYVAGTTTLSGSIATMDMCVRHFREASGCTVEAALEAASLHPAQLLGISHRKGTLEFGADADFIVLDDMLTVRETYIAGQQVWRK
Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.
Q6P0U0
A4Y4X5
THII_SHEPC
tRNA 4-thiouridine synthase
Shewanella
MKFIVKLYPEIMMKSKPVRMRFTKMLETNIRNVLKKVDEDAKVQRQWDRIMVMVPKHKPELAQAFGERLACIPGIAHVVQVDEYSFESVDDIYQQALPVYRDQIAGKTFCVRVKRTGDHDFNSIDVERYVGGGLNQFTDAIGVRLKNPDVTVNLEIDRDKLYMVTKRIEGLGGFPMATQEDVLSLISGGFDSGVSSYQFIKKGARTHYCFFNLGGAQHEIGVKQVAYHLWKTYGESHKVKFVSVPFEPVVAEILEKIDNGQMGVVLKRMMMRTAARIAERLGIQALVTGESLGQVSSQTLTNLNVIDRCTELLILRPLIAMDKQDIINESRRIGTEDFAKSMPEYCGVISQKPTVKAVLAKVEAEEKKFSEDLIDQIVAQAVTIDIREIAEQMDTRITETETVIAIETNEVVIDIRAPEEEEHKPLNIEGVEVKRIPFFKLATQFADLDKQKTYLLYCERGVMSKLQALYLIEQGYTNVKVYRP
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
A4Y4X5
Q30YB7
OTC_OLEA2
Ornithine carbamoyltransferase
Oleidesulfovibrio
MTKHFTQIRDLGYQAAWDVLRRAKEMKDSRHRSTLLEGKSAIMLFEKASTRTRVSFETAVHQLGGKTIFMTPAESQLGRSEPLRDTARVLSRYNDLMIVRTFGQEKIDELVEYGSIPVINALTDEGHPCQVMSDMLTIYERTPDLEKVRVAWVGDGNNMANSWIEAAIFFKFELFMAFPEGYEPDRNLLALAMQAGAKIFLTHDPAMAVDGAHYVNTDVWASMGQEEEQKKREKAFAGFCVDDALMAKAAPDARFMHCLPAHRGEEVTEDVFESPASIVWDQAENRLHMQKALIEWVMEG
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
Q30YB7
B8J031
EFP_DESDA
Elongation factor P
Desulfovibrio
MYSTTDFRKGLKIEVEGIPYEIVDFQHFKPGKGGAMVRTKLRNILTGRMQDITFRSGEKVNKPDLETRDMQFLYRQDDDLIFMDMTTYEQLQMPVSTTDGKEGFLKDGQECRVLLYKGNPLDIDIPVSMVLAVVETEPGAKGDTVSNVTKPAKLETGLVVQVPIFVNEGDRIKVDTRSKEYLGRE
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
B8J031
P80200
CGA1_HELPX
120 kDa protein
Helicobacter
MTNETIDQQPQTEAAFNPQQFINNLQVAFLKVDNAVASYDPDQKPIVDKNDRDNRQAFEGISQLREEYSNKAIKNPTKKNQYFSDFINKSNDLINKDNLIDVESSTKSFQKFGDQRYRIFTSWVSHQNDPSKINTRSIRNFMENIIQPPILDDKEKAEFLKSAKQSFAGIIIGNQIRTDQKFMGVFDESLKERQEAEKNGEPTGGDWLDIFLSFIFDKKQSSDVKEAINQEPVPHVQPDIATTTTDIQGLPPEARDLLDERGNFSKFTLGDMEMLDVEGVADIDPNYKFNQLLIHNNALSSVLMGSHNGIEPEKVSLLYGGNGGPGARHDWNATVGYKDQQGNNVATIINVHMKNGSGLVIAGGEKGINNPSFYLYKEDQLTGSQRALSQEEIQNKIDFMEFLAQNNAKLDNLSEKEKEKFRTEIKDFQKDSKAYLDALGNDRIAFVSKKDTKHSALITEFGNGDLSYTLKDYGKKADKALDREKNVTLQGSLKHDGVMFVDYSNFKYTNASKNPNKGVGVTNGVSHLEVGFNKVAIFNLPDLNNLAITSFVRRNLEDKLTTKGLSPQEANKLIKDFLSSNKELVGKTLNFNKAVADAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVEKKLESKSGNKNKMEAKAQANSQKDEIFALINKEANRDARAIAYAQNLKGIKRELSDKLENVNKNLKDFDKSFDEFKNGKNKDFSKAEETLKALKGSVKDLGINPEWISKVENLNAALNEFKNGKNKDFSKVTQAKSDLENSVKDVIINQKVTDKVDNLNQAVSVAKATGDFSRVEQALADLKNFSKEQLAQQAQKNESLNARKKSEIYQSVKNGVNGTLVGNGLSQAEATTLSKNFSDIKKELNAKLGNFNNNNNNGLKNEPIYAKVNKKKAGQAASLEEPIYAQVAKKVNAKIDRLNQIASGLGVVGQAAGFPLKRHDKVDDLSKVGLSRNQELAQKIDNLNQAVSEAKAGFFGNLEQTIDKLKDSTKHNPMNLWVESAKKVPASLSAKLDNYATNSHIRINSNIKNGAINEKATGMLTQKNPEWLKLVNDKIVAHNVGSVPLSEYDKIGFNQKNMKDYSDSFKFSTKLNNAVKDTNSGFTQFLTNAFSTASYYCLARENAEHGIKNVNTKGGFQKS
May be necessary for the transcription, folding, export, or function of the cytotoxin.
P80200
D4AZ24
ENG1_ARTBC
Laminarinase
Trichophyton
MKPYTTLPGVAVLVSLLTQSAHAAPFPSRADVVHTREQESAARPQPIVYKHERGVSNEIQYLPPDPQGHPTIIPFPTHISYVTFNSRPGAIHPPYPHLDISEASFKAEDSTCWYRGKPCEGVPHIPIVKGFDSIEKRSPAPQRHPPAPTKATAGYQFTNCTSTSNPGPTATSPTSGIPSQPSAPPATMAGQDIFQPIAKDPIPANIKSRDDHPVKANHIENPTGPISTNKFYANFFLGNQTSTTFTHPYTMIWAKGDKNASSFGMAISHVEPSQRATGEPNNKLPGNPVRYYINPVGIKSLVLSASELKESTTMSVAKPQAFSAQAILRPTGGSSESITFPLVQGMGFITAIYNNLQPAIQSAVLFRKVEPAGSPQGGIFKYKITLEDDKNWLLYVIPENGADPKLKLEGNKLISGPTGFKGVIQVAKNPSAEEGEGIYDKSAGSYATDIKISGSVGTDGTGTYKFSFEKAGKGAPLVMYALPHHVESFDDATKNTKKNMKLSTTTKGMATACVGDSWTMVEGNLPLSMDFAPWKPGSSSQVTLSEGAKNAIKAVAGNELSQDMELQTNLNSMYFSGKGLNKFAGAIYTVQELVGDKAAASGPLNSLKESFKRFVDNKQQIPLVYDNVWKGVVSSGTYEKGDTGLDFGNTLYNDHHFHYGYFILTAAILGKLDPAWLDANKAYVNMLVRDSGNSVDNDEHFPFSRAFDWYHGHSWAKGLFESSDGKDQESTSEDTMYAYAIKMWGKTSGDKSMEARGNLMLGILARTLNNYFLMKNDNVNQPKNFIGNKVTGILFENKIDHTTYFGANLEYIQGIHMLPLLPNSAYTRSAEFVKEEWEAMFASGAAAPAEKVTGGWKGVLYANLAIIDPEASWKYFAQPSLDLSSIDGGASRIWYLAYAAGEYSTYIAL
Probable endo-1,3(4)-beta-glucanase involved in the cell separation process.
D4AZ24
C5D2V2
PROA_GEOSW
Glutamyl-gamma-semialdehyde dehydrogenase
unclassified Geobacillus
MNELLIKAEQLQQAAKTLALLSTEEKNEALTRIAEALIKQKEWILQENEKDVALGKEQGLSPALIDRLQLTNERIEQIVDGVRQVADLPDPIGEIVEEWTRPNGLRIQTIRVPLGVIGMVYEARPNVTVDAASLCLKTGNAVLLRGSSSALHSNKALVHVMKEALRDSAIPADAIQLLEDTSREAAQQMFRLNGYLDVLIPRGGAGLIRSVIENATVPVLETGVGNCHIFIDESAQKQMAIDIVLNAKLQRPSVCNAVETVLIHQNWPYISELVETLHARGVELRGDSQLASSYSFIQQAAETDWSTEYLAPILAVKLVQNVKEAVDHINRYGTKHSEAIISEQNDNVRFFFQAIDAAVLYHNASTRFTDGEQFGYGAEIGISTQKLHARGPMGLRAITTTKSLVYGTGQIRS
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
C5D2V2
Q93V56
IPYR1_ARATH
Pyrophosphate phospho-hydrolase 1
Arabidopsis
MSEETKDNQRLQRPAPRLNERILSSLSRRSVAAHPWHDLEIGPGAPQIFNVVVEITKGSKVKYELDKKTGLIKVDRILYSSVVYPHNYGFVPRTLCEDNDPIDVLVIMQEPVLPGCFLRARAIGLMPMIDQGEKDDKIIAVCVDDPEYKHYTDIKELPPHRLSEIRRFFEDYKKNENKEVAVNDFLPSESAVEAIQYSMDLYAEYILHTLRR
Catalyzes the irreversible hydrolysis of pyrophosphate (PPi) to phosphate. The MgPPi(2-) complex binds to the enzyme only after a free Mg(2+) ion has bound (Ref.9). No activity with glycerol-3-phosphate, glucose-6-phosphate, p-nitrophenylphosphate, ADP, NADP(+), NAD(+),NADH, NADPH or phosphoribosyl pyrophosphate as substrates (Ref.9). Controls the equilibrium of gluconeogenic reactions in the heterotrophic growth phase of early seedling establishment. Determinates the rate of cytosolic glycolysis, providing carbon for seed storage lipid accumulation .
Q93V56
Q2IX94
RL9_RHOP2
50S ribosomal protein L9
Rhodopseudomonas
MEVILLERVAKLGQMGELVRVKDGYARNFLLPRGKALRATAANRDKYEHMKADLEARNIAAKAEAAKVAEKIDGHNVIVIRQASETGQLFGSVSVRDIVTSFEAEGVMISRSQILLDAPIKTIGKHAIEVAVHPEVEVGVSVTVARSAEEAERINRGEDISTRREDQDAAAEAIAAAGEFFDPDAVQDDEEQPVEQ
Binds to the 23S rRNA.
Q2IX94
Q54N80
FKBP3_DICDI
Rotamase
Dictyostelium
MNKFLIALLVLATLAVSFSQEIGVSILKTDTPKGECKGKTASIGDYISLKYVGKFEDGTVFDSSEIHGGFSFNFTIGERKVIPGLEIGTINICEGEKRSIKIPYQLAYGENGIENAIPPRTDIYFDLEVVSIEGAPAQPFYYQLIPSVGTIIAFSMLAGFIVLVKFIIKRYPDESNSKKPAPGKPKKTKAAKQN
PPIases accelerate the folding of proteins by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Q54N80
C5DX31
GSM1_ZYGRC
Glucose starvation modulator protein 1
Zygosaccharomyces
MTKKLSLELRQTRKPIQTACGFCHEKHLQCDVGRPCQNCRKRNIASFCRDKVKRRRKRKRSDASNFDKDEAATQTLNFNTVNPGEGSSSAMTQDEKNTGTTTATTTRTTTNFRSESKASSSTENISRAMKDPADTIIANSLLDKPTIGDTDDTGWGFGSIWTNDEYMTLNDLTSFASESMPNQLGPIEEQRSPRRTLGEPLARRYDSSQPFQYLNFGSKLHKTDSRPYISLEQPGNVPSIPAFTMNKGSNDEDASPQQKESQQMQLWQQQASQLQQQASQLQQQASQLQQQRTQQNEPVSEWTPFQLRLLIKTPKDLFDKKNLVKPHNYRKAYKDLLECLHKMFLGSYYRRQNGRWRPVSDDEDQMRRRLMRKEQLQHIAKSIGELYMPKFVALTSNMIEEDLLLQELVLQRSLLELENMSKLVNCTPICIWRRSGEICFVSNEFCSLTGFYKREILDQRRFIVEFMDHQSVVSYYDLFHEHLAFGPKDSTRTILNKDQAVYTECNLLLNNGSYLKCACCLTARRDAFNISLLLMGQFLPIFDVQ
Transcription factor which regulates nonfermentable carbon utilization.
C5DX31
P50420
CASK_CAPSU
Kappa-casein
Capricornis
MMKSFFLVVTILALTLPFLGAQEQNQEQPICCEKDERFFDDKIAKYIPIQYVLSRYPSYGLNYYQQRPVALINNQFLPYPYYAKPVAVRSPAQTLQWQVLPNTAPAKSCQDQPTTMARHPHPHLSFMAIPPKKDQDKTEIPTINTIASAEPTVHSTPTTEAIVNTVDNPEASSESIVSAPETNTAQVTSTEV
Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
P50420
P87020
PRA1_CANAL
58 kDa fibrinogen-binding mannoprotein
Candida
MNYLLFCLFFAFSVAAPVTVTRFVDASPTGYDWRADWVKGFPIDSSCNATQYNQLSTGLQEAQLLAEHARDHTLRFGSKSPFFRKYFGNETASAEVVGHFDNVVGADKSSILFLCDDLDDKCKNDGWAGYWRGSNHSDQTIICDLSFVTRRYLTQLCSSGYTVSKSKTNIFWAGDLLHRFWHLKSIGQLVIEHYADTYEEVLELAQENSTYAVRNSNSLIYYALDVYAYDVTIPGEGCNGDGTSYKKSDFSSFEDSDSGSDSGASSTASSSHQHTDSNPSATTDANSHCHTHADGEVHC
Cell surface protein involved in the host-parasite interaction during candidal infection. With MP65, represents a major component of the biofilm matrix. Sequesters zinc from host tissue and mediates leukocyte adhesion and migration. As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation. As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack, assisting the fungus in escaping host surveillance. Binds to host fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading to inhibition of complement activation. Mediates also human complement control and complement evasion through binding to C4BPA, another human complement inhibitor, as well as through binding to host integrin alpha-M/beta-2. Decreases complement-mediated adhesion, as well as uptake of C.albicans by human macrophages.
P87020
P24377
GVPM1_HALSA
Gas vesicle protein GvpM 1
Halobacterium
MEPTKDETHAIVEFVDVLLRDGAVIQADVIVTVADIPLIGISLRAAIAGMTTMTEYGLFEEWDAAHRQQSEAFTTSPTADRRED
Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. This protein could be important for the shape determination of the gas vesicle.
P24377
P0A1K8
SPAO_SALEN
Surface presentation of antigens protein SpaO
Salmonella
MSLRVRQIDRREWLLAQTATECQRHGQEATLEYPTRQGMWVRLSDAEKRWSAWIQPGDWLEHVSPALAGAAVSAGAEHLVVPWLAATERPFELPVPHLSCRRLCVENPVPGSALPEGKLLHIMSDRGGLWFEYLPELPAVGGGRPKMLRWPLRFVIGSSDTQRSLLGRIGIGDVLLIRTSRAEVYCYAKKLGHFNRVEGGIIVETLDIQHIEEENNTTETAETLPGLNQLPVKLEFVLYRKNVTLAELEAMGQQQLLSLPTNAELNVEIMANGVLLGNGELVQMNDTLGVEIHEWLSESGNGE
Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells.
P0A1K8
Q3JNY2
PHNC_BURP1
Phosphonates import ATP-binding protein PhnC
pseudomallei group
MDAIRIERLSKTFPNGRKGLEDIDLAIAPGEMVALIGASGSGKSTLLRQIASFSSSDARPSRIDIFGRSIQRDGRIARDVRRMRRDIGFVFQQFNLVDRLSVETNVLIGALARVPMWRRLAGRFSRADRALAAQALGEVGIAEHARERAANLSGGQQQRAALARALVQRARIILADEPIASLDPAASRRVMEMLRALNANHRLTVLVSLHQIDVALRFCPRVVALRAGRIVYDGPSAALTRERLHALYGDDAHLPFAVGDEVRPAAREAAGEPARRAPAAFDSAGSPDLPDSQPASPRRMLAASSMR
Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system.
Q3JNY2
A4SRD4
LEPA_AERS4
Ribosomal back-translocase LepA
Aeromonas
MKHIRNFSIIAHIDHGKSTLSDRLIQTCGGLSSREMQAQVLDSMDLERERGITIKAQSVTLNYQAQDGNTYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAMEMELEVVPVLNKIDLPAAEPERVAEEIEDIVGIDAIDAVRCSAKTGLGVDLVLEEIVARIPAPVGDPDAPLQALIIDSWFDSYLGVVSLVRIKNGSLKKNDKIKVMSTGQVWGVDRIGIFTPKQVDTQGLGCGEVGWVVCGIKDIHGAPVGDTLTQAKNGAEKALAGFKKVKPQVYAGLFPISSDDYESFRDALDKLSLNDASLFFEPESSTALGFGFRCGFLGMLHMEIIQERLEREYDLDLITTAPTVVYEIELNDGSTIHIDSPSAMPPVNNIKEMREPIAECNILLPQEYMGNVITLCIEKRGVQTNMVYHGNQVALTYEIPMAEVVLDFFDRLKSTSRGYASLDYGFKRFETSEMVRLDIMINGERVDALAIITHKENAQYRGRQVVEKMRELIPRQMFDIAIQASIGNQIIARSTVKALRKDVTAKCYGGDVSRKKKLLNKQKEGKKRMKSLGRVDVPQEAFLAILHVGKD
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.
A4SRD4
Q0IBC2
RECR_SYNS3
Recombination protein RecR
unclassified Synechococcus
MIDQFERLPGIGPRTAQRLALHLLRQPEEQIHSFADALLAARSQVGQCQTCFHLSAEPTCEICRNPERSIGMLCVVADSRDLLALERTREYAGRYHVLGGLISPMDGIGPEMLQISNLVKRVAADEINEVILALTPSVEGDTTSLYLARLLKPFTEVSRIAYGLPVGSELEYADDVTLSRALEGRRAVE
May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
Q0IBC2
Q884I3
LOLD_PSESM
Lipoprotein-releasing system ATP-binding protein LolD
Pseudomonas
MSDKAVLSCRNLGKSYEEGPESVVVLSGLQLELHPGERVAIVGTSGSGKSTLLNLLGGLDTPSEGSVWLAGEELSALGEKARGLLRNRALGFVYQFHHLLPEFTALENVCMPLLIGRTAIPEARQRATALLERVGLGHRLAHKPSELSGGERQRVAIARALINQPGLVMLDEPTGNLDHHTAQGIQDLMRELSTSSRTAFLIVTHDMSLARQMDRILRLEGGRLVEA
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
Q884I3
A9B9C4
PSBX_PROM4
Photosystem II reaction center X protein
Prochlorococcus
MAFPVLNLLLDVAVSSEAATNSAIGMIGSFLAAAAFIVVPAASFLIWVSQKDALERKR
Involved in the binding and/or turnover of quinones at the Q(B) site of Photosystem II.
A9B9C4
P58097
HSLO_CAUVC
Heat shock protein 33 homolog
Caulobacter
MTDIAPDTGVLDDVVSAFQIENLPVRGRVVRLGAAIDEVLTRHDYPEPVANLLGEACALAALVGSSLKFEGRLIVQAQGDGPVRYVVVDYDTSGGLRGYCRFDPEEVAAVSEGFVRPGAKTLLGGGVFIMTLDQGPDMDRYQGVTPIEGETLALCAEQYFAQSEQTPTRVRLAVGQADTGQGATWRAGGILIQVIAGDQARGETQDAWTHVQALFETTGEDELIDPTVSTPTLLWRLFNEDGVRLLDEKPLKAFCRCSEDRIGVVMDSFSAEEVAEMVEPDGKIHVTCEYCSRIYKLDPPGA
Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
P58097
B6JLX1
DDL_HELP2
D-alanylalanine synthetase
Helicobacter
MEFCVLFGGASFEHEISIVSAIALKEVLKDRIKHFIFLDENHHFYLIEASNMHSKYFAQIKEKKLPPLILAHNGLLKNSFLGTKIIELPLVINLVHGGDGEDGKLASLLEFYRIAFIGPRIEASVLSYNKYLTKLYAKDLGVKTLDYVLLNEKNRANALDLIKFNFPFIVKPSNAGSSLGVNVVKEEKELVYALDSAFEYSKEVLIEPFIQGVKEYNLAGCKIKTDFCFSYIEEPNKQEFLDFKQKYLDFSRNKAPKANLSNALEEQLKENFKKLYNDLFSGAIIRCDFFVIENEVYLNEINPIPGSLAHYLFDDFKTTLENLAQSLPKTPKIQVKNSYLLQIQKNK
Cell wall formation.
B6JLX1
Q7NK82
GPMA1_GLOVI
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1
Gloeobacter
MAHLILIRHGQSLWNAANKFTGWVDVPLSERGRAEATIASCKLRDYRVNVCFTSMLMRAIETAVITLTECDDICGGKIPIIKHEADDENWHGWDNYDGDPAAELPIYPTATLDERYYGDLQGLDKAETTAKYGKEQVQIWRRSYSVRPPGGESLEDTRKRVYPYFTNRILGHIKQGDNVLVAAHGNSLRSIIMILETLSEEEVPKVELATGVPIVYELDKAAHMLSKAVLTN
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
Q7NK82
A2ALI5
AJAP1_MOUSE
Adherens junction-associated protein 1
Mus
MWIQQLLGLSSMSIRWPGRSLGSHAWILIAMLQLAVDFPSCDSLGPGPEFRLLSRPQRPQRLWSLRSGPPTRLPTPAWSPRAARAERAHGPIQMQTPRARRAHRPRDQVATLGPKGGLTKPPAATRSSPSLASATASSSIVTAGAAEHQGLLRRGRRHTHDTEFNDFDFRGGRPTTETEFIAWGPTGDEDALESNTFPGGFGPTTVSILQTRKTTVATTTTTTAASTATAMTLQTKGVTESLDPWKRTPVGVSTTEPSTSPSSNGKDIQPPRILGETSGLAVHQIITITVSLIMVIAALITTLVLKNCCAPSGHTRRNSHQRKMNQQEESCQNLTDFTPARVPSSVDIFTAYNETLQCSHECVRASVPVYADETLHSTGEYKSTFNGNRTSSADRHLIPVAFVSEKWFEISC
Plays a role in cell adhesion and cell migration.
A2ALI5
Q2J6V2
ILVC_FRACC
Ketol-acid reductoisomerase type I
Frankia
MVEIYYDDDASLDVLADRKVAVIGYGSQGHAHALNLRDSGVDVRVGLPADSRSRARAEEEGLRVLTPAEASAEADIIMLLTPDTTHRTIYAESIAPHLTAGKALAFGHGFNIRYGLIEPPAGVDVFMVAPKGPGHLVRRVFEEGKGVPVLVAVEADASGNALAVALAYAKGIGGTRAGALRTTFTEETETDLFGEQAVLCGGASALVQAGFETLVEAGYTPEVAYFECLHELKLIVDLMYEGGISQMRYSISDTAEYGDVTRGPRVITPAVKAEMRKILDEIRDGAFAREWVAEDDNGRPNFTKLVAEGKQHPIEQVGAKLRPMMSWIA
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
Q2J6V2
P51580
TPMT_HUMAN
Thiopurine methyltransferase
Homo
MDGTRTSLDIEEYSDTEVQKNQVLTLEEWQDKWVNGKTAFHQEQGHQLLKKHLDTFLKGKSGLRVFFPLCGKAVEMKWFADRGHSVVGVEISELGIQEFFTEQNLSYSEEPITEIPGTKVFKSSSGNISLYCCSIFDLPRTNIGKFDMIWDRGALVAINPGDRKCYADTMFSLLGKKFQYLLCVLSYDPTKHPGPPFYVPHAEIERLFGKICNIRCLEKVDAFEERHKSWGIDCLFEKLYLLTEK
Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor . TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified.
P51580
A3CVT7
THIC_METMJ
Thiamine biosynthesis protein ThiC
Methanoculleus
MSLIEDARRGVVTEEMRIVAAAEGVTEDFVRRGVAEGHIVIPVSPYRRVKICGIGEGLRTKVNASIGTSTDMVDVDMEVEKVRQAERAGADTLMELSTGGDFLEIRRRVVEATTLSVGSVPLYQAFIEAARKRGAVVHMEPDDLFRITAEQAKLGTNFMAIHTGINYETMKRLQNQGRHGGLVSRGGAFMTAWMLHNEKENPLYSEFDYLLEILKEHEVTLSFGNGMRAGAVHDATDRAQVQELLINAELADKAHEQGVQTIIEGPGHIPVDEIQTNVVLQKRVTNRRPFYMLGPLVTDIAPGYDDRVAAIGAALSSSYGADFICYVTPAEHLALPTPEEVYEGVMSSRIAAHVGDMIKLKKRDADLEMGHARRDLDWERQFAVAMNPERARAIRDERMPADTDGCTMCGDYCALKIVGRHFNF
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
A3CVT7
Q98DG5
MSCL2_RHILO
Large-conductance mechanosensitive channel 2
Mesorhizobium
MLKEFQEFISKGNVMDLAVGVIIGAAFGKIVDSLVNDIIMPVIGAIFGGLDFNNYFVGLSSAVNATSLADAKKQGAVFAYGSFITVALNFVILAFIIFLMVKAVNNLRRRLEREKPATPAAPPPADVALLTEIRDLLARR
Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
Q98DG5
Q6EW15
RK14_NYMAL
50S ribosomal protein L14, chloroplastic
Nymphaea
MIQPQTLLNVADNSGARKLMCIRIIGASNYRYAHIGDVIVAVIKEAVPNMPLERSEVIRAVIVRTCKELKRDNGMIIRYDDNAAVVIDQEGNPKGTRVFGSIARELRQLNFTKIVSLAPEVL
Binds to 23S rRNA.
Q6EW15
B0R7F9
CAPPA_HALS3
Phosphoenolpyruvate carboxylase
Halobacterium
MVDVPRLMSTQHPDNATLPFFTAGDVIEGEDEIQEAYYVYSHLGCDEQMWDFEGKEGDEYAVKKLLSRYDEFFADHQLGTDVRLTVRGPNPDVEGSEAKILLEILESIPRSFDAARRFAGEYGLETTAPIFEVIVPMVTDADQLNAVHEYYERFVTGKADEAVWDGRTVEEWVGEFDPASITVIPLIEEREAMLAADDIVREYATAHDQDAVRVFLARSDPALNYGCLAADLINKVALQRLYEMSEATGVDVHPILGAGSAPFRGNLTPERAAATADAYSEVETFTVQSAFKYDYPVETVRDGVATLRDADLGAPPFPIDEARALAVIDRTADAYADQVDAIAGTVNRLSSYVPDRRARKLHVGLFGYAREVGENALPRAIGYTASLYAVGCPPTLLGAHALTDDDAAFVREAFPAYFDHLADAARYFNPRCTDVLDLDDDTLAAAVERVDVTPNSEHRAATDDAIDALQRGDDDALRSAIRRGARERQFLG
Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
B0R7F9
A4FUD4
PEX12_BOVIN
Peroxin-12
Bos
MAEHGAHITTASVVDDQPSIFEVVAQDSLMSAVRPALQHVVKVLAESNPAHFGFFWRWFDEIFTLLDLLLQQHYLSKTSASFSENFYGLKRIVMGDQHKLQRLANAGLPKQQFMKSIMFLVLLPYLKVKLEKLVSSLREEDEYSIHPPSSRWKRFYRAFLAAYPFVNMAWEGWFLVQQLRYILGKAQHHSPLLRLAGVRLGRLTVQDIQALEHKPAEASMMQLPAGSIGEKIKSALKKAVGGVALSLSTGLSVGVFFLQFLEWWYSSENQETIKSLTALPTPPPPVHLDYNSDSPLLPKMKTVCPLCRKNRVNDTVLATSGYVFCYRCVFHYVRSHQACPITGYPTEVQHLIKLYSPEN
Required for protein import into peroxisomes.
A4FUD4
A4YCM2
YIDC_SHEPC
Membrane protein YidC
Shewanella
MESQRNILLIGLLFVSFLLWQQWQADKAPKPVATESSLVANVASTHSADVPEADTGVPAAVAASKNLITVKTDQLDVQINPVGGDIVFAALVSHKMEQGKEQPFVLLEQTKDYTYIAQSGLIGRDGIDSSANGRAAFTTSATEFTLAEGQDTLEVPLTYVADNGVTYTKVFVFHRGKFNVDVDYKINNTSAAPLQVQMYGQIKQTIKPSESSMMMPTYRGGAFSTNDVRYEKYNFDDMAKSNLNQATLGGWAAMLQHYFVSAWVPPATDSNTIFSSVSAGGLANIGFRGAVYDIAPGASQEISSQFYVGPKDQAALSAISETLNLVVDYGFLWWLAVPIHWLLMFYQSFVGNWGVAIILITLTVRGLLFPLTKAQYTSMAKMRNLQPKLADLKERFGDDRQKMGQAMMELYKKEKVNPMGGCLPIILQMPIFIALYWVLLESFELRHAPFMLWIHDLSVQDPYYILPLLMGVSMFIMQKMQPIAPTMDPMQVKMMQWMPVIFTVFFLWFPSGLVLYWLVGNIVAIIQQKIIYAGLEKKGLK
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
A4YCM2
C6DF52
LOLA_PECCP
Outer-membrane lipoprotein carrier protein
Pectobacterium
MKKWLAISCLIAGMTSTAVYADAAKDLQGRLNKVNSFHANFSQKVTSADGAAVQEGEGELWLKRPNLFNWKTTSPDESTLISDGKTLWFYNPFVEQVTATWLKDATGNTPFILITRNDASDWNKYDVRQKGDDFELTPKSASGNLKQFAINVTTNGTIKQFTATEQDGQRSTYVLKNQQNAAVDAAQFTFTPPKGVTLDDQRQ
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
C6DF52
Q9WV23
CMAH_CRIGR
CMP-NeuAc hydroxylase
Cricetulus
KQTAETLLSLSPAETANLKEGINFFRNKTTGKEYILYKEKNHLKACKNLCKHQGGLFIKDIEDLDGRSVKCTKHNWKLDVSTMKYINPPGSFCQDELVVEMDGNDGLFLIELNPPNPWDSDPRTPEELAFGEVQITYLTHACMDLKLGDKRMVFDPWLIGPAFARGWWLLHEPPSDWLERLCKADLIYISHMHSDHLSYPTLKQLSQRRPDIPIYVGDTERPVFWNLDQSGVQLTNINVVPFGVWQQVDKNLRFMILMDGVHPEMDTCIIVEYKGHKILNTVDCTRPNGGRLPEKAALMMSDFAGGASGFPMTFSGGKFTEEWKAQFIKAERRKLLNYKAQLVKDLQPRIYCPFAGYFVESHPSDKYIKETNIKNDPIQLNNLIKKNCDVVTWTPRPGATLDLGRMLKDPTDSQGIIEPPEGTKIYKDSWDFGPYLSTLHSAVGDEIFLHSSWIKEYFTWAGFKSYNLVVRMIETDEDFNPFPGGYDYLVDFLDLSFPKERPSREHPYEEIRSRVDVVRYVVKHGLLWDDLYIGFQTRLQRDPDIYHHLFWNHFQIKLPLTPP
Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells.
Q9WV23
A1T876
PDXT_MYCVP
Pyridoxal 5'-phosphate synthase glutaminase subunit
Mycolicibacterium
MSAPQVGVLALQGDTREHLAALREAGAEARTVRRLDELNSVDALVIPGGESTAMSHLLREFGLLEPLRARLAEGMPAYGSCAGMILLATEIADAGVAGREALPLGGIDMTVRRNAFGRQVDSFEEDVEFEGLDGPVHAVFIRAPWVERVGPDVEVLARAGGHPVAVRQGKMLATAFHPEVTGDRRVHRLFVASLS
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
A1T876
Q2YAA5
NUOA_NITMU
NUO1
Nitrosospira
MNASATQATEIWPLVAYFFLVVMLVVGVMALSYIIGERHRSKATDEPFESGIVTVGLARFRLSAKFYLIAVFFVIFDVEAVFLFAWAVAFRELGWPGYIEAIIFISILGAALAYLWRLGALDWGPPRHSAGRFAKDSRSPNHAVVSK
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Q2YAA5
C4LC60
RNH_TOLAT
Ribonuclease H
Tolumonas
MLKQITLYTDGSCLGNPGPGGYAAVLIYKQHRKELAQGYELTTNNRMELMAAIAGLQSLSEPCQVRLTTDSQYVRQGITQWIHGWKKKGWKTANREPVKNVDLWLLLDSEIQRHDVEWFWVKGHSGHPENERCDELARNAALADSRLIDSGYPS
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
C4LC60
Q7V2K6
TSAD_PROMP
tRNA threonylcarbamoyladenosine biosynthesis protein TsaD
Prochlorococcus
MHKVLAIETSCDETSVSIVSNSGDIYKIHSNIVASQIEDHSKWGGVVPELAARKHLELLPFVLEQALEESKIRIEKIDVIASTVTPGLVGCLRVGSITARSLCTLYSKPFLGIHHLEGHLSSILFSKNYPKPPFLTLLVSGGHTELIKVGERRKMQRLGRSYDDAAGEAFDKVGRLLGLSYPGGPAIAKIAKKGNASKFNLPKCKISDKEGGFLKYDFSFSGLKTAVLRLVEKINLNGDEIPIPDIAASFERVVAEVLVERTIKCANDYGLDNIVVVGGVAANDTLRKMMISEACKKSIKVHLAPINLCTDNAAMIGAAALYRLKFKAYESSLKLGISGRLPIDQANTLYENKPPF
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.
Q7V2K6
A9BZY6
DAPE_DELAS
N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase
Delftia
MSRTLQLTEQLISLPSVTPEDAGCLELLADALQPMGFACERIDSGPDSFRVRNLWARRSGTGADRPVLVFAGHTDVVPTGPLEQWSSPPFVPTHRDGKLYGRGASDMKTSIAAFVVALEEFLAETPAPSFDIALLLTSDEEGPSVDGTKVVVELLRERGERLDWCIVGEPTSVERTGDMIKNGRRGTMSGRLTVKGIQGHIAYPQLARNPIHQALPALAELAATRWDEGNAFFPPTSWQISNMHGGTGASNVIPGHVTIDFNFRFCTESTAESLQQRVHAVLDHHGLEYELAWTIGGQPFLTTPGTLVNAVQAAIRAETGLETELSTTGGTSDGRFIAQICSQVVEVGPSNASIHKIDEHIVVADIEPIKNIYRRTLQELQRQQAV
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
A9BZY6
Q4J8L2
PDXT_SULAC
Pyridoxal 5'-phosphate synthase glutaminase subunit
Sulfolobus
MKVGVIAYQGSFEEHAIQLKRAMSKLNLTGEVIAVKKPKDVDLIDGVVIPGGESTTIGIIAEKLGVLDEIKAKINAGLPVLGTCAGAIMLAKDVSDAKVGKKSQPLIGTMDIQVVRNYYGRQRESFETDLDFRVIGGGKARVVFIRAPIIKRTWNDATALISFENGIVMAEQKNMLATTFHPELSESTIVHEYFLSKIKK
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
Q4J8L2
B3H6C3
FB311_ARATH
F-box protein At4g35733
Arabidopsis
MSEATVWSDLPGELLDHIANGLFSKVELLRFRSICKTFRSAVDSDKNFLDHLKRNRRRLLSPYSTGKTCSLSPAAFYRVVLSSYPDKGWLIKLQDAYVSSQKQLLSPLSRFSIKSSGKTLDLLEFTVSEIHQSYDVEYLYYNSTRASFNFARVVLAEDFVFIVDNYKKIWLCNSNESDSHWVRIMDEEVKLFSDIVFHKGYMYALDLTGAVWWISLSEFGIFQFGPSSTPMDYCDIDECKDKRFVEYCGDLCIVHRFSRKFRIKRVDIDMTVGFKVYKMDEELVEYVEVKSLGDKAFVMATDSCFSVLAREYYGCLENSIYFTEQNNVKVFKLGDGSITNMVDSSFQSCFQMLIPPLV
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
B3H6C3
B4R136
SNMP1_DROSI
Sensory neuron membrane protein 1
Sophophora
MQVPRVKLLMGSGAMFVFAIIYGWVIFPKILKFMISKQVTLKPGSDVRELWSNTPFPLHFYIYVFNVTNPDEVSEGAKPRLQEVGPFVFDEWKDKYDLEDDVVEDTVSFTMRNTFIFNPKESLPLTGEEEIILPHPIMLPGGISVQREKAAMMELVSKGLSIVFPNAKAFLKAKFMDLFFRGINVDCSSEEFSAKALCTVFYTGEVKQAKQVNQTHFLFSFMGQANHSDSGRFTVCRGVKNNKKLGKVVKFADEPEQDIWPDGECNNFVGTDSTVFAPGLKKEDGLWAFTPDLCRSLGAYYQHKSSYHGMPSMRYTLDLGDIRADEKLHCFCEDPEDLDTCPPKGTMNLAACVGGPLMASMPHFYLGDPKLVADVDGLNPNEKDHAVYIDFELMSGTPFQAAKRLQFNLDMESVEGIEPMKNLPKLILPMFWVEEGVQLNKTYTNLVKYTLFLGLKINSVLRWSLITFSLVGLMFSAYLFYHKSDSLDINSILKDNNKVDDVASTKEPMPPANPKQSSTVHPVQLPNTLIPGTNPATNPATHLKMEHRERY
Plays an olfactory role that is not restricted to pheromone sensitivity.
B4R136
Q88LM7
KDSB_PSEPK
CMP-2-keto-3-deoxyoctulosonic acid synthase
Pseudomonas
MSLEFTVVIPARLRSTRLPGKPLLLIAGKPMVQHVWEQARKSGASRVVIATDDTSILEACQAFGAEVMMTRADHESGTDRLAEVAAYLGLPADAIVVNVQGDEPLIPPVIIDQVAANLAAHPEAGIATLAEPIHEPETVFNPNAVKVVSDKNGLALTFSRAPLPWARDTFAKARDVLPEGVPYRRHIGMYAYRVGFLHDFVSWGPCWLEQAEALEQLRALWHGVRIHIEDAIEAPAVGVDTPEDLERVRRLLEA
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
Q88LM7
B4EE50
MNMA_BURCJ
tRNA-specific 2-thiouridylase MnmA
Burkholderia cepacia complex
MSKRRVVVGMSGGVDSSVTAWLLKEQGYDVVGLFMKNWEDDDDGEYCSTRQDWIDVVSVADLIGIDVEAVNFAAEYKDRVFAEFLREYSAGRTPNPDVLCNAEIKFKAFLDHAMSLDAEMIATGHYARVRERDGRFELLKAFDHTKDQSYFLHRLNQAQLSKTMFPLGEIPKTKVREIAAQIGLPNAKKKDSTGICFIGERPFRDFLNRYLPTKPGPMKTPDGKVVGEHIGLAFYTFGQRKGIGLGGSKSGSGEPWFVAAKDIASNTLYVVQGHDHPWLLSRELVAGNVSWVAGEPPADGFACGAKTRYRQADAACVFGLAATGAEAAGPAGEARFSLAFDDAQWAVTPGQSAVLYDGEICLGGGIIESAATGQPGQATSTGHAPALAEAR
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
B4EE50
B0TFZ0
YQGF_HELMI
Putative pre-16S rRNA nuclease
Heliomicrobium
MRIMGLDVGDKTIGVAVSDLMGWTAQGVATIRRSRLAADLEHLRELVKTYEVERIVCGLPRNMNGTYGPRAEGIRKFGSLVEKKLNIPVDYWDERLTTVAAQKTLIAGDLSRAKRKQVVDKLAAVLILQNYMDAKAHLAAKEQSKETSE
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
B0TFZ0
Q125B6
ARGB_POLSJ
NAG kinase
unclassified Polaromonas
MTQPTVTADDPDLSHVGPRDKAEILAQALPYIRKFHGKTMVIKYGGNAMTDPALQADFAEDVVLLKLVGMNPVVVHGGGPQIEAALNRLGKKGHFIQGMRVTDEETMEVVEWVLAGQVQQDIVGLINQAGGKAVGLTGRDGGLIRAQKLKMVDKDDPAKEHDIGFVGDIVSIDPSVVKALQDDAFIPVISPIGFGESNESYNINADVVAGKLATVLKAEKLVLLTNTPGVLNKAGELLTDLTAREIDDLFADGTISGGMLPKIEGALDAAKSGVNSVHIIDGRVPHAMLLEILTDQAYGTMIRSH
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
Q125B6
A0M2K0
RNY_GRAFK
Ribonuclease Y
Gramella
MEILIIVIAAVVGLALGFAIAKMLEKKQASGTIASAKKEAGSILKEAKAEGESIKKDKILQAKEKFIELKSEHEKVILSRDKKINDAEKRIKDKESHVSNELGKNKKLNKDLEEKVADYDHRLDFLEKKQEDIDKLHNSKVQQLEVISGLSAEDAKAQLIESLKDTAKADAMSIIQDTVEEAKLTAQQEARKIIINTIQRIGTEEAIENCVSVFNLESDDVKGRIIGREGRNIRALEAATGVEIIVDDTPEAIILSCFDSVRREVARLSLHKLVTDGRIHPARIEEVVKKTRKQIEEEIIDIGKRTVIDLGIHGLQPELIKMVGRMKYRSSYGQNLLQHSREVAKLCGVMAAELGLNPKLAKRAGLLHDIGKVPETETEVPHAILGMQWAEKHGEKPEVCNAIGAHHDEIEMNSLLSPIVQVCDAISGARPGARRQVLDSYIQRLKDLEEIAFGFGGVKKAYAIQAGRELRVIVESEKVSDEKASNLSFEISQKIQTDMTYPGQVKITVIRETRAVNVAK
Endoribonuclease that initiates mRNA decay.
A0M2K0
A1KB13
RS8_AZOSB
30S ribosomal protein S8
Azoarcus
MSMSDPIADMLTRIRNGQQAQKASVTMPSSKVKVAIAKVLQDEGYIEGFSVREGEGKAVLDVALKYYAGRPVIERIERVSRPGLRVYKGTDDLPRVMNGLGVAIVSTPKGVMTDRAARASHVGGEVICLVA
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
A1KB13
Q46Z04
PLSX_CUPPJ
Phosphate-acyl-ACP acyltransferase
Cupriavidus
MTIKIAIDCMGGDHGVSVTVPAAISFLASHDDAAVVLVGLPDAIQAQLKKLRAQDHPRVSVVPATEVITMDDPVEVALRKKKDSSMRVAVTQVKEGLAGACISAGNTGALMAVSRYVLKTLEGIERPAIATTIPNEQGWGTTVLDLGANADCEPEHLLQFARMAEAMVAVVDHKEHPTVGLLNIGEEVIKGNEVVKRAGELLRASELNFHGNVEGNDIFKGTTDIVVCDGFVGNVALKSTEGLAKMIGGMIKEEFTRSWFTKLLAGIAMPVLSRLAKRLDPARYNGASLLGLRGLVIKSHGSADAHSFEWAIKRGYDAAKNGVIERIARAFADKTSAAGAAPASPETAPTPHPSTRAA
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
Q46Z04
Q23116
DEC12_CAEEL
Probable 2,4-dienoyl-CoA reductase decr-1.2 [(3E)-enoyl-CoA-producing]
Caenorhabditis
MACKNPKKFFPIRKSPVLRDGAFKGKLVLVTGGGTGIGKAIATTFAHLRATVVIAARRMEKLEQTARDITKITGGTCEPFQMDIKDPGMVSDAFDKIDMKFGKVPEILVNNAAGNFIMATELLSSNAYGTIIDIVLKGTFNVTTELGKRCIQNKTGASITSITAGYARAGAPFIVPSAVSKAGVETMTKSLATEWSKYGLRFNAVSPGPIPTKGAWGRLNSGEMGDIAEKMKFLNPEGRVGSPEEVANLVAFISSDHMSFLNGAIIDLDGGQQHFNHGSHMGDFLHSWDHKNWEDAENLIRGRTGKEKA
Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
Q23116
Q9K1H0
BAMA_NEIMB
Outer membrane protein Omp85
Neisseria
MKLKQIASALMMLGISPLALADFTIQDIRVEGLQRTEPSTVFNYLPVKVGDTYNDTHGSAIIKSLYATGFFDDVRVETADGQLLLTVIERPTIGSLNITGAKMLQNDAIKKNLESFGLAQSQYFNQATLNQAVAGLKEEYLGRGKLNIQITPKVTKLARNRVDIDITIDEGKSAKITDIEFEGNQVYSDRKLMRQMSLTEGGIWTWLTRSNQFNEQKFAQDMEKVTDFYQNNGYFDFRILDTDIQTNEDKTKQTIKITVHEGGRFRWGKVSIEGDTNEVPKAELEKLLTMKPGKWYERQQMTAVLGEIQNRMGSAGYAYSEISVQPLPNAETKTVDFVLHIEPGRKIYVNEIHITGNNKTRDEVVRRELRQMESAPYDTSKLQRSKERVELLGYFDNVQFDAVPLAGTPDKVDLNMSLTERSTGSLDLSAGWVQDTGLVMSAGVSQDNLFGTGKSAALRASRSKTTLNGSLSFTDPYFTADGVSLGYDVYGKAFDPRKASTSIKQYKTTTAGAGIRMSVPVTEYDRVNFGLVAEHLTVNTYNKAPKHYADFIKKYGKTDGTDGSFKGWLYKGTVGWGRNKTDSALWPTRGYLTGVNAEIALPGSKLQYYSATHNQTWFFPLSKTFTLMLGGEVGIAGGYGRTKEIPFFENFYGGGLGSVRGYESGTLGPKVYDEYGEKISYGGNKKANVSAELLFPMPGAKDARTVRLSLFADAGSVWDGKTYDDNSSSATGGRVQNIYGAGNTHKSTFTNELRYSAGGAVTWLSPLGPMKFSYAYPLKKKPEDEIQRFQFQLGTTF
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
Q9K1H0
Q8ZAM2
TATA_YERPE
Sec-independent protein translocase protein TatA
Yersinia
MGSIGWAQLLIIAVIVVLLFGTNKLRTLGSDLGASIKGFKKAMGDDSQTPPTNVDKTSNDADFAKSITEKQQPVAKAEESKSHEKEQG
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
Q8ZAM2
A1KRT0
NUOH_NEIMF
NDH-1 subunit H
Neisseria
MIMQEWFQNLFAATLGLGDLGITVGLVVSVIVKIVIILIPLILTVAYLTYFERKVIGFMQLRVGPNVTGPWGLIQPFADVFKLLFKEVTRPKLSNKALFYIGPIMSLAPSFAAWAVIPFNEEWVLTNINIGLLYILMITSLSVYGVIIAGWASNSKYSFLGAMRASAQSISYEIAMSAALVCVVMVSGSMNFSDIVAAQAKGIAGGSVFSWNWLPLFPIFIVYLISAVAETNRAPFDVAEGESEIVAGHHVEYSGFAFALFFLAEYIFMILIAALTSLMFLGGWLSPFPQSWGFIGTPSAFWMFVKMAAVLYWYLWIRATFPRYRYDQIMRLGWKVLIPIGFAYIVILGVWMISPLNLWK
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
A1KRT0
A5G7Z5
TRMD_GEOUR
tRNA [GM37] methyltransferase
Geotalea
MKFDILTLFPAMFDGPLTESILKRAAEKGLIEVKLHNIRDFAFDRHSVTDDYPYGGGAGMVMKVEPLAACIEHAKVGSPRARVILTTPRGRSFNHAVAEELAREEALIIICGRYEGVDERVRELFVDDEISIGDFVLTGGEMAAMVLVDAVSRFVPGVLGSDESAVNDSFADGLLEYPQYTRPAEFRGLGVPSVLLSGNHQEIAKWRRRQSLGRTAASRPDLLTDAHLSASDREYLEELQRVAGSDG
Specifically methylates guanosine-37 in various tRNAs.
A5G7Z5
Q8JFY9
ENDUA_XENLA
XendoU-A
Xenopus
MASNRGQLNHELSKLFNELWDADQNRMKSGKDYRISLQGKAGYVPAGSNQARDSASFPLFQFVDEEKLKSRKTFATFISLLDNYEMDTGVAEVVTPEEIAENNNFLDAILETKVMKMAHDYLVRKNQAKPTRNDFKVQLYNIWFQLYSRAPGSRPDSCGFEHVFVGESKRGQEMMGLHNWVQFYLQEKRKNIDYKGYVARQNKSRPDEDDQVLNLQFNWKEMVKPVGSSFIGVSPEFEFALYTIVFLASQEKMSREVVRLEEYELQIVVNRHGRYIGTAYPVLLSTNNPDLY
Poly(U)-specific endoribonuclease involved in the processing of intron-encoded box C/D snoRNAs, such as U16 and U86. Releases products that have 2',3'-cyclic phosphate termini at the 3'-end.
Q8JFY9
Q9A5V1
HISX_CAUVC
Histidinol dehydrogenase
Caulobacter
MRRFLFSDPDFQTAFKAFLDERRGSPADVDAAVAGVLEAVRTQGIEALLDYSRRFDKVDLTAETIRVTAEEIEAGAAETPADVREAIAFAAARIRAYHSRQRPADQAWTDEAGVELGWRWTPLEAVGVYVPGGRAAYPSTVLMNAVPAQVAGVDRIAMVTPPGKLQPAVLAAAKEAGVTEIWRVGGAQAVAALAYGAGPIQPVDKIVGPGNAYVTAAKRRLYGVVGIDALAGPSEIVVVADNKNNPDWIAADLLSQAEHDPAAQSILITDDEAFAAAVEQAIAERLKTLATGEDAAASWRDHGAVIIAPLDESPALVDAIAPEHVEFALDNPERLSDRVRHAGAIFLGRVTPEAIGDYVAGSNHVLPTSRAARFQSGLSIYDFIKRTSIVKCDPASFAVLGPHTVALAKAEGLPAHALSASVRLPSGD
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Q9A5V1
Q821L7
DER_CHLCV
GTP-binding protein EngA
Chlamydia
MLRIAILGRPNVGKSSLFNRMCKRSLAIVNSQEGTTRDRLYGEIRGWSVPVQVIDTGGVDKDSEDHFQKHIYKQALAGANEADILLLVVDIRCGITEQDAELAKMLLPLNKPLILVANKADTFKDEHRIHELYKLGISEILAVSASHDKHIDKLLQRIKTLGNVPEVVEEFSEEEVEEEAVPSMELLSKEPLSDYEEEEIPFSTTSAPDKPLKIALIGRPNVGKSSIINGLLNEERCIIDNVPGTTRDNVDILYSHNDRSYLFIDTAGLRKMKSVKNSIEWISSSRTEKAIARADVCLLVIDAQHHLSSYDKRILSLISKHKKPHIILVNKWDLIEGVRMEHYIRDLRATDVYIGQSRILCISAATKRNLRHIFSSIDELYETVSSKVPTPVVNKTLASTLQKHHPQVINGRRLRIYYAIHKTATPFQFLLFINAKSLLTKHYECYLRNTLKSSFNLYGIPFDLEFKEKTKRTN
GTPase that plays an essential role in the late steps of ribosome biogenesis.
Q821L7
B3EP63
EFTU_CHLPB
Elongation factor Tu
Chlorobium
MAKEAYKRDKPHVNIGTIGHVDHGKTTLTAAITSVLAKAGNAEMREFGDIDKAPEERERGITISTAHVEYQTEKRHYAHIDCPGHADYIKNMITGAAQMDGAILVVAGTDGPMPQTREHILLARQVNVPALVVFLNKVDIADPELLELVELELRELLTEYDFPGDDIPIIKGSALKALEGDAEAEKAIMELMDAVDDYIPEPVRDVDKPFLMPVEDVFSISGRGTVGTGRIERGVVKINEEVELVGIKPTKKTVVTGIEMFQKILDQGQAGDNAGLLFRGVGKDEIERGMVVAKPGTITPHTKFKAEVYILKKEEGGRHTPFFNNYRPQFYFRTTDVTGAVTLPEGVEMVMPGDNLSIEVELIVPIAMDENLRFAIREGGRTVGAGTVTQIIE
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
B3EP63
Q0KCP3
UREG_CUPNH
Urease accessory protein UreG
Cupriavidus
MTQARTKKNPPLRVGVGGPVGSGKTTLLEMLCKAMRDRYDLVAITNDIYTKEDQRLLTVSGALPAERIMGVETGGCPHTAIREDASINLEAVDRMLARFPDADVVFIESGGDNLAATFSPELSDLTIYVIDVAGGEKIPRKGGPGITKSDLLVINKTDLAPYVGASLEVMESDARKMRGARPFVMGSVKSGQGLDEVIRFIERQGMLGV
Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
Q0KCP3
A1WMW4
LEPA_VEREI
Ribosomal back-translocase LepA
Verminephrobacter
MKHIRNFSIIAHIDHGKSTLADRLIERCGGLADRQMQAQVLDSMDLEKERGITIKAQTAALQYQARDGQVYQLNLIDTPGHVDFSYEVSRSLSACEGALLVVDASQGVEAQTVANCYTALELGVEVVPVLNKMDLPNADPDNAKAEIEDVIGIDATDAIPCSAKTGMGIDDILQAIVAKVPAPRGQADGPLRAMIIDSWFDSYVGVVMLVRVVDGRLLKGERIKMMASGAVYNADGLGVFTPANEPRDALAAGQVGYVIAGIKELQAAKVGDTITLEKKLPNNAGPAAQALPGFKEIQPQVFAGLYPTEASAYDSLRDALEKLKLNDASLHYEPEVSQALGFGFRCGFLGLLHMEIVQERLEREFDQDLITTAPSVVYQVVKADGQVLMVENPSKMPDQGRLSEIREPIVTVHLYMPQDYVGPVMTLANQKRGVQMNMAYHGRQVMLTYDMPLGEIVLDFFDKLKSVSRGYASMDYTFKEYRASDVVKVDILLNGDKVDALSIIVHRSQSQHRGRAVVAKMREIISRQMYDVAIQAAIGANIIARETIKALRKNVLAKCYGGDITRKRKLLEKQKAGKKRMKQIGSVEVPQEAFLAILQVQE
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.
A1WMW4
B8I2Q5
MUTS_RUMCH
DNA mismatch repair protein MutS
Ruminiclostridium
MGTVTPMMQQYLDIKEQYKDCILFFRLGDFYEMFFSDAELASRELEITLTGRDCGLEERAPMCGVPFHAADNYIARLVSKGYKVAICEQVEDPALAKGIVKRDVVKVVTPGTVTDITMLDERKNNYLMSVYKNGNFYGLASVDITTGDFYATRITWGNTRGKLLDEIAKYLPSEIIVNNELNSDNELTSEIKQRFNTYVSTFEETSFEYGNSMDILANHFEKQTLNIQEYDIAVNASGALLKYLESTQKVNLSHIQKFNSYALEEYMILDASSRRNLELTETMREKSKKGSLLWVLDKTMTSMGGRLLRKWIEQPLINHGDISLRLDAVEELKNKFMVRVEARELLKRVYDIERLMGKVVLGSVNCRDLIALKNSMCQIPYIKSLLNGFEAEYIKNCGEQLDCLEDVCNLIEVSIIDEPPVTIKEGGIIKDGYNPEVDKLRMASIQGKDWIAALEASQREKTGIKNLKVGFNRVFGYYIEVTKSYFSLVPEEYIRKQTLSNCERYITPELKEIEDTILGAEEKIIQLEYSLFVEIKEKIAEQLSRIKSTARALAEIDVLASLAEVADREGYCKPEVSLSDKIEIIEGRHPVVEKMTDKSGFVPNDTVLDMEEDRLAIITGPNMAGKSTYMRQTALIVLMAQIGSFVPAATAKIGLVDRIFTRVGASDDLASGQSTFMVEMSEVANILINATKRSLLVLDEIGRGTSTFDGLSIAWAVIEYIVNKEQLGCRTLFATHYHELTELEGKLPGIKNYCITVKEKGEDVIFLRKIIRGGADGSYGIQVAKLAGVPQSVIDRAKEILSNLDDADINRSGKARRIKKQVDGQLDLFAQAAKASADAEILEEIRKIDISRLTPIDSMNILYELQRKMNNRE
This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
B8I2Q5
Q97EW5
SYM_CLOAB
Methionyl-tRNA synthetase
Clostridium
MSEKKKFYITTPIYYPSAKLHIGNTYTTVASDALVRFKRLQGYDAFMLTGTDEHGQKIQRIAEDKGITPKAYVDEIVAGIKDLWKMMNISYDKFIRTTDEEHVKAVQKIVKKFYDNGDIYKSAYEGWYCTPCESFWTETQLVDGKCPDCGRPVEKTKEEAYFFKMSKYADRLIKYIEDHPDFIQPESRKNEMLNNFLKPGLQDLCISRSSFDWGIPITFDEKHVIYVWIDALSNYITALGYGSDNDELYNKFWPADLHLVGKDIIRFHTIYWPIMLMALDLPLPKQVFGHGWLLVDGGKMSKSKGNVVDPVVLINEFGTDPVRYYLLHEIPFGSDGLFNNEIFIKKINSDLANDLGNLVSRTAAMIEKYFDGSIQPPVDKEEIDNELIDMAISLPEKLDEDIKKLKIPEALDHIWDLIKRANKYIDETTPWVLAKDENKKARLGTVLYNLVESLRFVATTLTPFLPETGEKIKTQLNIELDTWESLSAFDGTRAGTKVSKGEVIFPRIDVDKKIEELNKLKEEQLKATRKMQPLKPEISIDDVDKLDLRVVKVLECEPVKKSKKLLKLKVELGGEERQVLSGISQFYKPEDLIGKKVVLVANLKPAKLMGQLSQGMILAVATDDDSKLYTLDIPEDIPTGSIVR
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Q97EW5
C0HL11
B1OKD_NIDOK
Brevinin-1OKd
Nidirana
FLGSIIGALAKGLPSLIALIKK
Antimicrobial peptide.
C0HL11
Q8W491
U73B3_ARATH
Flavonol 3-O-glucosyltransferase UGT73B3
Arabidopsis
MSSDPHRKLHVVFFPFMAYGHMIPTLDMAKLFSSRGAKSTILTTPLNSKIFQKPIERFKNLNPSFEIDIQIFDFPCVDLGLPEGCENVDFFTSNNNDDRQYLTLKFFKSTRFFKDQLEKLLETTRPDCLIADMFFPWATEAAEKFNVPRLVFHGTGYFSLCSEYCIRVHNPQNIVASRYEPFVIPDLPGNIVITQEQIADRDEESEMGKFMIEVKESDVKSSGVIVNSFYELEPDYADFYKSVVLKRAWHIGPLSVYNRGFEEKAERGKKASINEVECLKWLDSKKPDSVIYISFGSVACFKNEQLFEIAAGLETSGANFIWVVRKNIGIEKEEWLPEGFEERVKGKGMIIRGWAPQVLILDHQATCGFVTHCGWNSLLEGVAAGLPMVTWPVAAEQFYNEKLVTQVLRTGVSVGAKKNVRTTGDFISREKVVKAVREVLVGEEADERRERAKKLAEMAKAAVEGGSSFNDLNSFIEEFTS
Possesses quercetin 3-O-glucosyltransferase activity in vitro. Also active in vitro on benzoates and benzoate derivatives. Involved in stress or defense responses.
Q8W491
Q603L1
AROE_METCA
Shikimate dehydrogenase (NADP(+))
Methylococcus
MTQPDRYAVFGHPIEHSQSPRIHALFAAQTGQDLIYTAEDVPPDRFESCVRAFFDGGGRGLNCTIPLKEMAWLLADSRSGRAKRARAVNTLLLRADGSIFGDNTDGIGLLRDLRDNLGLNLAGTKILILGAGGATRGILAPLLAERPDRLVIANRTVATAETLTVEFGDLGPVEGCGFAALAGRRFDLIINATAASLSGELPPLPADILAPGGSCYDLAYAAEPTPFVRWGQEKQAVVSADGIGMLVEQAAEAFLLWRGVRPQTRPVIETLEAERRTAK
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Q603L1