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2.75k
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5.51k
AlphaFoldDB
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A6VM61
LUXS_ACTSZ
Autoinducer-2 production protein LuxS
Actinobacillus
MPLLDSFKVDHTKMQAPAVRIAKTMTTPKGDLITVFDLRFCVPNKEIMSPKGIHTLEHLFAGFMRAHLNSDEVEIIDISPMGCRTGFYMSLIGAPSERRVADAWLAAMHDILNVQDQSKIPELNIYQCGTYTEHSLSDAHATAQHVITRGIGINKNEELLLDESLLTE
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
A6VM61
Q3AW00
RSMH_SYNS9
rRNA (cytosine-N(4)-)-methyltransferase RsmH
unclassified Synechococcus
MPPFSHVPVLADAVVAGAEHLPHHNGVLIDATLGGGGHSALLLERFPGLRLIGLDQDPTARAAAAERLAAFADRVEILATNFASYTPPAPVLMVLADLGVSSPQLDVAERGFSFRLDGPLDMRMNPGSDGETAAELIDRLEENALADLIYGYGEERLSRRIARRIKADLAAQGPYEGTAALAYAVAGCYPPKARRGRIHPATRTFQALRIAVNDELAVLDRLLQQAPDWLETGGVMGVISFHSLEDRRVKTAFLQDERLERITRKPTVATDDEQNRNPRSRSAKWRLARRVNGC
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
Q3AW00
A8H0M9
E4PD_SHEPA
D-erythrose-4-phosphate dehydrogenase
Shewanella
MIRVAINGYGRIGRSILRALYESAKRDRIQIVAINELAKPEAMLHLTQYDTTHGRFHTQVKLDNQHMIIGDDAIKLLHEPDPAKLPWKEMDIDIVFEATGVINDRLECEAHIQAGAKQVLISHPSSSDVDATIVFGVNQDLLKAEHTVVSNASCTTNCIVPVIDVLDRHFEVKSGAITTIHSAMNDQQVIDAYHDDLRRTRAAGQSIIPVDTKLARGIERILPHMKDKFEAISVRVPTINVTAIDLSVTLNKRVDIETVNQVLKQATEGSFSGVVGFTNEPLVSCDFNHDPRSSIVDGTQTRVSDGHLVKLLLWCDNEWGFANRMLDTSLEMIKAKSRT
Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
A8H0M9
B1YS63
FABZ_BURA4
Beta-hydroxyacyl-ACP dehydratase
Burkholderia cepacia complex
MSTEKINLDIHKILTLLPHRYPILLVDRVLELEPHKGIKALKNVSINEPFFQGHFPKRPVMPGVLILEALAQAAALLTFAEEQPKDPENTLYYFVGIDGARFKRVVEPGDQLILNVTFERYIRGIWKFKAVAEVDGKVAAEAELMCTVKTADAAP
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
B1YS63
Q8TZV1
ALBA_PYRFU
DNA/RNA-binding protein Alba
Pyrococcus
MAEEHVVYIGKKPVMNYVLAVITQFNEGAKEVSIKARGRAISRAVDVAEIVRNRFLKDTVDIKEIKIGTEELPTADGRTTNTSTIEIVLERKV
Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
Q8TZV1
C4L3Z5
ISPH_EXISA
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
unclassified Exiguobacterium
MKVKKISPRGYCYGVVDAMKLANEAVANPDLPRPIHILGMIVHNRHVTQAFEDLGVKTVDGEDRMQALETIDRGTVVFTAHGISPLVRKRAIEKGLTIVDASCPDVLVTHDLIREKTAEGYDVIYIGKHGHPEPEGAIGVAPDHVHLIQYEHEIDQLPSRLFERKILVTNQTTMSQWDVSALIETIQARYPHVEVHNEICNATQVRQEAVAEQAGDCELLIVVGDPKSNNSNRLAQVSKEIAGTNAYRIGDLSELDLNWLEGVETVAVTSGASTPTPITKKVIDFLSQYDPDDLSTHDKTPFLELRSILPKVKALRK
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
C4L3Z5
Q9PP85
SYM_CAMJE
Methionyl-tRNA synthetase
Campylobacter
MRYITTPIYYVNDVPHLGHAYTTIIADTLARFYRLQGHETRFLTGTDEHGQKIEEAAKLRNSTPQEYADKISFEFKKLWDEFEITYDIYARTTDTRHIEFIKAMFLKMWQKGDIYKDEYEGHYCISCESFFTQSQLINDCSCPDCGKQTRILKEESYFFKLSKYQDKILQWYEEKDPILPKNKKNELINFVQNGLKDLSITRTSFDWGIKLPQEINDDKHIIYVWLDALFIYVSSLDFQNKGENAKFWPAHVHLVGKDILRFHAIYWPAFLMSVDLPLPKFIGAHGWWTKEGEKMSKSKGNVVKPKEVVDAYGSEAFRYFLLREVPFGNDGDFSENMLINRINAELSNEFGNLLNRIIGMSTKYSQGNISKEGVLKFYNAELNQAKEHLNLAVEFLENLQCNRYLEELFKALSVANLAISKYEPWSLIKENKHEQANALVALCANILAKTSLLLSPTLPKSSQKVALALNFEISSANYTKMILDNELLDFKANPCEALFPKVEKALLKQEIKEEPKKEESPKIKIDDFAKIEIKVAKVLDCQNIEGSEKLLKFQLELDDKEIRQVLSGIAKYYKASDLIGKQVCVISNLKKAKIFGHESDGMILSAKSGDKLVLIAPEQLVQNGSLVG
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Q9PP85
P55946
MT_ARIAR
Metallothionein
Arianta
SGKGKGDLCTAACKNEPCQCGSKCQCGEGCACASCKTCNCTSDGCKCGKECTGAASCKCNSSCSCK
The metallothioneins are involved in the cellular sequestration of toxic metal ions and regulation of essential trace elements.
P55946
Q2RMS3
RIMP_RHORT
Ribosome maturation factor RimP
Rhodospirillum
MALWGWRGVGRRPTFFVFASLAPIGRDFLRRNGDDARMMGHLEKLLAPTLDAMGYEVVRVTLLGSQNPTLQVMAERLDGVAMTVSDCETISRALGALLDVEDPIAGRYSLEISSPGIDRPLTRPKDYARFAGHEARIETDRLIEGHRRMKGLLLGIDEDRTVRLRLIEGKAAEDGTLPEVEIPFGAIVKAKLLLTDALIAKALKDAEALADEGEAAGGAVEGGVA
Required for maturation of 30S ribosomal subunits.
Q2RMS3
A5FX03
TIG_ACICJ
PPIase
Acidiphilium
MQVTETLTEGLKRGFTVVVPGSDLSEKREKRLAELSKTMQMPGFRPGKVPLSMVRKRFGDAVAAEVMEASVNEATERMINDRSLRPAVQPKVEVVRAEPDSDLEFTVELEVLPEVTIPDLKAISLTRPKAPVTEAEIDEAIARFAEQRAETEVVTEDRPAATGDILTVDFLGKRDGVPFEGGAGTDTDIELGGSGFIPGFAEQMEGMKAGETKVITVTFPEQYHAAELAGKEATFDITAKALKRRVAPVIDDAFAEANGFENLAEFRKFFADRLEQSRAGASRLKVKRALLDKLAEQADFPAPASLVDAEFAEIWRQVEAEKQAGRLDEEDAGKDEETLRADYRAIAERRVRLGLLVAEIGRTNNVQITEQDMRRAMIAEMQQFPGQEKMIMEFYQKNPRALDRLRGPIFEDKVVDYALELATVTDEEVSAEALFADTDD
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
A5FX03
A7GN87
RECU_BACCN
Recombination protein U homolog
Bacillus cereus group
MTIRYPNGKRYNQALQPQKTKMKKHTYGNRGMSLEEELNETNQYYLSHNIACVHKKPTPLQIVKVDYPARSAAVVREAYFKQPSTTDYNGVYKGKYIDFEAKETKNKTNFPLQNFHLHQIEHMKQVIAHDGIAFVIIKFTLYNEIYLLDAKHVISFWNRKDTGGRKSITKQEIEEHGSLLSCGYHPRIDYISILDMVYFS
Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.
A7GN87
Q83LM0
RLMI_SHIFL
rRNA (cytosine-C(5)-)-methyltransferase RlmI
Shigella
MSVRLVLAKGREKSLLRRHPWVFSGAVARMEGKASLGETIDIVDHQGKWLARGAYSPASQIRARVWTFDPSESIDIAFFSRRLQQAQKWRDWLAQKDGLDSYRLIAGESDGLPGITIDRFGNFLVLQLLSAGAEYQRAALITALQTLYPECAIYDRSDVAVRKKEGMELTHGLLTGELPPALLPIEEHGMNLLVDIHHGHKTAYYLDQRDSRLATRRYVENKRVLNCFSYTGGFAVSALMGGCSQVVSVDTSQEALDIARQNVELNKLDLSKAEFVRDDVFKLLRTYRDRGEKFDVIVMDPPKFVENKSQLMGACRGYKDINMLAIQLLNEGGILLTFSCSGLMTSDLFQKIIADAAIDAGRDVQFIEQFRQAADHPVIATYPEGLYLKGFACRVM
Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.
Q83LM0
B4NEU3
MTNB_DROWI
Probable methylthioribulose-1-phosphate dehydratase
Sophophora
MSLSIFKDLPDEHPRHLIPSLCRQFYHMGWVTGTGGGMSIKLNNEIYIAPSGVQKERMQPEDLFVQDISGKDLQLPPEIKGLTKSQCTPLFMLAYRHRKAGAVIHTHSQHAVMATLLWPGKTFQCTHLEMIKGVYDEADKRYLRYDEKLVVPIIENTPFERDLADSMYAAMMEYPGCSAILVRRHGVYVWGQTWEKAKAMSECYDYLFQLAVEMKKNGLDPEKFEPNC
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
B4NEU3
Q8PH20
HPPA_XANAC
Pyrophosphate-energized inorganic pyrophosphatase
Xanthomonas
MLEHYGLWLALGCAVLAIVYGIVSARWVVAQPSGNARMQEIAAAIQEGARAYLNRQYLTISVAGAVLFVLVGLFLSWYTAIGFALGAVLSGLAGYIGMNVSVRANVRTAEAARHGIGKAMDVAFRGGAITGMLVVGLGLLGVAGYFAVLQGMGLPLEQNLHALVGLAFGSSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTVIATMLLGSLTLADTGSHAVLYPLVLGGVSIIASIVGAAFVKVKDGGSIMGALYKGVIVSGVLAALAYWPITQSLMRDNIHGATALYACALIGLVLTGLIVWITEYYTGTQYTPVQHVASASTTGHGTNIIAGLGISMKSTALPVIAVCAAIWGAFHFGGLYGIAIAATAMLSMAGMIVALDAYGPITDNAGGIAEMAELPPEVRNITDPLDAVGNTTKAVTKGYAIGSAALAALVLFADYTHNLQAANPDQVYAFDLSDHTVIIGLLIGGLIPYLFGAMAMEAVGRAAGAVVEEVRRQFRELPGIMAGTAKPQYDRAVDMLTRSAIGEMIVPSLLPVVVPIIVGLLLGPRALGGLLIGTIVTGLFLAISMTTGGGAWDNAKKYIEDGHFGGKGSEAHKAAITGDTVGDPYKDTAGPAINPLIKIINIVALLLVPLL
Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.
Q8PH20
Q4FFP2
PSBD_NUPAD
Photosystem Q(A) protein
Nuphar
MTIALGRFTKEENDLFDIMDDWLRRDRFVFVGWSGLLLFPCAYFALGGWFTGTTFVTSWYTHGLASSYLEGCNFLTAAVSTPANSLAHSLLLLWGPEAQGDFTRWCQLGGLWTFVALHGAFGLIGFMLRQFELARSVQLRPYNAIAFSAPIAVFVSVFLIYPLGQSGWFFAPSFGVAAIFRFILFFQGFHNWTLNPFHMMGVAGVLGAALLCAIHGATVENTLFEDGDGANTFRAFNPTQAEETYSMVTANRFWSQIFGVAFSNKRWLHFFMLFVPVTGLWMSALGVVGLALNLRAYDFVSQEIRAAEDPEFETFYTKNILLNEGIRAWMAAQDQPHENLIFPEEVLPRGNAL
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors. D2 is needed for assembly of a stable PSII complex.
Q4FFP2
B0B7W5
GRPE_CHLT2
HSP-70 cofactor
Chlamydia
MTETPNTSSEEIQTSEPSPDNELQVLQQENANLKAELQEQNDRYLMALAEAENSRKRLQKERTEMMQYAVENALMDFLPPIESMEKALGFASQTSEEVKNWAIGFQMILQQFKQIFEEKGVVEYSSKGELFNPYLHEAVEIEETTTIPEGTILEEFTKGYKIGDRPIRVAKVKVAKLPAKGNSDSNEEKE
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
B0B7W5
O84874
GLGB_CHLTR
Glycogen branching enzyme
Chlamydia
MDPFFLNTQHVELLVSGKQSSPQDLLGIVSESLNQDRIVLFRPGAETVFVELRGKIQQAESHHSGIFSLPVMKGISPQDYRVYHQNGLLAHDPYAFPLLWGEIDSFLFHEGTHQRIYERMGAIPCEIDGVPGVRFIVWAPHAQRVSVIGDFNGWHGLVNPLHKVSDQGVWELFVPGLTAGACYKWEMVTESGQVLIKSDPYGKFFGPPPWSVSVVIDDSYEWTDSEWLEERIKKTEGPMNIYEVHVGSWRWQEGQPLNYKELADQLALYCKQMHYTHVELLPVTEHPLNESWGYQTTGYYAPTSRYGSFEDLQYFIDTMHQHGIGVILDWVPGHFPIDSFAMSGFDGTPLYEYTRNPSPLHPHWHTYTFDYAKPEVCNFLLGSVLFWIDKMHVDGIRVDAVSSMLYLDYGRYAGEWVPNRYGGRENLDAIRFLQQFNTVIHEKYPGVLTFAEESTTFPKITVSVEEGGLGFDYKWNMGWMHDTLHYFEKDFPYRPYHQSDLTFPQWYAFSERFLLPFSHDEVVHGKRSLIGKMPGDAWRQFAQLRLLLGYQICQPGKKLLFMGGEFGQGREWSPGRELDWELLDISYHQGVHLCSQELNALYVQSPQLWQADHLPSSFRWVDFSDVRNGVVAYLRFADADAKKALLCVHHFGVGYFPHYLLPILPLESCDLLMNTDDTRFGGSGKGFREPEILTPEIARQEREAAGLIEADDESGPDCWGLDIELPPSATLIFSVTLQ
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
O84874
Q8TCE6
DEN10_HUMAN
Protein FAM45A
Homo
MAAAEVADTQLMLGVGLIEKDTNGEVLWVWCYPSTTATLRNLLLRKCCLTDENKLLHPFVFGQYRRTWFYITTIEVPDSSILKKVTHFSIVLTAKDFNPEKYAAFTRILCRMYLKHGSPVKMMESYIAVLTKGICQSEENGSFLSKDFDARKAYLAGSIKDIVSQFGMETVILHTALMLKKRIVVYHPKIEAVQEFTRTLPALVWHRQDWTILHSYVHLNADELEALQMCTGYVAGFVDLEVSNRPDLYDVFVNLAESEITIAPLAKEAMAMGKLHKEMGQLIVQSAEDPEKSESHVIQDIALKTREIFTNLAPFSEVSADGEKRVLNLEALKQKRFPPATENFLYHLAAAEQMLKI
Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B. Seems to promote the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP-bound form.
Q8TCE6
B3QYJ4
RECR_CHLT3
Recombination protein RecR
Chloroherpeton
MRYTSHAVETLIDEFAKLPGIGRKTAQRLTMFILHEEKEKVESLAQALLDLKNKVSYCSLCQNVTDKEIDPCNICTSVKRDKRVVCVVEAPNDVLAFEKTNQYNGLYHVLHGVISPLDGVGPDDLKVKELIHRLSETDPETSIKEVILAINPTVEGETTVLYLSKLLKPLGVKVTRIARGIPIGTELEYIDDATLTRALEGRSEL
May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
B3QYJ4
B0R6G2
PYRG_HALS3
UTP--ammonia ligase
Halobacterium
MPTETEYDPSLGSKFVFVTGGVMSGLGKGITAASLGRLLSNAGFDVTAVKIDPYLNVDAGTMNPYQHGEVYVLDDGGEVDLDLGNYERFLDEDMTSDHNVTTGKVYQDVIERERSGDYLGKTVQIIPHVTDDIKRRVREAAEGSDVCLVEVGGTVGDIEGMPFLEALRQFSHEQDDEDILFTHVTLVPYSKNGEQKTKPTQHSVKELRSIGLQPDILVGRCEDRLDPDVREKIALFCDVPMDAVFSNPDVEDIYHVPLTVEEEGLDQYVMEQFDMVEDALPAAQRSTEWRDLVTRERTGEVDIALVGKYALEDAYMSIHEALKHASLEAGVEVNVLWVDSEKMHDHHERRIADADGIVVAGGFGSRGTAGKIDAIQHAREHDVPFLGLCLGFQLAVVEYARNVLGMTGAHSAEIDEDTEYPVIDLLPEQYDLEDLGGTMRLGAHETAIEPGTLAHDLYGATSCTERHRHRYEVNPEYIDDLTADGLTFSGEAGNRMEIVEHDDHPFFFGTQFHPEYRSRPTRASPPFVGLLDAVLERADVAPAGSDADVEVTN
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
B0R6G2
Q503L4
IAH1_DANRE
Isoamyl acetate-hydrolyzing esterase 1 homolog
Danio
MSALKRVIWPQIILFGDSITQFAFQANGWGSELCHKLERKCDVINRGLSGYNTRWAKIVLPRIVPVSDAPISAVTVFFGANDCALEDKNPTQHVPLQEFSENLKDIVRFLVSKGVSNDNIIFITPPPLLEADWEKECLLKGSPLNRLNSVAGQYAQACVQAAGESGVDVLDLWTLMQKDGQDFSVYLSDGLHLSDKGNQFVAEHLWTLLERRVSDLPFILPYWGDVDPKCPESSLLCD
Probable lipase.
Q503L4
Q12GX4
EFG1_POLSJ
Elongation factor G 1
unclassified Polaromonas
MSRATPIQNYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHDGAATMDWMEQEQERGITITSAATTCFWKGMDTSLPEHRINIIDTPGHVDFTIEVERSMRVLDGACMVYCAVGGVQPQSETVWRQANKYKVPRLAFVNKMDRTGANFFKVVEQMKLRLKASPVPMVIPIGAEENFTGVVDLLKMKAIIWDEASQGMKFTYSEIPAELVELAKEWREKMVEAAAESSEELMNKYLEEGDLTEAEIKLGIRTRTIASEIQPMYCGSAFKNKGVQRMLDAVIEFMPSPIDIPPVKGMDEDEAPVTRKADDEEKFSALAFKLMTDPFVGQLTFVRVYSGVLKKGDSVYNPIKGKKERIGRIVQMHANNREEVSEIRAGDIAACVGLKDVTTGETLCDPDAIVMLERMVFPEPVITQAVEPKTKADQEKMGIALQRLAQEDPSFRVKTDEESGQTLIAGMGELHLEIIVDRMKREFGVEANVGKPQVAYRETIRKTVEDAEGKFVRQSGGKGQYGHVVLKIEPNEAGKGIEFVDAIKGGVVPREYIPAVEKGINEAVTSGVLAGYPVVDVKVTLHFGSYHDVDSNELAFKMAAIFGFKEGCRKASPVILEPMMAVEVETPEDYAGNVMGDLSSRRGMVQGMEDMVGGGKAIKAEVPLSEMFGYSTTLRSMSQGRATYSMEFKHYSEAPRNVSEAIMASRAK
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Q12GX4
Q9MUJ7
PSAA_ARAAA
PsaA
Araucaria
VERDPIKTSFEKWAKPGHFSKTLSKGPNTTTWIWNLHADAHDFDSHTDDLEEISRKVFSAHFGQLAIILIWLSGMYFHGARFSNYEAWLSDPTHIKPSAQVVWPIVGQEILNGDVGGGFRGIQITSGFFQLWRASGITSELQLYCTAIGGLIFAGLMLFAGWFHYHKAAPKLAWFQDVESMLNHHLAGLLGLGSLSWAGHQVHVSLPINQLLDAGVDPKEIPLPHEFILNRDLLAQLYPSFAKGLTPFFTLNWSEYSDFLTFRGGLNPVTGGLWLTDTVHHHLAIAILFLIAGHMYRTNWSIGHSLKEILEAHKGPFTGEGHKGLYEILTTSWHAQLALNLAMLGSLTIVVAHHMYSMPPYPYLAIDYGTQLSLFTHHMWIGGFLIVGAAAHAAIFMVRDYDPTTQYNNLLDRVLRHRDAIISHLNWVCIFLGFHSFGLYIHNDTMSALGRPQDMFSDTAIQLQPIFAQWIQNTHASAPSLTAPDATASTSLTWGGGDLVAVGNKVALLPIPLGTADFLVHHIHAFTIHVTVLILLKGVLFARSSRLIPDKANLGFRFPCDGPGRGGTCQVSAWDHVFLGLFWMYNAISVVIFHFSWKMQSDVWGSISDQGVVTHITGGNFAQSSITINGWLRDFLWAQASQVIQSYGSSLSAYGLLFLGAHFVWAFSLMFLFSGRGYWQELIESIVWAHNKLKVAPAIQPRALSIVQGRAVGVAH
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin.
Q9MUJ7
Q5FFZ7
LIPB_EHRRG
Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase
Ehrlichia
MEWKIESLPVPYDKAMCFMQQRVEGIANKTQDELVWLLEHFPLYTAGTSARSEELLTDSLFPVYSTGRGGKYTYHGPGQRIAYVMMDLKARDKCNVRLYVETLGEWIVKTLKHFSIRSYFNPNLIGVWVNHNGSEKKIAAFGIRIRKWITYHGVSINVFTDLSHYSGIIPCGIKEYGITSLKTLGVNILYEEFDVVLKKEFNKVFCNC
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
Q5FFZ7
B5FFR4
METE_ALIFM
Methionine synthase, vitamin-B12 independent isozyme
Aliivibrio
MTTESKTKTVTHILGYPRVGAQRELKFAQEKYWRGEIEQKELLAVGSELRQRHWKDQSASGLDFVTAGDFAWYDHVLTTSLLLGHVPARHNNGFPDLDTLFKVGRGQSQNSCGCGEAASDMTKWFNTNYHYIVPEFSKNDKFNVSWSQLFDEIAEAQKQGHNVKPVLLGPLSYLWLGKEVNDEEVEQGFDRLSLLPRLLTAYQAIFSKLSALGVEWVQIDEPILALELPKAWADSFKLAYQVIQSDVKLLLTTYFDGVEHHLDKITKLAVNGLHIDVSAAPDQLDAIVSALPKEWVLSVGAVNGRNVWRADLERLHERLQPVKEALGDKLWIASSCSLLHSPVDLEQETELSKETLQWFAFAKQKLREVTLLADALDGNQNAILACHQYSQPLRERESAEHINKPAVQQRLAAITPALAERAEAYSVRAQHQAEKLGLPLLPTTTIGSFPQTSDIRQQRSAYRTGKLNEQDYVTAMKGHIADAVERQERLDLDVLVHGEAERNDMVEYFAENLNGFQATRFGWVQSYGSRCVKPAIVVADIEREAPITVSWTQYAQSLTTKQMKGMLTGPVTILGWTFPREDITRKEIAQQLALVLRDEVSDLQQAGINIIQIDEPAIREGLPIKKSDQKAYLDWAVEAFKISAASAKSETQIHTHMCYSEFNEIIESVAALDADVITIETSRSNMELLKAFEDFNYPNEIGPGVYDIHSPNIPSQEWIVDLIETAAARVPVERLWVNPDCGLKTRNWKETEAALENMVKAAKALRKKWQSNAA
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
B5FFR4
Q66C72
SYM_YERPS
Methionyl-tRNA synthetase
Yersinia
MAQVAKKILVTCALPYANGSIHLGHMLEHIQADIWVRFQRMRGNQVHFICADDAHGTPIMLKAQQMGIEPEQMIAEMSQEHQQDFAGFAISYDNYHSTHSDENRELSSLIYGRLKANGYIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKAPEQYGDNCEVCGATYSPTELIDPKSAVSGATPVMRESEHFFFDLPAFSDMLQAWTRSGALQEQVANKMQEWFDSGLQQWDITRDAPYFGFEVPDAPGKYFYVWLDAPIGYMGAFKNLCDKRGDLDFDEFWGKDAKTDLYHFIGKDIVYFHSLFWPAMLEGSNFRKPTNLFVHGYVTVNGAKMSKSRGTFIKAGTYLKYLDADCLRYYYAAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFAGQLADQLADPVLYKTFTDAATSIADAYNNRESGKAIREIMALADVANRYVDEQAPWVVAKQEGHDADLHAICSMGINLFRVLMTYLKPVLPSLTERTEAFLNTELTWDSIEQPLLGHSITAFKALFNRIDLDKVNEMVASSKEDMAPATRVTGPLADDPIQETISFDDFAKVDMRIALIQQAEFVEGSDKLLKLTLELGGETRQIFSGIRSAYPDPKALEGRMTVMVANLAPRKMRFGVSEGMVMTAGPGGSDIFLLSPDSGAQPGMQVK
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Q66C72
Q9A0A6
Y865_STRP1
DegV domain-containing protein SPy_0865/M5005_Spy0672
Streptococcus
MKLAVITDSTATLPTDLKQDKAIFSLDIPVIIDDETYFEGRNLSIDDFYQKMADSQNLPKTSQPSLSELDNLLGLLSSKGYTHVIGLFLAGGISGFWQNIQFLAEEHPEIEMAFPDSKITSAPLGSMVKNVLDWSRQGMTFQAILNKLQEQIDGTTAFIMVDDLNHLVKGGRLSNGSALLGNLLSIKPILRFDEEGKIVVYEKVRTEKKAMKRLVEILNDLIADGQYNVFIIHSKAQDKADYLKRLLQDSGYQYDIEEVHFGAVIATHLGEGAIAFGVTPRL
May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.
Q9A0A6
Q8N3J3
HROB_HUMAN
Homologous recombination OB-fold protein
Homo
MACSLQKLFAVEEEFEDEDFLSAVEDAENRFTGSLPVNAGRLRPVSSRPQETVQAQSSRLLLLHPTAPSEALGLPDLDLCLPASSTPSADSRPSCIGAAPLRPVSTSSSWIGNQRRVTVTEVLRETARPQSSALHPLLTFESQQQQVGGFEGPEQDEFDKVLASMELEEPGMELECGVSSEAIPILPAQQREGSVLAKKARVVDLSGSCQKGPVPAIHKAGIMSAQDESLDPVIQCRTPRPPLRPGAVGHLPVPTALTVPTQQLHWEVCPQRSPVQALQPLQAARGTIQSSPQNRFPCQPFQSPSSWLSGKAHLPRPRTPNSSCSTPSRTSSGLFPRIPLQPQAPVSSIGSPVGTPKGPQGALQTPIVTNHLVQLVTAASRTPQQPTHPSTRAKTRRFPGPAGILPHQQSGRSLEDIMVSAPQTPTHGALAKFQTEIVASSQASVEEDFGRGPWLTMKSTLGLDERDPSCFLCTYSIVMVLRKQAALKQLPRNKVPNMAVMIKSLTRSTMDASVVFKDPTGEMQGTVHRLLLETCQNELKPGSVLLLKQIGVFSPSLRNHYLNVTPNNLVHIYSPDSGDGSFLKPSQPFPKDSGSFQHDVAAKPEEGFRTAQNLEAEASPEEELPEADDLDGLLSELPEDFFCGTSS
DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis.
Q8N3J3
Q49162
ACDE1_METMA
ACDS complex carbon monoxide dehydrogenase subunit epsilon 1
Methanosarcina
MVDTTKNTKLFTSYGVTTSKAVNPDMVAKMISKAKRPLFVVGTGVLRPEVLDRAVKIAQKANIPIAATGSSLKGFLDKGVDAKYINLHQLGFYLTDPAWPGLDGKGNYDTIIVLEFKKYYINQVLSGTKNFSNVKAISIGRDYIQNATMSFGNISREDHYAALDELIDNL
Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.
Q49162
Q24QI7
HISZ_DESHY
ATP phosphoribosyltransferase regulatory subunit
Desulfitobacterium
MPRSSLGLRIPEGMHDLLPDELALQEQAETSALDLFKAWAYQKVATPTLEYGACIQPVEEEGDSFFKLFDRQGHVLVLRPELTTSIARMVSTRMRGTAFPLRLCYAADVFRYSKSHKQEFRQVGVELIGSASSAADAEVVALAIEALRKIGGMDFQINLGHMGIFTGIMAELGVPQEFQLHYQEKLARKDFVGIERLVKDYGFETRVQDVLLKLPHLHGKEDMLDQVLEWSRRPSLLEAVNALRQVYRYLKDFGVQDYVSLDLGILRGFSYYTGAVFEGYVPGVGFPVVEGGRYDALYGDFGEDAPATGFAINLKAIIEQMVCSNAERPEVLVYGSDVSKVIAEARKLRQTGKRVEMCLESLTQEQAMESAECKGIKEVVCAR
Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
Q24QI7
A1WW09
DTD_HALHL
Gly-tRNA(Ala) deacylase
Halorhodospira
MITVIQRTGSARVRVGGEVVGEIERGLVALVCAVHGDGSAQAQRLAERVLGYRVFPDAEGRMNGSALDLGCGVLAVPQFTLAADTRKGMRPSFGPAADPQTGQALFETFLEALRERATGPVASGVFGADMQVELVNDGPVTFWLEAPPRPAGPV
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
A1WW09
B5FUG6
GCSP_SALDC
Glycine dehydrogenase (aminomethyl-transferring)
Salmonella
MTQTLSQLENRGAFIERHIGPDAAQQQEMLNAVGAESLNALTGQIVPKDIQLATPPQVGEAATEYAALAELKAIAGRNKRFTSYIGMGYTAVQLPPVILRNMLENPGWYTAYTPYQPEVSQGRLEALLNFQQVTLDLTGLDMASASLLDEATAAAEAMAMAKRVSKLKNANRFFVASDVHPQTLDVVRTRAETFGFDVIVDDAAKALDHQDVFGVLLQQVGSTGEIHDYSALISELKARKVIVSVAADFMALVLLTAPGKQGADIVFGSAQRFGVPMGYGGPHAAFFAAKDEFKRSMPGRIIGVSKDAAGNTALRMAMQTREQHIRREKANSNICTSQVLLANIASLYAVYHGPVGLKRIANRIHRLTDILAAGLQQKGLKLRHAHYFDTLCVEVADKAAVLARAEAAEINLRSDIHNAVGITLDETTTRENVAQLFNVLLGGSHGLNIETLDKDVALDSRSIQQSMLRDDAILTHPVFNRYHSETEMMRYMHSLERKDLALNQAMIPLGSCTMKLNAAAEMIPITWPEFAELHPFCPPEQAEGYHQMISQLSDWLVKLTGYDAVCMQPNSGAQGEYAGLLAIRHYHESRNEGHRDICLIPASAHGTNPASAHMAGMQVVVVACDKNGNIDLDDLRAKAEQHAANLSCIMVTYPSTHGVYEETIREVCEVVHQFGGQVYLDGANMNAQVGITSPGFIGADVSHLNLHKTFCIPHGGGGPGMGPIGVKAHLAPFVPGHSVVQIEGMLTRQGAVSAAPFGSASILPISWMYIRMMGAEGLKQASQVAILNANYIASRLKDAYPVLYTGRDGRVAHECILDIRPLKEETGISELDIAKRLIDYGFHAPTMSFPVAGTLMVEPTESEGKAELDRFIDAMLAIRAEIDQVKAGVWPLEDNPLVNAPHIQSELVAEWAHPYSREVAVFPAGVADKYWPTVKRLDDVYGDRNLFCSCVPISDYQ
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
B5FUG6
Q9LXD9
PME51_ARATH
Pectin methylesterase 51
Arabidopsis
MSSILILLFSLFLFSSPSSSSRHHHHHNSGDTSPVNPSSSLAAQIRLACNATRYPDQCVSSLSEQGRVPPDPKPIQIIHSAISFSFQNLKTAQSKIKSIVDSSVGNLNRTNAANTCLQLLTYSEHRTQSTDQALTRGKIKDARAWMSAALVYQYDSWSALKYVNDTSQVGETMSFLDGLIHVTSNALSMMVSYDNFGDNVASWTYPATERDGFWEKTGPGLGLDPSTGLNLGFPSGLKEDVTVCKDGKCGYKTVQDAVNAAPEDNGMRKFVIKISEGVYEENVIVPFEKKNVVFIGDGMGKTVITGSLNAGMPGITTYNTATVGVVGDGFMARDLTFQNTAGPDAHQAVAFRSDSDFSLIENCEFLGNQDTLYAHGLRQFYKNCRIQGNVDFIFGNSAAVFQDCEILIAPRQINPEKGEKNAVTAQGRIDPSQSTGFVFLNCLINGTEEYMKLFKANPKVHKNFLGRPWKDYSRTVFIGCNLEALITPDGWLPWSGDFALKTLYYGESKNTGPGSDRSQRVSWSSQIPDEHVHVYSVANFIQADEWASMSA
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Q9LXD9
Q5KWS2
APT_GEOKA
Adenine phosphoribosyltransferase
Geobacillus thermoleovorans group
MDLKQYITIVPDFPKPGIMFKDITTLMDNGPAYKYATDQIVQYAREKQIEIVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVVRVEYGLEYGTDVLTMHKDAIKPGQRVLITDDLLATGGTMRATIDLVEQLGGVVAGLAFLIELTELGGRKKLEGYDILTLMQF
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Q5KWS2
Q09485
RAPSN_CAEEL
43 kDa receptor-associated protein of the synapse homolog
Caenorhabditis
MGQRQAKQHMQAGVKLYHQRHYAQAINKWRQSLNRLNNAEDRFITLGYLAQALCDQGEYEGMLSYALSQMQLATDQNDSAMKCEAFLNLAKAYERLADFTKALQYGKASLEHPSMDPRTPGYAHLTIALAHLGMSQFQQCLESFESAMNVANETSDRLLELQICVGLGSLFTLLRDITKALIFLRNALAIVQSVTVDDVHAKYRCLILYHLSVALRMKGSLVDAKEACDEASQLAVEMGNRAIHARCMCSLADIYRELGESEAKETITKSWARYEDAYRVMRGANDKMGEVLVLSSMAKSASESRSHYTGQCECQAIQLNKKCIEIANQIGCKHVVLKCHLRLAELYSQLNDDDSEETARRAASRLTQEMQLFCNFCGQRYGLKDESLQALRCSHIFHEKCLHTYLLQRTDQTCPKCRCRAVLSDNISIRSSIASTIDVQSPSTSFAPPGGVATPLVSAAAELGDITPQATLTRRSQQDKILRGAEKDIDRVDRSLARLKSQQSAAANACSAVAVPSPEVPSTTASCASEPILTASTTSQSHTHSNANHKPPPPPRKPCCSQAALPPSSIVALPPAMPLAEDGPLVITHTPTVTDV
Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction.
Q09485
Q6G5C8
EFTS_BARHE
Elongation factor Ts
Bartonella
MSITAAQVKELRELSGAGMMDCKAALAETNGDMEAAVDWLRKKGIAKADKKAGRTAAEGLIGVVSQDLSAVLVEINSETDFVARNDVFQDIVRNVATAALGTEGSIDAVCASFYPGSEKTVEATIKDAIATIGENMTFRRSAKLSVEDGVVATYIHNSVAEGLGKLGVLVAIETTGNKKAAAAFGRQVAMHIAATNPLALTAEDVDSSAIEREKAIFSEQARQSGKPENIIEKMVEGRMRKFFEEVVLLSQAFVMNPDITVDAALKDAEKSIGAPAKITAFIRFALGEGVEKEESDFAAEVAAAAKG
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Q6G5C8
P84022
SMAD3_HUMAN
SMAD family member 3
Homo
MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
P84022
Q3K5V9
COQ7_PSEPF
2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase
Pseudomonas
MTTQRHYSPIDRLLLQADAAMRTLLPFSGQPYRPSPAIVQPDVQMSDEDIRHVAGLMRINHTGEVCAQALYQGQALTAKLPQVREAMEHAAEEEIDHLVWCEQRIHQLGSHTSVLNPLFYGMSFGIGAVAGLISDKVSLGFVAATEHQVCKHLNEHLEQLPAEDEKSRAILEQMRIDEEHHAESALEAGGFRFPAPVKFGMSLLAKVMTKSTYRI
Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
Q3K5V9
B1M4N1
RNPH_METRJ
tRNA nucleotidyltransferase
Methylobacterium
MRPSKRAADELRPVSLERAVSRYAEGSCLVSFGNTRVLCTASLEERAPPWLRGSGKGWVTAEYAMLPRATHERTRREVGSGKPSGRTQEIQRLIGRSLRAVTNLPAMGERQITIDCDVIQADGGTRTAAITGAWVALHDCFAWMRTRSIISVDPLRDHVAAVSCGLYKGTPVLDLDYAEDSAAETDANFVLTGRGGIVEVQGTAEMEPFTQEQLLELLGLARAGTERLVALQKEAIA
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
B1M4N1
Q8MA04
MATK_CHAGL
Intron maturase
Chaetosphaeridium
MERNKNYYINVFHKQAENDLNFNKFYFYFFQETFYCLAYKQVSYKFLQNNVFIKKKKKFSFFNLKRTIRSMRNQNYKESFFFIEQKKLSKKLLFSKLFYELLQEILKCILEISFKIKKNPKISSYSTMSSIHGPFISFEENLIYFPVAIQSYLPNRVHPELIVRILRSYNLDVNLFHFLRNIVHNGLYILSPPFLLNFGFRSLSTIFFNIYAYEIDLGFLSFLKLQKDLPQKYQTELDIFSSSRKITFYFKNYSDFNNLKKIDQIERKYNNIIDYGPIYYLRYSNILLISLNLIKKNANFFQLIYIRFFHLRFHFLFAKNLVKKISFNQDQIFFLGFLVFFFYTKIQIRIKLKKCLVNFIKLEKKICINVPIKLLIIFLSKNGFCDISGNSKSKLSWSVLQDIEIIEKFRRLWLTISGYYSGSSNKYCLKIVLYILRYSCAKTLACKHKMSLKKIWKKYTLNLSVTLKFQTGKKKFLSFSHFKDFHKDEKSWQLNLKETNSIVYTFWN
Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.
Q8MA04
B0B9I2
RECF_CHLT2
DNA replication and repair protein RecF
Chlamydia
MRVLSLFLKDFRNYTDLRLELGPEMNSIFGLNAQGKTNLLEALYILSLGRSFRTSRLTDAIRFGASHFFIEAVFSHKEVFHTLSIQVDKKGKKILFDGAPITKLSELVGLFPVILFSIKDIAIIEGSPSERRRFLDLLLAQASDKYTEHISLYHKALDQRNASIKAQNQKAISAWNSPLIAYGSLVAFLRNECTKKLNTIFQTLWDNTLKETLSLRYESSLITEESPTLNDIASNYYEQLRIANTKDLDLGYTMVGPHRDELLLTINDLPVAKFSSEGQKHSLLAVLRFAECVYLQEEFCIHPLLCMDDIHACLDQQRLDQLLQLSNSLGQVVTTSTICPDHRSTTSCIFHVTQAQVSLVAPQSL
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
B0B9I2
Q9BUH8
BEGIN_HUMAN
Brain-enriched guanylate kinase-associated protein
Homo
MEKLSALQEQKGELRKRLSYTTHKLEKLETEFDSTRHYLEIELRRAQEELEKVTEKLRRIQSNYMALQRINQELEDKLYRMGQHYEEEKRALSHEIVALNSHLLEAKVTIDKLSEDNELYRKDCNLAAQLLQCSQTYGRVHKVSELPSDFQERVSLHMEKHGCSLPSPLCHPAYADSVPTCVIAKVLEKPDPASLSSRLSDASARDLAFCDGVEKPGPRPPYKGDIYCSDTALYCPEERRRDRRPSVDAPVTDVGFLRAQNSTDSAAEEEEEAEAAAFPAGFQHEAFPSYAGSLPTSSSYSSFSATSEEKEHAQASTLTASQQAIYLNSRDELFDRKPPATTYEGSPRFAKATAAVAAPLEAEVAPGFGRTMSPYPAETFRFPASPGPQQALMPPNLWSLRAKPGTARLPGEDMRGQWRPLSVEDIGAYSYPVSAAGRASPCSFSERYYGGAGGSPGKKADGRASPLYASYKADSFSEGDDLSQGHLAEPCFLRAGGDLSLSPGRSADPLPGYAPSEGGDGDRLGVQLCGTASSPEPEQGSRDSLEPSSMEASPEMHPAARLSPQQAFPRTGGSGLSRKDSLTKAQLYGTLLN
May sustain the structure of the postsynaptic density (PSD).
Q9BUH8
P18779
TERB_ALCSP
Tellurium resistance protein TerB
Alcaligenes
MRMSFFDKVKGALTSGREELTRQVGRYKNKKFMQGTVAVCARIAVASDGVSSEEKQKMIGFLRSSEELKVFDTAEVIEFFNKLVTSFDFDLEIGKGETMKYILALKDQPEAAQLALRVGICR
Not yet known.
P18779
Q32RS9
PSBC_STAPU
Protein CP-43
Staurastrum
MKTLYSLRRFYHVETLFNGNLAVSGRDQETTGFAWWAGNARLINLSGKLLGAHVAHAGLIVFWAGAMNLFEVAHFVPEKPMYEQGLILLPHLATLGWGIGPGGEVVDTFPYFVSGVLHLISSAVLGFGGVYHALIGPETLEESFPFFGYVWKDKNKMTTILGIHLIILGLGAFLLVFKAVWFGGVYDTWAPGGGDVRKITNLTLNPGVIFGYLLKSPFGGEGWIVSVDNMEDIIGGHVWLGAICIFGGIWHILTKPFAWARRAFIWSGEAYLSYSLAAISMMGFIACCFVWFNNTAYPSEFYGPTGPEASQAQAFTFLVRDQRLGANVGSAQGPTGLGKYLMRSPTGEIIFGGETMRFWDLRAPWLEPLRGPNGLDLAKLKKDIQPWQERRSAEYMTHAPLGSLNSVGGVATEINAVNYVSPRSWLSTSHFVLGFFFFIAHLWHAGRARAAAAGFEKGIDRETEPVFFMNPLN
One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII. PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
Q32RS9
C4K2G3
RL18_RICPU
50S ribosomal protein L18
spotted fever group
MRSAKLKFEKRRSRIRHKISKTSHSVRLSIFKSGRHIYAQIIDDSKSITIAAASTLDEKIKKLKKSHCNIENAIKVGEEIAKKADSAGIQDVVFDRGGYKYHGVVKALADAAREKIKF
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
C4K2G3
Q9UBN7
HDAC6_HUMAN
Tubulin-lysine deacetylase HDAC6
Homo
MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNLAEVKKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAPQPAKPRLAERMTTREKKVLEAGMGKVTSASFGEESTPGQTNSETAVVALTQDQPSEAATGGATLAQTISEAAIGGAMLGQTTSEEAVGGATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATLDQTTSEEAPGGTELIQTPLASSTDHQTPPTSPVQGTTPQISPSTLIGSLRTLELGSESQGASESQAPGEENLLGEAAGGQDMADSMLMQGSRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKFGEDMPHPH
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events . Histone deacetylases act via the formation of large multiprotein complexes . In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin . Required for cilia disassembly; via deacetylation of alpha-tubulin . Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy . Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer . In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome . Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy .
Q9UBN7
A0A0E0RXA9
FSL3_GIBZE
Fusarielin biosynthesis cluster protein 3
Fusarium
MSVTRLSEPLQNILLQDLRNFYDRASRIATLSVSAIAAIKSAWTRGSPFAAATALYPTNEEGKYVIQAEGIRMEFTNYGGAVTNLWLNNSRGEEVDIVLGLDHARDYEDYPKNPYLNGAIGRYAGFMRGGRFDMDGESYQVATNAHNGSSTFNGGDRGWGRSILDIGSHTENSITFVLFDRSWNGFPGTAASCLTHTVTPYEWRVAFGVTPTKKPGPINMSQQAFFNLDGFKKKNLTGSVPVSDKTVRDHKLHLPLSGLRFETDALGLSTGDILGNPRGSEYDFWSASRRIGDVLEKPYMGICDRCQKRQYHNHNPSGAYDTIFQLGRSQPWNKEDVPAAILSSPESGISMKLYSDQEALHVHTWSQKEFPLKLKKGQGQGMVPQHGGISFEMQDWPDGLNHPEWRRESKTIWGMDGLYTAFSSYRFSVDKTEP
Epimerase; part of the gene cluster that mediates the biosynthesis of fusarielins F, G and H, decaketide compounds with 5 methylations and a decaline core that act as mycoestrogens as they stimulate growth of MCF-7 breast cancer cells . The initial compound in the pathway is produced by the reducing polyketide synthase FSL1. FSL1 lacks an active enoyl reductase (ER) domain and biosynthesis of fusarielins relies on the trans-acting enoyl reductase FSL5, before it is released through hydrolysis catalyzed by the thioesterase FSL2 . Fusarielins F, G, and H have a C11=C12 cis double bond and is fully reduced between C10 and C11 and between C12 and C13. FSL3 can be involved in the formation of the C11=C12 cis double bond by moving a hypothetical C10=C11 or C12=C13 trans double bond to form prefusarielin . Prefusarielin is oxygenated at C15 and C16 by the cytochrome P450 monooxygenase FSL4, resulting in fusarielin F, which subsequently is epoxidized into fusarielin G by the same enzyme . The final step in the pathway is a reduction of the carboxylic acid moiety to yield fusarielin H via a still undetermined mechanism .
A0A0E0RXA9
P43236
CATK_RABIT
Protein OC-2
Oryctolagus
MWGLKVLLLPVVSFALHPEEILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPPSRSHSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENYGCGGGYMTNAFQYVQRNRGIDSEDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNVNHAVLAVGYGIQKGNKHWIIKNSWGESWGNKGYILMARNKNNACGIANLASFPKM
Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.
P43236
Q97EK1
IF1_CLOAB
Translation initiation factor IF-1
Clostridium
MSKEDVIEMQGTVLESLPNAMFEVELESGQKILAHISGKLRMNFIRILPGDKVTVELSPYDLTRGRITWRAK
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
Q97EK1
P65212
KDPC_MYCBO
Potassium-translocating ATPase C chain
Mycobacterium tuberculosis complex
MRRQLLPALTMLLVFTVITGIVYPLAVTGVGQLFFGDQANGALLERDGQVIGSAHIGQQFTAAKYFHPRPSSAGDGYDAAASSGSNLGPTNEKLLAAVAERVTAYRKENNLPADTLVPVDAVTGSGSGLDPAISVVNAKLQAPRVAQARNISIRQVERLIEDHTDARGLGFLGERAVNVLRLNLALDRL
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
P65212
A7I4X5
RS7_METB6
30S ribosomal protein S7
Methanoregula
MAEAEVKAQPEGDAAPQSKALLFNKWDVSEVKVTDPSLVRYVNLTPQIIPHSCGKFSRQEFNKANMMIVERLINRLMQTENNTGKKQLAIGIVRDAFELINKKTKRNPIEVLVEAIGNTGPREETVRLKYGGINVPKSVDTAPLRRVDSAIGFIAEAVWKSSRKSKKPASAILADELIAASKGDAKCYSVGKKEEKERIAKSAR
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
A7I4X5
Q1MA52
LEUD_RHIL3
Isopropylmalate isomerase
Rhizobium
MDKFVKLTGVAAPLPVVNVDTDMIIPKDYLKTIKRTGLGTGLFAEARYNEDGSENPDFVLNKPAYRDAKILVAGDNFGCGSSREHAPWALLDFGIRCVISTSFADIFYNNCFKNGILPIKVSQEDLDKLMDDASRGSNAILTVDLENLEITGPDGGLIKFDLDEFKRHCLLNGLDDIGLTLEKGKAIDSFEKKNAASHPWAA
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Q1MA52
Q5QP82
DCA10_HUMAN
WD repeat-containing protein 32
Homo
MFPFGPHSPGGDGSAGAGAEEPTPHEGQAAATGPPSPLHPGADATHPPPPARSPRRPGAPSLSPAPRSGELGLPGAPESSTASAPGEPSPPSPPCRRPGPDCRAKSRGRHGLGAGLGGPGARLFGWLKERSLGRGLFVDPARDNFRTMTSLYGSIHPADSVYLSTRTHGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLSEAHEDCVNNIRFLDNRLFATCSDDTTIALWDLRKLNTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRYTEDGCPHKKFFHTRFLMRMRLTPDCSKMLISTSSGYLLILHDLDLTKSLEVGSYPILRARRTTSSSDLTTSSSSSGPRVSGSPCHHSDSNSSEKHMSRASQREGVSPRNSLEVVTPEVLGESDHGNCITSLQLHPKGWATLLRCSSNSDDEECTCVYEFQEGAPVRPVSPRCSLRLTHYIEEANVGRGYIKELCFSPDGRMISSPHGYGIRLLGFDKQCSELVDCLPKEASPLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPKF
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Q5QP82
Q1LUK1
MIC13_DANRE
MICOS complex subunit MIC13
Danio
MAAKIFPVVKFATKVTIAGGALYVAYDSGLLGGSNEGSVALARAKSAIPPAVDEWMKYFGFELPATPKIEFSPLDAWNSGVQKSIHALSVAPSTVGDYTKQGLQYVKDLSK
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MIC10 into the MICOS complex.
Q1LUK1
Q5PGH0
MSBA_SALPA
Lipid A export ATP-binding/permease protein MsbA
Salmonella
MHNDKDLSTWQTFRRLWPTIAPFKAGLIVAGIALILNAASDTFMLSLLKPLLDDGFGKTDRSVLLWMPLVVIGLMILRGITSYISSYCISWVSGKVVMTMRRRLFGHMMGMPVAFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILVVLAPIVSIAIRVVSKRFRSISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNKMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFAILDSEQEKDEGKRVIDRATGDLEFRNVTFTYPGREVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGHILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEEYSREQIEEAARMAYAMDFINKMDNGLDTIIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLMIAHRLSTIEQADEIVVVEDGIIVERGTHSELLAQHGVYAQLHKMQFGQ
Involved in lipopolysaccharide (LPS) biosynthesis. Translocates lipid A-core from the inner to the outer leaflet of the inner membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Q5PGH0
O97398
CTR_PHACE
Chymotrypsin
Phaedon
MKVALVVLALFGVSLAASIDNIEIPPSKNIYVEPINQPEVDPSLEIVNGQEVVPHSIPYQIFLVASAGETSWTCGGSLITKRYVLTAAHCIQGAKSVHVTLGAHNLAKHEASKVTVNGRSWVIHEKYDSTNIDNDIGVIQLERNLTLTRSIQLARLPSLRDVGINLEGRTATVSGWGLTNGIFQTTTDVLRANNTIISNKECNDVFKIVQPTEVCLSIAGGRSACSGDSGGPLVIDNVQHGIVSYGSSYCRSTPSVFTRVSSYLNWLQTHSEWRAQ
Serine protease with chymotryptic and collagenolytic activities.
O97398
Q5L0P0
RNH2_GEOKA
Ribonuclease HII
Geobacillus thermoleovorans group
MKRYTVKDIEALLPKLGADDPRWEMLRQDERKSVQALLARFERQKARRHAIEQRWEELMRYERELYAAGVRRIAGIDEAGRGPLAGPVVAAAVILPKDAYLPGLDDSKRLTPEKREALFAQIEACAVAIGIGIVSAAEIDERNIYEATRQAMAKAVNALSPPPEHLLVDAMAVPCPLPQQRLIKGDANSASIAAASVIAKVTRDRWMKELDRRYPQYGFARHMGYGTPEHFEAIRRYGVTPEHRRSFAPVREVLKASEQL
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Q5L0P0
B4TQ44
END8_SALSV
Endonuclease VIII
Salmonella
MPEGPEIRRAADNLEAAIKGKPLTDVWFAFAQLKPYESQLTGQIVTRIETRGKALLTHFSNGLTLYSHNQLYGVWRVIDTGEIPQTTRILRVRLQTADKTILLYSASDIEMLTADQLTTHPFLQRVGPDVLDARLTPEEVKARLLSPRFRNRQFSGLLLDQAFLAGLGNYLRVEILWQVGLTGQHKAKDLNEAQLNALSHALLDIPRLSYTTRGQADENKHHGALFRFKVFHRDGEACERCGGIIEKTTLSSRPFYWCPHCQK
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
B4TQ44
B4S4S7
RBFA_PROA2
Ribosome-binding factor A
Prosthecochloris
MSIRTGKVSSLLQKELSSIFEKELPRSGPLLTIVEVKVTADLGIARVYVSLIGSEKERGLLMEHLQNETKYIRKLLSSRIRHQFRRIPELEFYEDEQYDKARRIEELLKEALNRPGEEQTES
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.
B4S4S7
O69267
GRPE_LYSSH
HSP-70 cofactor
Lysinibacillus
MIMRRIQVTETTENKDLVQGDVQAETATEEVERSEVQEEIELSVEEQYEANVAELQAKLDDDEENRHLRLRADFDNMRRRQQLDGEAAEKYRAQSLLSDLLPVLDNFERALQVETTSEETASIIKGIEMVYRSLLEATVFEGLQVIKAEGEQFDPNIHQAVMQEQDSEKETGVVLRELQKGYILKDRVLRPTMVSVNE
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
O69267
Q93ZV7
LA1_ARATH
La protein 1
Arabidopsis
MSIPCLTEETAKTVLRQVEFYFSDSNLPIDDFLKKTVTESEDGLVSLALICSFSKMRGYLKLGDSKGDDIPEDTIKAVADTLRTSSALKISDDGKKVGRSTELLKLEDLIEQLNARTVAASPFSYDVKREDVESFFSQYGKVNSVRMPRHVAESRIFSGVALVEFPTEEDAQNVMKQNLVFAGQELELKPKKEFDNEREKDEVKFANYQPQKGSANQKNGSDHKNNSAYEPDYPKGLIISFTLKRSAEEGTTEQKSSEEPTDKTMEESETKPADTPDADKENTGEVQAEGAEDEDDEKEEKGALATHKDNKDVVLREDLKAVFGKFGDVKFVDFKMGSETGYLRFDEPEASQKARAAAVLANEGGLAVKNFIAVLEPVIGEAEKEYWTLLRSKDRFDKGGRGGRGGRRGGRFGRKRGSDSPGGRWNKSQKVEA
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.
Q93ZV7
P15922
PEHX_DICCH
Exo-poly-alpha-D-galacturonosidase
Dickeya
MKVITFSRRSALASIVATCLMSTPALAATAQAPQKLQIPTLSYDDHSVMLVWDTPEDTSNITDYQIYQNGQLIGLASQNNDKNSPAKPYISAFYKSDAANFHHRIVLQNAKVDGLKAGTDYQFTVRTVYADGTTSNDSNTVTTTTTAVPKVINITQYGAKGDGTTLNTSAIQKAIDACPTGCRIDVPAGVFKTGALWLKSDMTLNLLQGATLLGSDNAADYPDAYKIYSYVSQVRPASLLNAIDKNSSAVGTFKNIRIVGKGIIDGNGWKRSADAKDELGNTLPQYVKSDNSKVSKDGILAKNQVAAAVATGMDTKTAYSQRRSSLVTLRGVQNAYIADVTIRNPANHGIMFLESENVVENSVIHQTFNANNGDGVEFGNSQNIMVFNSVFDTGDDSINFAAGMGQDAQKQEPSQNAWLFNNFFRHGHGAVVLGSHTGAGIVDVLAENNVITQNDVGLRAKSAPAIGGGAHGIVFRNSAMKNLAKQAVIVTLSYADNNGTIDYTPAKVPARFYDFTVKNVTVQDSTGSNPAIEITGDSSKDIWHSQFIFSNMKLSGVSPTSISDLSDSQFNNLTFSNLRSGSSPWKFGTVKNVTVDGKTVTP
Contributes significantly to bacterial utilization of polygalacturonate and the induction of pectate lyase in the presence of extracellular pectic polymers.
P15922
B3N666
IHOG_DROER
Interference hedgehog
Sophophora
MTLLTSSLLLFSLLTSRLEAIPVLEKSPAHPAHSAHPAHPSHPSPGVRILRAPESLVAPLGDEVVLECETSLQPERFEWSHRSSRSQGAGFKYLRTGTAKANVSQEAAISRLRVLVREDTLGEYRCVGWFGPLVVTSTIARLELASTSLVGAQESESPLQWRVAAGNSVLWSCGQQVQSNPSASWSYYRNGVEIKPEFIGTNGNLILSNVSSESSGSYSCQATNPASGERIQLPGLLQLQVTPEQRSLSKSPHLLKGQPSSQEITIREGSSLLLLCPGVGSPPPTVVWSSPDVVGAVKNKRSKVFGHALEISDTRVQDAGTYICFQDNGVRPALEHYIKVHVEQPPQIVRPPWADLTNEGDRLKLECEATGVPSPEIYWLLNGHSSIDDTEAELSNNFLILHSVLKRHAGYVQCFARNRLGEHSAGTLLQVNPKQIQEPRESGGTHRPKPNQGSKQKQMYPPSPPNVTRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGKRKNWQTTNDNIPYGKPKWNSELGKSFTASVTDLKPQHTYRFRILAVYSNNDNKESNTSAKFYLQPGAALDPMPVPELLEIEEYSETAVVLHWSLASDADEHLITGYYAYYRPSSSAGEYFKATIEGAHARSFKIAPLETATMYEFKLQSFSAVSASEFSALKQGRTQRPKTSTTEEPTLQMGDRDTTTPSHNETFNMSPMLTGTLGGGAVLTLLLISICLCVCRRRSSRSRGNNPNKPRMAELRDDFVPLGNCSPTKQRQRTRHIHITLNPLAQQQQGMEEKNDTDQDAPYYQRPSSYDYDPGLRRMSSSSLRRSQRTLERAGGSNGSNNGNNNNLNQSTETGPVENPGKPGRVLMKRPRLSSRSENLSSGSLNSVGV
Mediates response to the active Hedgehog (Hh) protein signal in embryos, functioning upstream or at the level of patched (ptc).
B3N666
B0XW47
AMPP3_ASPFC
Prolidase
Aspergillus subgen. Fumigati
MMAAVDAILAGKYPAKAHARRVAESLQSYRNGCPGIVYLEAQKTRLIEDNDEPAPFRQRRPFFYLSGCPLPDSCLVYDLSEDQLTLFIPPVDPEDVIWSGLPMSTEEAQNQYDVDRVLVTTELNSTLASIVSSHGGKAIAFTIADQVSESTQFHGFSEVNHSVLKGVIEQSRVVKDEYEVALLRKANDISAKAHIAAIKASQTAVNEREIEGAFIATCIANGAREQSYHPIVACGENGATLHYGKNDDTLIDPVTNQKKRNVLIDAGGEYRTYCADITRVIPVGGKFTAETRQIYDIVLQMQTECIAMLKEGVQWEDVHAHAHRVAIRGLLKLGILRGAEDEIFEKRVSVAFFPHGLGHYLGMDTHDTGGNPNYADKDTMFRYLRVRGRLPAGSVITVEPGVYFCRFIIEPYIKSPESNKYIDTNVLDRYWRVGGVRIEDNVLVTKDGYDNLTTAPKAVDELERLAAS
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
B0XW47
B5XNB5
RS4_KLEP3
30S ribosomal protein S4
Klebsiella
MARYLGPKLKLSRREGTDLFLKSGVRAIDTKCKIEQAPGQHGARKPRLSDYGVQLREKQKVRRMYGVLERQFRNYYKEAARLKGNTGENLLALLEGRLDNVVYRMGFGATRAEARQLVSHKAIMVNGRVVNIASYQVKANDVVSIREKAKKQSRVKAALELAEQREKPTWLEVDAGKMEGTFKRQPERSDLSADINEHLIVELYSK
With S5 and S12 plays an important role in translational accuracy.
B5XNB5
B3A0M2
SLS4_TRYBB
Sphingomyelin synthase
Trypanosoma
MISYPFFSLSPPGLVPPPMAVPPVEMYSGSFWNRMRKPLPLRTQVIRFTVVFVIVSFILAVALQITHERMPDPKVTKPLPDLGFELLTKVPGMYVLADCCIGFLNILSVFTAFKLYLLHRHCVGSGEPELPCNIPGVSRFFLSVWLCKENCRIELRNIHTIAWIRFITSYALLLLFRSAVIVMTSLPAPDDLCQDPPKIENPVKNVILTVLTAGGGSIHCGDLMYSGHTVILTLHLMFHWIYGAMVHWSFRPVVTVVAIFGYYCIVASRFHYTDDVLVAIYLTIATFIAVGHNADGAPWQLQLFIRWWPCCGANSREVTEDSQPVMVAFKSEELDEMNGVLEGRQKKHGGVGDGESLMFKCGAYV
Bidirectional lipid cholinephosphotransferase capable of converting inositol phosphorylceramide (IPC) to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Essential for viability of the pathogenic bloodstream stage of this human protozoan parasite and, consequently, can be considered as potential drug target.
B3A0M2
B1I5R2
COBQ_DESAP
Cobyric acid synthase
Candidatus Desulforudis
MTARVLMVQGTSSSAGKSLIVAGLCRLYARRGFRVAPFKSQNMALNSYATPDGREIGRAQALQAEAAGVPPHVDMNPILLKPTGEAGSQVVLLGRPLGVYKPANYYALKEKLWPLAAAALDRLRADADLVFAEGAGSPAEINLRPHDIANMEVALYAGASVLLVGDIERGGVFASLLGTMELLAERERELVAGFVVNKFRGDEELLRPGLALIGARTGRPVLGVLPYLHDLHLDEEDSVGLSGRGKAPAPGDLAVAVIRLPRISNYTDFLPLETENGVALCYVDRPQELDGAHAVILPGSKETLADLAWLRRRGLDRALRDFAARGKPLLGICGGFQMLGRTIREGGQTVAGLGLLPVRTRFASEKRTVQVRGVTAEGVWGIPGGLSVRGYEIHRGFSEVCGGRPCFLLGGQGTGLAPEGCAAEEGYVAGTYLHGCFDSDTYRTQWIAAVRRLAGLPARPSEQPGFAARRQRDLDRIADLLAERIGVERLDGILGL
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
B1I5R2
B7LQN3
SYY_ESCF3
Tyrosyl-tRNA synthetase
Escherichia
MASSNLIKQLQERGLVAQVTDEEALAERLAQGPIALYCGFDPTADSLHLGHLVPLLCLKRFQQAGHKPVALVGGATGLIGDPSFKAAERKLNTEETVQEWVDKIRKQVAPFLDFDCGENSAIAANNYDWFGNMNVLTFLRDIGKHFSVNQMINKEAVKQRLNREDQGISFTEFSYNLLQGYDFACLNKLYGVSLQIGGSDQWGNITSGIDLTRRLHQNQVFGLTVPLITKADGTKFGKTEGGAVWLDPKKTSPYKFYQFWINTADADVYRFLKFFTFMSIEEINALEEEDKNSGKAPRAQYVLAEQVTRLVHGEEGLQAAKRITECLFSGSLSALSEADFEQLAQDGVPMVEMEKGADLMQALVDSELQPSRGQARKTIASNAVTINGEKQSDPEYFFKEEDRLFGRFTLLRRGKKNYCLICWK
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
B7LQN3
B2JJK2
ATPD_PARP8
F-type ATPase subunit delta
Paraburkholderia
MAELATIARPYAEALFGVAEAGDIAAWSTLVQELAQVARLPDVLSIASSPKVSRAQISDLLLAAVKSPLKDNAQAKNLVQMLVDNHRLPLLPEIATQFEELKNAREGAADALIVSAFPLEGAQLDGLVASLERKFKRKLKPTVQVDSSLIGGVRVTVGDEVLDTSVRARLASMQTALTA
This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
B2JJK2
Q9ERD9
I23O1_RAT
Indoleamine-pyrrole 2,3-dioxygenase
Rattus
MPHSQISPAEGSRRILEEYHIDEDVGFALPHPLEELPDTYRPWILVARNLPKLIENGKLREEVEKLPTLRTEELRGHRLQRLAHLALGYITMAYVWNRGDDDIRKVLPRNLAVPYCELSEKLGLPPILSYADCVLANWKKKDPNGPMTYENMDILFSFPGGDCDKGFFLVSLMVEIAASPAIKAIPTVSSAVEHQDPKALEKALCSIAASLEKAKEIFKRMRDFVDPDTFFHVLRIYLSGWKGNPKLPEGLLYEGVWDTPKKFSGGSAGQSSIFQSLDVLLGIKHDVGEGSAAEFLQEMREYMPPAHRNFLSSLESAPPVREFVILRRNEDLKEAYNECVNGLVSLRMFHLSIVDTYIVKPSKQKPMGGHKSEEPSNTENRGTGGTDVMNFLRSVKDTTKKALLSWP
Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection.
Q9ERD9
Q75VB5
MATK_QUECE
Intron maturase
Quercus
MEEFQGYLELDRFRQHDFLYPFIFREYSYALAHGHGLNRYMLLENIGYDNKSSLLIVKRLITTMYQQNYLIISANDSKQNPFFGYNKNLHSKILSEGFAIIVEIPFYLRLISSLEGAEIVRFYNLRSIHSIFPFLEEKFPHLNYSADILIPYPAHLEILVQTLRYRVKDASYLHLLRFFLHEYSNCNSLIITNKSISIFSKSNPRFFLFLYNSYLCEYESIFLFLRNQSSHLRLTSSGVLFERLCLYRKIEHFAEVFANDFPVIPCFLKDPFMHYVRYQGKSILASKDTPLLMNKWKSYLVNLWQCHFDVWSHAASIRINQLSKHSLDFLSYFSSVRRNPAVVRNQMLENSFLLNNAPNKLDTIVPIIPLIGSLAKAKFCNAVGHPISKLTRADLSDFEIINRFLHICRNLSHYYSGSSKKKNMYRIKYILRLSCVKTLARKHKSTARAFLKRVDSEFFQEFFTEEGGFISLIFPRASFALRRLYSGRVWYLDIIFINGLSNHE
Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.
Q75VB5
A4XI81
DTD_CALS8
Gly-tRNA(Ala) deacylase
Caldicellulosiruptor
MRAVVQRVKRASVAVDGNAVGEIDKGLCILLGVANDDTEEDANYLCEKIVNLRIFEDETSKFNLSLKDIDGEVLVVSNFTVMGDARKGRRPNFMFAADKEKAERLYNYFVERLKGLAKKVECGIFQAHMEVEIVNDGPVTILLDSKKVF
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
A4XI81
A6WX66
SECB_BRUA4
Protein-export protein SecB
Brucella
MSDKAAGEVKNGNGATAEPSLNILAQYVKDLSFESPGAPLSLRPREKAPSININVNVNANPLSETDFDVVLTLEAKAVDGKDVLFNTELVYGGVFRIQGIPQEHMLPLLFIECPRLLFPFARQIIADATRNGGYPPLMIDPIDFAQMFQQRMAEEQAKSAVKS
One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.
A6WX66
Q2NIC5
CDC6_METST
ORC1-type DNA replication protein
Methanosphaera
MNNIFKTINNKDSIFLTKKYLDHRFIPETLPHRDEKIKSIAQYWVESLDKITPPDITIYGKTGTGKTAVTLYAKKQLEEVAAEQNLNIRVEYIRCTDYNTEYQILARLCQQLGKPVPYRGWTKAEVVNAFRNLFKKNILGEDLILIVILDEVDVILKNDGDNILYTLTRTDNVAITSISNYIDFKQFIKPKVKSSLRDREIVFPPYNAQQLIDILKERSKVSFSEGAISEGVIALCSALAAKEEGDARYALDLLKTSGEIADEKESSVIEESFVKEAKDRIEHSKIIDVVVTLPIQQQKVLESITYLTKKREEITSGRLYEVYQDLAKNDKVSYRRIFDFINELEMLGLISTNTISRGRGKGRTNIITLQCDIELIDKALIYKD
Involved in regulation of DNA replication.
Q2NIC5
O09112
DUS8_MOUSE
Neuronal tyrosine threonine phosphatase 1
Mus
MAGDRLPRKVMDAKKLASLLRGGPGGPLVIDSRSFVEYNSCHVLSSVNICCSKLVKRRLQQGKVTIAELIQPATRSQVDATEPQDVVVYDQSTRDASVLAADSFLSILLSKLDGCFDSVAILTGGFATFSSCFPGLCEGKPATLPSMSLSQPCLPVPSVGLTRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKPDFICESRFMRIPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSLKLLAALQTDGPHLGTPEPLMGPAAGIPLPRLPPSTSESAATGSEAATAAREGSPSAGGDAPIPSTAPATSALQQGLRGLHLSSDRLQDTNRLKRSFSLDIKSAYAPSRRPDFPGPPDPGEAPKLCKLDSPSGGTLGLPSPSPDSPDSVPECRPRPRRRRPPASSPARSPAHGLGLNFGDTARQTPRHGLSALSAPGLPGPGQPAGPGGWVPPLDSPGTPSPDGPWCFSPEGAQGPGAVFSAFGRVSAGAPGPGNSSSSGGGGGGGGGGGGGGGGGGSSSSNSSSSSSSSSSSSSSSSSSSDLRRRDVRTGWPEEPAADAQFKRRSCQMEFEEGMVEGRARGEELAALGKQTSFSGSVEVIEVS
Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation . Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues (Probable).
O09112
Q99PT1
GDIR1_MOUSE
Rho-GDI alpha
Mus
MAEQEPTAEQLAQIAAENEEDEHSVNYKPPAQKSIQEIQELDKDDESLRKYKEALLGRVAVSADPNVPNVIVTRLTLVCSTAPGPLELDLTGDLESFKKQSFVLKEGVEYRIKISFRVNREIVSGMKYIQHTYRKGVKIDKTDYMVGSYGPRAEEYEFLTPMEEAPKGMLARGSYNIKSRFTDDDKTDHLSWEWNLTIKKEWKD
Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.
Q99PT1
P91124
RIC19_CAEEL
ICA1 homolog
Caenorhabditis
MAAQFYERNTSGMNADRFMTRLTDESTVNTMQRHYWTARQFIRTKLGKKEDEHLEASDNELDTCLNLYRSVHGTSFQLLNNVDNYANFLLDETLVQNVLGKYLKEKGKIDKTEAVGRILIAVGRSLLFSSHRLNAARIGVSTFYNKLSVFVERAIGDCSQTIEAVQMCRTEYRGSLLWMKKTSEELDPEVDGSMEKFREAQTTVKSNKERLDRLKTDTLQKVDLLSASRSNLLSYVLTHYQNELYEYYSKTSRAFETLAENINCYNNYDFEILSHLATGTKPERERKSEKEESAKTSQPRGNEEELKNLLFGRESPQFGEEEVQDESRSQCDSPLIEDVDDERRKTGDLLDLESAASIAFPIGPLATLFDTSSFVPPILPPPKPNAVSDDILSLFDGNKANSSGKEASATTMDWQSLIDGFDRENEDNLL
May be involved in neurotransmitter secretion . In association with the GTPase activator protein tbc-8 activates rab-2 during dense core vesicle maturation in cholinergic motoneurons .
P91124
Q5M7E0
F210A_XENLA
Protein FAM210A
Xenopus
MHLLRTLLLRSNTSNISLLTKCSFRASPLHKWPISLRSGSQISLLPTEQKKWLHSQPKQQDTATKTPVHDLPSGIQHQSEETSPSARSSISTDPSSIAEEDPLQDQSIGLLKRFKKTFRQHGKVLIPVHLVTSSIWFGSFYYAAMQGVNVVPFLEYIGLPDGIVNILKNSQGGNALTAYAMYKIATPARYTVTLGGTSVSVKYLRKYGYLSTPPLVKDYFQDRMEETKELFTEKMEETRDIISGKMEETKDRISEKLQETKDRVAFRKKKNEDME
May play a role in the structure and strength of both muscle and bone.
Q5M7E0
Q48AB7
CYOE_COLP3
Heme O synthase
Colwellia
MPSVINTGHHHFSISNIFANWRAYYDITKPKVVALLVLTALVGMSLSVPGALPWQRLIPAMLGIGLLSSAAAAINHIVDEKIDTVMGRTHNRPLPAGKISVTNAIVFATSIALLGFIILYALVNPLTAFLTLAGLVGYSFVYTMYLKRATPQNITIGGLAGAIPPLLGWTAMTNEVVPNALLLVLIIFTWTPPHFWALAIHRKNDYAKVNIPMLPVTHGVSFTKTQILLYTVLLFVVCLLPYLVGMSNWLYLIGACSLNLIFFGYAWQLKFNAKEGTAMATFKFSIIHLMLLFIILLLDHYWLPMG
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
Q48AB7
Q08185
RBS5_MESCR
Ribulose bisphosphate carboxylase small subunit, chloroplastic 5
Mesembryanthemum subgen. Cryophytum
MASSLMSNAATTMAAATTTAQANMVAPFNGLKSISAFPVTRKNNDITSVASNGGRVQCMVWPPLGMKKFETLSYLPPLSEESLLKEVQYLLNNGWVPCLEFEPTHGFVYREHGNTPGYYDGRYWTMWKLPMFGCTDPSQVVAELEEAKKAYPEAFIRIIGFDNVRQVQCVSFIAYKPASYGA
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site. Although the small subunit is not catalytic it is essential for maximal activity.
Q08185
B3PMI7
RS15_META1
30S ribosomal protein S15
Metamycoplasma
MVSKQKIEELVKKFGRNAKDTGHLPVQIAILTEKIESLKKHFEANKKDLHSMRGFIAKVNHRKALLSHLKSSNYELYLETIKALNIRK
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
B3PMI7
P0DD98
RL10_STRP3
50S ribosomal protein L10
Streptococcus
MSEAIIAKKAEQVELIAEKMKAAASIVVVDSRGLTVDQDTVLRRSLRESGVEFKVIKNSILTRAAEKAGLDELKDVFVGPSAVAFSNEDVIAPAKVINDFTKTADALEIKGGAIEGAVSSKEEIQALATLPNREGMLSMLLSVLQAPVRNVAYAVKAVAENKEGAA
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
P0DD98
A9KNS9
END4_LACP7
Endonuclease IV
Lachnospiraceae
MLKIGSHVGMSGKEAFFGSAKEAHSYDANTFMVYTGAPQNTRRKDISDLRLEEGFEFMKQHGISDIVIHAPYIINLGNSVNLDTYSLAVDFLAKEMERTKAFRSKYLVLHPGAHVGAGVDAGIKQIVQGLNEVLTRDTDLYIALETMAGKGSEIGRNFEELARIYDGVKYNDRLRVCFDTCHTNDAGYDVVNDFDGVIEQFDKLIGKEQIAVFHINDSKNDRGASKDRHENIGFGTLGFDAISYIVHHSDFIEVPKILETPYVSLPNEKEKSLPPYRYEIEMLRNSVFDPQILEKIQNNR
Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
A9KNS9
P56579
PTHC_ECOLI
Glucitol/sorbitol permease IIC component
Escherichia
MIETITHGAEWFIGLFQKGGEVFTGMVTGILPLLISLLVIMNALINFIGQHRIERFAQRCAGNPVSRYLLLPCIGTFVFCNPMTLSLGRFMPEKYKPSYYAAASYSCHSMNGLFPHINPGELFVYLGIASGLTTLNLPLGPLAVSYLLVGLVTNFFRGWVTDLTTAIFEKKMGIQLEQKVHLAGATS
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The enzyme II complex composed of SrlA, SrlB and SrlE is involved in glucitol/sorbitol transport. It can also use D-mannitol.
P56579
A1B9F0
TRMFO_PARDP
Folate-dependent tRNA(M-5-U54)-methyltransferase
Paracoccus
MEPIHIIGAGLAGSEAAWQIARAGVPVVLHEMRPQVATFAHRTGDCAEMVCSNSFRSDDDRMNAVGQLHWEMRAAGGLIMAMADRHRLPAGGALAVDRDAFSQAVTQALQAEPLVSFQPGEISDLPSEGHWIVATGPLTSEALGRSIRSLTGEGSLAFFDAIAPIVHAESIDMSICWRQSRYDKGETEEERTAYINCPMTREDYEGFIDALLAADKTEFHEGETAGYFDGCLPIEVMAERGRETLRHGPMKPVGLTNAHNPAEKPYAVVQLRRDNALGTLYNIVGFQTKMKYGAQVDVFRRIPGLQDASFARLGGIHRNTFLNSPRLIDDRLRLRARPHLRFAGQVTGVEGYVESAAMGLLAGRMAAAEALGRDLPPPPATTSMGALVSHITGGADAKTFQPMNVNFGLYPPLDAMRGGRKGRKDRYPAYTDRAKADFQQWVAGES
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
A1B9F0
A8AKQ2
DPO4_CITK8
DNA polymerase IV
Citrobacter
MRKIIHVDMDCFYAAVEMRDNPALRDIPIAIGGSRERRGVISTANYPARKFGVRSAMPTGMALKLCPHLTLLPGRFEAYKEASQHIREIFSRYTSRIEPLSLDEAYLDVTDSTYCHGSATLIAQEIRQTIFNELQLTASAGIAPVKFLAKIASDLNKPNGQYVITPADVPEFLKTLPLGKIPGVGKVSAARLETMGLRTCEDVQKYDLAMLLKRFGKFGRVLWERSQGIDERDVNNERLRKSIGVERTLAEDIHEWAECEAIIERLYPELERRLAKVKPDLLIARQGVKLKFNDFQLTTQEHVWPRLSKDDLITTARKTWNERRGGRGVRLVGLHVTLLDPQLERQLLLGL
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
A8AKQ2
A5VYR4
QUEA_PSEP1
Queuosine biosynthesis protein QueA
Pseudomonas
MRVADFSFELPDSLIARHPLAERHGSRLLVLDGPTGALAHRQFPDLLDYLRPGDLMVFNNTRVIPARLFGQKASGGKLEVLVERVLDSHRVLAHVRASKAPKVGAVILIDGGGEAEMVARHDTLFELRFTEEVLPLLDRVGHMPLPPYIDRPDEGADRERYQTVYAQRAGAVAAPTAGLHFDEALLEKIADKGVERAFVTLHVGAGTFQPVRVDKIEDHHMHKEWLEVGQDVVDAIEACRARGGRVIAVGTTSVRSLESAARDGVLKAFSGDTDIFIYPGRPFHVVDALVTNFHLPESTLLMLVSAFAGYPETMAAYAAAVEHGYRFFSYGDAMFITRNPAPRGPEDQA
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
A5VYR4
P52632
STA5B_RAT
Signal transducer and activator of transcription 5B
Rattus
MAMWIQAQQLQGDALHQMQALYGQHFPIEVRHYLSQWIESQAWDSIDLDNPQENIKATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANNGSSPAGSLADAMSQKHLQINQTFEELRLITQDTESELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRLEHLCQQLPIPGPVEEMLAEVNATITDIISALSTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRRGAESVTEEKFTILFDSQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFREPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNSSSNHLEDYNSMSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVYSKYYTPVPCERATAKAADGYVKPQIKQVVPEFVNASTDAGSGATYMDQAPSPVVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHAQS
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.
P52632
A6V0A6
RLMH_PSEA7
rRNA (pseudouridine-N3-)-methyltransferase RlmH
Pseudomonas
MRLRLIAVGSRMPRWVEEGWQEYVKRLPAELSLELVEIPLNTRGKNADVARLIRQEGEAMLARVQPGERVVTLEVEGRPWSTEQLARELDRWRLDARTVNLMVGGPEGLAPEVCARSEQRWSLSPLTLPHPLVRILVGEQIYRAWTVLSGHPYHK
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
A6V0A6
Q8CIH9
PUR1_MOUSE
Glutamine phosphoribosylpyrophosphate amidotransferase
Mus
MELEELGIREECGVFGCIASGDWPTQLDVPHVITLGLVGLQHRGQESAGIVTSDGSAVPKFRVHKGMGLVNHVFTEDNLKKLYDSNLGIGHTRYATTGKCELENCQPFVVETLHGKIAVAHNGELVNAARLRKKLLRQGIGLSTSSDSEMITQLLAYTPPQEKDDAPDWVARIKNLMKEAPAAYSLVIMHRDFIYAVRDPYGNRPLCIGRLMPVSDVNDKEKKSSETEGWVVSSESCSFLSIGARYCHEVKPGEIVEISRHGIRTLDIIPRSNGDPVAFCIFEYVYFARPDSMFEDQMVYTVRYRCGQQLAIEAPVEADLVSTVPESATPAALGYATKCGLPYVEVLCKNRYVGRTFIQPNMRLRQLGVAKKFGVLSDNFKGKRIVLIDDSIVRGNTISPIIKLLKESGAKEVHIRVASPPIKYPCFMGINIPTKEELIANKPEFDCLAEYLGANSVVYLSVEGLVSSVQQEIKFKKQKVKKHDIAIQENGNGLEYFEKTGHCTACLTGQYPVELEW
Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
Q8CIH9
A8W3C2
RR14_CUSEX
30S ribosomal protein S14, plastid
Cuscuta subgen. Monogynella
MARKSLIQRNKKRQKLELKYHWIRGSSKKEIHRVPLLSDKWEIYVKLQSSPRNSAPTRLHRRCFLTGRPRANYRDFGLSGHILREMVQACLLPGATRSSW
Binds 16S rRNA, required for the assembly of 30S particles.
A8W3C2
A1S6D3
AROA_SHEAM
5-enolpyruvylshikimate-3-phosphate synthase
Shewanella
MDQLRLEPVSRVNGVVNIPGSKSISNRALLLATLASGETTLVNLLDSDDIRHMLNALKSLGVNFTLSDDKTVCTLNGLGGPIQTDKAFELFLGNAGTAMRPLCAALTLGTGEFTLTGEPRMEERPIGDLVDALRQLGADIRYLKNDGFPPLTINATGLAGGVVEIDGSLSSQFLTALLMVAPLAKGAVTIAVKGELVSKPYIDITLDLMAKFGVTVVNDNYQRFEIASGQHYVSPGKVLVEGDASSASYFLAAGAIGGGEVKVTGVGRLAVQGDVKFADALAAMGADIEWGEDYIIARGSKLHGIDMDMNHIPDAAMTIATAALFAEGTTRMSNIYNWRIKETDRLAAMATELRKVGAKVEEGHDYIQITPPVKPVHAEIDTYNDHRMAMCFSLLAFADCGVTINDPGCTSKTFPDYFNRFANLAKPD
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
A1S6D3
Q0ASI7
ENGB_MARMM
Probable GTP-binding protein EngB
Maricaulis
MGAVALDHLPEPDRLEVAFAGRSNVGKSSLINALTNQKGLARASGEPGRTRELNFFNVEGGDLRIVDLPGYGYAKAPKPVVEKWTRLTKAFLRGRVNLKRVYLLIDSRHGLKDVDLKIMDVFDEAAVSYQVVLTKTDKIKPPAVKRLIGETGEKIARRPAAFPRVIATSSAKQDGVDQLRAEIVALLPDMG
Necessary for normal cell division and for the maintenance of normal septation.
Q0ASI7
P48550
KCNJ6_RAT
Potassium channel, inwardly rectifying subfamily J member 6
Rattus
MTMAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYVTSEILWGYRFTPVLTLEDGFYEVDYNSFHETHETSTPSLSAKELAELANRAELPLSWSVSSKLNQHAELETEEEEKNPEELTERNGDVANLENESKV
This potassium channel is controlled by G proteins. It may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium or cesium.
P48550
Q54K00
AATR2_DICDI
Aromatic amino acid aminotransferase DDB_G0287711
Dictyostelium
MTEKSNIIKDYTYFLSKRGKLKEASPIRSLFQYSSLPGMISLGGGLPNASTFPFKSINIELKDGSKLEIEGSDLEEAFQYSPTPGLPRLQKALKDLQIRQHNLCPPDEAGKEWNLIISNGSQESLANAFEVLIDDNDSIITENPTYSGTLSILKPLSLNICGIETDRYGMIPEKLQRLLSEWDHSKFKFPRVIYLIPCGQNPSGTTMNHQRKLDIYSICSKYNLLIIEDDPYYYLQFESSENADDDDGASCSSLNLGKSLLSMDVDGRVLRFDSLSKILSSGLRIGFVTGNKQLLEKINFHQQSTTLHSSGLSQAVVLSLLNKWGVEKWNQHISFIQRFYLEKRNQMIDSIDKHLKGLVEFNIPSAGMFIWFKLPVEDSKTLIFKNAVEKKILLVPGISFSTDSTKPSQFVRASYSTASKEQIDEAIKRFADLLNEELKK
Has aromatic amino acid transaminase activity.
Q54K00
A8F3G2
RIMM_PSELT
Ribosome maturation factor RimM
Pseudothermotoga
MSDYVVIGKITKTHGLFGSVKVLPLTNALEVFQKLENVFIKNDAQSNTHRLQIEEIRKAGKGFLIKFSGIDDEERARKIVGLSLAVRVTDLPKPKSPNEYYYYELLNVEVLDQSGNFIGRVEDIIQTGSNEVAVVKNGSFEMLIPVIHDYIIKFEKRKRLVVKVPEWI
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
A8F3G2
Q7VPP1
ATPG_HAEDU
F-ATPase gamma subunit
Haemophilus
MAGAKEIRTKIASVRNTQKITKAMEMVATSKMRKTQERMAAGRPYSETIRKVISHIAKGSIGYKHPFLIERDVKKVGYLVISTDRGLCGGLNINLFKTTLNEFKAWKDKDVSVELGLVGSKGVSFYQSIGLKVRAHITGLGDSPEMERIVGAVNEMINAYRNGEVDMVCIAYNRFENTMSQKTVIAQLLPLPKLENDELETKCSWDYLYEPNPQVLLDSLLIRYLETQVYQAVVDNLASEQAARMVAMKAATDNAGALIDELQLVYNKARQASITNELNEIVAGAAAI
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
Q7VPP1
Q9UL52
TM11E_HUMAN
Transmembrane protease serine 11E catalytic chain
Homo
MMYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFTTDKLYAEFGREASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHMLLICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHCCGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNPARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSKTGI
Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position.
Q9UL52
Q5WWN7
PROA_LEGPL
Glutamyl-gamma-semialdehyde dehydrogenase
Legionella
MNTDIANQLRAAKKATTDLNLIQSDTRTIILETLAANLEKHIENIIQENQKDLSLMLEQDPRYDRLLLNKERILSLANDVRKVASLPNPLGVSLLEKSMPNGLSIKKITVPLGVIAVIYESRPNVTIDIFSLCFKSGNVCILKGGKEAHFTNSYLLLLIKNTLKNFNINTDIVCLLPPERALMTQLLNATGLVDLCIPRGSQNLINFVRDNAKIPVIETGAGIVHTYFDKSGDLGKGKKIINNAKTRRVSVCNALDTLIIHADRLKDLPELVETLSQKHVIIYADQDAYHVLDKNYPEQLLIKAKPQDFGHEFLDYKLAIKTVPNIKAAIGHIQQFSSHHSEAIIAEDESAIDQFLIEVDAAAVYANASTAFTDGGEFGLGAEIGISTQKVHARGPMGLEALTSYKWVIRGTGQIRD
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
Q5WWN7
A0A1D8PDZ1
RL34B_CANAL
60S ribosomal protein L34-B
Candida
MAQRVTYRRRNPYNTRSNKIKVVKTPGGKLVAQHVKKAASRVKCGDCGSALAGISTLRPRQYAQVSKTHKTVQRAYGGSRCANCVKERIVRAFLIEEQKIVKRVLKEQQDKEKKAAKKTGKK
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
A0A1D8PDZ1